S. L. Mayo

发表

Using molecular dynamics simulations to predict domain swapping of computationally designed protein variants

Po-Ssu Huang, L. M. Thomas, S. L. Mayo, 2015 .

Full-sequence computational design and solution structure of a thermostable protein variant.

Geoffrey K. Hom, S. L. Mayo, P. S. Shah, 2007, Journal of molecular biology.

Enzyme-like proteins by computational design

S. L. Mayo, D. Bolon, Daniel N. A. Bolon, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Computational protein design.

S. L. Mayo, A. Street, 1999, Structure.

De novo backbone and sequence design of an idealized α/β-barrel protein: evidence of stable tertiary structure

S. L. Mayo, A. Stern, J. Hoch, 2003 .

Conformational splitting: A more powerful criterion for dead‐end elimination

S. L. Mayo, N. Pierce, J. Desmet, 2000, J. Comput. Chem..

Modulating calmodulin binding specificity through computational protein design.

Julia M. Shifman, S. L. Mayo, J. Shifman, 2002, Journal of molecular biology.

De novo protein design: fully automated sequence selection.

S. L. Mayo, B. Dahiyat, 1997, Science.

DREIDING: A generic force field for molecular simulations

S. L. Mayo, W. Goddard, B. D. Olafson, 1990 .

Exploring the origins of binding specificity through the computational redesign of calmodulin

Julia M. Shifman, S. L. Mayo, J. Shifman, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Probing the role of packing specificity in protein design.

S. L. Mayo, B. Dahiyat, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Protein design automation

S. L. Mayo, B. Dahiyat, 1996, Protein science : a publication of the Protein Society.

Computational design and experimental verification of a symmetric protein homodimer

Stephen L Mayo, S. L. Mayo, Po-Ssu Huang, 2015, Proceedings of the National Academy of Sciences.

Protein stability engineering insights revealed by domain-wide comprehensive mutagenesis

Marie L. Ary, S. L. Mayo, Alex Nisthal, 2018, Proceedings of the National Academy of Sciences.

Energy functions for protein design.

S. A. Marshall, S L Mayo, Shannon A. Marshall, 1999, Current opinion in structural biology.

Contribution of surface salt bridges to protein stability.

S L Mayo, S. L. Mayo, P. Strop, 2000, Biochemistry.

Electrostatics significantly affect the stability of designed homeodomain variants.

S. A. Marshall, Stephen L Mayo, Shannon A. Marshall, 2002, Journal of molecular biology.

Evaluation of the energetic contribution of an ionic network to beta‐sheet stability

Stephen L Mayo, S. L. Mayo, Kirsten S Lassila, 2002, Protein science : a publication of the Protein Society.

Protein building blocks preserved by recombination

Christopher A. Voigt, S. L. Mayo, C. Voigt, 2002, Nature Structural Biology.

Polar residues in the protein core of Escherichia coli thioredoxin are important for fold specificity.

S. L. Mayo, D. Bolon, 2001, Biochemistry.

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases.

S. L. Mayo, F. Arnold, A. Baumschlager, 2017, ACS synthetic biology.

Library analysis of SCHEMA‐guided protein recombination

Frances H Arnold, Christopher A. Voigt, Christopher A Voigt, 2003, Protein science : a publication of the Protein Society.

Iterative approach to computational enzyme design

Roberto A. Chica, Donald Hilvert, Stephen L. Mayo, 2012, Proceedings of the National Academy of Sciences.

Precision is essential for efficient catalysis in an evolved Kemp eliminase

Donald Hilvert, Stephen L. Mayo, Peer R. E. Mittl, 2013, Nature.

Achieving stability and conformational specificity in designed proteins via binary patterning.

S. A. Marshall, S L Mayo, Shannon A. Marshall, 2001, Journal of molecular biology.

Design, structure and stability of a hyperthermophilic protein variant

Stephen L. Mayo, S. L. Mayo, S. Malakauskas, 1998, Nature Structural Biology.

