Alessio Ciulli

发表

Automated Determination of Nuclear Magnetic Resonance Chemical Shift Perturbations in Ligand Screening Experiments: The PICASSO Web Server

Antonio Rosato, Andrea Giachetti, Vincenzo Laveglia, 2021, J. Chem. Inf. Model..

Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein–Protein Interactions

Alessio Ciulli, A. Ciulli, Teresa A F Cardote, 2015, ChemMedChem.

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Kwok-Ho Chan, Michael Zengerle, Alessio Ciulli, 2014, Science.

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

Chris Abell, Stefan Knapp, Frank von Delft, 2013, Journal of medicinal chemistry.

Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking.

Chris Abell, João P G L M Rodrigues, Rolf Boelens, 2014, Biochemistry.

A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

Chris Abell, Alessio Ciulli, D. Scott, 2009, Chembiochem : a European journal of chemical biology.

Dissecting fragment-based lead discovery at the von Hippel-Lindau protein:hypoxia inducible factor 1α protein-protein interface.

Andreas Thomann, Alessio Ciulli, Dennis L. Buckley, 2012, Chemistry & biology.

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.

Xavier Lucas, Alessio Ciulli, A. Ciulli, 2017, Current opinion in structural biology.

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach

Christian Sieg, Edith Sim, Elena Polycarpou, 2017, British journal of pharmacology.

Fragment-based approaches to enzyme inhibition.

Chris Abell, Alessio Ciulli, C. Abell, 2007, Current opinion in biotechnology.

Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate

Chris Abell, Dimitri Y Chirgadze, Tom L Blundell, 2008, Chembiochem : a European journal of chemical biology.

NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes

Alessio Ciulli, A. Ciulli, David M. Dias, 2014, Progress in biophysics and molecular biology.

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

Julien Michel, William L. Jorgensen, Craig M. Crews, 2012, Journal of the American Chemical Society.

Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology

Alessio Ciulli, A. Ciulli, Carles Galdeano, 2016, Future medicinal chemistry.

Biophysical screening for the discovery of small-molecule ligands.

Alessio Ciulli, A. Ciulli, 2013, Methods in molecular biology.

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Chris Abell, Tom L Blundell, Alessio Ciulli, 2009, Angewandte Chemie.

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby, Peter Greb, Michael Galant, 2019, Nature Chemical Biology.

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Pedro Soares, Sarah Hewitt, Alessio Ciulli, 2014, Journal of medicinal chemistry.

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

Chris Abell, Alessio Ciulli, C. Abell, 2013, Proceedings of the National Academy of Sciences.

Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.

Chris Abell, Tom L Blundell, Alessio Ciulli, 2010, Journal of the American Chemical Society.