G. Simig

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CONDENSED 1,3,5-TRIAZEPINES - IV THE SYNTHESIS OF 2,3-DIHYDRO-1H-IMIDAZO-[1,2-a] [1,3,5] BENZOTRIAZEPINES

K. Lempert, B. Ágai, G. Hornyak, 1983 .

Basicity-Tuned Reactivity: diaza-[1,2]-Wittig versus diaza-[1,3]-Wittig Rearrangements of 3,4-Dihydro-2H-1,2,3-benzothiadiazine 1,1-Dioxides

G. Simig, Z. Kelemen, Balázs Volk, 2020, The Journal of organic chemistry.

Synthesis and evaluation of 5-HT(2A) and 5-HT(2C) receptor binding affinities of novel pyrimidine derivatives.

G. Simig, É. Schmidt, K. Tihanyi, 2002, Bioorganic & medicinal chemistry letters.

Efficient synthesis of Nb-thioacyltryptamine derivatives by a three-component Willgerodt–Kindler reaction, and their transformation to 1-substituted-3,4-dihydro-β-carbolines

G. Simig, Balázs Volk, P. Slégel, 2015 .

Stereochemistry and enantiomeric purity of a novel anxiolytic agent, deramciclane fumarate.

G. Simig, L. Ladányi, T. Mezei, 1999, Chirality.

Thermal Ring Contraction Reactions of 9-Aryl-5H,7H-[1,2,5]thiadiazolo[3,4-h][2,3,4]benzothiadiazepine 6,6-Dioxides. Experimental and Computational Studies for Understanding the Course of the Transformations.

G. Simig, T. Kégl, Balázs Volk, 2017, The Journal of organic chemistry.

Towards Tianeptine Analogues: Synthesis of New Ring Systems Containing a Dibenzo[c,f][1,2]thiazepine S,S-Dioxide Core

G. Simig, Balázs Volk, L. Kiss, 2022, Synthesis.

A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.

G. Simig, M. Spedding, L. Hársing, 2015, European journal of pharmacology.

Synthesis and Chemistry of 1,2,3-Benzothiadiazine 1,1-Dioxide Derivatives: A Comprehensive Overview

G. Simig, Balázs Volk, Imre Gyűjtő, 2020 .

Manufacturing Synthesis of 5-Substituted Phthalides

G. Simig, Balázs Volk, F. Faigl, 2010 .

First total synthesis of the β-carboline alkaloids trigonostemine A, trigonostemine B and a new synthesis of pityriacitrin and hyrtiosulawesine

G. Simig, Balázs Volk, M. Milen, 2019, Tetrahedron Letters.

Lithiation of 2-aryl-2-methyl-1,3-dioxolanes with PMDTA-complexed butyllithium

G. Simig, Balázs Volk, J. Kupai, 2017 .

The reaction of α-chloro-α,α-diphenylacetamides with potassium n-cyanoanilide

K. Lempert, G. Simig, 1975 .

Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT₇ receptor antagonist activity.

G. Simig, M. Spedding, G. Szénási, 2011, Journal of medicinal chemistry.

Lithiation of 2-(chloroaryl)-2-aryl-1,3-dioxolanes with butyllithium activated by N,N,N′,N″,N″-pentamethyldiethylenetriamine

G. Simig, M. Porcs-Makkay, A. Komáromi, 2008 .

Synthesis of 4-methyl-2H-1,2,3-benzothiadiazine 1,1-dioxides and their further transformation via alkylation and reduction steps

G. Simig, Balázs Volk, G. Tóth, 2019, Synthetic Communications.

Synthesis, Alkylation and Reduction of 4‐Aryl‐2H‐1,2,3‐benzothiadiazine 1,1‐dioxides

G. Simig, Balázs Volk, G. Tóth, 2019, ChemistrySelect.

Study on the Lithiation Reaction of 3-Diisopropylcarbamoyl-N-pivaloylphenylethylamine

G. Simig, Balázs Volk, J. Halász, 2019, Periodica Polytechnica Chemical Engineering.

Synthesis and further transformations of 8-chloro-3,4-dihydroisoquinoline

G. Simig, Balázs Volk, J. Halász, 2018, Tetrahedron.

Synthesis of 4-unsubstituted 2H-1,2,3-benzothiadiazine 1,1-dioxides via ortho lithiation of protected benzaldehyde derivatives

