Wai Hoong Chang

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An informatics consult approach for generating clinical evidence for treatment decisions

Spiros Denaxas, Richard J. B. Dobson, Harry Hemingway, 2021, BMC Medical Informatics and Decision Making.

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, Journal of Translational Medicine.

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

Wai Hoong Chang, Alvina G. Lai, 2020, BMC Cancer.

Pan-cancer genomic amplifications underlie a Wnt hyperactivation phenotype associated with stem cell-like features leading to poor prognosis

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, bioRxiv.

Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

Wai Hoong Chang, Alvina G. Lai, 2019, British Journal of Cancer.

Pan-cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, bioRxiv.

Late effects of cancer in children, teenagers and young adults: Population-based study on the burden of 183 conditions, in-patient and critical care admissions and years of life lost

Wai Hoong Chang, M. Katsoulis, Yen Yi Tan, 2021, The Lancet regional health. Europe.

Multimorbidity patterns and risk of hospitalisation in children: A population cohort study of 3.6 million children in England, with illustrative examples from childhood cancer survivors

Wai Hoong Chang, Sheng-Chia Chung, D. Hargrave, 2022, The Lancet regional health. Europe.

Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study

Wai Hoong Chang, A. Banerjee, D. Pillay, 2020, BMJ Open.

Increased burden of cardiovascular disease in people with liver disease: unequal geographical variations, risk factors and excess years of life lost

Wai Hoong Chang, Sheng-Chia Chung, G. Foster, 2021, medRxiv.

There is no health without mental health: Challenges ignored and lessons learned

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2022, Clinical and translational medicine.

Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England.

Wai Hoong Chang, S. Denaxas, Yen Yi Tan, 2022, The Lancet. Healthy longevity.

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Wai Hoong Chang, A. Loudon, P. Simmonds, 2019, Nature Communications.

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers

Wai Hoong Chang, A. Lai, W. H. Chang, 2022, Nature medicine.

Comparative genomic analysis of crustacean hyperglycemic hormone (CHH) neuropeptide genes across diverse crustacean species

Wai Hoong Chang, Alvina G. Lai, 2018, F1000Research.

Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, British Journal of Cancer.

Increased burden of cardiovascular disease in people with liver disease: unequal geographical variations, risk factors and excess years of life lost

Wai Hoong Chang, Sheng-Chia Chung, G. Foster, 2022, Journal of Translational Medicine.

Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project

Wai Hoong Chang, A. Need, M. Bleda, 2021, BMC Research Notes.

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, BMC Cancer.

An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, Molecular Medicine.

Estimating excess mortality in people with cancer and multimorbidity in the COVID-19 emergency

A. Banerjee, H. Hemingway, Wai Hoong Chang, 2020, medRxiv.

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2022, Nature Medicine.

Mixed evolutionary origins of endogenous biomass-depolymerizing enzymes in animals

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2018, BMC Genomics.

The hypoxic tumour microenvironment: A safe haven for immunosuppressive cells and a therapeutic barrier to overcome.

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2020, Cancer letters.

Pan-cancer analyses of the associations between 109 pre-existing conditions and cancer treatment patterns across 19 adult cancers

Wai Hoong Chang, Alvina G. Lai, A. Lai, 2022, medRxiv.

The pan‐cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, Annals of the New York Academy of Sciences.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES MARROW

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019 .

Injury primes mutation-bearing astrocytes for dedifferentiation in later life

Wai Hoong Chang, A. Riccio, S. Marguerat, 2023, Current Biology.

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Wai Hoong Chang, A. Loudon, P. Simmonds, 2019, Nature Communications.

The circadian clock components BMAL1 and REV-ERB regulate flavivirus replication

Wai Hoong Chang, Alvina G. Lai, T. Baumert, 2019 .

Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance

Wai Hoong Chang, Alvina G. Lai, D. Forde, 2019, Cancer communications.

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia

Wai Hoong Chang, Alvina G. Lai, W. H. Chang, 2019, bioRxiv.

Dual prognostic role for 2-oxoglutarate oxygenases in ten diverse cancer types: Implications for cell cycle regulation and cell adhesion maintenance

Wai Hoong Chang, Alvina G. Lai, D. Forde, 2018, bioRxiv.