P. G. Wells

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Controlling chemical hazards: fundamentals of the management of toxic chemicals

Raymond Côté, P. G. Wells, 1991 .

A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice

P. G. Wells, C. Nicol, Maureen L. Harrison, 1995, Nature Genetics.

Fetal oxidative stress mechanisms of neurodevelopmental deficits and exacerbation by ethanol and methamphetamine.

P. G. Wells, Shama Bhatia, Danielle M. Drake, 2016, Birth defects research. Part C, Embryo today : reviews.

Impact of Oxidative Stress on Development

P. G. Wells, Lutfiya Miller-Pinsler, Aaron M. Shapiro, 2014 .

Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency

P. G. Wells, S. D. de Morais, 1989, Hepatology.

Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoin-enhanced oxidative stress.

P. G. Wells, Julia P Abramov, Julia P. Abramov, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Oxidative damage in chemical teratogenesis.

P. G. Wells, C. Nicol, R. Laposa, 1997, Mutation research.

Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.

P. G. Wells, M. Wiley, N. Shibata, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)‐dependent, reactive oxygen species (ROS)‐mediated mechanism

P. G. Wells, Crystal J J Lee, L. L. Gonçalves, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Enhanced tumorigenesis in p53 knockout mice exposed in utero to high-dose vitamin E.

P. G. Wells, Connie S. Chen, 2006, Carcinogenesis.

In vitro and in vivo biotransformation and covalent binding of benzo(a)pyrene in Gunn and RHA rats with a genetic deficiency in bilirubin uridine diphosphate-glucuronosyltransferase.

P. G. Wells, Z. Hu, Z. Hu, 1992, The Journal of pharmacology and experimental therapeutics.

Modulation of benzo[a]pyrene bioactivation by glucuronidation in lymphocytes and hepatic microsomes from rats with a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.

P. G. Wells, Z. Hu, 1994, Toxicology and applied pharmacology.

Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.

P. G. Wells, D. S. Vienneau, U. DeBoni, 1995, Cancer research.

Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies☆

P. G. Wells, Lutfiya Miller-Pinsler, Aaron M. Shapiro, 2015, Redox biology.

Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.

P. G. Wells, L. Winn, 1999, Free radical biology & medicine.

Effect of thyrotoxicosis on liver blood flow and propranolol disposition after long‐term dosing

P. G. Wells, G. Wilkinson, A. Wood, 1983, Clinical pharmacology and therapeutics.

DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice☆

P. G. Wells, Zhengping Jia, Shama Bhatia, 2019, Redox biology.

Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoin-enhanced oxidative stress.

P. G. Wells, Julia P Abramov, Julia P. Abramov, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Evidence for Ras-dependent signal transduction in phenytoin teratogenicity.

P. G. Wells, L. Winn, 2002, Toxicology and applied pharmacology.

Biochemical toxicology of chemical teratogenesis.

P. G. Wells, L. Winn, Peter G. Wells, 1996, Critical reviews in biochemistry and molecular biology.

Reduced tumorigenesis in p53 knockout mice exposed in utero to low‐dose vitamin E

P. G. Wells, J. Squire, Connie S. Chen, 2009, Cancer.

The Role of Biotransformation in Developmental Toxicity

P. G. Wells, L. Winn, 2018 .

New Zealand white rabbit progeny exposed in utero to methanol are resistant to skeletal anomalies reported for rodents, but exhibit a novel vertebral defect.

P. G. Wells, J. N. Sweeting, 2015, Reproductive toxicology.

Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture

P. G. Wells, Lutfiya Miller-Pinsler, Amy M. Sharma, 2015, Archives of Toxicology.

Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent

P. G. Wells, Lutfiya Miller-Pinsler, 2016, Archives of Toxicology.

The free radical spin trapping agent phenylbutylnitrone reduces fetal brain DNA oxidation and postnatal cognitive deficits caused by in utero exposure to a non-structurally teratogenic dose of ethanol: a role for oxidative stress.

