Thomas Hartung

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Towards tailored assays for cell-based approaches to toxicity testing.

Gian Paolo Rossini, Thomas Hartung, T. Hartung, 2012, ALTEX.

Computational Approaches to Chemical Hazard Assessment

Thomas Hartung, Thomas Luechtefeld, T. Luechtefeld, 2017, ALTEX.

From in vivo to in vitro: The medical device testing paradigm shift.

Thomas Hartung, Dayna Kerecman Myers, Alan M Goldberg, 2017, ALTEX.

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

Martin Paparella, Aldert Piersma, Nathalie Delrue, 2015, Archives of Toxicology.

CIIPro: a new read‐across portal to fill data gaps using public large‐scale chemical and biological data

Hao Zhu, Wenyi Wang, Sunil M. Shende, 2016, Bioinform..

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Barry Hardy, Francois Busquet, Alice Krebs, 2020, ALTEX.

The integrated project ReProTect: a novel approach in reproductive toxicity hazard assessment.

Michael Schwarz, Thomas Hartung, Lars Hareng, 2005, Reproductive toxicology.

t4 Workshop Report

Alexandra Maertens, Thomas Hartung, Jinchun Sun, 2017, ALTEX.

Making big sense from big data in toxicology by read-across.

Thomas Hartung, T. Hartung, 2016, ALTEX.

How will the fabless model survive?

Nick Yu, Thomas Hartung, Felicia James, 2006, DAC '06.

Validation and quality control of replacement alternatives - Current status and future challenges

Mardas Daneshian, Thomas Hartung, Marcel Leist, 2012 .

Systems Toxicology II: A Special Issue.

Thomas Hartung, Shana J Sturla, Robert Kavlock, 2017, Chemical research in toxicology.

Pre-clinical characterization of [11C]R05013853 as a novel radiotracer for imaging of the glycine transporter type 1 by positron emission tomography

Anil Kumar, Yun Zhou, Dean F. Wong, 2013, NeuroImage.

Green Toxicology-Know Early About and Avoid Toxic Product Liabilities.

Alexandra Maertens, Thomas Hartung, T. Hartung, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

Mardas Daneshian, Thomas Hartung, Bastian Zimmer, 2016, ALTEX.

Probabilistic hazard assessment for skin sensitization potency by dose–response modeling using feature elimination instead of quantitative structure–activity relationships

Alexandra Maertens, Thomas Hartung, Thomas Luechtefeld, 2015, Journal of applied toxicology : JAT.

21st Century Cell Culture for 21st Century Toxicology.

Thomas Hartung, David Pamies, T. Hartung, 2017, Chemical research in toxicology.

Mechanistic validation.

Martin Stephens, Sebastian Hoffmann, Thomas Hartung, 2013, ALTEX.

Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Uwe Marx, Scott Boyer, Mardas Daneshian, 2018, ALTEX.

FutureTox III: Bridges for Translation.

Raymond R Tice, Thomas B Knudsen, David Watson, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

t4 report*: Toward Good Read-Across Practice (GRAP) Guidance

Hao Zhu, Mark T. D. Cronin, Alexandra Maertens, 2016, ALTEX.

The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium

Melvin E. Andersen, Patrick D. McMullen, Thomas Hartung, 2016, Front. Pharmacol..

Missing the Difference Between Big Data and Artificial Intelligence in RASAR Versus Traditional QSAR.

Thomas Hartung, Thomas Luechtefeld, Dan Marsh, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

ECVAM Good Cell Culture Practice Task Force Report 1

Michael Balls, David Lewis, Thomas Hartung, 2002, Alternatives to laboratory animals : ATLA.

Alternative in vitro assays in nanomaterial toxicology.

Thomas Hartung, Enrico Sabbioni, T. Hartung, 2011, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.

Uwe Marx, Murat Cirit, Hajime Kojima, 2016, ALTEX.

Food for thought ... on alternative methods for nanoparticle safety testing.

Thomas Hartung, T. Hartung, 2010, ALTEX.