G. Simig, Balázs Volk, M. Porcs-Makkay, 2014 .

Lithiation of 2‐Aryl‐2‐(chloroaryl)‐1,3‐dioxolanes and Its Application in the Synthesis of New ortho‐Functionalized Benzophenone Derivatives

G. Simig, M. Porcs-Makkay, G. Lukács, 2004 .

Lithiation of 2-(chloroaryl)-2-methyl-1,3-dioxolanes and application in synthesis of new ortho-functionalized acetophenone derivatives

G. Simig, M. Porcs-Makkay, G. Lukács, 2003 .

Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines

G. Simig, Balázs Volk, J. Halász, 2018, Molecules.

Synthesis of a new tetracyclic ring system: pyrrolotriazepinoquinazolinone derivatives

G. Simig, Balázs Volk, A. Dancsó, 2015 .

Transformation of 2H-1,2,3-benzothiadiazine 1,1-dioxides variously substituted at the aromatic ring, via nucleophilic substitution and demethylation reactions

G. Simig, Balázs Volk, G. Tóth, 2020, Synthetic Communications.

Synthesis of 4‐Unsubstituted 2H‐1,2,3‐Benzothiadiazine 1,1‐Dioxides via ortho Lithiation of Protected Benzaldehyde Derivatives.

G. Simig, Balázs Volk, M. Porcs-Makkay, 2014 .

Synthesis of 4,6‐Dichloro‐ and 4,6‐Difluorophthalides: a Systematic Study on the Lithiation of 3,5‐Dihalo‐N,N‐diisopropylbenzamides

G. Simig, Balázs Volk, Balázs Molnár, 2011 .

8-Methoxyisoquinoline derivatives through ortho-selective metalation of 2-(3-methoxyphenyl)ethylamine

G. Simig, M. Schlosser, 1991 .

Interesting transformations of methylenedioxy-substituted ortho-(pivaloylaminomethyl)benzaldehyde

G. Simig, P. Ábrányi‐Balogh, Balázs Volk, 2019, Chemical Monthly.

Lithiation of 2‐(Chloroaryl)‐2‐methyl‐1,3‐dioxolanes and Application in Synthesis of New ortho‐Functionalized Acetophenone Derivatives.

G. Simig, M. Porcs-Makkay, G. Lukács, 2003 .

New practical synthesis of 5‐formylindole

G. Simig, J. Fetter, F. Bertha, 2005 .

Lithiation of 2‐Aryl‐2‐(chloroaryl)‐1,3‐dioxolanes and Its Application in the Synthesis of New ortho‐Functionalized Benzophenone Derivatives.

G. Simig, M. Porcs-Makkay, G. Lukács, 2005 .

Efficient syntheses of the versatile phthalide building blocks, 5,6-diaminoisobenzofuran-1(3H)-one and 5H,7H-furo[3,4-f][2,1,3]benzothiadiazol-5-one

G. Simig, Balázs Volk, A. Dancsó, 2012 .

ortho-Selective metalation and electrophilic substitution of benzylamine derivatives

G. Simig, M. Schlosser, 1988 .

New, Lithiation-Based Synthesis of Tofisopam, a 2,3-Benzodiazepine Type Anxiolytic Drug

G. Simig, Balázs Volk, G. Lukács, 2014 .

2,3-Benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects

G. Simig, M. Spedding, L. Hársing, 2008, Neurochemistry International.

The reaction of N-cyanoamines with 1-(t-butyl)-3,3-diphenylaziridinone: A general method for the synthesis of 1-alkyl-, 1-aralkyl- and 1-aryl-5,5-diphenylhydantoins and -glycocyamidines

K. Lempert, G. Simig, G. Czira, 1975 .

Synthesis of a New Tetracyclic Ring System: Pyrrolotriazepinoquinazolinone Derivatives.

G. Simig, Balázs Volk, A. Dancsó, 2015 .

Synthesis of a new compound family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin-4(5H)-ones

G. Simig, P. Ábrányi‐Balogh, Balázs Volk, 2014 .

Manufacture of High-Purity Meloxicam via Its Novel Potassium Salt Monohydrate

G. Simig, Balázs Volk, M. Porcs-Makkay, 2009 .

Synthesis and base-mediated rearrangement of 3-acetyl-2-methyl-3,4-dihydro-2H-1,2,3-benzothiadiazine 1,1-dioxides