P. G. Wells, Aaron M. Shapiro, Lutfiya Miller, 2013, Free radical biology & medicine.

Embryonic catalase protects against endogenous and phenytoin‐enhanced DNA oxidation and embryopathies in acatalasemic and human catalase‐expressing mice

P. G. Wells, Julia P Abramov, Julia P. Abramov, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

BIOCHEMICAL DETERMINANTS OF CHEMICAL TERATOGENESIS: STUDIES WITH PHENYTOIN, BENZO(A)PYRENE AND RELATED XENOBIOTICS

P. G. Wells, 1993 .

Pharmacological Studies on the in vivo Cataractogenicity of Acetaminophen in Mice and Rabbits

P. G. Wells, P. Basu, M. Avaria, 1988 .

Biochemical changes associated with the potentiation of acetaminophen hepatotoxicity by brief anesthesia with diethyl ether.

P. G. Wells, E. C. To, 1986, Biochemical pharmacology.

Effect of diethyl ether on the bioactivation, detoxification, and hepatotoxicity of acetaminophen in vitro and in vivo.

P. G. Wells, E. C. To, 1986, Advances in experimental medicine and biology.

Cataractogenicity and bioactivation of naphthalene derivatives in lens culture and in vivo.

P. G. Wells, S. Kubow, P. Basu, 1989, Lens and eye toxicity research.

Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation.

P. G. Wells, P. Kim, U. DeBoni, 1997, Free radical biology & medicine.

Receptor- and reactive intermediate-mediated mechanisms of teratogenesis.

P. G. Wells, P. Harper, G. McCallum, 2010, Handbook of experimental pharmacology.

Brain glucose-6-phosphate dehydrogenase protects against endogenous oxidative DNA damage and neurodegeneration in aged mice.

P. G. Wells, W. Jeng, Margaret M. Loniewska, 2013, ACS chemical neuroscience.

Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer.

P. G. Wells, T. J. Preston, M. Wiley, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Oxoguanine Glycosylase 1 Protects Against Methamphetamine-Enhanced Fetal Brain Oxidative DNA Damage and Neurodevelopmental Deficits

P. G. Wells, W. Jeng, Andrea W. Wong, 2008, The Journal of Neuroscience.

Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.

P. G. Wells, L. Winn, 1997, Free radical biology & medicine.

Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species.

P. G. Wells, C. Nicol, R. Laposa, 2005, Toxicology and applied pharmacology.

In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis.

P. G. Wells, B. Lubek, B. Wilson, 1989, Toxicology and applied pharmacology.

12.08 – The Role of Biotransformation in Developmental Toxicity

P. G. Wells, 2010 .

Sensitivity to methylmercury toxicity is enhanced in oxoguanine glycosylase 1 knockout murine embryonic fibroblasts and is dependent on cellular proliferation capacity.

P. G. Wells, J. McPherson, L. Tamblyn, 2013, Toxicology and applied pharmacology.

Oxoguanine glycosylase 1 (OGG1) protects cells from DNA double‐strand break damage following methylmercury (MeHg) exposure

P. G. Wells, J. McPherson, L. Tamblyn, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues.

P. G. Wells, L. Liu, 1995, Free radical biology & medicine.

Free Radical Intermediates of Phenytoin and Related Teratogens

P. G. Wells, T. Parman, Guoman Chen, 1998, The Journal of Biological Chemistry.

Methanol exposure does not produce oxidatively damaged DNA in lung, liver or kidney of adult mice, rabbits or primates.

P. G. Wells, M. Siu, J. N. Sweeting, 2011, Toxicology and applied pharmacology.

Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.

P. G. Wells, P. Kim, 1996, Cancer research.

Cockayne syndrome B protects against methamphetamine-enhanced oxidative DNA damage in murine fetal brain and postnatal neurodevelopmental deficits.

P. G. Wells, Andrea W. Wong, G. McCallum, 2011, Antioxidants & redox signaling.

Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV‐infected patients: toxicological and pathological implications

P. G. Wells, Maureen L. Harrison, S. Walmsley, 1997, AIDS.

An embryoprotective role for glucose‐6‐phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis

P. G. Wells, L. Tsui, J. Zieleński, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity

P. G. Wells, M. Wiley, T. Parman, 1999, Nature Medicine.

Phenytoin covalent binding and embryopathy in mouse embryos co-cultured with maternal hepatocytes from mouse, rat, and rabbit.

