Adam J Pawson

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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage‐gated ion channels

Christopher Southan, Stephen PH Alexander, Jörg Striessnig, 2017, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Catalytic receptors

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2017, British journal of pharmacology.

Class A Orphans (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Helen E. Benson, Michael Spedding, Richard R. Neubig, 2020 .

The IUPHAR/BPS Guide to PHARMACOLOGY database (GtoPdb) in 2018: new features and updates

Joanna L. Sharman, Michael Spedding, Jamie A. Davies, 2018 .

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2017, British journal of pharmacology.

Why data citation isn't working, and what to do about it

Peter Buneman, Yinjun Wu, Simon D Harding, 2020, Database J. Biol. Databases Curation.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

Christopher Southan, John A Peters, Elena Faccenda, 2019, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

Accessing Expert‐Curated Pharmacological Data in the IUPHAR/BPS Guide to PHARMACOLOGY

Elena Faccenda, Simon D Harding, Adam J Pawson, 2018, Current protocols in bioinformatics.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channels

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2017, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Christopher Southan, Jörg Striessnig, John A Peters, 2019, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

Christopher Southan, John A Peters, Elena Faccenda, 2019, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

Arthur Christopoulos, Christopher Southan, Jörg Striessnig, 2019, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

Christopher Southan, John A Peters, Elena Faccenda, 2019, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Arthur Christopoulos, Christopher Southan, John A Peters, 2019, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Ligand‐gated ion channels

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors

Christopher Southan, John A Peters, Elena Faccenda, 2019, British journal of pharmacology.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2019, Nucleic Acids Res..

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2020, Immunology.

The Concise Guide to Pharmacology 2013/14: Ligand-Gated Ion Channels

Adam J Pawson, Stephen P. H. Alexander, M. Spedding, 2013, British journal of pharmacology.

A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development

Adam J Pawson, C. Southan, M. Spedding, 2020 .

International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands

Adam J Pawson, Stephen P. H. Alexander, Wen Chiy Liew, 2013, Pharmacological Reviews.

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors

Stephen PH Alexander, John A Peters, Elena Faccenda, 2013, British journal of pharmacology.

Diversity of actions of GnRHs mediated by ligand-induced selective signaling

Adam J Pawson, K. Morgan, R. Millar, 2008, Frontiers in Neuroendocrinology.

Gonadotropin-releasing hormone receptors.

Adam J Pawson, Kevin Morgan, Stuart Maudsley, 2004, Endocrine reviews.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Arthur Christopoulos, Christopher Southan, Stephen PH Alexander, 2017, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Overview

Stephen PH Alexander, John A Peters, Elena Faccenda, 2015, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2017, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2015, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Christopher Southan, Stephen PH Alexander, Eamonn Kelly, 2015, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors

Arthur Christopoulos, Christopher Southan, Stephen PH Alexander, 2017, British journal of pharmacology.

The Concise Guide to Pharmacology 2013/14: Overview

Adam J Pawson, Stephen P. H. Alexander, A. A. Khan, 2013, British journal of pharmacology.

The Concise Guide to Pharmacology 2013/14: Catalytic Receptors

Adam J Pawson, Stephen P. H. Alexander, M. Spedding, 2013, British journal of pharmacology.

International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands

Adam J Pawson, Stephen P. H. Alexander, Wen Chiy Liew, 2013 .

Gonadotrophin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Adam J Pawson, A. IJzerman, L. Heitman, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2017, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2017, British journal of pharmacology.

Approved drug and clinical target curation in the IUPHAR/BPS Guide to PHARMACOLOGY

Adam J. Pawson, Helen E. Benson, Christopher Southan, 2014 .

Cytoskeletal Reorganization Dependence of Signaling by the Gonadotropin-releasing Hormone Receptor*

Adam J Pawson, Stuart Maudsley, R. Millar, 2004, Journal of Biological Chemistry.

Gonadotropin-releasing Hormone-induced Activation of Diacylglycerol Kinase-ζ and Its Association with Active c-Src*

Adam J Pawson, P. Barran, Stuart Maudsley, 2004, Journal of Biological Chemistry.

Nuclear stabilization of beta-catenin and inactivation of glycogen synthase kinase-3beta by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope.

Adam J Pawson, Stuart Maudsley, R. Millar, 2007, Molecular endocrinology.

Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.

Adam J Pawson, K. Tsutsui, H. Parkington, 2008, Endocrinology.

Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical.

