J. Karn

发表

Toward a physical map of the genome of the nematode Caenorhabditis elegans.

A. Coulson, J. Sulston, S. Brenner, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA.

J. Karn, P. Vaglio, A. Murchie, 2004, Journal of molecular biology.

Short-Chain Fatty Acids from Periodontal Pathogens Suppress Histone Deacetylases, EZH2, and SUV39H1 To Promote Kaposi's Sarcoma-Associated Herpesvirus Replication

J. Karn, Xiaolan Yu, Abdel-Malek Shahir, 2014, Journal of Virology.

New bacteriophage lambda vectors with positive selection for cloned inserts.

S. Brenner, J. Karn, L. Barnett, 1983 .

Molecular analysis of the unc-54 myosin heavy-chain gene of Caenorhabditis elegans

Sydney Brenner, Jonathan Karn, J. Karn, 1981, Nature.

Viruses, Mark Thy Message Well.

J. Karn, Fengchun Ye, 2016, Cell host & microbe.

Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".

Gabriele Varani, Mohammad Afshar, Ben Davis, 2004, Journal of molecular biology.

Periodic features in the amino acid sequence of nematode myosin rod.

J. Karn, A. Mclachlan, J Karn, 1983, Journal of molecular biology.

PHOSPHORYLATION OF NUCLEAR PROTEINS AT TIMES OF GENE ACTIVATION

J. Karn, V. Allfrey, Edward M. Johnson, 1973 .

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P‐TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression

J. Karn, M. Chance, Benlian Wang, 2015, Proteomics.

A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.

J. Karn, J. Mellors, E. Acosta, 2020, Journal of Infectious Diseases.

Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis

J. Karn, A. F. Karim, Xuedong Ding, 2016, Scientific Reports.

HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function

J. Karn, A. Spivak, D. Margolis, 2016, Front. Immunol..

Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.

J. Karn, G. Varani, F. Aboul-Ela, 1996, Nucleic acids research.

The HIV Tat-TAR interaction, a novel target for drug discovery

J. Karn, G. Varani, E. Felder, 1998 .

Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells

J. Karn, K. Leskov, S. Valadkhan, 2022, PLoS pathogens.

Detecting Sources of Immune Activation and Viral Rebound in HIV Infection

J. Karn, Alon Herschhorn, D. Kaufmann, 2022, bioRxiv.

New bacteriophage lambda vectors with positive selection for cloned inserts.

S. Brenner, J. Karn, L. Barnett, 1983, Methods in enzymology.

Oral abstracts of the 21st International AIDS Conference 18–22 July 2016, Durban, South Africa

Michael I. Jordan, Donald A. Jackson, J. G. Ndirangu, 2016, Journal of the International AIDS Society.

An HIV-induced mechanism for T cell quiescence and proviral latency

J. Karn, F. Niazi, K. Leskov, 2021 .

Characterization of the non-histone nuclear proteins associated with rapidly labeled heterogeneous nuclear RNA.

J. Karn, V. Allfrey, G. Vidali, 1977, The Journal of biological chemistry.

A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation

J. Karn, J. Yates, J. Moresco, 2014, Genes & development.

Tat transactivation A gene-specific role for the Ssu 72 RNAPII CTD phosphatase in HIV-1 Material Supplemental

Katherine A. Jones, J. Karn, J. Yates, 2014 .

Sequence‐Specific Binding of DNA by Non‐Histone Proteins and Their Migration from Cytoplasm to Nucleus During Gene Activation

J. Karn, V. Allfrey, Edward M. Johnson, 2008 .

Reduction of the HIV-1 reservoir in T cells from persons with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells ex vivo

Michele D. Sobolewski, J. Karn, J. Mellors, 2022, bioRxiv.

Regulation of cell cycle duration by c-myc levels.

J. Karn, J. Watson, W. Vedeckis, 1989, Oncogene.

Distribution of NG, NG,-dimethylarginine in nuclear protein fractions.

J. Karn, V. Allfrey, G. Vidali, 1977, Biochemical and biophysical research communications.

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

J. Karn, P. Bacchetti, E. Scully, 2018, Proceedings of the National Academy of Sciences.

Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.

J. Karn, M. Krieg, M. Gait, 1996, Journal of molecular biology.

A new BET on the control of HIV latency

J. Karn, 2013, Cell cycle.

Molecular biology of HIV: new insights into the virus life‐cycle

J. Karn, A. Cann, 1989, AIDS.

The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder.