P. G. Wells, M. Wiley, T. Ozolins, 1995, Biochemical pharmacology.

Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans

P. G. Wells, J. Oates, P. Stacpoole, 1980, Diabetologia.

Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.

P. G. Wells, J. Zubovits, S. Wong, 1989, Toxicology and applied pharmacology.

In vivo murine studies on the biochemical mechanism of acetaminophen cataractogenicity.

P. G. Wells, L. Winn, B. Lubek, 1995, Canadian journal of physiology and pharmacology.

A developmental role for ataxia-telangiectasia mutated in protecting the embryo from spontaneous and phenytoin-enhanced embryopathies in culture.

P. G. Wells, Y. Bhuller, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Variable in vivo embryoprotective role for ataxia-telangiectasia-mutated against constitutive and phenytoin-enhanced oxidative stress in atm knockout mice.

P. G. Wells, Y. Bhuller, W. Jeng, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

A new target for thalidomide

P. G. Wells, 2018, Nature Chemical Biology.

Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.

P. G. Wells, R. Arlen, 1996, The Journal of pharmacology and experimental therapeutics.

In Utero Origins of Cancer: Maternal Dietary Vitamin E, Fetal Oxidative DNA Damage, and Postnatal Carcinogenesis in p53 Knockout Mice

P. G. Wells, Connie S. Chen, 2004, Annals of the New York Academy of Sciences.

Methanol exposure does not lead to accumulation of oxidative DNA damage in bone marrow and spleen of mice, rabbits or primates

P. G. Wells, M. Siu, J. N. Sweeting, 2011, Molecular carcinogenesis.

Toxicologic enhancement by a combination of drugs which deplete hepatic glutathione: acetaminophen and doxorubicin (adriamycin).

P. G. Wells, J. Oates, R. Harbison, 1980, Toxicology and applied pharmacology.

Methamphetamine oxidative stress, neurotoxicity, and functional deficits are modulated by nuclear factor-E2-related factor 2.

P. G. Wells, Annmarie Ramkissoon, 2015, Free radical biology & medicine.

Developmental role of nuclear factor E2-related factor 2 in mitigating methamphetamine fetal toxicity and postnatal neurodevelopmental deficits.

P. G. Wells, Annmarie Ramkissoon, 2013, Free radical biology & medicine.

Western Analysis of Breast Cancer 1 Protein (BRCA1).

P. G. Wells, Danielle M. Drake, 2019, Methods in molecular biology.

Modulation of embryonic glutathione peroxidase activity and phenytoin teratogenicity by dietary deprivation of selenium in CD-1 mice.

P. G. Wells, T. Ozolins, D. L. Siksay, 1996, The Journal of pharmacology and experimental therapeutics.

Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture

P. G. Wells, Lutfiya Miller-Pinsler, Amy M. Sharma, 2016, Archives of Toxicology.

Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice.

P. G. Wells, M. Wong, Peter G. Wells, 1988, Teratogenesis, carcinogenesis, and mutagenesis.

Prostaglandin H synthase-1-catalyzed bioactivation of neurotransmitters, their precursors, and metabolites: oxidative DNA damage and electron spin resonance spectroscopy studies.

P. G. Wells, Annmarie Ramkissoon, Luisa L. Gonçalves, 2009, Chemical research in toxicology.

Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

P. G. Wells, C. Guillemette, P. A. Gregory, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Oxidative Stress and Species Differences in the Metabolism, Developmental Toxicity, and Carcinogenic Potential of Methanol and Ethanol

P. G. Wells, M. Siu, J. N. Sweeting, 2013 .

Species- and strain-dependent teratogenicity of methanol in rabbits and mice.

P. G. Wells, M. Wiley, M. Siu, 2011, Reproductive toxicology.

Species differences in methanol and formic acid pharmacokinetics in mice, rabbits and primates.

P. G. Wells, M. Siu, J. N. Sweeting, 2010, Toxicology and applied pharmacology.

Rapid and sensitive assays using high-performance liquid chromatography to measure the activities of phase II drug metabolising enzymes: glucuronyl transferase and sulfotransferase.

P. G. Wells, E. C. To, 1984, Journal of chromatography.

Protective role of endogenous catalase in baseline and phenytoin-enhanced neurodevelopmental and behavioral deficits initiated in utero and in aged mice.