Regulatory acceptance of read-across.

Nicole Kleinstreuer, Thomas Hartung, Thomas Luechtefeld, 2018, ALTEX.

Analysis of Draize Eye Irritation Testing and its Prediction by Mining Publicly Available 2008–2014 REACH Data

Hao Zhu, Alexandra Maertens, Thomas Hartung, 2016, ALTEX.

Toward Good In Vitro Reporting Standards.

Sebastian Hoffmann, Thomas Hartung, Paul Whaley, 2019, ALTEX.

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

Andrew Worth, Stephen W. Edwards, Stefan Scholz, 2014, Regulatory toxicology and pharmacology : RTP.

Integrated testing strategies for safety assessments.

Alexandra Maertens, Thomas Hartung, Andre Kleensang, 2013, ALTEX.

Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare.

Thomas Hartung, Joanne Zurlo, T. Hartung, 2012, ALTEX.

Towards quality assurance and quality control in untargeted metabolomics studies

David M. Herrington, Richard D. Beger, Katrice A. Lippa, 2019, Metabolomics.

Big-data and machine learning to revamp computational toxicology and its use in risk assessment.

Thomas Hartung, Thomas Luechtefeld, Craig Rowlands, 2018, Toxicology research.

The Human Toxome Project

Melvin E Andersen, Alexandra Maertens, Thomas Hartung, 2015, ALTEX.

The exposome - a new approach for risk assessment.

Alexandra Maertens, Thomas Hartung, Denis Sarigiannis, 2020, ALTEX.

Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners

Thomas Hartung, Richard D Beger, John A. Bowden, 2020, Metabolomics.

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems.

Mardas Daneshian, Andras Dinnyes, Paul Jennings, 2018, ALTEX.

Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility

Thomas Hartung, Thomas Luechtefeld, Dan Marsh, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the global performance of eight in silico skin sensitization models using human data.

Alexandra Maertens, Thomas Hartung, Petra Kern, 2020, ALTEX.

Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods.

Bas J Blaauboer, Thomas Hartung, Katya Tsaioun, 2016, ALTEX.

Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry.

Alexandra Maertens, Thomas Hartung, Emily Golden, 2021, ACS sustainable chemistry & engineering.

Alexandra Maertens, Thomas Hartung, Vy Tran, 2021, Frontiers in Artificial Intelligence.

Lipopolysaccharide- and Lipoteichoic Acid-Induced Tolerance and Cross-Tolerance: Distinct Alterations in IL-1 Receptor-Associated Kinase1

Thomas Hartung, T. Hartung, Liwu Li, 2002, The Journal of Immunology.

Food for thought ... on the evolution of toxicology and the phasing out of animal testing.

Thomas Hartung, Marcel Leist, T. Hartung, 2008, ALTEX.

t4 report: Toward Good Read-Across Practice (GRAP) Guidance

Alexandra Maertens, Nicole Kleinstreuer, Thomas Hartung, 2016, ALTEX.

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

Thomas Hartung, Marcel Leist, T. Hartung, 2013, Archives of Toxicology.

A Modular Approach to the ECVAM Principles on Test Validity

Valérie Zuang, Andrew Worth, Silvia Casati, 2004, Alternatives to laboratory animals : ATLA.

The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology.

Mardas Daneshian, Thomas Hartung, Marcel Leist, 2010, ALTEX.

Diagnosis: toxic!--trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations.

Sebastian Hoffmann, Thomas Hartung, T. Hartung, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Food for thought... on animal tests.

Thomas Hartung, T. Hartung, 2008, ALTEX.

Developmental toxicity testing from animal towards embryonic stem cells.

Thomas Hartung, Cristian Pellizzer, Susanne Bremer, 2005, ALTEX.

Toxicity testing in the 21st century: Better results, less use of animals

Daniel Krewski, Thomas Hartung, Kevin M. Crofton, 2008 .

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment.

