M. Peitsch

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SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

N. Guex, M. Peitsch, 1997, Electrophoresis.

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

M. Peitsch, A. Sewer, J. Hoeng, 2020, Computational and structural biotechnology journal.

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis

M. Peitsch, R. Laaksonen, J. Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.

Ashraf Elamin, Julia Hoeng, Manuel C Peitsch, 2016, Regulatory toxicology and pharmacology : RTP.

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

Manuel C. Peitsch, Kim Ekroos, Julia Hoeng, 2016, International journal of molecular sciences.

Verification of systems biology research in the age of collaborative competition

M. Peitsch, R. Norel, D. Vitkup, 2011, Nature Biotechnology.

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility.

M. Peitsch, V. Belcastro, J. Hoeng, 2018, Drug discovery today.

Novel approaches to develop community-built biological network models for potential drug discovery

Martin Hofmann-Apitius, Manuel C. Peitsch, Julia Hoeng, 2017, Expert opinion on drug discovery.

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure

Samik Ghosh, Barry Hardy, Joh Dokler, 2017, F1000Research.

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure

Samik Ghosh, Barry Hardy, Joh Dokler, 2017, F1000Research.

Mechanistic Network Models in Safety and Toxicity Evaluation of Nutraceuticals

M. Peitsch, J. Hoeng, I. Gonzalez-Suarez, 2016 .

Enhancement of COPD biological networks using a web-based collaboration interface

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2015, F1000Research.

Proteomics for systems toxicology

Manuel C. Peitsch, Ashraf Elamin, Sophie Dijon, 2014, Computational and structural biotechnology journal.

Case study: the role of mechanistic network models in systems toxicology.

Julia Hoeng, Marja Talikka, Manuel C Peitsch, 2014, Drug discovery today.

The species translation challenge—A systems biology perspective on human and rat bronchial epithelial cells

Theodore Sakellaropoulos, Leonidas G Alexopoulos, Erhan Bilal, 2014, Scientific Data.

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling.

M C Peitsch, M. Peitsch, 1996, Biochemical Society transactions.

Protein modelling for all.

M C Peitsch, Alexander V. Diemand, N. Guex, 1999, Trends in biochemical sciences.

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

M. Peitsch, J. Hoeng, B. Titz, 2018, International journal of molecular sciences.

Next-generation tobacco and nicotine products

M. Peitsch, J. Hoeng, A. Hayes, 2018 .

The application of systems biology to drug discovery.

M. Peitsch, M. Labow, Mischa Reinhardt, 2006, Current opinion in chemical biology.

Research Article Understanding the limits of animal models as predictors of hu- man biology: lessons learned from the sbv IMPROVER Species Translation Challenge

M. Peitsch, R. Norel, G. Stolovitzky, 2014 .

Text mining for biology - the way forward: opinions from leading scientists

L. Grivell, M. Peitsch, J. Blake, 2008, Genome Biology.

Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, and Lipidomics in Predictive Mechanistic Toxicology

David A. Drubin, M. Peitsch, A. Sewer, 2014 .

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

Michael B. Stadler, M. Peitsch, V. Belcastro, 2013, BMC Genomics.

Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects.

M. Peitsch, A. Sewer, K. Luettich, 2015, Journal of proteomics.

Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana tomentosiformis

M. Peitsch, N. Ivanov, N. Sierro, 2013, Genome Biology.

The tobacco genome sequence and its comparison with those of tomato and potato

M. Peitsch, N. Ivanov, N. Sierro, 2014, Nature Communications.

Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1).

M C Peitsch, M Mirotsou, M. Peitsch, 1997, American journal of human genetics.

Human aspects of the management of drug discovery knowledge.

M. Peitsch, T. Davenport, 2005, Drug Discovery Today : Technologies.

The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities.

M. Peitsch, J. Tschopp, K. Preissner, 1988, Biochemistry.

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Manuel C. Peitsch, Marcel Geertz, Julia Hoeng, 2014, Toxicology mechanisms and methods.

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx

M C Peitsch, N V Ivanov, M. Peitsch, 2017, Toxicology research.

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

M. Peitsch, J. Hoeng, N. Ivanov, 2022, The AAPS journal.

Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches

M. Peitsch, A. Sewer, J. Hoeng, 2018, Current Opinion in Toxicology.

The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status.

Carine Poussin, Julia Hoeng, Stéphanie Boué, 2017, Computational toxicology.

A Systems Toxicology Approach to Investigating the Cardiovascular Effects of Cigarette Smoke and Environmental Pollutants in ApoE -Deficient Mice

M. Peitsch, J. Hoeng, S. Boué, 2015 .

Construction of a Computable Network Model of Tissue Repair and Angiogenesis in the Lung

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013 .

Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Frontiers in Pharmacology.