P. G. Wells, Aaron M. Shapiro, Audrey A Tran, 2012, Reproductive toxicology.

A high-performance liquid chromatographic assay for reduced and oxidised glutathione in embryonic, neonatal, and adult tissues using a porous graphite electrochemical detector.

P. G. Wells, G. Carro-Ciampi, C. Turner, 1988, Journal of pharmacological methods.

Biochemical mechanisms of drug toxicity

P. G. Wells, D. Grant, J. Uetrecht, 2022, Atkinson's Principles of Clinical Pharmacology.

Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome.

P. G. Wells, S. D. de Morais, J. Uetrecht, 1992, Gastroenterology.

Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains.

P. G. Wells, P. Basu, B. Lubek, 1988, Toxicology and applied pharmacology.

Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations.

P. G. Wells, L. Winn, P. Kim, 1998, The Journal of pharmacology and experimental therapeutics.

Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders

P. G. Wells, Shama Bhatia, Danielle M. Drake, 2019, Birth defects research.

Progression and metastasis in a transgenic mouse breast cancer model: effects of exposure to in vivo hypoxia.

P. G. Wells, R. Hill, T. Kalliomäki, 2009, Cancer letters.

Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model

P. G. Wells, R. Hill, T. Kalliomäki, 2008, BMC Cancer.

Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation

P. G. Wells, Danielle M. Drake, 2021, Redox biology.

Symposium Article GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE

P. G. Wells, C. Guillemette, P. A. Gregory, 2004 .

Atm‐null mice exhibit enhanced radiation‐induced birth defects and a hybrid form of embryonic cell death indicating a teratological suppressor function for ATM

P. G. Wells, R. Laposa, E. Xu, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Hypoxia Provokes Base Excision Repair Changes and a Repair-Deficient, Mutator Phenotype in Colorectal Cancer Cells

P. G. Wells, R. Bristow, S. Gallinger, 2014, Molecular Cancer Research.

Oxidative DNA damage in the in utero initiation of postnatal neurodevelopmental deficits by normal fetal and ethanol-enhanced oxidative stress in oxoguanine glycosylase 1 knockout mice.

P. G. Wells, Lutfiya Miller-Pinsler, Daniel J Pinto, 2015, Free radical biology & medicine.

Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.

P. G. Wells, Jeffrey T Henderson, Gordon P McCallum, 2010, Birth defects research. Part C, Embryo today : reviews.

Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture.

P. G. Wells, L. L. Gonçalves, Crystal J. J. Lee, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity.

P. G. Wells, L. Winn, 1995, Molecular pharmacology.

Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.

P. G. Wells, W. K. Yu, 1995, Toxicology and applied pharmacology.

Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice.

P. G. Wells, H. Vo, 1989, Toxicology and applied pharmacology.

Acute lethal toxicity of hydrocarbons and chlorinated hydrocarbons to two planktonic crustaceans: The key role of organism-water partitioning

P. G. Wells, W. Shiu, D. Mackay, 1986 .

Microscale Testing in Aquatic Toxicology: Advances, Techniques, and Practice

P. G. Wells, C. Blaise, P. Wells, 1997 .

Hyperthermia‐mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer

P. G. Wells, T. Spence, C. Allen, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Neurodegeneration from Drugs and Aging‐Derived Free Radicals

P. G. Wells, Aaron M. Shapiro, Annmarie Ramkissoon, 2013 .

Human interindividual variation in lymphocyte UDP-glucuronosyltransferases as a determinant of in vitro benzo[a]pyrene covalent binding and cytotoxicity.

P. G. Wells, Zhuo-han Hu, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Antisense evidence for nuclear factor-kappaB-dependent embryopathies initiated by phenytoin-enhanced oxidative stress.