Evaluating and optimizing computational protein design force fields using fixed composition-based negative design

Stephen L Mayo, S. L. Mayo, Oscar Alvizo, 2008, Proceedings of the National Academy of Sciences.

The beta-beta-alpha fold: explorations in sequence space.

S L Mayo, S. L. Mayo, C. Sarisky, 2001, Journal of molecular biology.

The bba Fold: Explorations in Sequence Space

Stephen L. Mayo, S. L. Mayo, C. Sarisky, 2001 .

The ββα fold: explorations in sequence space11Edited by M. F. Summers

S. L. Mayo, C. Sarisky, 2001 .

De novo protein design: towards fully automated sequence selection.

S L Mayo, S. L. Mayo, B. Dahiyat, 1997, Journal of molecular biology.

Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants.

Stephen L Mayo, S. L. Mayo, Po-Ssu Huang, 2015, Journal of molecular biology.

Development and Validation of Methods for Multi-State Design and Combinatorial Library Design

S. L. Mayo, 2009 .

Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020

S. L. Mayo, R. Knight, J. Petrosino, 2021, Microbiome.

Circular dichroism determination of class I MHC‐peptide equilibrium dissociation constants

S. L. Mayo, B. D. Olafson, J. Holton, 1997, Protein science : a publication of the Protein Society.

Coupling backbone flexibility and amino acid sequence selection in protein design

S L Mayo, S. L. Mayo, A. Su, 1997, Protein science : a publication of the Protein Society.

Attempts to develop an enzyme converting DHIV to KIV.

S. L. Mayo, F. S. Lee, K. Oki, 2019, Protein engineering, design & selection : PEDS.

Cell‐free protein synthesis enables high yielding synthesis of an active multicopper oxidase

S. L. Mayo, A. Rosenzweig, Alex Nisthal, 2016, Biotechnology journal.

Particulate methane monooxygenase contains only mononuclear copper centers

Matthew O. Ross, S. L. Mayo, B. D. Olafson, 2019, Science.

Guide-directed DNA cleavage by a prokaryotic Argonaute protein induces chromosome recombination in Escherichia coli

S. L. Mayo, Shangyu Huang, Kaihang Wang, 2021 .

Direct visualization reveals dynamics of a transient intermediate during protein assembly

S. L. Mayo, Xin Zhang, Y. Mou, 2011, Proceedings of the National Academy of Sciences.

Trading accuracy for speed: A quantitative comparison of search algorithms in protein sequence design.

Christopher A. Voigt, S. L. Mayo, C. Voigt, 2000, Journal of molecular biology.

Kinetics and mechanisms of electron transfer between blue copper proteins and electronically excited chromium and ruthenium polypyridine complexes

S. L. Mayo, H. Gray, B. Brunschwig, 1985 .

Computational method to reduce the search space for directed protein evolution

Frances H. Arnold, Christopher A. Voigt, Stephen L. Mayo, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Genome manipulation by guide-directed Argonaute cleavage

S. L. Mayo, Shangyu Huang, Kaihang Wang, 2022, bioRxiv.

A structural study of Hypocrea jecorina Cel5A

S. L. Mayo, F. Arnold, Toni M. Lee, 2011, Protein science : a publication of the Protein Society.

Phenalene−phosphazene complexes: injection of electron spin density into the cyclotriphosphazene ring system

S. L. Mayo, R. Haddon, J. H. Marshall, 1985 .

Phenalene - Phosphazene Complexes: Injection of Electron Spin Density Into the Cyclotriphosphazene Ring System.

S. L. Mayo, R. Haddon, J. H. Marshall, 1986 .

Radical performance enhancements for combinatorial optimization algorithms based on the dead-end elimination theorem

D. Benjamin Gordon, Stephen L. Mayo, S. L. Mayo, 1998, Journal of Computational Chemistry.

Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state

S. L. Mayo, D. McComsey, B. Maryanoff, 1989 .

Long-range electron transfer in heme proteins.

S L Mayo, S. L. Mayo, H. Gray, 1986, Science.

