Daniel F Tardiff

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From Yeast to Patients: The Audacity and Vision of Susan Lindquist.

Vikram Khurana, Chee Yeun Chung, Daniel F Tardiff, 2017, Cell systems.

An introductory bioinformatics exercise to reinforce gene structure and expression and analyze the relationship between gene and protein sequences

Daniel F Tardiff, Craig A. Almeida, Daniel Tardiff, 2004, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

Bonnie Berger, Ernest Fraenkel, Marc Vidal, 2017, Cell systems.

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models

Joshua A. Kritzer, Ernest Fraenkel, Susan Lindquist, 2010, Disease Models & Mechanisms.

Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.

Daniel F Tardiff, S. Schaus, S. Lindquist, 2017, ACS chemical neuroscience.

Neural tissue microphysiological systems in the era of patient-derived pluripotent stem cells

James D. White, Daniel F Tardiff, W. Raja, 2019, Microfluidic Cell Culture Systems.

Toward stem cell-based phenotypic screens for neurodegenerative diseases

Daniel F Tardiff, S. Lindquist, V. Khurana, 2015, Nature Reviews Neurology.

A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional.

Daniel F Tardiff, S. Lacadie, M. Rosbash, 2006, Molecular cell.

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

Daniel F Tardiff, G. Petsko, Robert H. Brown, 2011, PLoS biology.

Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation.

Daniel F Tardiff, M. Moore, M. Rosbash, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease.

Daniel F Tardiff, S. Lindquist, D. Tardiff, 2012, Drug discovery today. Technologies.

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Daniel F Tardiff, S. Lindquist, K. Caldwell, 2014, Proceedings of the National Academy of Sciences.

Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly.

Daniel F Tardiff, M. Rosbash, D. Tardiff, 2006, RNA.

L30 binds the nascent RPL30 transcript to repress U2 snRNP recruitment.

Daniel F Tardiff, J. Vilardell, Sara Macias, 2008, Molecular cell.

In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants.

Daniel F Tardiff, S. Lacadie, S. Kadener, 2006, Genes & development.

Rosbash to transcription elongation mutants In vivo commitment to yeast cotranscriptional splicing is sensitive data

Daniel F Tardiff, S. Lacadie, S. Kadener, 2006 .

From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies.

Daniel F Tardiff, J. Piotrowski, Daniel Tardiff, 2019, Methods in molecular biology.

Distinct Mechanisms and Polyglutamine Proteotoxicity through -Synuclein, α Models of TDP-43 Protein, Different 8-Hydroxyquinolines Protect Molecular Bases of Disease:

Daniel F Tardiff, G. Caldwell, Michelle L. Tucci, 2013 .

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms*

Daniel F Tardiff, S. Lindquist, K. Caldwell, 2011, The Journal of Biological Chemistry.

Binds the Nascent RPL 30 Transcript to Repress U 2 snRNP Recruitment

Daniel F Tardiff, J. Vilardell, Sara Macias, 2022 .

Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma

Daniel F Tardiff, C. Badr, Baolong Su, 2022, bioRxiv.

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.

Daniel F Tardiff, K. Rhodes, J. Piotrowski, 2018, Cell reports.

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models

Daniel F Tardiff, C. Badr, Baolong Su, 2023, Science Translational Medicine.

Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Daniel F Tardiff, K. Rhodes, D. Selkoe, 2022, Neurotherapeutics.

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Daniel F Tardiff, D. Selkoe, V. Khurana, 2022, Neurotherapeutics.

Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson’s Disease

Daniel F Tardiff, K. Rhodes, M. Lucas, 2022, Molecular Neurobiology.

Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons

Daniel F Tardiff, S. Buchwald, S. Lindquist, 2013, Science.

Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons

Michael D. Pluth, Daniel F Tardiff, S. Buchwald, 2013, Science.

Revised Escherichia coli selenocysteine insertion requirements determined by in vivo screening of combinatorial libraries of SECIS variants.

Daniel F Tardiff, C. Noren, L. Neely, 2003, Nucleic acids research.

From yeast to patient neurons and back again: Powerful new discovery platforms

Daniel F Tardiff, S. Lindquist, V. Khurana, 2014, Movement disorders : official journal of the Movement Disorder Society.

Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking

Daniel F Tardiff, M. Rosbash, K. Abruzzi, 2007, Proceedings of the National Academy of Sciences.