J. Karn, K. Leskov, Fengchun Ye, 2022, Trends in immunology.

CBF‐1 promotes transcriptional silencing during the establishment of HIV‐1 latency

J. Karn, M. Tyagi, 2007, The EMBO journal.

New insights into transcription elongation control of HIV-1 latency and rebound.

J. Karn, U. Mbonye, F. Kizito, 2023, Trends in immunology.

The rapid non-polar transport of auxin in the phloem of intact Coleus plants

J. Karn, M. Goldsmith, D. A. Cataldo, 1974, Planta.

Transcriptional and posttranscriptional regulation of HIV-1 gene expression.

Jonathan Karn, J. Karn, C. Stoltzfus, 2012, Cold Spring Harbor perspectives in medicine.

High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.

J. Karn, P. Butler, C. Dingwall, 1993, Journal of molecular biology.

HIV‐1 tat protein stimulates transcription by binding to a U‐rich bulge in the stem of the TAR RNA structure.

M. Singh, J. Karn, I. Ernberg, 1990, The EMBO journal.

COVID-19 plasma exosomes promote proinflammatory immune responses in peripheral blood mononuclear cells

J. Karn, G. McComsey, T. McIntyre, 2022, Scientific reports.

Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

J. Karn, C. Harding, S. Sieg, 2018, Nature Communications.

Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly Responsible for Human Immunodeficiency Virus Type 1 Tat-Activated Transcriptional Elongation

J. Karn, C. Isel, C. Bourgeois, 2002, Molecular and Cellular Biology.

Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial

J. Karn, M. Mathews, M. Spino, 2016, PloS one.

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

J. Karn, K. Lassen, M. Tyagi, 2008, Journal of Virology.

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.

J. Karn, Xiaolan Yu, Abdel-Malek Shahir, 2015, Virology.

Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.

J. Karn, U. Mbonye, 2014, Virology.

Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

J. Karn, U. Mbonye, 2011, Current HIV research.

T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.

Jonathan Karn, J. Karn, Young Kyeung Kim, 2011, Journal of molecular biology.

Novel bacteriophage lambda cloning vector.

S. Brenner, J. Karn, L. Barnett, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic nucleotide phosphodiesterases of Hyalophora cecropia silkmoth fat body.

J. Karn, G. R. Wyatt, C. Filburn, 1977, Biochimica et biophysica acta.

An isotopic assay of cyclic 3',5'-nucleotide phosphodiesterase with aluminum oxide columns.

J. Karn, C. Filburn, 1973, Analytical biochemistry.

Differential phosphorylation and turnover of nuclear acidic proteins during the cell cycle of synchronized HeLa cells.

J. Karn, V. Allfrey, G. Vidali, 1974, The Journal of biological chemistry.

Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells

J. Karn, M. Morales, Yun Wang, 2012, Journal of NeuroVirology.

Tobacco mosaic virus induces the synthesis of a family of 3' coterminal messenger RNAs and their complements.

J. Karn, P. Goelet, 1982, Journal of molecular biology.

Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation.

J. Karn, C. Isel, Jonathan Karn, 1999, Journal of molecular biology.

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication.

J. Karn, G. Varani, E. Felder, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins

Michael J. Gait, Mohinder Singh, Clare E. Pritchard, 1994, Nucleic Acids Res..

Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA

John A. Robinson, J. Karn, G. Varani, 2011, PLoS pathogens.

Nucleotide sequence of tobacco mosaic virus RNA.

J. Karn, M. Akam, P. Butler, 1982, Proceedings of the National Academy of Sciences of the United States of America.

The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein.

J. Karn, G. Varani, J Karn, 1995, Journal of molecular biology.

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

J. Karn, G. Landreth, S. Valadkhan, 2016, Journal of NeuroVirology.

Immunological identification of the genes encoding the four myosin heavy chain isoforms of Caenorhabditis elegans.

J. Karn, F. Stockdale, D. Miller, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Cloning nematode myosin genes.

J. Karn, N. Dibb, D. Miller, 1985, Cell and muscle motility.

Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle

J. Karn, A. McLachlan, 1982, Nature.

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) Recruits CoREST 2 Transcription Repressor Complexes to Silence HIV Following Proviral Reactivation 3 in Microglial Cells

J. Karn, K. Nguyen, S. Valadkhan, 2021 .

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

J. Karn, Won-Kyung Cho, C. Dobrowolski, 2021, bioRxiv.

Inhibition of the H3K27 demethylase UTX enhances the epigenetic 1 silencing of HIV proviruses and induces HIV-1 DNA hypermethylation

J. Karn, Won-Kyung Cho, C. Dobrowolski, 2021 .

Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.