Adam J Pawson, Stuart Maudsley, R. Millar, 2003, Endocrinology.

Gonadotropin-Releasing Hormone (GnRH) Antagonists Promote Proapoptotic Signaling in Peripheral Reproductive Tumor Cells by Activating a Gαi-Coupling State of the Type I GnRH Receptor

Adam J Pawson, Stuart Maudsley, R. Millar, 2004, Cancer Research.

GnRH Receptor-Coupling State of the Type Ii α Tumor Cells by Activating a G Promote Proapoptotic Signaling in Peripheral Reproductive Gonadotropin-Releasing Hormone ( GnRH ) Antagonists

Adam J Pawson, Stuart Maudsley, R. Millar, 2004 .

GnRH, Gonadotropins, Gonadal Steroids and Reproduction

Adam J Pawson, A. Thomson, Stuart Maudsley, 2007 .

Gonadotropin-Releasing Hormone Functionally Antagonizes Testosterone Activation of the Human Androgen Receptor in Prostate Cells through Focal Adhesion Complexes Involving Hic-5

Adam J Pawson, A. Thomson, Stuart Maudsley, 2007, Neuroendocrinology.

Targeting mediators of Wnt signalling pathways by GnRH in gonadotropes.

Adam J Pawson, E. Faccenda, E. Stavrou, 2010, Journal of molecular endocrinology.

Nuclear Stabilization of (cid:1) -Catenin and Inactivation of Glycogen Synthase Kinase-3 (cid:1) by Gonadotropin-Releasing Hormone: Targeting Wnt Signaling in the Pituitary Gonadotrope

Adam J Pawson, Stuart Maudsley, R. Millar, 2007 .

Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology

Adam J Pawson, R. Millar, A. Roseweir, 2010, Brain Research.

Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion.

Adam J Pawson, K. Morgan, M. Millar, 2007, Molecular endocrinology.

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for beta-arrestin-independent internalization.

Adam J Pawson, K. Ronacher, R. Millar, 2004, Endocrinology.

Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene.

Adam J Pawson, Stuart Maudsley, Z. Naor, 2007, Molecular endocrinology.

Sheep exhibit novel variations in the organization of the mammalian type II gonadotropin-releasing hormone receptor gene.

Adam J Pawson, K. Morgan, R. Millar, 2004, Endocrinology.

Elucidation of mechanisms of the reciprocal cross talk between gonadotropin-releasing hormone and prostaglandin receptors.

Adam J Pawson, S. Stojilkovic, K. Morgan, 2010, Endocrinology.

A new photoreactive antagonist cross-links to the N-terminal domain of the gonadotropin-releasing hormone receptor

Adam J Pawson, C. McArdle, R. Millar, 1999, Molecular and Cellular Endocrinology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

Arthur Christopoulos, Adam J. Pawson, Michael Spedding, 2019, British Journal of Pharmacology.

The Guide to PHARMACOLOGY portal: A one-stop pharmacology shop

Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, 2013 .

The pituitary effects of GnRH.

Adam J Pawson, A. Mcneilly, A. McNeilly, 2005, Animal reproduction science.

Outside-in and inside-out signaling: the new concept that selectivity of ligand binding at the gonadotropin-releasing hormone receptor is modulated by the intracellular environment.

Adam J Pawson, R. Millar, 2004, Endocrinology.

Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment.

Adam J Pawson, Stuart Maudsley, K. Morgan, 2005, Endocrinology.

Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology.

Adam J Pawson, Stuart Maudsley, K. Morgan, 2003, Reproduction.

The Concise Guide to Pharmacology 2013/14: Transporters

Adam J Pawson, Stephen P. H. Alexander, M. Spedding, 2013, British journal of pharmacology.

Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling.

Adam J Pawson, S. Langdon, Stuart Maudsley, 2008, Molecular endocrinology.

Class A Orphans (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

Adam J Pawson, Stephen P. H. Alexander, Wen Chiy Liew, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.

Adam J Pawson, K. Morgan, R. Millar, 2006, Endocrinology.

A novel mammalian receptor for the evolutionarily conserved type II GnRH

Adam J Pawson, Stuart Maudsley, M. Millar, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity*

Adam J Pawson, P. Barran, M. Bowers, 2005, Journal of Biological Chemistry.

Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization.

Adam J Pawson, E. Faccenda, Stuart Maudsley, 2008, Endocrinology.

GnRH-Mediated DAN Production Regulates the Transcription of the GnRH Receptor in Gonadotrope Cells

Adam J Pawson, P. Barran, Stuart Maudsley, 2007, NeuroMolecular Medicine.