Hilda Witters, Anne Gourmelon, Emilio Benfenati, 2013, Regulatory toxicology and pharmacology : RTP.

Food for thought... on cell culture.

Thomas Hartung, T. Hartung, 2007, ALTEX.

The dawning of a new age of toxicology.

Thomas Hartung, Marcel Leist, Pierluigi Nicotera, 2008, ALTEX.

Lessons Learned from Alternative Methods and their Validation for a New Toxicology in the 21st Century

Thomas Hartung, T. Hartung, 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

From the exposome to mechanistic understanding of chemical-induced adverse effects.

Benno Schwikowski, Rolf Altenburger, Wibke Busch, 2017, Environment international.

Evidence-based toxicology for the 21st century: opportunities and challenges.

Sebastian Hoffmann, Richard A Becker, Thomas Hartung, 2013, ALTEX.

Animal use for science in Europe.

Mardas Daneshian, Francois Busquet, Thomas Hartung, 2015, ALTEX.

An in vitro pyrogen safety test for immune-stimulating components on surfaces.

Thomas Hartung, T. Hartung, M. Hasiwa, 2007, Biomaterials.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Barry Hardy, Francois Busquet, Alice Krebs, 2019, ALTEX.

Systematic Review of Membrane Components of Gram-Positive Bacteria Responsible as Pyrogens for Inducing Human Monocyte/Macrophage Cytokine Release

Thomas Hartung, T. Hartung, Christoph Rockel, 2012, Front. Pharmacol..

Optimisation of pyrogen testing in parenterals according to different pharmacopoeias by probabilistic modelling.

Sebastian Hoffmann, Thomas Hartung, Thomas Montag, 2005, Journal of endotoxin research.

Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program.

Melvin E Andersen, Richard A Becker, Thomas Hartung, 2014, ALTEX.

Food for Thought … Systems Toxicology

Thomas Hartung, Joanna Jaworska, Leo Bonilla, 2012 .

The Emergence of Systematic Review in Toxicology

Sebastian Hoffmann, Thomas Hartung, Kay Dickersin, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Skin Sensitisation and Epidermal Disposition: The Relevance of Epidermal Disposition for Sensitisation Hazard Identification and Risk Assessment

Silvia Casati, Thomas Hartung, David Basketter, 2007, Alternatives to laboratory animals : ATLA.

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t(4)).

Thomas Hartung, Costanza Rovida, C. Rovida, 2009, ALTEX.

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Melvin E. Andersen, Alexandra Maertens, Thomas Hartung, 2016, Scientific Reports.

Food for thought...on alternative methods for chemical safety testing.

Thomas Hartung, T. Hartung, 2010, ALTEX.

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Takashi Tsukamoto, Thomas Hartung, Justin Hanes, 2016, Proceedings of the National Academy of Sciences.

Novel chemical hazard characterisation approaches

Emilio Benfenati, Thomas Hartung, Elisabet Berggren, 2016 .

3D - a new dimension of in vitro research.

Thomas Hartung, T. Hartung, 2014, Advanced drug delivery reviews.

MPTP’s Pathway of Toxicity Indicates Central Role of Transcription Factor SP1

Alexandra Maertens, Thomas Hartung, Thomas Luechtefeld, 2015, Archives of Toxicology.

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Anna Forsby, Thomas Hartung, András Dinnyés, 2016, Archives of Toxicology.

That which must not, can not be... A reply to the EChA and EDF responses to the REACH analysis of animal use and costs.

Thomas Hartung, Costanza Rovida, 2009, ALTEX.

Food for thought... on evidence-based toxicology.

Thomas Hartung, 2009, ALTEX.

Analysis of Publically Available Skin Sensitization Data from REACH Registrations 2008–2014

Alexandra Maertens, Thomas Hartung, Thomas Luechtefeld, 2016, ALTEX.

Animal testing and its alternatives - the most important omics is economics.

Thomas Hartung, Costanza Rovida, Marcel Leist, 2018, ALTEX.

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain.

