Jennifer C. Lee

发表

Performance of in silico splice tools used at the GGC for decision-making in molecular diagnosis

Julie R. Jones, Michael J. Friez, Xuemei Shi, 2021 .

Tryptophan probes at the alpha-synuclein and membrane interface.

Jennifer C. Lee, C. Pfefferkorn, Jennifer C Lee, 2010, The journal of physical chemistry. B.

Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli

Jennifer C. Lee, G. Shearer, D. H. Kohl, 2005, The FEBS journal.

α-Synuclein Tertiary Contact Dynamics

Harry B. Gray, Jay R. Winkler, John J. Kozak, 2007 .

Structural Features of Membrane-bound Glucocerebrosidase and α-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy*

Frank Heinrich, Joseph E. Curtis, Ellen Sidransky, 2014, The Journal of Biological Chemistry.

Tertiary Contact Formation in α-Synuclein Probed by Electron Transfer

Harry B. Gray, Jay R. Winkler, Jennifer C. Lee, 2005 .

Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.

Jennifer C. Lee, A. Grishaev, E. Sidransky, 2015, Biochemical and biophysical research communications.

Saposin C protects glucocerebrosidase against α-synuclein inhibition.

Jennifer C. Lee, E. Sidransky, J. Gruschus, 2013, Biochemistry.

α-Synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in Parkinson's disease

Harry B. Gray, Jay R. Winkler, Ralf Langen, 2004 .

Physical Chemistry in Biomedical Research: From Cuvettes toward Cellular Insights.

Jennifer C. Lee, Jessica D. Flynn, 2017, The journal of physical chemistry letters.

Copper(II) enhances membrane-bound α-synuclein helix formation.

Jennifer C. Lee, Heather R. Lucas, H. Lucas, 2011, Metallomics : integrated biometal science.

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

Jennifer C. Lee, R. McGlinchey, 2015, Proceedings of the National Academy of Sciences.

Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.

Jennifer C. Lee, N. Tjandra, G. Piszczek, 2011, Archives of biochemistry and biophysics.

Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures.

Jennifer C. Lee, D. Otzen, J. S. Pedersen, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Taking a Bite Out of Amyloid: Mechanistic Insights into α-Synuclein Degradation by Cathepsin L.

Jennifer C. Lee, R. McGlinchey, Gifty A Dominah, 2017, Biochemistry.

NMR structure of calmodulin complexed to an N-terminally acetylated α-synuclein peptide.

Jennifer C. Lee, J. Gruschus, Alexander S. Maltsev, 2013, Biochemistry.

Cathepsin K is a potent disaggregase of α-synuclein fibrils.

Jennifer C. Lee, R. Walker, R. McGlinchey, 2020, Biochemical and biophysical research communications.

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease

Jennifer C. Lee, E. Sidransky, N. Tayebi, 2019, The Journal of Biological Chemistry.

5-fluoro-D,L-tryptophan as a dual NMR and fluorescent probe of α-synuclein.

Jennifer C. Lee, C. Pfefferkorn, 2012, Methods in molecular biology.

Segmental 13 C-Labeling and Raman Microspectroscopy of α-Synuclein Amyloid Formation.

Jennifer C. Lee, Zhiping Jiang, Jessica D. Flynn, 2018, Angewandte Chemie.

The N terminus of α-synuclein dictates fibril formation

Jennifer C. Lee, Jiansen Jiang, Jared A. Shadish, 2021, Proceedings of the National Academy of Sciences.

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease Related C-Terminal Truncations.

Jennifer C. Lee, Jiansen Jiang, X. Ni, 2019, Journal of molecular biology.

Molecular Origin of pH‐Dependent Fibril Formation of a Functional Amyloid

Jennifer C. Lee, Zhiping Jiang, R. McGlinchey, 2014, Chembiochem : a European journal of chemical biology.

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

Jennifer C. Lee, Dexter N. Dean, 2020, The Journal of Biological Chemistry.

Linking Parkinson's Disease and Melanoma: Interplay Between α‐Synuclein and Pmel17 Amyloid Formation

Jennifer C. Lee, Dexter N. Dean, 2021, Movement disorders : official journal of the Movement Disorder Society.

Raman fingerprints of amyloid structures.

Jennifer C. Lee, Jessica D. Flynn, 2018, Chemical communications.

Membrane remodeling by α-synuclein and effects on amyloid formation.

Jennifer C. Lee, Zhiping Jiang, Michel de Messieres, 2013, Journal of the American Chemical Society.

Iron upregulates melanogenesis in cultured retinal pigment epithelial cells.

Jennifer C. Lee, A. Maminishkis, J. Dunaief, 2014, Experimental eye research.

Membrane Interactions of α-Synuclein Probed by Neutrons and Photons.

Jennifer C. Lee, Upneet Kaur, 2021, Accounts of chemical research.

Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.

Jennifer C. Lee, S. Grieco, J. Dunaief, 2012, The American journal of pathology.

Increased endothelin 1 expression in adult-onset minimal change nephropathy with acute renal failure.