G. Simig, Balázs Volk, Imre Gyűjtő, 2016 .

Consecutive alkylation–reduction reactions of 2H-1,2,3-benzothiadiazine 1,1-dioxide derivatives. Synthesis of 2-alkyl-, 3-alkyl-, and 2,3-dialkyl-3,4-dihydro-2H-1,2,3-benzothiadiazine 1,1-dioxides

G. Simig, Balázs Volk, M. Porcs-Makkay, 2015 .

Alkylation of 2H-1,2,3-benzothiadiazine 1,1-dioxides. Formation of a new family of mesoionic compounds

G. Simig, Balázs Volk, M. Porcs-Makkay, 2014 .

Rearrangement of o-(pivaloylaminomethyl)benzaldehydes: an experimental and computational study

G. Simig, P. Ábrányi‐Balogh, Balázs Volk, 2020, Beilstein journal of organic chemistry.

8‐Methoxy‐1,2,3,4‐tetrahydroisoquinoline Through ortho‐Selective Metalation of 2‐(3‐Methoxyphenyl)ethylamine.

G. Simig, M. Schlosser, 2010 .

A New Route to Isoindole Intermediates

G. Simig, 1990 .

New Practical Synthesis of 5-Formylindole.

G. Simig, J. Fetter, F. Bertha, 2005 .

3-Amino-2-arylpropanoic acids by electrophilic substitution of 2-arylethylamines at the benzylic position

G. Simig, M. Schlosser, 1991 .

Three complementary methods offering access to 5-substituted 1,2,3,4-tetrahydroisoquinolines

G. Simig, M. Schlosser, H. Geneste, 1998 .

Application of the systems chemistry approach on the ammonolysis of 1-ethoxycarbonyl- and 1-phenoxycarbonyl-3-(2-thienyl)oxindoles. A method to predict reactivity.

G. Simig, I. Csizmadia, Balázs Volk, 2012, The Journal of organic chemistry.

Simple and condensed β-lactams. Part 5. The synthesis of some (5RS,6SR)-2-(2-formylaminoethylthio)-6-(2-methyl-1,3-dioxolan-2-yl)carbapenem-3-carboxylic acid derivatives and related compounds

K. Lempert, G. Hornyak, G. Simig, 1986 .

Simple and condensed β-lactams. Part 7. Side chain extensions of some azetidin-2-one derivatives, and the formation of melillo's lactone, a strategic intermediate in the total synthesis of thienamycin, from 3-acetyl-1-benzyl-4-cyanomethylazetidin-2-one

K. Lempert, G. Hornyak, G. Simig, 1986 .

Synthesis of aminomethylazetidines regioselective reactions of mesyloxymethylazetidinones with nucleophiles II

G. Simig, G. Czira, J. Fetter, 2006 .

Regioselective reactions of mesyloxymethylazetidinones with nucleophiles I. Cleavage of the azetidinone ring, azetidinone-aziridine ring transformations

G. Simig, G. Czira, J. Fetter, 2006 .

Simple and condensed β-lactams-I : The application of diketene in β-lactam synthesis. The synthesis and functional group manipulations of diethyl 3-acetyl-4-oxoazetidine-2,2-dicarboxylates

K. Lempert, G. Hornyak, G. Simig, 1985 .

(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.

Endre Hegedus, Tibor Mezei, G. Simig, 2008, Journal of medicinal chemistry.

A trifluoromethyl group directed semipinacol rearrangement: synthesis of α-(trifluoroacetyl) diarylmethanes

G. Hornyak, G. Simig, J. Fetter, 1997 .

Synthesis of 1,2-dihydroisoquinoline-3-carbaldehydes

G. Simig, 1992 .

Synthesis of α-(trifluoromethyl)phenylacetonitrile. Anomalous reactions of α-tosyloxy-α-(trifluoromethyl)phenylacetonitrile with sodium borohydride

G. Simig, D. Bózsing, G. Németh, 1996 .

Synthesis of 4-Amino-5H-1,2-oxathiole 2,2-Dioxides by Cyclization of Cyanohydrin Mesylates. New Routes to β-Amino and β-Keto Sulfonic Acids

G. Simig, László Poszávácz, 1997 .

Condensed 1,3,5-triazepines-II. The synthesis of 2,3-dihydro-1H-imidazo[1,2-a] [1,3,5]benzotriazepin-5(6H)-ones and -thiones

K. Lempert, B. Ágai, G. Hornyak, 1976 .

The reduction of triarylcarbenium ions by n-nucleophiles. The operation of the intramolecular version of the Olah–Svoboda mechanism in the reductive cyclization of the tris-(2,6-dimethoxyphenyl)carbenium ion

K. Lempert, G. Simig, P. Huszthy, 1985 .

The reduction of triarylcarbenium ions by alcohols: simple hydride transfer or concerted breakdown of ortho-adducts ?