Valérie Zuang, Thomas Hartung, Chantra Eskes, 2010, ALTEX.

The value of alternative testing for neurotoxicity in the context of regulatory needs.

Thomas Hartung, Chantra Eskes, Erwin van Vliet, 2006, Environmental toxicology and pharmacology.

A Modular Approach to the Extended One-generation Reproduction Toxicity Study

Thomas Hartung, Matt Dent, George Daston, 2009, Alternatives to laboratory animals : ATLA.

Critical evaluation of the use of dogs in biomedical research and testing in Europe.

Mardas Daneshian, Thomas Hartung, Marcel Leist, 2011, ALTEX.

Inhibition of microglial inflammation by the MLK inhibitor CEP‐1347

Thomas Hartung, Pietro Ghezzi, Marcel Leist, 2005, Journal of neurochemistry.

Food for thought ... on alternative methods for cosmetics safety testing.

Thomas Hartung, T. Hartung, 2008, ALTEX.

ECVAM key area topical toxicity : Update on activities

Valérie Zuang, Thomas Hartung, Chantra Eskes, 2006 .

Food for thought... on the economics of animal testing.

Thomas Hartung, T. Hartung, A. Bottini, 2009, ALTEX.

The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis.

Valérie Zuang, Thomas Hartung, Chantra Eskes, 2007, Toxicology.

Food for Thought ... on mapping the human toxome.

Thomas Hartung, T. Hartung, Mary McBride, 2011, ALTEX.

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Thomas Hartung, Judy Strickland, Daniel P. Russo, 2019, Environmental health perspectives.

Guidance on Good Cell Culture Practice

Michael Balls, Thomas Hartung, Glyn Stacey, 2007 .

The Assessment of Repeated Dose Toxicity In Vitro: A Proposed Approach

Raffaella Corvi, Paul Jennings, Thomas Hartung, 2006, Alternatives to laboratory animals : ATLA.

Toward a 3D model of human brain development for studying gene/environment interactions

Thomas Hartung, Georgina Harris, David Pamies, 2013, Stem Cell Research & Therapy.

Novel Pyrogen Tests Based on the Human Fever Reaction

Thomas Hartung, Sandra Coecke, Matthias Fischer, 2001, Alternatives to laboratory animals : ATLA.

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test.

Mardas Daneshian, Sebastian Hoffmann, Thomas Hartung, 2013, ALTEX.

Cytokine induction by purified lipoteichoic acids from various bacterial species – Role of LBP, sCD14, CD14 and failure to induce IL‐12 and subsequent IFN‐γ release

Thomas Hartung, Siegfried Morath, T. Hartung, 2002, European journal of immunology.

A primer on systematic reviews in toxicology

Julie E Goodman, Sebastian Hoffmann, Thomas Hartung, 2017, Archives of Toxicology.

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation

Thomas Hartung, Sandra Coecke, T. Hartung, 2005, Journal of neurochemistry.

Skin irritation: prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals.

Sebastian Hoffmann, Thomas Hartung, Thomas Cole, 2005, Regulatory toxicology and pharmacology : RTP.

Utility of the adverse outcome pathway concept in drug development

Thomas Hartung, T. Hartung, 2017, Expert opinion on drug metabolism & toxicology.

International validation of pyrogen tests based on cryopreserved human primary blood cells.

Sebastian Hoffmann, Thomas Hartung, Marlies Halder, 2006, Journal of immunological methods.

An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".

Bas J Blaauboer, Edward Carney, Emanuela Corsini, 2011, ALTEX.

Endogenous cortisol determines the circadian rhythm of lipopolysaccharide‐ but not lipoteichoic acid‐inducible cytokine release

Thomas Hartung, Florian Gantner, Albrecht Wendel, 2006, European journal of immunology.

Stage‐specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Katharina Nöh, Sebastian Niedenführ, Falk Schreiber, 2017, Toxicology and applied pharmacology.

Barriers to validation: a report by the European Partnership fo Alternative Approaches to Animal Testing (EPAA) Working Group 5.

