I. Sayers

Stuart G. Parker, Martin J. Connolly, Ian Sayers, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?

I. Sayers, I. Hall, K. Kuokkanen, 2021, Frontiers in Allergy.

Promoter polymorphism in the 5‐lipoxygenase (ALOX5) and 5‐lipoxygenase‐activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population

I. Sayers, B. Beghé, S. Holgate, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The cysteinyl‐leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma

I. Sayers, B. Beghé, S. Holgate, 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells

C. Billington, I. Sayers, I. Hall, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Defining a role for lung function associated gene GSTCD in cell homeostasis

K. Probert, I. Sayers, I. Hall, 2019, Respiratory Research.

INVITED REVIEW SERIES: MOLECULAR TECHNIQUES FOR RESPIRATORY DISEASES

I. Sayers, I. Hall, R. Hall, 2018 .

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

L. Wain, N. Shrine, M. S. Artigas, 2017, PloS one.

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.

Blair H. Smith, L. Wain, M. Obeidat, 2011, American journal of respiratory and critical care medicine.

Characterization of protocadherin‐1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation

D. Postma, I. Sayers, G. Koppelman, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Genetics of Asthma: Insights From Genome Wide Association Studies

I. Sayers, M. Portelli, R. Cooper, 2021 .

Phenotypic and functional translation of IL33 genetics in asthma.

L. Wain, N. Shrine, C. Billington, 2020, The Journal of allergy and clinical immunology.

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

L. Wain, N. Shrine, I. Sayers, 2021, medRxiv.

Genetic Associations and Architecture of Asthma-COPD Overlap

Sina A. Gharib, L. Wain, N. Shrine, 2022, Chest.

Chapter 28 Asthma

I. Sayers, D. Shaw, M. Portelli, 2014, Handbook of Pharmacogenomics and Stratified Medicine.

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro

C. Billington, M. Obeidat, I. Sayers, 2016, PloS one.

HTR4 gene structure and altered expression in the developing lung

C. Billington, I. Sayers, I. Hall, 2013, Respiratory Research.

Mice, rats, hamsters and gerbils

I. Sayers, Stephen Smith, 2010 .

Evaluation of Differentiated Human Bronchial Epithelial Cell Culture Systems for Asthma Research

Ian Sayers, I. Sayers, C. Bosquillon, 2012, Journal of allergy.

Evidence of a genetic contribution to lung function decline in asthma.

I. Sayers, G. Koppelman, 2011, The Journal of allergy and clinical immunology.

Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

I. Sayers, A. Henry, T. Sharp, 2021, ERJ Open Research.

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

Carlos Flores, David C Nickle, Nick Shrine, 2017, The Lancet. Respiratory medicine.

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma

L. Wain, I. Sayers, M. Tobin, 2014, PloS one.

Asthma

I. Sayers, D. Shaw, M. Portelli, 2014, The Lancet.

Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations

I. Sayers, I. Adcock, Sile Hu, 2021, Frontiers in Allergy.

Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort

I. Sayers, D. Strachan, S. Ring, 2009, Thorax.

β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study

I. Sayers, D. Strachan, I. Hall, 2006, The Lancet.

Polymorphisms in the interleukin‐4 and interleukin‐4 receptor α chain genes confer susceptibility to asthma and atopy in a Caucasian population

Tom R. Gaunt, I. Sayers, B. Beghé, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection

L. Wain, N. Shrine, R. Allen, 2022, European Respiratory Journal.

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

D. Postma, I. Sayers, J. Vonk, 2016, European Respiratory Journal.

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium

I. Sayers, C. Brightling, C. Stewart, 2011, Thorax.

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients

I. Sayers, G. Koppelman, P. Howarth, 2017, Allergy.

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

D. Postma, I. Sayers, I. Hall, 2009, The Journal of allergy and clinical immunology.

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

L. Wain, N. Shrine, R. Allen, 2017, The Lancet. Respiratory medicine.

Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease

I. Sayers, B. Beghé, A. Wardlaw, 2010, Allergy.

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development

I. Sayers, I. Hall, S. K. Merid, 2016, Respiratory Research.

Evidence for Mesozoic Marine Source in the Western Gulf of Thailand

I. Sayers, R. White, P. Farrimond, 2016 .

Genetic risk factors for the development of allergic disease identified by genome-wide association

I Sayers, I. Sayers, E. Hodge, 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Epithelial cell dysfunction, a major driver of asthma development

I. Sayers, M. Nawijn, D. Knight, 2020, Allergy.

IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.

I. Sayers, I. Hall, A. McKenzie, 2013, The Journal of allergy and clinical immunology.

Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

I. Sayers, J. Holloway, A. Tulah, 2013, BMC Medical Genetics.

The secretory tailpiece isoform of IgE is not associated with Allergy

I. Sayers, A. Aslam, A. Wheatley, 2008, Allergy.

Genetic basis for personalized medicine in asthma

I. Sayers, M. Portelli, 2012, Expert review of respiratory medicine.

The Importance of Lys-352 of Human Immunoglobulin E in FcϵRII/CD23 Recognition*

Alan C. Spivey, Ian Sayers, I. Sayers, 2004, Journal of Biological Chemistry.

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease

I. Sayers, I. Hall, J. Cockcroft, 2016, Chronic respiratory disease.

Effects of atopy and grass pollen season on histamine H₄ receptor expression in human leukocytes.

I. Sayers, I. Hall, E. Hodge, 2013, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Pro-Inflammatory Effects in ex vivo Human Lung Tissue of Respirable Smoke Extracts from Indoor Cooking in Nepal.

C. Billington, I. Sayers, I. Hall, 2020, Annals of the American Thoracic Society.

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Hakeem G. Almabrazi, Sina A. Gharib, Blair H. Smith, 2023, Nature Genetics.

Inhaled corticosteroids and long acting β2 agonists can help patients with COPD

I. Sayers, P. van Eerdewegh, B. Beghé, 2003, Thorax.

Approach to preventive health care and welfare in rabbits

I. Sayers, 2010, In Practice.

Pharmacogenetics and asthma: false hope or new dawn?

I. Sayers, I. Hall, 2007, European Respiratory Journal.

Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid

C. Billington, I. Sayers, I. Hall, 2017, F1000Research.