Distance dependence of photoinduced long-range electron transfer in zinc/ruthenium-modified myoglobins

S. L. Mayo, H. Gray, M. Albin, 1988 .

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums

Stefan Mihalas, Stephen L Mayo, Julia M. Shifman, 2006, Proceedings of the National Academy of Sciences.

A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins.

S. L. Mayo, D. Datta, D. Tirrell, 2002, Journal of the American Chemical Society.

Designed oligomers of cyanovirin-N show enhanced HIV neutralization

S. L. Mayo, P. Bjorkman, Priyanthi N. P. Gnanapragasam, 2011, Proceedings of the National Academy of Sciences.

Long-range electron transfer in structurally engineered pentaammineruthenium (histidine-62) cytochrome c

S. L. Mayo, H. Gray, T. Meade, 1989 .

Long-Range Electron Transfer in Ruthenium-Modified Proteins

S. L. Mayo, C. Lieber, H. Gray, 1988 .

Correction: Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme

S. L. Mayo, J. Cashman, M. Redinbo, 2012, PLoS ONE.

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme

S. L. Mayo, J. Cashman, M. Redinbo, 2011, PloS one.

Automated design of the surface positions of protein helices

S. L. Mayo, B. Dahiyat, Stephen L. Mayo, 1997, Protein science : a publication of the Protein Society.

ProtaBank: A repository for protein design and engineering data

Roberto A Chica, Benjamin D Allen, Stephen L Mayo, 2018, bioRxiv.

Designed protein G core variants fold to native‐like structures: Sequence selection by ORBIT tolerates variation in backbone specification

S. L. Mayo, S. A. Ross, C. Sarisky, 2001, Protein science : a publication of the Protein Society.

Mechanism of an ATP-independent Protein Disaggregase

S. L. Mayo, Alex Nisthal, K. Shen, 2013, The Journal of Biological Chemistry.

Computational protein design promises to revolutionize protein engineering.

Benjamin D Allen, Stephen L Mayo, Benjamin D. Allen, 2007, BioTechniques.

Computationally focusing the directed evolution of proteins

Christopher A. Voigt, C A Voigt, S L Mayo, 2001, Journal of cellular biochemistry. Supplement.

Computational Design of the β-Sheet Surface of a Red Fluorescent Protein Allows Control of Protein Oligomerization

S. L. Mayo, Y. Mou, T. Wannier, 2015, PloS one.

Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library

Marco A Mena, Patrick S Daugherty, Stephen L Mayo, 2006, Nature Biotechnology.

NMR-detected conformational exchange observed in a computationally designed variant of protein Gbeta1.

S. L. Mayo, K. Crowhurst, 2008, Protein engineering, design & selection : PEDS.

A multi-substrate single-file model for ion-coupled transporters.

S. L. Mayo, H. Lester, S. Mager, 1996, Biophysical journal.

Impact of remote mutations on metallo‐β‐lactamase substrate specificity: Implications for the evolution of antibiotic resistance

S. L. Mayo, P. Oelschlaeger, J. Pleiss, 2005, Protein science : a publication of the Protein Society.

Designing proteins for therapeutic applications.

S. A. Marshall, Stephen L Mayo, G. A. Lazar, 2003, Current opinion in structural biology.

Repacking the Core of T4 lysozyme by automated design.

Stephen L Mayo, Brian W Matthews, S. L. Mayo, 2003, Journal of molecular biology.

Structure of a protein G helix variant suggests the importance of helix propensity and helix dipole interactions in protein design

S L Mayo, S. L. Mayo, P. Strop, 2000, Protein science : a publication of the Protein Society.

Computational design of an integrin I domain stabilized in the open high affinity conformation

Junichi Takagi, Stephen L. Mayo, Timothy A. Springer, 2000, Nature Structural Biology.

Exact rotamer optimization for protein design

D. Benjamin Gordon, Geoffrey K. Hom, Stephen L. Mayo, 2003, J. Comput. Chem..

Prudent modeling of core polar residues in computational protein design.