Gianni Dal Negro, Thomas Hartung, Irene Manou, 2008, Alternatives to laboratory animals : ATLA.

Optimisation of the Post-validation Process

Thomas Hartung, Barry Phillips, Laura Gribaldo, 2008, Alternatives to laboratory animals : ATLA.

Cell Activation of Human Macrophages by Lipoteichoic Acid Is Strongly Attenuated by Lipopolysaccharide-binding Protein*

Thomas Hartung, Cordula Stamme, T. Hartung, 2006, Journal of Biological Chemistry.

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Ali Khademhosseini, Thomas Hartung, Anthony Atala, 2017, Scientific Reports.

ECVAM retrospective validation of in vitro micronucleus test (MNT)

Raffaella Corvi, Sebastian Hoffmann, Thomas Hartung, 2008, Mutagenesis.

Opinion versus evidence for the need to move away from animal testing.

Thomas Hartung, T. Hartung, 2017, ALTEX.

Supporting read-across using biological data.

Nicole Kleinstreuer, Thomas Hartung, Thomas Luechtefeld, 2016, ALTEX.

Systems Toxicology: Real World Applications and Opportunities

Gary R. Mirams, Imran Shah, Paul Jennings, 2017, Chemical research in toxicology.

Guidance on Good Cell Culture Practice

Michael Balls, Thomas Hartung, Glyn Stacey, 2005, Alternatives to laboratory animals : ATLA.

Consensus report on the future of animal-free systemic toxicity testing.

Mardas Daneshian, Thomas B Knudsen, Francois Busquet, 2014, ALTEX.

Dendritic Cells as a Tool for the Predictive Identification of Skin Sensitisation Hazard

Valérie Zuang, Silvia Casati, Thomas Hartung, 2005, Alternatives to laboratory animals : ATLA.

Toward a New Toxicology — Evolution or Revolution?

Thomas Hartung, T. Hartung, 2008, Alternatives to laboratory animals : ATLA.

CD36 is a sensor of diacylglycerides

Thomas Hartung, T. Hartung, B. Beutler, 2005, Nature.

Chemical regulators have overreached

Thomas Hartung, Costanza Rovida, C. Rovida, 2009, Nature.

3S – Systematic, Systemic, and Systems Biology and Toxicology

Raffaella Corvi, Nicole Kleinstreuer, Andre Levchenko, 2019, ALTEX.

The Principles of Weight of Evidence Validation of Test Methods and Testing Strategies

Valérie Zuang, Silvia Casati, Raffaella Corvi, 2006, Alternatives to laboratory animals : ATLA.

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis.

Andre Levchenko, Thomas Hartung, Anna Bal-Price, 2016, Lab on a chip.

Towards quality assurance and quality control in untargeted metabolomics studies

Richard D. Beger, Mukesh Verma, Daniel Raftery, 2019, Metabolomics.

ECVAM's ongoing activities in the area of acute oral toxicity.

Thomas Hartung, Agnieszka Kinsner-Ovaskainen, Pilar Prieto, 2009, Toxicology in vitro : an international journal published in association with BIBRA.

Thresholds of Toxicological Concern - Setting a threshold for testing below which there is little concern.

Thomas Hartung, T. Hartung, 2017, ALTEX.

[Development of a cell culture model for septic shock multiorgan failure]

Thomas Hartung, A. Wendel, 1993, ALTEX.

In vitro pyrogen test--A new test method for solid medical devices.

Thomas Hartung, Richard Zeller, Albrecht Wendel, 2007, Journal of biomedical materials research. Part A.

International validation of novel pyrogen tests based on human monocytoid cells.

Sebastian Hoffmann, Thomas Hartung, Sandra Coecke, 2005, Journal of immunological methods.

E-cigarettes and the need and opportunities for alternatives to animal testing.

Thomas Hartung, T. Hartung, 2016, ALTEX.

