Edwin K Silverman

发表

Molecular networks in Network Medicine: Development and applications

Marco Angelini, Jan Baumbach, John Quackenbush, 2020, Wiley interdisciplinary reviews. Systems biology and medicine.

Statistical considerations for the analysis of massively parallel reporter assays data

Corwin M Zigler, Edwin K Silverman, Dandi Qiao, 2020, Genetic epidemiology.

Estimating drivers of cell state transitions using gene regulatory network models

Daniel Schlauch, John Quackenbush, Kimberly Glass, 2016, bioRxiv.

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module

Xiaobo Zhou, Maksim Kitsak, Edwin K Silverman, 2018, Scientific Reports.

PBAT: tools for family-based association studies.

Christoph Lange, Edwin K Silverman, Dawn DeMeo, 2004, American journal of human genetics.

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

Seunggeun Lee, Tamar Sofer, Xihong Lin, 2018, bioRxiv.

On the association analysis of genome‐sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows

Christoph Lange, Edwin K Silverman, Michael H Cho, 2017, Genetic epidemiology.

A global network for network medicine

Jan Baumbach, Edwin K Silverman, Jean-Luc Balligand, 2020, NPJ systems biology and applications.

Combining Disease Models to Test for Gene–Environment Interaction in Nuclear Families

Christoph Lange, Edwin K Silverman, Stijn Vansteelandt, 2011, Biometrics.

A flexible and nearly optimal sequential testing approach to randomized testing: QUICK‐STOP

Ingo Ruczinski, Christoph Lange, Edwin K Silverman, 2019, Genetic epidemiology.

Network medicine approaches to the genetics of complex diseases.

Edwin K Silverman, Joseph Loscalzo, E. Silverman, 2012, Discovery medicine.

Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease.

Yasutaka Nakano, Edwin K Silverman, Emiel F M Wouters, 2008, American journal of respiratory and critical care medicine.

Genomic screening and replication using the same data set in family-based association testing

Christoph Lange, Kristel Van Steen, Edwin K Silverman, 2005, Nature Genetics.

Imaging Advances in Chronic Obstructive Pulmonary Disease. Insights from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) Study

Raúl San José Estépar, Edwin K Silverman, Eric A Hoffman, 2019, American journal of respiratory and critical care medicine.

Testing and Estimating Gene–Environment Interactions in Family‐Based Association Studies

Christoph Lange, Edwin K Silverman, Kady Schneiter, 2008, Biometrics.

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Yang Sun, Lester Kobzik, Weiliang Qiu, 2016, American journal of respiratory and critical care medicine.

Characterisation of COPD heterogeneity in the ECLIPSE cohort

Edwin K Silverman, Bartolome Celli, Ruth Tal-Singer, 2010, Respiratory research.

Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD.

Raúl San José Estépar, Shin Matsuoka, Edwin K Silverman, 2010, Respiratory medicine.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Harry J de Koning, Edwin K Silverman, Matthijs Oudkerk, 2017, Nature Genetics.

Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice

John Quackenbush, Kimberly Glass, Guo-Cheng Yuan, 2015, Nature Medicine.

CT metrics of airway disease and emphysema in severe COPD.

Raúl San José Estépar, Edwin K Silverman, Raúl San José Estépar, 2009, Chest.

Chronic obstructive pulmonary disease phenotypes: the future of COPD.

Edwin K Silverman, Jonathan G Goldin, Emiel F M Wouters, 2010, American journal of respiratory and critical care medicine.

Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.

John Quackenbush, Christoph Lange, Weiliang Qiu, 2015, Human molecular genetics.

Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis.

Courtney Crim, Edwin K Silverman, Ruth Tal-Singer, 2015, Annals of the American Thoracic Society.

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

Ingo Ruczinski, Christoph Lange, James W Baurley, 2009, American journal of human genetics.

PRIMUS: rapid reconstruction of pedigrees from genome-wide estimates of identity by descent.

Jeffrey Staples, Edwin K Silverman, Deborah A Nickerson, 2014, American journal of human genetics.

COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Nicola A Hanania, Jennifer G. Dy, Raúl San José Estépar, 2019, Chronic obstructive pulmonary diseases.

The clinical and genetic features of COPD-asthma overlap syndrome

Edwin J R van Beek, Edwin K Silverman, Craig P Hersh, 2014, European Respiratory Journal.

A genome-wide association study of chronic obstructive pulmonary disease in Hispanics.

