James F Blake

Identification and evaluation of molecular properties related to preclinical optimization and clinical fate.

James F Blake, J. Blake, 2005, Medicinal chemistry (Shariqah (United Arab Emirates)).

Integrating cheminformatic analysis in combinatorial chemistry.

James F Blake, J. Blake, 2004, Current opinion in chemical biology.

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Dolores Diaz, Jianping Yin, Michael Burkard, 2016, Journal of medicinal chemistry.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.

April Wong, J. E. Robinson, Jim Li, 2009, Bioorganic & medicinal chemistry letters.

Structure-based generation of viable leads from small combinatorial libraries.

James F Blake, J. Blake, E. Laird, 2004, Current opinion in drug discovery & development.