ECVAM's Approach to Intellectual Property Rights in the Validation of Alternative Methods

Thomas Hartung, Jens P. Linge, T. Hartung, 2007, Alternatives to laboratory animals : ATLA.

Evidence-Based Toxicology.

Sebastian Hoffmann, Thomas Hartung, T. Hartung, 2016, Advances in experimental medicine and biology.

Good Cell Culture Practice for stem cells and stem-cell-derived models.

Anton Simeonov, Mardas Daneshian, Yasunari Kanda, 2016, ALTEX.

Good cell culture practices &in vitro toxicology.

Thomas Hartung, Chantra Eskes, Sandra Coecke, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Food for Thought … Integrated Testing Strategies for Safety Assessments

Alexandra Maertens, Thomas Hartung, Andre Kleensang, 2013 .

Mapping the human toxome by systems toxicology.

Liang Zhao, Alexandra Maertens, Thomas Hartung, 2014, Basic & clinical pharmacology & toxicology.

From "Weight of Evidence" to Quantitative Data Integration using Multicriteria Decision Analysis and Bayesian Methods

Igor Linkov, Ivan Rusyn, Thomas Hartung, 2015, ALTEX.

Radiosynthesis of [5-[ 11C]methanesulfonyl-2-((S)-2,2,2- trifluoro-1-methyl-ethoxy)-phenyl]-[5-(tetrahydro-pyran-4-yl)-1, 3-dihydro-isoindol-2-yl]-methanone ([ 11C]RO5013853), a novel PET tracer for the glycine transporter type i (GlyT1)

Thomas Hartung, Daniel P. Holt, Robert F. Dannals, 2011 .

Development, validation and applications of the monocyte activation test for pyrogens based on human whole blood.

Mardas Daneshian, Thomas Hartung, T. Hartung, 2009, ALTEX.

Metabolism: A Bottleneck in In Vitro Toxicological Test Development

Andrew Worth, Silvia Casati, Raffaella Corvi, 2006, Alternatives to laboratory animals : ATLA.

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation.

Paul Jennings, Thomas Hartung, Walter Pfaller, 2004, ALTEX.

t 4 report * Supporting Read-Across Using Biological Data

Nicole Kleinstreuer, Thomas Hartung, Thomas Luechtefeld, 2016 .

Food for thought ... on in silico methods in toxicology.

Sebastian Hoffmann, Thomas Hartung, T. Hartung, 2009, ALTEX.

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 1: technical description.

Paul Jennings, Thomas Hartung, Walter Pfaller, 2004, ALTEX.

Role of Lipoteichoic Acid in the Phagocyte Response to Group B Streptococcus1

Osamu Takeuchi, Douglas T. Golenbock, Thomas Hartung, 2005, The Journal of Immunology.

Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation

Emanuela Corsini, Paul Cullinan, Raymond Agius, 2007, Alternatives to laboratory animals : ATLA.

Protecting more than animals.

Thomas Hartung, Alan M Goldberg, 2006, Scientific American.

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

Thomas Hartung, Hennicke Kamp, Xiaoqi Jiang, 2017, Archives of Toxicology.

Food for Thought ... Read-Across Approaches – Misconceptions , Promises and Challenges Ahead

Richard A. Becker, Thomas Hartung, Nicholas Ball, 2014 .

Correlating in vitro data to in vivo findings for risk assessment.

Thomas Hartung, John C Lipscomb, Donna L Mendrick, 2014, ALTEX.

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.

Valérie Zuang, Sebastian Hoffmann, Thomas Hartung, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

ECVAM's Response to the Changing Political Environment for Alternatives: Consequences of the European Union Chemicals and Cosmetics Policies

Andrew Worth, Silvia Casati, Raffaella Corvi, 2003, Alternatives to laboratory animals : ATLA.

Physiologically-based Kinetic Modelling (PBK Modelling): Meeting the 3Rs Agenda

Ursula Gundert-Remy, Martin Spendiff, Alan Boobis, 2007, Alternatives to laboratory animals : ATLA.

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment.

