Laurence H Pearl

发表

Modeling of a 14 kDa RUVBL2-Binding Domain on a medium resolution Cryo-EM density.

Mohinder Pal, Carlos F Rodriguez, Hugo Muñoz-Hernandez, 2020, Journal of chemical information and modeling.

Structural basis for recruitment of BRCA2 by PALB2

Alan Ashworth, Laurence H Pearl, A. Ashworth, 2009, EMBO reports.

The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR).

Richard Harris, Laurence H Pearl, L. Pearl, 2004, Journal of molecular biology.

Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange

Sibylle Mittnacht, Michelle D Garrett, Laurence H Pearl, 2006, The EMBO journal.

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.

Chrisostomos Prodromou, Bin Hu, Philippe Meyer, 2003, Molecular cell.

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

Stefan Knapp, Laurence H Pearl, L. Pearl, 2008, The EMBO journal.

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.

Laurence H Pearl, L. Pearl, G. de Murcia, 2002, Nucleic acids research.

Visualization of DNA‐induced conformational changes in the DNA repair kinase DNA‐PKcs

Pablo Chacón, Laurence H Pearl, Oscar Llorca, 2003, The EMBO journal.

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

Laurence H Pearl, Oscar Llorca, L. Pearl, 2005, Structure.

Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.

Chrisostomos Prodromou, Mehdi Mollapour, Giuliano Siligardi, 2003, European journal of biochemistry.

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Paul Workman, Edward McDonald, Chrisostomos Prodromou, 2005, Bioorganic & medicinal chemistry letters.

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

Mike Wood, Brian Dymock, Xavier Barril, 2007, Journal of medicinal chemistry.

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

Paul Workman, Chrisostomos Prodromou, Laurence H Pearl, 2013, Nature chemical biology.

Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin.

Laurence H Pearl, L. Pearl, K. Willison, 2002, Journal of molecular biology.

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

Paul Workman, Chrisostomos Prodromou, Laurence H Pearl, 2006, Chemistry & biology.

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

Laurence H Pearl, L. Pearl, 2005, Current opinion in genetics & development.

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

Paul Workman, Rainer Cramer, Chrisostomos Prodromou, 2002, Molecular cell.

Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the β‐clamp

Laurence H Pearl, L. Pearl, S. Roe, 2003, The EMBO journal.

Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.

Stefano Stifani, Laurence H Pearl, L. Pearl, 2002, Structure.

Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.

Laurence H Pearl, Oscar Llorca, L. Pearl, 2006, Molecular cell.

Structural and mechanistic insights into ras association domains of phospholipase C epsilon.

Fernando Rodrigues-Lima, Peter Gierschik, Matilda Katan, 2006, Molecular cell.