Probing the Structure and Function of the Tachykinin Neurokinin-2 Receptor through Biosynthetic Incorporation of Fluorescent Amino Acids at Specific Sites*

Manuel Peitsch, Horst Vogel, André Chollet, 1996, The Journal of Biological Chemistry.

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS‐CoV-2 infection in reconstituted human airway epithelia

M. Peitsch, J. Hoeng, W. Schlage, 2021, Biochemistry and Biophysics Reports.

Systems Biology Approaches for Compound Testing

David A. Drubin, M. Peitsch, A. Sewer, 2013 .

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product.

M. Peitsch, V. Belcastro, J. Hoeng, 2017, Chemical research in toxicology.

Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract

M. Peitsch, A. Sewer, K. Luettich, 2019, Front. Genet..

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2019, ALTEX.

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

M. Peitsch, J. Hoeng, S. Boué, 2020, Toxicology reports.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding.

M. Peitsch, R. Martinez, M. Muñoz, 1994, The Journal of biological chemistry.

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.

M. Peitsch, J. Hoeng, S. Boué, 2013, Atherosclerosis.

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

Rémi H. J. Dulize, M. Peitsch, V. Belcastro, 2019, Toxicology reports.

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

Rémi H. J. Dulize, M. Peitsch, B. Titz, 2020, Journal of Inflammation.

Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma.

M. Peitsch, J. Tschopp, G. Schmitz, 1991, The Journal of biological chemistry.

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

M. Peitsch, K. Luettich, J. Hoeng, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors.

M. Peitsch, A. Mazurov, J. Hoeng, 2019, Phytochemistry.

Other Compounds From Tobacco With Potential Impact on Neurodegenerative Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Scientific substantiation of the absence of Environmental Tobacco Smoke (ETS) emission during use of the Electrically Heated Tobacco System (EHTS)

M. Peitsch, M. Nordlund, M. Mitova, 2019 .

Scientific substantiation of the absence of combustion and no smoke formation in the Electrically Heated Tobacco Product (EHTP)

M. Peitsch, M. Nordlund, J. Schaller, 2019 .

Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients

M. Peitsch, J. Hoeng, A. Kondylis, 2020, Inflammatory bowel diseases.

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures.

M. Peitsch, J. Hoeng, E. Guedj, 2020, Toxicology letters.

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

M. Peitsch, V. Belcastro, B. Titz, 2019, Archives of Toxicology.

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

M. Peitsch, J. Hoeng, E. Guedj, 2019, Internal and Emergency Medicine.

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2019, ALTEX.

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium

M. Peitsch, A. Sewer, K. Luettich, 2017, Clinical medicine insights. Circulatory, respiratory and pulmonary medicine.

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2016, Chemical research in toxicology.

Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2.2.

M. Peitsch, J. Hoeng, N. Ivanov, 2016, Regulatory toxicology and pharmacology : RTP.

Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.

M. Peitsch, J. Hoeng, F. Martin, 2015, Toxicology in vitro : an international journal published in association with BIBRA.

Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke.

M. Peitsch, A. Sewer, J. Hoeng, 2016, Regulatory toxicology and pharmacology : RTP.

Systems biology approach for evaluating the biological impact of environmental toxicants in vitro.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2014, Chemical research in toxicology.

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro

M. Peitsch, V. Belcastro, A. Sewer, 2015, Bioinformatics and biology insights.

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™)

M. Peitsch, S. Gebel, J. Hoeng, 2014, Gene regulation and systems biology.

Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium.

M. Peitsch, J. Hoeng, E. Guedj, 2021, Food and Chemical Toxicology.

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids

M. Peitsch, J. Hoeng, K. Koshibu, 2022, Frontiers in Pharmacology.

Quantitative proteomics analysis using 2 D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modi fi ed risk tobacco product on the lung proteome in C 57 BL / 6 mice

M. Peitsch, J. Hoeng, Marcel Geertz, 2016 .

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice.

M. Peitsch, J. Hoeng, Marcel Geertz, 2016, Journal of proteomics.

Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review

M. Peitsch, J. Hoeng, S. Boué, 2019, Regulatory toxicology and pharmacology : RTP.

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Chemico-biological interactions.

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis

Rémi H. J. Dulize, M. Peitsch, V. Belcastro, 2016, Inhalation toxicology.

A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.

M. Peitsch, Ashutosh Kumar, A. Sewer, 2020, American journal of physiology. Heart and circulatory physiology.

Electronic Nicotine Delivery Products

M. Peitsch, S. Maeder, Maurice Smith, 2021 .

Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC-MS deconvolution procedures.