Thomas Hartung, Beate I Escher, Gerald Ankley, 2016, Environmental science & technology.

CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data.

Daniel P Russo, Thomas Hartung, Judy Strickland, 2016, Bioinformatics.

Cryopreservation of human whole blood for pyrogenicity testing.

Thomas Hartung, Stefan Fennrich, Albrecht Wendel, 2004, Journal of immunological methods.

Systems Toxicology

Thomas B Knudsen, Thomas Hartung, Julia Hoeng, 2015, International journal of toxicology.

t4 Workshop Report*

Alexandra Maertens, Thomas Hartung, Jinchun Sun, 2017, ALTEX.

Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test

Hilda Witters, Alexandra Maertens, Sebastian Hoffmann, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[Detection of Pyrogens using human whole blood]

Thomas Hartung, Albrecht Wendel, T. Hartung, 1996, ALTEX.

From alternative methods to a new toxicology.

Thomas Hartung, T. Hartung, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review.

Sebastian Hoffmann, Richard A Becker, Thomas Hartung, 2016, Environment international.

t 4 Workshop Report * State-ofthe-Art of 3 D Cultures ( Organs-ona-Chip ) in Safety Testing and Pathophysiology

Mardas Daneshian, Thomas Hartung, Robert Landsiedel, 2014 .

Developing microphysiological systems for use as regulatory tools--challenges and opportunities.

Melvin E Andersen, Donald E Ingber, Thomas Hartung, 2014, ALTEX.

Review: Toxicometabolomics

Thomas Hartung, Andre Kleensang, Mounir Bouhifd, 2013, Journal of applied toxicology : JAT.

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

Sangeeta Khare, Carsten Kneuer, Uwe Marx, 2015, ALTEX.

Analysis of Public Oral Toxicity Data from REACH Registrations 2008–2014

Alexandra Maertens, Thomas Hartung, Thomas Luechtefeld, 2016, ALTEX.

The human whole blood pyrogen test - lessons learned in twenty years.

Thomas Hartung, T. Hartung, 2015, ALTEX.

Toxicity Testing in the 21st Century Beyond Environmental Chemicals

David M. Reif, Mardas Daneshian, Jean-Pierre Valentin, 2018, ALTEX.

Biological and medical applications of a brain-on-a-chip

Thomas Hartung, David Pamies, Helena T Hogberg, 2014, Experimental biology and medicine.

Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC - a t4 report.

Thomas Hartung, T. Hartung, 2010, ALTEX.

The need for strategic development of safety sciences.

Francois Busquet, Thomas Hartung, T. Hartung, 2017, ALTEX.

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US.

Thomas Hartung, T. Hartung, 2018, ALTEX.

Designing Validation Studies More Efficiently According to the Modular Approach: Retrospective Analysis of the EPISKIN Test for Skin Corrosion

Sebastian Hoffmann, Thomas Hartung, T. Hartung, 2006, Alternatives to laboratory animals : ATLA.

The Practical Application of Three Validated In Vitro Embryotoxicity Tests

Aldert Piersma, Thomas Hartung, Horst Spielmann, 2006, Alternatives to laboratory animals : ATLA.

Toward a 3 D model of human brain development for studying gene / environment interactions

Thomas Hartung, Georgina Harris, Lena Smirnova, 2015 .

Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats.

Sebastian Hoffmann, Thomas Hartung, Agnieszka Kinsner-Ovaskainen, 2009, Regulatory toxicology and pharmacology : RTP.

Food for thought ... on globalisation of alternative methods.

Thomas Hartung, T. Hartung, A. Bottini, 2007, ALTEX.

Strategies to Replace in Vivo Acute Systemic Toxicity Testing: The Report and Recommendations of ECVAM Workshop 501,2

Silvia Casati, Thomas Hartung, Sandra Coecke, 2004, Alternatives to laboratory animals : ATLA.

In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints.

Thomas Hartung, Erwin van Vliet, Leonora Buzanska, 2010, Neurotoxicology.