J. Karn, F. Kashanchi, Geetaram Sahu, 2015, Virology.

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

M. Adams, J. Karn, K. Fujinaga, 2014, Molecular and Cellular Biology.

Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation

J. Karn, Sichun Yang, Benlian Wang, 2018, The Journal of Biological Chemistry.

The Molecular Basis for Human Immunodeficiency Virus Latency.

J. Karn, U. Mbonye, 2017, Annual review of virology.

Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress

J. Karn, S. Bicciato, M. Forcato, 2021, EMBO molecular medicine.

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

J. Karn, K. Leskov, S. Valadkhan, 2021, bioRxiv.

Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.

J. Karn, K. Vlahovicek, C. Herrmann, 2023, Cell reports.

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

J. Karn, J. Finch, S. Heaphy, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Control of human immunodeficiency virus replication by the tat, rev, nef and protease genes.

J. Karn, J Karn, 1991, Current opinion in immunology.

An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb

John A. Robinson, J. Karn, G. Varani, 2018, Nucleic acids research.

Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein

Gabriele Varani, John A. Robinson, Thomas C. Leeper, 2009, Proceedings of the National Academy of Sciences.

Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family.

J. Karn, M. Krause, N. Dibb, 1989, Journal of molecular biology.

Stimulation of Tat‐associated kinase‐independent transcriptional elongation from the human immunodeficiency virus type‐1 long terminal repeat by a cellular enhancer

J. Karn, M. West, 1999, The EMBO journal.

Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type‐1 transcription elongation complex

J. Karn, N. Keen, M. Churcher, 1997, The EMBO journal.

Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1.

J. Karn, M. Krieg, M. Krieg, 1999, Journal of molecular biology.

Preventing Premature RNA Release at Immunodeficiency Virus Type 1 Tat by Spt5 Cooperates with Human

J. Karn, M. West, C. Bourgeois, 2014 .

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

J. Karn, M. Chance, G. Gokulrangan, 2013, PLoS pathogens.

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

J. Karn, 2011, Current opinion in HIV and AIDS.

Recruitment of TFIIH to the HIV LTR is a rate‐limiting step in the emergence of HIV from latency

J. Karn, Shwu‐Yuan Wu, C. Chiang, 2006, The EMBO journal.

Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

J. Karn, M. West, C. Bourgeois, 2002, Molecular and Cellular Biology.

Terminator Sequences Preventing Premature RNA Release at Immunodeficiency Virus Type 1 Tat by Spt 5 Cooperates with Human

J. Karn, M. West, C. Bourgeois, 2002 .

Activation of Human Immunodeficiency Virus Transcription in T Cells Revisited: NF-κB p65 Stimulates Transcriptional Elongation

J. Karn, M. West, A. D. Lowe, 2001, Journal of Virology.

Tat , a novel regulator of HIV transcription and latency

J. Karn, 2001 .

Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.

J. Karn, N. Keen, M. Gait, 1996, Proceedings of the National Academy of Sciences of the United States of America.

RNA recognition by the human immunodeficiency virus Tat and Rev proteins.

J. Karn, M. Gait, Michael J. Gait, 1993, Trends in biochemical sciences.

Cross-talk between microglia and neurons regulates HIV latency

J. Karn, P. Knapp, Fengchun Ye, 2019, PLoS pathogens.

Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

J. Karn, N. Greenspan, P. Pandiyan, 2021, Nature Communications.

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

J. Karn, B. Das, C. Dobrowolski, 2017, mBio.

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

J. Karn, D. Margolis, K. Keedy, 2011, Journal of Virology.

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

J. Karn, M. Tyagi, R. Pearson, 2010, Journal of Virology.

Sequence analysis of mutations that affect the synthesis, assembly and enzymatic activity of the unc-54 myosin heavy chain of Caenorhabditis elegans.

D. M. Brown, J. Karn, R. Waterston, 1985, Journal of molecular biology.

Paramyosin gene (unc-15) of Caenorhabditis elegans. Molecular cloning, nucleotide sequence and models for thick filament structure.

S. Brenner, J. Karn, A. Mclachlan, 1989, Journal of molecular biology.

Molecular Biology of Muscle Development

J. Karn, David M. Miller, N. Dibb, 1987 .

A molecular rheostat: Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression

J. Karn, P. Butler, D. Mann, 1994 .

A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells

J. Karn, A. Komar, B. Mazumder, 2021, Journal of virology.

Tackling Tat.

