Harvey J Clewell

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A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment.

Harvey J Clewell, Melvin E Andersen, Hugh A Barton, 2001, Environmental health perspectives.

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).

Harvey J Clewell, Melvin E Andersen, Patrick D McMullen, 2019, ALTEX.

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.

Harvey J Clewell, Melvin E Andersen, Tami S McMullin, 2016, Regulatory toxicology and pharmacology : RTP.

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop.

Harvey J Clewell, Kannan Krishnan, Ursula Gundert-Remy, 2014, Regulatory toxicology and pharmacology : RTP.

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.

Bas J Blaauboer, Harvey J Clewell, Mardas Daneshian, 2012, ALTEX.

Fuel Jettisoning by U.S. Air Force Aircraft. Volume II. Fuel Dump Listings.

Harvey J Clewell, 1980 .

Fuel Jettisoning by U.S. Air Force Aircraft. Volume I. Summary and Analysis.

Harvey J Clewell, 1980 .

Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.

Harvey J Clewell, Melvin E Andersen, Martin B Phillips, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Use of Markov Chain Monte Carlo Analysis with a Physiologically‐Based Pharmacokinetic Model of Methylmercury to Estimate Exposures in U.S. Women of Childbearing Age

Harvey J Clewell, Bruce C Allen, C Eric Hack, 2007, Risk analysis : an official publication of the Society for Risk Analysis.

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

Andrew Worth, Bertrand Desprez, Martina Klaric, 2019, Regulatory toxicology and pharmacology : RTP.

Bayesian Analysis of A Rat Formaldehyde DNA–Protein Cross-Link Model

Harvey J Clewell, Yu-Mei Tan, Bruce C Allen, 2010, Journal of toxicology and environmental health. Part A.

Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".

Harvey J Clewell, Melvin E Andersen, Kim Boekelheide, 2011, ALTEX.

Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate

Harvey J Clewell, Jerry Campbell, P Robinan Gentry, 2011, Critical reviews in toxicology.

Making sense of human biomonitoring data: Findings and recommendations of a workshop

Harvey J Clewell, Chris D Money, Richard D Phillips, 2007, Journal of Exposure Science and Environmental Epidemiology.

The Effect of Fuel Composition on Groundfall from Aircraft Fuel Jettisoning.

Harvey J Clewell, 1981 .

How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.

Harvey J Clewell, Barbara D Beck, Elaina M Kenyon, 2008, Toxicology and applied pharmacology.

Physiologically based pharmacokinetic model use in risk assessment--Why being published is not enough.

Harvey J Clewell, Hisham A El-Masri, John F Wambaugh, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene.

Harvey J Clewell, Melvin E Andersen, M. Andersen, 2007, Regulatory toxicology and pharmacology : RTP.

Revised assessment of cancer risk to dichloromethane: part I Bayesian PBPK and dose-response modeling in mice.

Harvey J Clewell, Dale J Marino, P Robinan Gentry, 2006, Regulatory toxicology and pharmacology : RTP.

Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry.

Harvey J Clewell, Ramesh Sarangapani, P Robinan Gentry, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration.

Harvey J Clewell, Melvin E Andersen, M. Andersen, 2002, Regulatory toxicology and pharmacology : RTP.

Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps.

George Loizou, Harvey J Clewell, Hugh A Barton, 2008, Regulatory toxicology and pharmacology : RTP.

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds.

Bas J Blaauboer, Harvey J Clewell, Miyoung Yoon, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling

Harvey J Clewell, Yu-Mei Tan, Kai H Liao, 2007, Journal of Exposure Science and Environmental Epidemiology.

Development of Pbpk Models for Pfoa and Pfos for Human Pregnancy and Lactation Life Stages

Harvey J Clewell, Melvin E Andersen, Matthew P Longnecker, 2013, Journal of toxicology and environmental health. Part A.

Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.

Harvey J Clewell, Melvin E Andersen, Russell S. Thomas, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure.

Harvey J Clewell, Melvin E Andersen, Bruce C Allen, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action.

Harvey J Clewell, Kannan Krishnan, Kenneth T Bogen, 2008, Regulatory toxicology and pharmacology : RTP.

Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment

Harvey J Clewell, Melvin E Andersen, Andy Nong, 2010, Journal of toxicology and environmental health. Part A.

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.