Qi Yan, Wei Chen, Edwin K Silverman, 2015, Annals of the American Thoracic Society.

SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development.

Edwin K Silverman, Véronique Lefebvre, Craig P Hersh, 2011, American journal of respiratory and critical care medicine.

Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Seung Han Baek, Shikang Liu, Edwin K Silverman, 2019, Human molecular genetics.

Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

Christoph Lange, Edwin K Silverman, Ross Lazarus, 2009, American journal of respiratory and critical care medicine.

Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study.

Raúl San José Estépar, Christoph Lange, Edwin K Silverman, 2014, Annals of the American Thoracic Society.

Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort

Ingo Ruczinski, Edwin K Silverman, Douglas Curran-Everett, 2016, Genetic epidemiology.

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.

Edwin K Silverman, Michael H Cho, Craig P Hersh, 2012, Human molecular genetics.

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Edwin K Silverman, Michael H Cho, Craig P Hersh, 2014, Respiratory Research.

GOLD 2011 disease severity classification in COPDGene: a prospective cohort study.

Edwin K Silverman, Douglas Curran-Everett, Terri H Beaty, 2013, The Lancet. Respiratory medicine.

Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta‐analysis of 16,707 Subjects

Edwin K Silverman, Terri H Beaty, Michael H Cho, 2017, American journal of respiratory cell and molecular biology.

A Family-Based Association Test for Repeatedly Measured Quantitative Traits Adjusting for Unknown Environmental and/or Polygenic Effects

Christoph Lange, Edwin K Silverman, Scott T Weiss, 2004, Statistical applications in genetics and molecular biology.

Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.

Edwin K Silverman, Michael H Cho, Eric A Hoffman, 2011, American journal of respiratory and critical care medicine.

Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema.

Edwin K Silverman, Craig P Hersh, Rasika A Mathias, 2009, American journal of respiratory cell and molecular biology.

The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease: quantitative CT analysis.

Raúl San José Estépar, Shin Matsuoka, Edwin K Silverman, 2011, Academic radiology.

The SERPINE2 gene is associated with chronic obstructive pulmonary disease.

Christoph Lange, Edwin K Silverman, Scott T Weiss, 2006, American journal of human genetics.

Lung volumes and emphysema in smokers with interstitial lung abnormalities.

Katherine P Andriole, Raúl San José Estépar, Ramin Khorasani, 2011, The New England journal of medicine.

Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.

Edwin K Silverman, Scott T Weiss, Elad Ziv, 2004, American journal of respiratory and critical care medicine.

Airway wall attenuation: a biomarker of airway disease in subjects with COPD.

Raúl San José Estépar, Shin Matsuoka, Edwin K Silverman, 2009, Journal of applied physiology.

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

Edwin K Silverman, Douglas Curran-Everett, Terri H Beaty, 2014, Respiratory Research.

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

Jianwen Cai, Tao Wang, Charles Kooperberg, 2019, PLoS genetics.

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes

Albert-László Barabási, Marc Vidal, Megha Padi, 2017, npj Systems Biology and Applications.

Exacerbations in chronic obstructive pulmonary disease: do they contribute to disease progression?

Edwin K Silverman, E. Silverman, 2007, Proceedings of the American Thoracic Society.

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

Raúl San José Estépar, Edwin K Silverman, Terri H Beaty, 2014, American journal of respiratory and critical care medicine.

Computed Tomography Phenotypes in Severe, Early-Onset Chronic Obstructive Pulmonary Disease

Edwin K Silverman, Craig P Hersh, Francine L Jacobson, 2007, COPD.

Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease.

Edwin K Silverman, Michael H Cho, Craig P Hersh, 2009, American journal of respiratory cell and molecular biology.

DNA methylation profiling in human lung tissue identifies genes associated with COPD

John Quackenbush, Kimberly Glass, Edwin K Silverman, 2016, Epigenetics.

Pulmonary lobe segmentation based on ridge surface sampling and shape model fitting.

Edwin K Silverman, Jennifer Dy, Hiroto Hatabu, 2013, Medical physics.

Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease.

Christoph Lange, Edwin K Silverman, Scott T Weiss, 2004, American journal of respiratory and critical care medicine.

Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease.

Michael Bamshad, Christoph Lange, Edwin K Silverman, 2016, American journal of respiratory and critical care medicine.

Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team.

Courtney Crim, Edwin K Silverman, Bartolome Celli, 2014, American journal of respiratory and critical care medicine.