Jennifer C. Lee, K. Chou, H. Fang, 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

ORIGINAL INVESTIGATIONS Pathogenesis and Treatment of Kidney Disease and Hypertension Increased Endothelin 1 Expression in Adult-Onset Minimal Change Nephropathy With Acute Renal Failure

Jennifer C. Lee, K. Chou, H. Fang, 2005 .

Defining an amyloid link Between Parkinson’s disease and melanoma

Jennifer C. Lee, Dexter N. Dean, 2020, Proceedings of the National Academy of Sciences.

Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils.

Jennifer C. Lee, M. Watson, 2022, Journal of molecular biology.

pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence.

Jennifer C. Lee, Dexter N. Dean, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly.

Jennifer C. Lee, C. Pfefferkorn, Thai Leong Yap, 2011, Biochemistry.

Effect of dioxygen on copper(II) binding to alpha-synuclein.

Jennifer C. Lee, H. Lucas, 2010, Journal of inorganic biochemistry.

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease*

Jennifer C. Lee, S. Bezrukov, P. Gurnev, 2015, The Journal of Biological Chemistry.

Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III.

Jennifer C. Lee, R. Walker, J. Gruschus, 2015, Biochimica et biophysica acta.

Emerging Role for Copper-Bound α-Synuclein in Parkinson’s Disease Etiology

Jennifer C. Lee, H. Lucas, 2012 .

Segmental Deuteration of α-Synuclein for Neutron Reflectometry on Tethered Bilayers.

Jennifer C. Lee, J. Gruschus, F. Heinrich, 2017, The journal of physical chemistry letters.

Mutational analysis of sigma70 region 4 needed for appropriation by the bacteriophage T4 transcription factors AsiA and MotA.

Jennifer C. Lee, K. Severinov, D. Hinton, 2006, Journal of molecular biology.

Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17

Jennifer C. Lee, C. Pfefferkorn, R. McGlinchey, 2010, Proceedings of the National Academy of Sciences.

α-Synuclein Structures Probed by 5-Fluorotryptophan Fluorescence and 19F NMR Spectroscopy

Jennifer C. Lee, H. Gray, S. B. Harkins, 2006 .

Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein

Jennifer C. Lee, M. Strub, Emma I. O’Leary, 2018, The Journal of Biological Chemistry.

Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity.

Jennifer C. Lee, E. Sidransky, Thai Leong Yap, 2013, Molecular genetics and metabolism.

α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases*

Jennifer C. Lee, W. Westbroek, E. Sidransky, 2011, The Journal of Biological Chemistry.

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores

Jennifer C. Lee, J. Lippincott-Schwartz, D. Raible, 2019, Proceedings of the National Academy of Sciences.

Tryptophan Probes of TDP-43 C-Terminal Domain Amyloid Formation.

Jennifer C. Lee, Sydney O. Shuster, 2021, The journal of physical chemistry. B.

CXC Chemokines Bind to Unique Sets of Selectivity Determinants That Can Function Independently and Are Broadly Distributed on Multiple Domains of Human Interleukin-8 Receptor B

Jennifer C. Lee, P. Murphy, S. Ahuja, 1996, The Journal of Biological Chemistry.

N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism.

Jennifer C. Lee, M. Watson, 2019, Biochemistry.

Biophysics of α-synuclein membrane interactions.

Jennifer C. Lee, C. Pfefferkorn, Zhiping Jiang, 2012, Biochimica et biophysica acta.

Why Study Functional Amyloids? Lessons from the Repeat Domain of Pmel17.

Jennifer C. Lee, R. McGlinchey, 2018, Journal of molecular biology.

In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning

Jennifer C. Lee, J. Lippincott-Schwartz, H. Pasolli, 2020, Nature Communications.

Cloning, heterologous expression, and characterization of recombinant class II cytochromes c from Rhodopseudomonas palustris.

Julia G. Lyubovitsky, Jennifer C. Lee, H. Gray, 2003, Biochimica et biophysica acta.

Alpha-synuclein lipid-dependent membrane binding and translocation through the α-hemolysin channel.

Jennifer C. Lee, A. Berezhkovskii, S. Bezrukov, 2014, Biophysical journal.

Lysophospholipid-containing membranes modulate the fibril formation of the repeat domain of a human functional amyloid, pmel17.

Jennifer C. Lee, Zhiping Jiang, 2014, Journal of molecular biology.

Reversing the amyloid trend: Mechanism of fibril assembly and dissolution of the repeat domain from a human functional amyloid.

Jennifer C. Lee, R. McGlinchey, 2017, Israel journal of chemistry.

Raman spectral imaging of 13C2H15N-labeled α-synuclein amyloid fibrils in cells.

Jennifer C. Lee, Jessica D. Flynn, M. Watson, 2020, Biophysical chemistry.

Unroofing site-specific α-synuclein–lipid interactions at the plasma membrane

Jennifer C. Lee, Upneet Kaur, 2020, Proceedings of the National Academy of Sciences.