Stephen L Mayo, S. L. Mayo, S. A. Ross, 2003, Journal of molecular biology.

Exhaustive mutagenesis of six secondary active-site residues in Escherichia coli chorismate mutase shows the importance of hydrophobic side chains and a helix N-capping position for stability and catalysis.

Stephen L Mayo, Peter Kast, S. L. Mayo, 2007, Biochemistry.

Hydroxyl Groups in the ββ Sandwich of Metallo-β-lactamases Favor Enzyme Activity: A Computational Protein Design Study

Stephen L. Mayo, Peter Oelschlaeger, S. L. Mayo, 2005 .

ProtaBank: A repository for protein design and engineering data

Benjamin D. Allen, Paul M. Chang, S. L. Mayo, 2019, Protein science : a publication of the Protein Society.

Computational design of co-assembling protein–DNA nanowires

Chin-Lin Guo, Stephen L. Mayo, Jiun-Yann Yu, 2015, Nature.

Intrinsic beta-sheet propensities result from van der Waals interactions between side chains and the local backbone.

S L Mayo, S. L. Mayo, A. Street, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

S. L. Mayo, H. Lester, R. Howard, 2023, bioRxiv.

Combinatorial methods for small-molecule placement in computational enzyme design

Benjamin D Allen, Stephen L Mayo, Benjamin D. Allen, 2006, Proceedings of the National Academy of Sciences.

Guanidinium chloride induction of partial unfolding in amide proton exchange in RNase A.

S. L. Mayo, R. L. Baldwin, R. Baldwin, 1993, Science.

Generation and analysis of proline mutants in protein G.

Eun Jung Choi, Stephen L Mayo, S. L. Mayo, 2006, Protein engineering, design & selection : PEDS.

Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries

Roberto A Chica, Benjamin D Allen, Stephen L Mayo, 2010, Proceedings of the National Academy of Sciences.

bound calciums /calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two 2+ Ca

Julia M. Shifman, S. L. Mayo, Stefan Mihalas, 2006 .

Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin

S. L. Mayo, P. Wolynes, T. Shen, 2007, Proceedings of the National Academy of Sciences.

Monomerization of Far-Red Fluorescent Proteins

S. L. Mayo, R. McIsaac, R. Campbell, 2017, bioRxiv.

Site-specific modification of α-helical peptides with electron donors and acceptors

S. L. Mayo, B. Dahiyat, T. Meade, 1996 .

De novo design of biocatalysts.

Christopher A. Voigt, Christopher A Voigt, Stephen L Mayo, 2002, Current opinion in chemical biology.

NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics.

Kevin W Plaxco, S. A. Marshall, Stephen L Mayo, 2003, Journal of molecular biology.

Electron transfer in structurally engineered metalloproteins

S. L. Mayo, 1988 .

Electrostatics in computational protein design.

Stephen L Mayo, Christina L. Vizcarra, S. L. Mayo, 2005, Current opinion in chemical biology.

A search algorithm for fixed‐composition protein design

Geoffrey K. Hom, Stephen L. Mayo, S. L. Mayo, 2006, J. Comput. Chem..

Recovery of Red Fluorescent Protein Chromophore Maturation Deficiency through Rational Design

S. L. Mayo, R. Chica, Antonia T. Pandelieva, 2012, PloS one.

Engineering Transcriptional Regulator Effector Specificity Using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor.

Joseph T. Meyerowitz, Stephen L Mayo, Richard M Murray, 2016, ACS synthetic biology.

The structure of a far‐red fluorescent protein, AQ143, shows evidence in support of reported red‐shifting chromophore interactions

S. L. Mayo, T. Wannier, 2014, Protein science : a publication of the Protein Society.

A de novo designed protein–protein interface

Stephen L Mayo, John J Love, S. L. Mayo, 2007, Protein science : a publication of the Protein Society.

Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function

Stephen L Mayo, Christina L. Vizcarra, S. L. Mayo, 2007, Proceedings of the National Academy of Sciences.

Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes.

Frances H Arnold, Christopher D Snow, Stephen L Mayo, 2012, Protein engineering, design & selection : PEDS.

Conformational splitting: A more powerful criterion for dead-end elimination

Stephen L. Mayo, Niles A. Pierce, Jan A. Spriet, 2000, J. Comput. Chem..

A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins.

S. L. Mayo, D. Datta, D. Tirrell, 2002, Journal of the American Chemical Society.

GRID: A high‐resolution protein structure refinement algorithm

Stephen L. Mayo, Mohsen Chitsaz, S. L. Mayo, 2013, J. Comput. Chem..

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

S. L. Mayo, H. Lester, R. Howard, 2023, bioRxiv.

De novo backbone and sequence design of an idealized alpha/beta-barrel protein: evidence of stable tertiary structure.

S. L. Mayo, J. Hoch, F. Offredi, 2003, Journal of molecular biology.

Branch-and-terminate: a combinatorial optimization algorithm for protein design.

D B Gordon, S L Mayo, S. L. Mayo, 1999, Structure.

Optimization Strategies for the Design of Protein Sequences and Combinatorial Mutation Libraries

Christina L. Vizcarra, S. L. Mayo, Oscar Alvizo, 2009 .

Adaptation of a fast Fourier transform‐based docking algorithm for protein design

Po-Ssu Huang, Stephen L. Mayo, John J. Love, 2005, J. Comput. Chem..

Dioxane contributes to the altered conformation and oligomerization state of a designed engrailed homeodomain variant

Geoffrey K. Hom, S. L. Mayo, J. K. Lassila, 2005, Protein science : a publication of the Protein Society.

An improved pairwise decomposable finite‐difference Poisson–Boltzmann method for computational protein design

Chen Zeng, Ned S. Wingreen, Stephen L. Mayo, 2008, J. Comput. Chem..

Mechanism of an ATP-independent Protein Disaggregase

S. L. Mayo, Alex Nisthal, K. Shen, 2013, The Journal of Biological Chemistry.

De novo protein design: fully automated sequence selection.

S. L. Mayo, B. Dahiyat, 1997, Science.

Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles

Alex Nisthal, Benjamin D Allen, Stephen L Mayo, 2010, Proceedings of the National Academy of Sciences.

A designed apoplastocyanin variant that shows reversible folding.

S. L. Mayo, D. Datta, 2002, Biochemical and biophysical research communications.

Preprocessing of rotamers for protein design calculations

Geoffrey K. Hom, Stephen L Mayo, S. L. Mayo, 2004, J. Comput. Chem..

A structural study of Hypocrea jecorina Cel5A

S. L. Mayo, F. Arnold, Toni M. Lee, 2011, Protein science : a publication of the Protein Society.

Protein hydrogen exchange in denaturant: quantitative analysis by a two-process model.

S. L. Mayo, H. Qian, Andrew Morton, 1994, Biochemistry.

NMR-detected conformational exchange observed in a computationally designed variant of protein Gbeta1.

S. L. Mayo, K. Crowhurst, 2008, Protein engineering, design & selection : PEDS.

Structural, kinetic, and thermodynamic studies of specificity designed HIV‐1 protease

S. L. Mayo, C. Schiffer, Oscar Alvizo, 2012, Protein science : a publication of the Protein Society.

Engineering Transcriptional Regulator Effector Specificity using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor

Joseph T. Meyerowitz, S. L. Mayo, R. Murray, 2015, bioRxiv.

Pairwise calculation of protein solvent-accessible surface areas.

S L Mayo, A. C. Street, S. L. Mayo, 1998, Folding & design.

Computationally designed variants of Escherichia coli chorismate mutase show altered catalytic activity.

Stephen L Mayo, Peter Oelschlaeger, S. L. Mayo, 2005, Protein engineering, design & selection : PEDS.

Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries

Benjamin D. Allen, S. L. Mayo, R. Chica, 2010, Proceedings of the National Academy of Sciences.