Family‐Based Rare Variant Association Analysis: A Fast and Efficient Method of Multivariate Phenotype Association Analysis

Sungho Won, Edwin K Silverman, Dandi Qiao, 2016, Genetic epidemiology.

A multivariate family-based association test using generalized estimating equations: FBAT-GEE.

Christoph Lange, Xin Xu, Edwin K Silverman, 2003, Biostatistics.

Identification of early interstitial lung disease in smokers from the COPDGene Study.

Raúl San José Estépar, Shin Matsuoka, Edwin K Silverman, 2010, Academic radiology.

Collapsibility of lung volume by paired inspiratory and expiratory CT scans: correlations with lung function and mean lung density.

Raúl San José Estépar, Shin Matsuoka, Edwin K Silverman, 2010, Academic radiology.

Whole exome sequencing analysis in severe chronic obstructive pulmonary disease

Michael Bamshad, Ingo Ruczinski, Christoph Lange, 2018, Human molecular genetics.

Clinical practice. Alpha1-antitrypsin deficiency.

Edwin K Silverman, E. Silverman, R. Sandhaus, 2009, New England Journal of Medicine.

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Edwin K Silverman, Daniel Bernstein, Kiran Musunuru, 2018, Circulation. Genomic and precision medicine.

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Edwin K Silverman, Vilmundur Gudnason, Thomas Lumley, 2012, American journal of respiratory and critical care medicine.

Quantitative Computed Tomography of the Lungs and Airways in Healthy Nonsmoking Adults

Edwin K Silverman, Douglas Curran-Everett, Eric A Hoffman, 2012, Investigative radiology.

Applying Functional Genomics to Chronic Obstructive Pulmonary Disease.

Edwin K Silverman, E. Silverman, 2018, Annals of the American Thoracic Society.

The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.

Edwin K Silverman, Amund Gulsvik, Per Bakke, 2006, American journal of respiratory and critical care medicine.

Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes.

Nicola A Hanania, Susan Murray, Edwin K Silverman, 2011, Radiology.

CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.

Edwin K Silverman, Michael H Cho, Craig P Hersh, 2012, American journal of respiratory cell and molecular biology.

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Christoph Lange, Manuel Mattheisen, Edwin K Silverman, 2014, The Lancet. Respiratory medicine.

CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study

Edwin K Silverman, Hans-Ulrich Kauczor, Douglas Curran-Everett, 2018, Radiology.

Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers.

Raúl San José Estépar, Shin Matsuoka, Edwin K Silverman, 2010, Chest.

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

Xiaofeng Zhu, Thomas Meitinger, Christoph Lange, 2007, PLoS genetics.

Using the noninformative families in family-based association tests: a powerful new testing strategy.

Christoph Lange, Edwin K Silverman, Dawn DeMeo, 2003, American journal of human genetics.

Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk.

Edwin K Silverman, James D Crapo, Elizabeth A Regan, 2015, Annals of the American Thoracic Society.

IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.

Charlie Strange, Edwin K Silverman, James K Stoller, 2008, American journal of respiratory cell and molecular biology.

Whole‐Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease

Christoph Lange, Edwin K Silverman, Terri H Beaty, 2018, American journal of respiratory cell and molecular biology.

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

Raúl San José Estépar, Edwin K Silverman, Terri H Beaty, 2015, American journal of respiratory and critical care medicine.

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease.

Edwin K Silverman, Scott T Weiss, D C Rao, 2002, American journal of human genetics.

An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease.

Edwin K Silverman, Isabelle Romieu, David Coultas, 2010, American journal of respiratory and critical care medicine.

Apolipoprotein E Genotype Predicts 24-Month Bayley Scales Infant Development Score

Joel Schwartz, Edwin K Silverman, Scott T Weiss, 2003, Pediatric Research.

Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers.

Raúl San José Estépar, Carlos S. Mendoza, Edwin K Silverman, 2013, American journal of respiratory and critical care medicine.

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring

John Quackenbush, Kimberly Glass, Guo-Cheng Yuan, 2015, Genome Medicine.

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

Gonçalo Abecasis, Dan M Roden, Christopher M Haggerty, 2018, JAMA.

CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society.

Edwin K Silverman, Hans-Ulrich Kauczor, Eric A Hoffman, 2015, Radiology.

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Christian Gieger, Ingo Ruczinski, H Lester Kirchner, 2017, Nature Genetics.