Jacob I. Ayers

发表

Trans-Channel Fluorescence Learning Improves High-Content Screening for Alzheimer's Disease Therapeutics

Atul J. Butte, Michael J. Keiser, Stanley B. Prusiner, 2021 .

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Jacob I. Ayers, S. Prusiner, G. Carlson, 2021, Neuron.

Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

Jacob I. Ayers, D. Borchelt, J. Ayers, 2020, Acta Neuropathologica.

Prion-like mechanisms in amyotrophic lateral sclerosis.

Jacob I. Ayers, N. Cashman, J. Ayers, 2018, Handbook of clinical neurology.

The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Jacob I. Ayers, A. Kincaid, A. Aguzzi, 2011, PLoS pathogens.

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

Jacob I. Ayers, A. Kincaid, Jason C. Bartz, 2010, Journal of Virology.

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

Jacob I. Ayers, Eric A. Vitriol, D. Borchelt, 2018, iScience.

ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor Neurons

Jacob I. Ayers, Eric A. Vitriol, D. Borchelt, 2018, bioRxiv.

Enhanced Neurite Outgrowth and Regeneration in ALS Resistant Motor Neurons from SOD1 Mutant Mouse Models

Jacob I. Ayers, Eric A. Vitriol, D. Borchelt, 2018 .

Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice

Jacob I. Ayers, A. Kincaid, Jason C. Bartz, 2016, Journal of Virology.

Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates

Jacob I. Ayers, D. Borchelt, B. Giasson, 2020, Neuroscience Letters.

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Jacob I. Ayers, D. Borchelt, S. Fromholt, 2015, Acta Neuropathologica.

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

Jacob I. Ayers, D. Borchelt, T. Golde, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease

Jacob I. Ayers, D. Borchelt, J. Valentine, 2014, Journal of neurochemistry.

Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces.

Jacob I. Ayers, S. Bartelt-Hunt, B. Giasson, 2018, Colloids and surfaces. B, Biointerfaces.

Trans-channel fluorescence learning improves high-content screening for Alzheimer’s disease therapeutics

Michael J. Keiser, Daniel R. Wong, Jacob I. Ayers, 2021, Nature Machine Intelligence.

Expanding spectrum of prion diseases.

Jacob I. Ayers, Nick A. Paras, S. Prusiner, 2020, Emerging topics in life sciences.

Prion-like Spreading in Tauopathies

Jacob I. Ayers, D. Borchelt, B. Giasson, 2018, Biological Psychiatry.

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

Jacob I. Ayers, Nick A. Paras, S. Prusiner, 2022, Proceedings of the National Academy of Sciences.

Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Jacob I. Ayers, D. Borchelt, Guilian M. Xu, 2021, Acta Neuropathologica Communications.

Experimental transmissibility of mutant SOD1 motor neuron disease

Jacob I. Ayers, D. Borchelt, Guilian M. Xu, 2014, Acta Neuropathologica.

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Jacob I. Ayers, D. Borchelt, N. Cashman, 2020, PloS one.

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Jacob I. Ayers, D. Borchelt, P. Hart, 2019, G3: Genes, Genomes, Genetics.

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

Jacob I. Ayers, D. Borchelt, J. Ayers, 2018, PloS one.

Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1

Jacob I. Ayers, D. Borchelt, J. Ayers, 2018, bioRxiv.

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Jacob I. Ayers, D. Borchelt, T. Golde, 2014, Proceedings of the National Academy of Sciences.

Mechanisms for Prion Strain Targeting in the Central Nervous System

Jacob I. Ayers, J. Ayers, 2010 .

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Jacob I. Ayers, S. Prusiner, G. Carlson, 2021, Neuron.

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

Jacob I. Ayers, P. Hart, B. Giasson, 2018, Journal of Virology.

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Jacob I. Ayers, B. Giasson, N. Rutherford, 2016, Journal of Virology.

Robust CNS pathology in transgenic mice following peripheral injection of α-synuclein 1 fibrils 2 3 Running title : Peripheral routes of α-synuclein injection 4 5

Jacob I. Ayers, B. Giasson, N. Rutherford, 2016 .

Prion Interference Is Due to a Reduction in Strain-Specific PrPSc Levels

Jacob I. Ayers, A. Kincaid, J. Bartz, 2006, Journal of Virology.

Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism

Jacob I. Ayers, A. Kincaid, J. Bartz, 2008, Journal of Virology.

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Jacob I. Ayers, D. Borchelt, J. Troncoso, 2014, Acta Neuropathologica Communications.

Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Jacob I. Ayers, D. Borchelt, S. Fromholt, 2023, Viruses.

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

Bryan F. Shaw, Jacob I. Ayers, J. Ayers, 2017, The Journal of Biological Chemistry.

Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models

Jacob I. Ayers, D. Borchelt, J. Valentine, 2017, Journal of neurochemistry.

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Jacob I. Ayers, D. Borchelt, J. Glass, 2016, Acta Neuropathologica.

Challenges in Applying Audio Classiﬁcation Models to Datasets Containing Crucial Biodiversity Information

Jacob I. Ayers, M. Tobler, C. Schurgers, 2021 .

Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions

Jacob I. Ayers, S. Prusiner, W. Seeley, 2023, Proceedings of the National Academy of Sciences of the United States of America.