Robert J Kavlock, Harvey J Clewell, Melvin E Andersen, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.

Harvey J Clewell, Melvin E Andersen, Richard S Judson, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model.

Harvey J Clewell, Melvin E Andersen, Anne E. Loccisano, 2012, Reproductive toxicology.

Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

Harvey J Clewell, Weihsueh A Chiu, H. Clewell, 2006, Regulatory toxicology and pharmacology : RTP.

Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model.

Harvey J Clewell, Melvin E Andersen, Anne E. Loccisano, 2011, Regulatory toxicology and pharmacology : RTP.

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Robert J Kavlock, Harvey J Clewell, Melvin E Andersen, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Harvey J Clewell, Melvin E Andersen, Salil N Pendse, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation.

Harvey J Clewell, P Robinan Gentry, H. Clewell, 2003, Regulatory toxicology and pharmacology : RTP.

Use of a Physiologically Based Pharmacokinetic Model to Identify Exposures Consistent With Human Biomonitoring Data for Chloroform

Harvey J Clewell, Yu-Mei Tan, Kai H Liao, 2006, Journal of toxicology and environmental health. Part A.

Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment.

Bas J Blaauboer, Harvey J Clewell, Miyoung Yoon, 2015, Toxicology.

Hormesis and Adaptive Cellular Control Systems

Harvey J Clewell, Melvin E Andersen, Annie M Jarabek, 2008, Dose-Response.

Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report.

Harvey J Clewell, Janice W Yager, Elaina M Kenyon, 2007, Toxicology and applied pharmacology.

Development of a Screening Approach to Interpret Human Biomonitoring Data on Volatile Organic Compounds: Reverse Dosimetry on Biomonitoring Data for Trichloroethylene

Harvey J Clewell, Yu-Mei Tan, Kai H Liao, 2007, Risk analysis : an official publication of the Society for Risk Analysis.

Development and specification of physiologically based pharmacokinetic models for use in risk assessment.

Harvey J Clewell, Rebecca A Clewell, H. Clewell, 2008, Regulatory toxicology and pharmacology : RTP.

On the incorporation of chemical-specific information in risk assessment.

Bas J Blaauboer, Harvey J Clewell, Melvin E Andersen, 2008, Toxicology Letters.

Physiologically based pharmacokinetic/toxicokinetic modeling.

Harvey J Clewell, Melvin E Andersen, Rebecca A Clewell, 2012, Methods in molecular biology.

Exposure assessment and risk characterization for perfluorooctanoate in selected consumer articles.

Harvey J Clewell, Annette M Shipp, Robert C Buck, 2005, Environmental science & technology.

Evaluation of Physiologically Based Pharmacokinetic Models in Risk Assessment: An Example with Perchloroethylene

Harvey J Clewell, Melvin E Andersen, P Robinan Gentry, 2005, Critical reviews in toxicology.

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

Harvey J Clewell, Rebecca A Clewell, David R Mattie, 2007, Journal of toxicology and environmental health. Part A.

Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode‐of‐Action‐Based Cancer Risk Assessment for Chloroform

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2007, Risk analysis : an official publication of the Society for Risk Analysis.

Interspecies Dose Extrapolation for Inhaled Dimethyl Sulfate: A PBPK Model-Based Analysis using Nasal Cavity N7-Methylguanine Adducts

Harvey J Clewell, Hugh A Barton, Ramesh Sarangapani, 2004, Inhalation Toxicology.

Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations.

Harvey J Clewell, Dale J Marino, P Robinan Gentry, 2006, Regulatory toxicology and pharmacology : RTP.

Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model.

Harvey J Clewell, Melvin E Andersen, Miyoung Yoon, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach.

Harvey J Clewell, Hugh A Barton, Justin G Teeguarden, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2006, Toxicology.

Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans.

Harvey J Clewell, H. Clewell, Yuching Yang, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Harvey J Clewell, Miyoung Yoon, Salil N Pendse, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2008, Toxicology letters.

An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion.

Harvey J Clewell, Andrew Maier, P Robinan Gentry, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Application of pharmacokinetic data to the risk assessment of inhaled manganese.

Harvey J Clewell, Melvin E Andersen, David C Dorman, 2006, Neurotoxicology.

Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results

Harvey J Clewell, Melvin E Andersen, Miyoung Yoon, 2012, Critical reviews in toxicology.