Doyle J Cassar

发表

Drugging the undruggable: a computational chemist's view of KRASG12C.

Michael S Bodnarchuk, Jason G Kettle, Graeme Robb, 2021, RSC medicinal chemistry.

Structure-based design and pharmacokinetic optimization of covalent allosteric inhibitors of the mutant GTPase KRASG12C.

Doyle J Cassar, J. Breed, D. Ogg, 2020, Journal of medicinal chemistry.

Chirality Control in Planar Chiral Cobalt Oxazoline Palladacycles

Doyle J Cassar, D. Villemin, S. Coles, 2015 .

Covalent inhibitors of the GTPase KRASG12C: a review of the patent literature

Doyle J Cassar, J. Kettle, 2020, Expert opinion on therapeutic patents.

Enantioselective Synthesis and Application to the Allylic Imidate Rearrangement of Amine-Coordinated Palladacycle Catalysts of Cobalt Sandwich Complexes

Doyle J Cassar, C. Richards, D. Hughes, 2013, Chemistry.

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.

Doyle J Cassar, Nichola L. Davies, J. Breed, 2022, Journal of medicinal chemistry.

Switchable, Reagent‐Controlled Diastereodivergent Photocatalytic Carbocyclisation of Imine‐Derived α‐Amino Radicals

Doyle J Cassar, T. Hamlin, Jamie A. Leitch, 2021, Angewandte Chemie.

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.

Doyle J Cassar, Nichola L. Davies, J. Breed, 2023, Journal of medicinal chemistry.

Regioselective, stereoselective, and conformationally controlled synthesis of (η4-tetraarylcyclobutadiene)(η5-carbomethoxycyclopentadienyl)cobalt metallocenes.

Doyle J Cassar, D. Villemin, C. Richards, 2012, Organic Letters.