J. Karn, Jonathan Karn, 1999, Journal of molecular biology.

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

J. Karn, K. Khalili, R. Kamiński, 2015, Scientific Reports.

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR / Cas 9 Gene Editing SUPPLEMENTARY MATERIALS

J. Karn, K. Khalili, R. Kamiński, 2016 .

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events

J. Karn, J. Tilton, Caroline O Tabler, 2014, Journal of Virology.

The histone deacetylase inhibitor vorinostat ( SAHA ) increases the susceptibility of uninfected 1 CD 4 + T cells to HIV by increasing the kinetics and efficiency of post-entry viral events 2 3

J. Karn, J. Tilton, Caroline O Tabler, 2014 .

The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells

J. Karn, Fengchun Ye, Nirmala Ramanath, 2018, Journal of Neuroimmune Pharmacology.

A new selective phage cloning vector, λ2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI

S. Brenner, J. Karn, M. Gait, 1984 .

Phasmids: hybrids between ColE1 plasmids and E. coli bacteriophage lambda.

S. Brenner, J. Karn, G. Cesareni, 1982, Gene.

Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation

J. Karn, M. Altfeld, S. Lewin, 2018, The Journal of infectious diseases.

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

J. Karn, R. Rojas, B. Das, 2017, Retrovirology.

Bacterial Short Chain Fatty Acids Push All The Buttons Needed To Reactivate Latent Viruses.

J. Karn, Fengchun Ye, 2015, Stem cell epigenetics.

Negative Feedback Regulation of HIV-1 by Gene Editing Strategy

J. Karn, K. Khalili, T. Malcolm, 2016, Scientific Reports.

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

Fan Yang, Kamel Khalili, Fang Li, 2014, Proceedings of the National Academy of Sciences.

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) Recruits CoREST Transcription Repressor Complexes to Silence HIV Following Proviral Reactivation in Microglial Cells

J. Karn, K. Leskov, S. Valadkhan, 2021, bioRxiv.

Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro.

J. Karn, M. Gait, M. Churcher, 1993, Proceedings of the National Academy of Sciences of the United States of America.

OP 8.2 – 00033 Interleukin-2 administration is a potent latency reversal agent in people with treated HIV infection

J. Karn, D. Moisi, K. Leskov, 2022, Journal of virus eradication.

Corrigendum: Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

J. Karn, K. Khalili, R. Kamiński, 2016, Scientific Reports.

Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation.

J. Karn, M. Altfeld, S. Lewin, 2018 .

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

J. Karn, R. Rojas, B. Das, 2017, Retrovirology.

Regulation of hiv 1 gene expression by the rna binding proteins tat and rev

J. Karn, C. Dingwall, M. Skinner, 1991 .

Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.

S. Brenner, J. Karn, L. Barnett, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial

J. Karn, J. Safrit, D. Douek, 2022, Nature Medicine.

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

J. Karn, I. Ernberg, C. Dingwall, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA.

J Grasby, J. Karn, J. Grasby, 1993, Journal of molecular biology.

Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein.

J. Karn, S. Iwai, D. Mann, 1992, Nucleic acids research.

New insights into the mechanism of HIV-1 trans-activation.

J. Karn, J Karn, M A Graeble, 1992, Trends in genetics : TIG.

Special issue: Structural and molecular biology of HIV.

J. Karn, M. Summers, 2011, Journal of molecular biology.

Nucleotide sequence of tobacco mosaic virus RNA ( oligonucleotide primers / cDNA library / RNA polymorphism / eukaryotic ribosome binding / leaky amber termination )

J. Karn, P. Butler, G. Lomonossoff, 2022 .

Impact of Tamoxifen on Vorinostat-Induced HIV Expression in Women on Antiretroviral Therapy (ACTG A5366:The MOXIE trial).

J. Karn, D. Kuritzkes, K. Squires, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

PD-1 dependent expansion of Amphregulin+FOXP3+ cells is associated with oral immune dysfunction in HIV patients on therapy

J. Karn, D. McDonald, N. Greenspan, 2021, bioRxiv.

Progress in anti-HIV structure-based drug design.

J. Karn, M. Gait, 1995, Trends in biotechnology.

Transformation of growth factor-dependent myeloid stem cells with retroviral vectors carrying c-myc.