P. G. Wells, S. Mémet, Julia C Kennedy, 2004, Molecular pharmacology.

Sex- and OGG1-dependent reversal of in utero ethanol-initiated changes in postnatal behaviour by neonatal treatment with the histone deacetylase inhibitor trichostatin A (TSA) in oxoguanine glycosylase 1 (Ogg1) knockout mice

P. G. Wells, Shama Bhatia, M. Ly, 2021, Toxicology Letters.

Embryonic prostaglandin H synthase‐2 (PHS‐2) expression and benzo[α]pyrene teratogenicity in PHS‐2 knockout mice 1

P. G. Wells, T. Parman, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity.

P. G. Wells, Annmarie Ramkissoon, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Phenytoin embryotoxicity: role of enzymatic bioactivation in a murine embryo culture model.

P. G. Wells, M. Wiley, S. Kubow, 1989, Teratology.

Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.

P. G. Wells, M. Wong, L. M. Helston, 1989, Teratology.

Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.

P. G. Wells, M. Nagai, G S Greco, 1989, Toxicology and applied pharmacology.

Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.

P. G. Wells, J. T. Lum, Peter G. Wells, 1986, Teratology.

Analysis of the toxicologically relevant metabolites of phenytoin in biological samples by high-performance liquid chromatography.

P. G. Wells, J. T. Lum, N. A. Vassanji, 1985, Journal of chromatography.

Human prostaglandin H synthase (hPHS)-1- and hPHS-2-dependent bioactivation, oxidative macromolecular damage, and cytotoxicity of dopamine, its precursor, and its metabolites.

P. G. Wells, Annmarie Ramkissoon, 2011, Free radical biology & medicine.

Quantifying Activity for Repair of the DNA Lesion 8-Oxoguanine by Oxoguanine Glycosylase 1 (OGG1) in Mouse Adult and Fetal Brain Nuclear Extracts Using Biotin-Labeled DNA.

P. G. Wells, Shama Bhatia, 2019, Methods in molecular biology.

Measurement of the Oxidative DNA Lesion 8-Oxoguanine (8-oxoG) by ELISA or by High-Performance Liquid Chromatography (HPLC) with Electrochemical Detection.

P. G. Wells, Danielle M. Drake, Aaron M. Shapiro, 2019, Methods in molecular biology.

Embryonic catalase protects against ethanol embryopathies in acatalasemic mice and transgenic human catalase-expressing mice in embryo culture.

P. G. Wells, Lutfiya Miller-Pinsler, 2015, Toxicology and applied pharmacology.

Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent

P. G. Wells, Lutfiya Miller-Pinsler, 2016, Archives of Toxicology.

A role for glutathione, independent of oxidative stress, in the developmental toxicity of methanol.

P. G. Wells, M. Wiley, M. Siu, 2013, Toxicology and applied pharmacology.

Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice.

P. G. Wells, Aaron M. Shapiro, Lutfiya Miller, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase.

P. G. Wells, Lutfiya Miller, 2011, Toxicology and applied pharmacology.

Tetracycline‐dependent regulation of formamidopyrimidine DNA glycosylase in transgenic mice conditionally reduces oxidative DNA damage in vivo

P. G. Wells, R. Laposa, J. Henderson, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Base excision repair of reactive oxygen species–initiated 7,8-dihydro-8-oxo-2′-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs

P. G. Wells, T. J. Preston, Jeffrey T Henderson, 2009, Molecular Cancer Therapeutics.

Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

P. G. Wells, M. Wong, 1989, Journal of Pharmacology and Experimental Therapeutics.

Erratum: A teratologic suppressor role for p53 in benzo[a]pyrene–treated transgenic p53–deficient mice

P. G. Wells, C. Nicol, Maureen L. Harrison, 1995, Nature Genetics.

Methamphetamine-enhanced embryonic oxidative DNA damage and neurodevelopmental deficits.

P. G. Wells, W. Jeng, Andrea W. Wong, 2005, Free radical biology & medicine.

In vitro bioactivation of phenytoin to a reactive free radical intermediate by prostaglandin synthetase, horseradish peroxidase, and thyroid peroxidase.

P. G. Wells, S. Kubow, Stan Kubow, 1989, Molecular pharmacology.

Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.

P. G. Wells, W. Jeng, 2010, ACS chemical neuroscience.

Prostaglandin H synthase‐catalyzed bioactivation of amphetamines to free radical intermediates that cause CNS regional DNA oxidation and nerve terminal degeneration 1

P. G. Wells, Annmarie Ramkissoon, W. Jeng, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin.

P. G. Wells, L. Winn, P. Kim, 1997, The Journal of pharmacology and experimental therapeutics.

Delayed enhancement of acetaminophen hepatotoxicity by general anesthesia using diethyl ether or halothane.

