Paul E Brennan

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Robert B A Quinlan, Paul E Brennan, P. Brennan, 2021, RSC chemical biology.

Chemical probes and inhibitors of bromodomains outside the BET family† †The authors declare no competing interests.

Paul E Brennan, P. Brennan, D. Hay, 2016, MedChemComm.

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j

Frank von Delft, Brian D Marsden, Patrick Collins, 2015, Chemical science.

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

Stefan Knapp, Robert S Paton, Susanne Müller, 2014, Angewandte Chemie.

A chemical toolbox for the study of bromodomains and epigenetic signaling

Shili Duan, Mathieu Lupien, Stefan Knapp, 2018, bioRxiv.

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Alexander Pautsch, Stefan Knapp, Roman Fischer, 2016, ACS chemical biology.

Recent Progress in Histone Demethylase Inhibitors.

Akane Kawamura, Christopher J Schofield, Paul E Brennan, 2016, Journal of medicinal chemistry.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Daniel Zaidman, Nir London, Frank von Delft, 2019, Journal of the American Chemical Society.