J. Karn, J. Parrington, S. M. Green, 1989, Oncogene.

A new selective phage cloning vector, lambda 2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI.

S. Brenner, J. Karn, M. Gait, 1984, Gene.

The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency

J. Karn, Qiang Zhou, Xiaohui Wang, 2018, PLoS pathogens.

Regulatory and essential light-chain-binding sites in myosin heavy chain subfragment-1 mapped by site-directed mutagenesis.

J. Karn, R. Jakes, A. Newman, 1989, Journal of molecular biology.

Phosphorylation of DNA-binding nuclear acidic proteins and gene activation in the HeLa cell cycle.

J. Karn, V. Allfrey, G. Vidali, 1974, Cold Spring Harbor Symposia on Quantitative Biology.

Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.

Brigitte E. Sanders-Beer, R. Siliciano, J. Karn, 2023, AIDS research and human retroviruses.

The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells

J. Karn, Fengchun Ye, Nirmala Ramanath, 2018, Journal of Neuroimmune Pharmacology.

[Murine retrovirus vector expressing env gene of human immunodeficiency virus type 1 (HIV-1)].

J. Karn, T. Kimura, 1991, Uirusu.

Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

J. Karn, C. Harding, S. Sieg, 2018, Nature Communications.

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency

J. Karn, P. Cannon, G. N. Llewellyn, 2017, Journal of NeuroVirology.

Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda

J. Karn, W. Boom, D. Winner, 2022, Retrovirology.

Flexible regions of RNA structure facilitate co-operative Rev assembly on the Rev-response element.

J. Karn, A. Kelley, P. Butler, 1996, Journal of molecular biology.

Early nuclear events in the induction of lymphocyte proliferation by mitogens. Effects of concanavalin A on the phosphorylation and distribution of non-histone chromatin proteins.

J. Karn, V. Allfrey, E. Johnson, 1974, The Journal of biological chemistry.

The genes sup-7 X and sup-5 III of C. elegans suppress amber nonsense mutations via altered transfer RNA

J. Karn, R. Waterston, L. Barnett, 1983, Cell.

Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells

J. Karn, M. Morales, Yun Wang, 2012, Journal of NeuroVirology.

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

J. Karn, A. Telenti, A. Ciuffi, 2019, mBio.

The human immunodeficiency virus long terminal repeat includes a specialised initiator element which is required for Tat-responsive transcription.

J. Karn, K. Rittner, M. Gait, 1995, Journal of molecular biology.

Methods for cDNA cloning and sequencing tobacco mosaic virus RNA.

J. Karn, P. Goelet, 1984, Gene.

A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon

J. Karn, D. Khan, P. Fox, 2023, Nature communications.

Sensitive detection of RNA using strand-specific M13 probes.

J. Karn, J. Frampton, P. Goelet, 1982, Gene.

RNA binding by the tat and rev proteins of HIV-1.

J T Finch, J. Karn, J. Finch, 1991, Biochimie.

Trans-Activation Requires the Binding of the HIV-1 Tat Protein to Tar RNA

J. Karn, I. Ernberg, C. Dingwall, 1991 .

The Influence of Blood pH on Peripheral Vascular Tone: Possible Role of Proteases and Vaso-Active Polypeptides

J. Karn, N. Back, H. Wilkens, 1970 .

Virology and immunology

J. Karn, 1995 .

Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells

Daniel J. Blankenberg, J. Karn, M. Gerschenson, 2023, International journal of molecular sciences.

Sex differences in HIV Persistence and Reservoir Size during Aging.

J. Karn, S. Gianella, M. Strain, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A Reliable Primary Cell Model for HIV Latency: The QUECEL (Quiescent Effector Cell Latency) Method.

J. Karn, U. Mbonye, C. Dobrowolski, 2022, Methods in molecular biology.

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.

J. Karn, Xiaolan Yu, Abdel-Malek Shahir, 2015, Virology.

Human immunodeficiency virus 1 tat protein binds transactivation-responsive region ( TAR ) RNA in vitro ( transactivation / RNA-binding proteins / gene synthesis / andsense RNA )

J. Karn, I. Ernberg, C. Dingwall, 2022 .

Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation

J. Karn, Sichun Yang, Benlian Wang, 2018, The Journal of Biological Chemistry.

A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315).

J. Karn, J. Mellors, E. Acosta, 2020, The Journal of infectious diseases.

J. Karn, K. Lassen, M. Tyagi, 2008, Journal of Virology.