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins.

Bikash R. Sahoo, Jennifer C. Lee, A. Ramamoorthy, 2020, ACS chemical neuroscience.

Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease.

Jennifer C. Lee, R. McGlinchey, 2013, Biochemical Society transactions.

Energy transfer ligands of the GluR2 ligand binding core.

Jennifer C. Lee, M. Strub, A. Petrik, 2010, Biochemistry.

Molecular details of α-synuclein membrane association revealed by neutrons and photons.

Jennifer C. Lee, F. Heinrich, Zhiping Jiang, 2015, The journal of physical chemistry. B.

Apolipoprotein C-III Nanodiscs Studied by Site-Specific Tryptophan Fluorescence.

Jennifer C. Lee, C. A. Brisbois, 2016, Biochemistry.

The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c

Harry B Gray, Jay R Winkler, I-Jy Chang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of α-synuclein amyloid formation by phosphatidylglycerol micellar tubules.

Jennifer C. Lee, K. Gawrisch, Zhiping Jiang, 2018, Biochimica et biophysica acta. Biomembranes.

Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants.

Jennifer C. Lee, H. Gray, Summer L. Bernstein, 2008, The journal of physical chemistry. B.

α-Synuclein: Stable compact and extended monomeric structures and pH dependence of dimer formation

Jennifer C. Lee, H. Gray, Summer L. Bernstein, 2004, Journal of the American Society for Mass Spectrometry.

Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern

Jennifer C. Lee, A. Rovini, S. Bezrukov, 2019, Scientific Reports.

Evidence for copper-dioxygen reactivity during alpha-synuclein fibril formation.

Jennifer C. Lee, S. DeBeer, Myoung-Soon S. Hong, 2010, Journal of the American Chemical Society.

Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy

Jennifer C. Lee, R. Walker, Jennifer C Lee, 2017, The Journal of Biological Chemistry.

Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III

Jennifer C. Lee, Yi He, Michel de Messieres, 2014, Biochemistry.

Copper(II) Binding to α-Synuclein, the Parkinson’s Protein

Jennifer C. Lee, H. Gray, J. Winkler, 2008, Journal of the American Chemical Society.

Watching liquid droplets of TDP-43CTD age by Raman spectroscopy

Jennifer C. Lee, Sydney O. Shuster, 2021, The Journal of biological chemistry.

Folding energy landscape of cytochrome cb562

Jennifer C. Lee, H. Gray, J. Winkler, 2009, Proceedings of the National Academy of Sciences.

Site-specific collapse dynamics guide the formation of the cytochrome c′ four-helix bundle

Jennifer C. Lee, H. Gray, J. Winkler, 2007, Proceedings of the National Academy of Sciences.

Interplay between α-synuclein amyloid formation and membrane structure.

Jennifer C. Lee, Emma I. O’Leary, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Alpha-synuclein tertiary contact dynamics.

Harry B Gray, John J Kozak, Jay R Winkler, 2007, The journal of physical chemistry. B.

Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease.

Harry B Gray, Ralf Langen, Jay R Winkler, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The cytochrome c folding landscape revealed by electron-transfer kinetics.

Jennifer C. Lee, H. Gray, J. Winkler, 2002, Journal of molecular biology.

Cytochrome c′ folding triggered by electron transfer: Fast and slow formation of four-helix bundles

Jennifer C. Lee, Jay R Winkler, H. B. Gray, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Depth of α-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation.

Frank Heinrich, Jennifer C. Lee, R. Pastor, 2012, Biophysical journal.

Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners

Jennifer C. Lee, J. Clarke, S. Shammas, 2013, Journal of molecular biology.

The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17.

Jennifer C. Lee, Thai Leong Yap, R. McGlinchey, 2011, Physical chemistry chemical physics : PCCP.

Equilibrium unfolding of the poly(glutamic acid)20 helix.

Jennifer C. Lee, J. Onuchic, P. Jennings, 2007, Biopolymers.

Structural features of cytochrome c′ folding intermediates revealed by fluorescence energy-transfer kinetics

Jennifer C. Lee, H. Gray, F. Tezcan, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative Estimation of Channeling in the Gycolytic Pathway in Intact Escherichia coli

Jennifer C. Lee, 2006 .

Identification of the minimal copper(II)-binding alpha-synuclein sequence.

Jennifer C. Lee, M. Jackson, 2009, Inorganic chemistry.

Contents of Volumes in the Metal Ions in Life Sciences Series

Jennifer C. Lee, T. Bayer, H. Gray, 2019, Metal Ions in Bio-Imaging Techniques.

Synchronous vs asynchronous chain motion in alpha-synuclein contact dynamics.

J. J. Kozak, Jennifer C. Lee, H. Gray, 2009, Journal of Physical Chemistry B.

Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells

Jennifer C. Lee, Jessica D. Flynn, S. Lacy, 2020, Chembiochem : a European journal of chemical biology.

Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue level.

Jennifer C. Lee, A. Nagy, J. Gruschus, 2011, Biochemistry.