K. Lempert, G. Simig, P. Huszthy, 1982 .

The reaction of tris(4-methoxyphenyl)methyl chloride with sodium methoxide—non-operation of single electron transfer pathways

K. Lempert, G. Simig, K. Vékey, 1982 .

Synthesis of 1,2-dihydroisoquinoline-3-carbaldehydes. [Erratum to document cited in CA117(15):150854e]

G. Simig, M. Schlosser, 1993 .

Medicinal chemistry of 5-HT5A receptor ligands: a receptor subtype with unique therapeutical potential.

G. Simig, G. Bagdy, Balázs Volk, 2010, Current topics in medicinal chemistry.

Rosuvastatin manganse, copper, iron and zinc salts with high photochemical stability

G. Simig, Balázs Volk, J. Barkóczy, 2010 .

Efficient synthesis of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones

G. Simig, Balázs Volk, A. Dancsó, 2016 .

Chemistry of an Unexplored Heterocyclic Ring System: Versatile Synthesis of 5‐Aryl‐2,3,4‐benzothiadiazepine 2,2‐dioxides

G. Simig, Balázs Volk, J. Fetter, 2015 .

New Practical Synthesis of Tenidap

G. Simig, Márta Porcs-Makkay and, 2000 .

Synthesis of 4-(trifluoromethyl)isoquinolines. Influence of trifluoromethyl group on the Pictet–Gams ring closure reaction

G. Simig, László Poszávácz, 2001 .

Unusual behaviour of N-cinnamoyl-2-hydroxy-2-(trifluoromethyl)-arylethylamines in pictet-gams cyclization. Synthesis of 2-styryl-5-aryl-5-trifluoromethyl-2-oxazolines

G. Simig, László Poszávácz, 2000 .

K. Lempert, G. Hornyak, G. Simig, 2001 .

New practical synthesis of panomifene. The effect of 2-trifluoromethyl substituent on the stereoselectivity of dehydration of 1,1,2-triarylethanols

G. Simig, G. Németh, Rita Kapiller-Dezsőfi, 1996 .

Synthesis of 1,4-diarylpyrrolotriazepine derivatives by two diverse strategies

G. Simig, Balázs Volk, A. Dancsó, 2016, Monatshefte für Chemie - Chemical Monthly.

Synthesis of Three New Tricyclic Ring Systems: Pyrrolotriazepines Condensed with an Imidazole, a Triazole, or a Tetrazole Ring

G. Simig, Balázs Volk, A. Dancsó, 2015, Synlett.

On the occurrence of the SN (ANRORC) mechanism in the amination of substituted 1, 3, 5-triazines

G. Simig, H. Plas, C. Landheer, 2010 .

Study on the Alkylation Reactions of N(7)-Unsubstituted 1,3-Diazaoxindoles

G. Simig, Balázs Volk, J. Halász, 2017, Molecules.

Literature Survey and Further Studies on the 3-Alkylation of N-Unprotected 3-Monosubstituted Oxindoles. Practical Synthesis of N-Unprotected 3,3-Disubstituted Oxindoles and Subsequent Transformations on the Aromatic Ring

G. Simig, Balázs Volk, E. Kókai, 2016, Molecules.

Condensed 1,3,5-triazepines-III. Derivatives of 4,5-dihydro-[1,3,5]triazepino[1,2-a]benzimidazole

K. Lempert, B. Ágai, G. Hornyak, 1976 .

New Manufacturing Procedure of Cetirizine

G. Simig, F. Bartha, Balázs Volk, 2012 .

New synthesis of a late-stage tetracyclic key intermediate of lumateperone

G. Simig, Balázs Volk, T. Nagy, 2022, Beilstein journal of organic chemistry.

Manufacturing synthesis of lumateperone tosylate based on a new resolution process of a key intermediate

G. Simig, Balázs Volk, M. Milen, 2022, Tetrahedron.

Synthesis of new 1,2‐dihydrophthalazines

G. Simig, G. Lukács, 2002 .

Catalyst‐ and Solvent‐Free Room Temperature Synthesis of α‐Aminophosphonates: Green Accomplishment of the Kabachnik–Fields Reaction

G. Simig, Balázs Volk, A. Dancsó, 2023, ChemistrySelect.