Richard Lonsdale

发表

Methodology Development in Directed Evolution: Exploring Options when Applying Triple‐Code Saturation Mutagenesis

Beibei Liu, Ge Qu, Zhoutong Sun, 2018, Chembiochem : a European journal of chemical biology.

Expanding the Armory: Predicting and Tuning Covalent Warhead Reactivity

Richard Lonsdale, Richard A Ward, Nichola L. Davies, 2017, J. Chem. Inf. Model..

Effects of Dispersion in Density Functional Based Quantum Mechanical/Molecular Mechanical Calculations on Cytochrome P450 Catalyzed Reactions.

Adrian J Mulholland, Richard Lonsdale, A. Mulholland, 2012, Journal of chemical theory and computation.

Large-Scale Density Functional Theory Transition State Searching in Enzymes.

Adrian J. Mulholland, Chris-Kriton Skylaris, David J. Wales, 2014, The journal of physical chemistry letters.

Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple Code Saturation Mutagenesis of an Alcohol Dehydrogenase

Manfred T. Reetz, Zhoutong Sun, Guangyue Li, 2016 .

CH‐Activating Oxidative Hydroxylation of 1‐Tetralones and Related Compounds with High Regio‐ and Stereoselectivity.

Gheorghe-Doru Roiban, Richard Lonsdale, Rubén Agudo, 2015 .

Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase

Manfred T. Reetz, Zhoutong Sun, Aitao Li, 2016 .

Compound I reactivity defines alkene oxidation selectivity in cytochrome P450cam.

Adrian J Mulholland, Richard Lonsdale, A. Mulholland, 2010, The journal of physical chemistry. B.

Trends in predicted chemoselectivity of cytochrome P450 oxidation: B3LYP barrier heights for epoxidation and hydroxylation reactions.

Lars Olsen, Patrik Rydberg, Richard Lonsdale, 2014, Journal of molecular graphics & modelling.

Does Compound I Vary Significantly between Isoforms of Cytochrome P450?

Jeremy N. Harvey, Adrian J. Mulholland, Julianna Oláh, 2011, Journal of the American Chemical Society.

Determinants of Reactivity and Selectivity in Soluble Epoxide Hydrolase from Quantum Mechanics/Molecular Mechanics Modeling

Lars Ridder, Adrian J. Mulholland, Richard Lonsdale, 2012, Biochemistry.

In pursuit of an accurate spatial and temporal model of biomolecules at the atomistic level: a perspective on computer simulation

Adrian J. Mulholland, Robin A. Richardson, Sarah A. Harris, 2015, Acta crystallographica. Section D, Biological crystallography.

Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution.

Zhoutong Sun, Manfred T Reetz, Richard Lonsdale, 2015, Angewandte Chemie.

Computational enzymology.

Adrian J Mulholland, Kara E Ranaghan, Richard Lonsdale, 2010, Chemical communications.

Inclusion of Dispersion Effects Significantly Improves Accuracy of Calculated Reaction Barriers for Cytochrome P450 Catalyzed Reactions

Jeremy N. Harvey, Adrian J. Mulholland, Richard Lonsdale, 2010 .

Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single‐ versus Double‐Code Saturation Mutagenesis

Zhoutong Sun, Guangyue Li, Richard Lonsdale, 2016, Chembiochem : a European journal of chemical biology.

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

Carlos G. Acevedo-Rocha, Adrian J. Mulholland, Manfred T. Reetz, 2018 .

Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution.

Zhoutong Sun, Aitao Li, Manfred T Reetz, 2016, Angewandte Chemie.