Emerging Targets of the GnRH Receptor: Novel Interactions with Wnt Signalling Mediators

Adam J Pawson, S. Gardner, 2008, Neuroendocrinology.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Adam J Pawson, Stephen P. H. Alexander, L. Kaczmarek, 2021, British journal of pharmacology.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, 2015, Nucleic Acids Res..

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, 2013, Nucleic Acids Res..

A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12.

Adam J Pawson, K. Morgan, D. Conklin, 2003, Endocrinology.

Activation of Mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent

Adam J Pawson, Z. Naor, R. Millar, 2006, Molecular and Cellular Endocrinology.

A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture.

Adam J Pawson, J. Wildenhain, M. Bradley, 2012, Stem cell research.

Identification of Human GnIH Homologs, RFRP-1 and RFRP-3, and the Cognate Receptor, GPR147 in the Human Hypothalamic Pituitary Axis

Adam J Pawson, H. Minakata, K. Tsutsui, 2009, PloS one.

Identification of Ser153 in ICL2 of the Gonadotropin-releasing Hormone (GnRH) Receptor as a Phosphorylation-independent Site for Inhibition of Gq Coupling*

Adam J Pawson, Z. Naor, R. Millar, 2005, Journal of Biological Chemistry.

The Concise Guide to Pharmacology 2013/14: Enzymes

Adam J Pawson, Stephen P. H. Alexander, M. Spedding, 2013, British journal of pharmacology.

A mutational analysis of the roles of cytoplasmic domains of the gonadotropin-releasing hormone receptor in coupling and internalization

Adam J Pawson, 1999 .

A single amino acid substitution in transmembrane helix VI results in overexpression of the human GnRH receptor.

Adam J Pawson, R. Millar, J. Hapgood, 1998, European journal of endocrinology.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Alasdair J. G. Gray, Joanna L. Sharman, Adam J. Pawson, 2017, Nucleic Acids Res..

Gonadotrophin-releasing hormone receptors in GtoPdb v.2021.3

Adam J Pawson, A. IJzerman, L. Heitman, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

The Concise Guide to Pharmacology 2013/14: Ion Channels

Adam J Pawson, Stephen P. H. Alexander, W. Catterall, 2013, British journal of pharmacology.

The Concise Guide to Pharmacology 2013/14: Nuclear Hormone Receptors

Adam J Pawson, Stephen P. H. Alexander, M. Spedding, 2013, British journal of pharmacology.

GnRH analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand- induced-selective-signalling

Adam J Pawson, S. Langdon, K. Morgan, 2008 .

Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment.

Adam J Pawson, J S Davidson, J. Hapgood, 1997, Biochemistry.

Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations.

Adam J Pawson, R. Millar, K. Pfleger, 2008, Endocrinology.

Gonadotrophin-releasing hormone receptors in GtoPdb v.2023.1

Adam J Pawson, A. IJzerman, L. Heitman, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

IUPHAR/BPS guide to pharmacology

Adam J. Pawson, Christopher Southan, Jamie A. Davies, 2020 .

IUPHAR-DB: updated database content and new features

Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, 2012, Nucleic Acids Res..

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage‐gated ion channels

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2017, British journal of pharmacology.

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2015, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage‐gated ion channels

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2017, British journal of pharmacology.

Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY

Adam J. Pawson, Jamie A. Davies, Elena Faccenda, 2018, ACS omega.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels

Adam J Pawson, Stephen P. H. Alexander, C. Southan, 2017, British journal of pharmacology.

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Adam J Pawson, Stephen P. H. Alexander, Nc-Iuphar, 2013, Nucleic Acids Res..

Gonadotropin-Releasing Hormone (GnRH) Antagonists Promote Proapoptotic Signaling in Peripheral Reproductive Tumor Cells by Activating a Gαi-Coupling State of the Type I GnRH Receptor

Adam J Pawson, Stuart Maudsley, R. Millar, 2004, Cancer Research.

International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands

Adam J Pawson, Stephen P. H. Alexander, Wen Chiy Liew, 2013, Pharmacological Reviews.

Targeting mediators of Wnt signalling pathways by GnRH in gonadotropes.

Adam J Pawson, E. Faccenda, E. Stavrou, 2010, Journal of molecular endocrinology.

IUPHAR-DB: updated database content and new features

Adam J Pawson, Nc-Iuphar, M. Spedding, 2012, Nucleic Acids Res..