P. G. Wells, M. Ku, P. Ramji, 1986, Fundamental and applied toxicology : official journal of the Society of Toxicology.

In vitro murine embryotoxicity of cyclophosphamide in embryos co-cultured with maternal hepatocytes: development and application of a murine embryo-hepatocyte co-culture model.

P. G. Wells, M. Wiley, T. Ozolins, 1995, Toxicology.

Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid.

P. G. Wells, G. Kalabis, 1990, Journal of Pharmacology and Experimental Therapeutics.

Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.

P. G. Wells, S. D. de Morais, S. Chow, 1992, Toxicology and applied pharmacology.

DNA Damage and Repair Hypoxia Provokes Base Excision Repair Changes and a Repair-De fi cient , Mutator Phenotype in Colorectal Cancer Cells

P. G. Wells, R. Bristow, S. Gallinger, 2014 .

Expression of human oxoguanine glycosylase 1 or formamidopyrimidine glycosylase in human embryonic kidney 293 cells exacerbates methylmercury toxicity in vitro.

P. G. Wells, T. J. Preston, G. McCallum, 2013, Toxicology and applied pharmacology.

Potential molecular targets mediating chemical teratogenesis: in vitro peroxidase-catalyzed phenytoin metabolism and oxidative damage to proteins and lipids in murine maternal hepatic microsomes and embryonic 9000g supernatant.

P. G. Wells, Ling Liu, L. Liu, 1995, Toxicology and applied pharmacology.

Phenytoin-initiated hydroxyl radical formation: characterization by enhanced salicylate hydroxylation.

P. G. Wells, P. Kim, 1996, Molecular pharmacology.

Antisense Evidence for Nuclear Factor-κB–Dependent Embryopathies Initiated by Phenytoin-Enhanced Oxidative Stress

P. G. Wells, K. Ha, J. Im, 2004 .

In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis.

P. G. Wells, L. Liu, Peter G. Wells, 1994, Toxicology and applied pharmacology.

Differential effects of antiepileptic drugs on neonatal outcomes

Gregory P. Lee, Mike R. Schoenberg, P. G. Wells, 2012, Epilepsy & Behavior.

Evidence for embryonic peroxidase-catalyzed bioactivation and glutathione-dependent cytoprotection in phenytoin teratogenicity: modulation by eicosatetraynoic acid and buthionine sulfoximine in murine embryo culture.

P. G. Wells, M. Wiley, A. F. Miranda, 1994, Toxicology and applied pharmacology.

Characterization of Epigenetic Histone Activation/Repression Marks in Sequences of Genes by Chromatin Immunoprecipitation-Quantitative Polymerase Chain Reaction (ChIP-qPCR).

P. G. Wells, J. Matthews, Shama Bhatia, 2019, Methods in molecular biology.

Breast cancer 1 (BRCA1) protection in altered gene expression and neurodevelopmental disorders due to physiological and ethanol-enhanced reactive oxygen species formation.

P. G. Wells, I. Kerrebijn, Shama Bhatia, 2023, Free radical biology & medicine.

Reduced DNA oxidation in aged prostaglandin H synthase-1 knockout mice.

P. G. Wells, Annmarie Ramkissoon, W. Jeng, 2011, Free radical biology & medicine.

Reduced tumorigenesis in p53 knockout mice exposed in utero to low‐dose vitamin E

P. G. Wells, J. Squire, Connie S. Chen, 2009, Cancer.

Significance of the phenytoin reactive arene oxide intermediate its oxepin tautomer and clinical factors modifying their roles in phenytoin induced teratology

P. G. Wells, R. Harbison, 1980 .

The peroxynitrite pathway in development: phenytoin and benzo[a]pyrene embryopathies in inducible nitric oxide synthase knockout mice.

P. G. Wells, M. Wiley, S. Kasapinovic, 2004, Free radical biology & medicine.

Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase.

P. G. Wells, M. Wiley, M. Siu, 2013, Reproductive toxicology.