Christof von Kalle

发表

Genome Editing Technologies: Defining a Path to Clinic: Genomic Editing: Establishing Preclinical Toxicology Standards, Bethesda, Maryland 10 June 2014.

Jacqueline Corrigan-Curay, Marina O'Reilly, Donald B Kohn, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task.

Achim Hekler, Carola Berking, Dirk Schadendorf, 2019, European journal of cancer.

Patient-Centered Mobile Health Data Management Solution for the German Health Care System (The DataBox Project)

Daniela Richter, Christof von Kalle, Titus Josef Brinker, 2018, JMIR cancer.

Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review

Achim Hekler, Carola Berking, Dirk Schadendorf, 2018, Journal of medical Internet research.

Comparing artificial intelligence algorithms to 157 German dermatologists: the melanoma classification benchmark.

Achim Hekler, Carola Berking, Dirk Schadendorf, 2019, European journal of cancer.

Teledermatology: Comparison of Store-and-Forward Versus Live Interactive Video Conferencing

Achim Hekler, Carola Berking, Wiebke Sondermann, 2018, Journal of medical Internet research.

A convolutional neural network trained with dermoscopic images performed on par with 145 dermatologists in a clinical melanoma image classification task.

Achim Hekler, Carola Berking, Dirk Schadendorf, 2019, European journal of cancer.

Superior skin cancer classification by the combination of human and artificial intelligence.

Tim Holland-Letz, Achim Hekler, Carola Berking, 2019, European journal of cancer.

Enhanced classifier training to improve precision of a convolutional neural network to identify images of skin lesions

Achim Hekler, Christof von Kalle, Titus J Brinker, 2019, PloS one.

Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

Roland Eils, Thomas Zichner, Hans Lehrach, 2016, Nature Medicine.

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Roland Eils, Christian Drosten, Christof von Kalle, 2020, Nature Biotechnology.

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.

Hung Fan, Alessandro Aiuti, Jacqueline Corrigan-Curay, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts

Jürgen Weitz, Christof von Kalle, Benedikt Brors, 2017, EMBO molecular medicine.

Pathologist-level classification of histopathological melanoma images with deep neural networks.

Tim Holland-Letz, Achim Hekler, Carola Berking, 2019, European journal of cancer.

Hot spots of retroviral integration in human CD34+ hematopoietic cells.

Alessandro Aiuti, Christof von Kalle, Manfred Schmidt, 2007, Blood.

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

Luca Biasco, Alessandro Aiuti, Christof von Kalle, 2011, EMBO molecular medicine.

Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity

Michael Rothe, Christof von Kalle, Raffaele Fronza, 2014, Science Translational Medicine.

Prediction of melanoma evolution in melanocytic nevi via artificial intelligence: A call for prospective data.

Carola Berking, Wiebke Sondermann, Dirk Schadendorf, 2019, European journal of cancer.

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites.

Christof von Kalle, Richard Gabriel, Hanno Glimm, 2012, Human gene therapy methods.

NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer.

David Bonekamp, Kortine Kleinheinz, Matthias Schlesner, 2018, Cancer discovery.

Deep neural networks are superior to dermatologists in melanoma image classification.

Tim Holland-Letz, Achim Hekler, Jochen S. Utikal, 2019, European journal of cancer.

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells.

Christof von Kalle, Roger Garsia, Robert Finlayson, 2009, Nature medicine.

High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion

Christof von Kalle, Danilo Pellin, Alessandro Ambrosi, 2010, PloS one.

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

Christof von Kalle, Alessandro Ambrosi, Luigi Naldini, 2009, The Journal of clinical investigation.

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases.

Christof von Kalle, Jakub Tolar, Richard Gabriel, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

TALEN-based gene correction for epidermolysis bullosa.

Christof von Kalle, Jakub Tolar, Richard Gabriel, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

and insertional genotoxicity Cell culture assays reveal the importance of retroviral vector design for

Christof von Kalle, Christopher Baum, Ute Modlich, 2006 .

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.

Gianluigi Zanetti, Christof von Kalle, Alessandra Biffi, 2011, Blood.

Integration Frequency and Intermolecular Recombination of rAAV Vectors in Non-human Primate Skeletal Muscle and Liver.

Christof von Kalle, Manfred Schmidt, C. von Kalle, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Suppressive myeloid cells are a hallmark of severe COVID-19

Christian Drosten, Matthias Becker, Joachim L. Schultze, 2020, medRxiv.

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Roland Eils, Rainer König, Gary D Bader, 2014, Cancer cell.

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.

Christine Kinnon, Christof von Kalle, Dick de Ridder, 2007, The Journal of clinical investigation.

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

Christof von Kalle, Jakub Tolar, Richard Gabriel, 2017, Molecular therapy. Methods & clinical development.

A Skin Cancer Prevention Facial-Aging Mobile App for Secondary Schools in Brazil: Appearance-Focused Interventional Study

Sven Schneider, Wiebke Sondermann, Dirk Schadendorf, 2018, JMIR mHealth and uHealth.

Mutations in ROGDI Cause Kohlschütter-Tönz Syndrome.

Zlatko Trajanoski, Stephan Pabinger, Christof von Kalle, 2012, American journal of human genetics.

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.

Bruce Aronow, Christof von Kalle, Jean Weissenbach, 2007, The Journal of clinical investigation.

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.

Christine Kinnon, Christof von Kalle, Michael Hubank, 2008, The Journal of clinical investigation.

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.

Christof von Kalle, Niraja Dighe, Alaine T. Ruthe, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Stem-cell gene therapy for the Wiskott-Aldrich syndrome.

Christof von Kalle, Christoph Klein, Rainer Blasczyk, 2010, The New England journal of medicine.

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Alexander Sczyrba, Andreas Keller, Christian Drosten, 2020, Cell.

Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells

Christof von Kalle, Manfred Schmidt, Peiman Hematti, 2004, PLoS biology.

TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice

Christof von Kalle, Manfred Schmidt, Wahiba Chaara, 2015, European journal of immunology.

Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

Christof von Kalle, C. von Kalle, D. Nettelbeck, 2014, Proceedings of the National Academy of Sciences.

Integrative genomic and transcriptomic analysis of leiomyosarcoma

Roland Eils, Kortine Kleinheinz, Matthias Schlesner, 2018, Nature Communications.

Fanconi anemia gene editing by the CRISPR/Cas9 system.

Christof von Kalle, Jakub Tolar, Richard Gabriel, 2015, Human gene therapy.

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

Christof von Kalle, Raffaele Fronza, Manfred Schmidt, 2016, Molecular therapy. Nucleic acids.

Side effects of retroviral gene transfer into hematopoietic stem cells.

Christof von Kalle, Christopher Baum, David A. Williams, 2003, Blood.

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.

Christof von Kalle, Manfred Schmidt, Salima Hacein-Bey-Abina, 2003, The New England journal of medicine.

Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.

Till Acker, Christof von Kalle, Stefan Fröhling, 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Analyzing the Number of Common Integration Sites of Viral Vectors – New Methods and Computer Programs

Christof von Kalle, Richard Gabriel, Hanno Glimm, 2011, PloS one.

High-resolution analysis of the human T-cell receptor repertoire

Christof von Kalle, Raffaele Fronza, Hanno Glimm, 2015, Nature Communications.

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Roland Eils, David Bonekamp, Kortine Kleinheinz, 2019, Nature Communications.