M. Peitsch, J. Hoeng, N. Ivanov, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The clove (Syzygium aromaticum) genome provides insights into the eugenol biosynthesis pathway

M. Peitsch, G. Glauser, N. Ivanov, 2022, Communications biology.

Protein Tertiary Structure Modeling

N. Guex, M. Peitsch, T. Schwede, 2001, Current protocols in protein science.

Isolation and Properties of Apolipoprotein a for Therapeutic Use

J. E. Doran, M. Peitsch, P. Lerch, 1989 .

Impact of aerosols on liver xenobiotic metabolism: A comparison of two methods of exposure.

M. Peitsch, J. Hoeng, K. Renggli, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model

M. Peitsch, F. Springer, P. Augat, 2020, Archives of Toxicology.

DNA fragmentation during apoptosis is caused by frequent single-strand cuts.

M. Peitsch, J. Tschopp, J. Tschopp, 1993, Nucleic acids research.

In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures

M. Peitsch, K. Luettich, J. Hoeng, 2020, SLAS technology.

The apoptosis endonucleases: cleaning up after cell death?

M. Peitsch, J. Tschopp, H. Mannherz, 1994, Trends in cell biology.

Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I.

M. Peitsch, R. S. Coyne, J. Casanova, 1994, The Journal of biological chemistry.

Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge

M. Peitsch, V. Belcastro, A. Mchardy, 2022, BMC Genomics.

Protein Homology Modeling

N. Guex, M. Peitsch, T. Schwede, 2011 .

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

John H. Miller, Rémi H. J. Dulize, M. Peitsch, 2021, Archives of Toxicology.

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

M. Peitsch, J. Hoeng, Sylvain Gubian, 2019, BMC Bioinformatics.

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

M. Peitsch, J. Hoeng, Sam Ansari, 2018, Inhalation toxicology.

The Science behind the Tobacco Heating System

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2017 .

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells.

M. Peitsch, J. Hoeng, C. Poussin, 2016, Toxicology.

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion.

M. Peitsch, J. Hoeng, C. Poussin, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

M. Peitsch, J. Hoeng, S. Boué, 2015, Inhalation toxicology.

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice.

M. Peitsch, R. Laaksonen, J. Hoeng, 2012, Atherosclerosis.

Construction of a computable cell proliferation network focused on non-diseased lung cells

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2011, BMC Systems Biology.

28-day rat inhalation study: how systems toxicology complements OECD inhalation studies

M. Peitsch, J. Hoeng, Sam Ansari, 2015 .

Alternatives to Animal Use in Risk Assessment of Mixtures

M. Peitsch, J. Hoeng, A. Iskandar, 2020, International journal of toxicology.

Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors

M. Peitsch, K. Luettich, J. Hoeng, 2020, Current research in toxicology.

Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations.

M. Peitsch, J. Hoeng, Yanfang Ren, 2019, Journal of dentistry.

Application of systems pharmacology to identify exposure response markers in peripheral blood after switching to a candidate modified risk tobacco product: the Tobacco Heating System 2.1 (THS 2.1)

M. Peitsch, J. Hoeng, F. Martin, 2015 .

Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond

M. Peitsch, J. Hoeng, A. Hayes, 2019, Critical reviews in toxicology.

A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, Bioinformatics and biology insights.

Human organotypic nasal epithelial tissue culture as an in vitro model to evaluate effects of cigarette smoke of a candidate Modified Risk Tobacco Product: the Tobacco Heating System 2.2

M. Peitsch, J. Hoeng, A. Elamin, 2015 .

Reduced impact of a prototypic modified risk tobacco product compared with conventional cigarette smoke on exposed human and rat primary normal bronchial epithelial cells

M. Peitsch, D. Messinis, J. Hoeng, 2014 .

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers.

M. Peitsch, V. Belcastro, A. Sewer, 2013, American journal of physiology. Lung cellular and molecular physiology.

State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products

M. Peitsch, J. Hoeng, S. Boué, 2020 .

Summary of Evidence on the Cytotoxic Effects on Bronchial Epithelial Cells of IQOS

M. Peitsch, E. Veljkovic, P. Picavet, 2018 .

Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program.

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2016, Regulatory toxicology and pharmacology : RTP.

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes.

M. Peitsch, A. Sewer, K. Luettich, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

M. Peitsch, R. Eils, H. Fröhlich, 2021, Scientific Reports.

Divergence Weighted Independence Graphs for the Exploratory Analysis of Biological Expression Data

Yang Xiang, Manuel C. Peitsch, Joe Whittaker, 2013 .

Mitochondria as a possible target for nicotine action

M. Peitsch, K. Luettich, J. Hoeng, 2019, Journal of Bioenergetics and Biomembranes.

Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity.

M. Peitsch, J. Tschopp, B. Lowin, 1995, Current topics in microbiology and immunology.

Identification of Key Charged Residues of Human Interleukin-5 in Receptor Binding and Cellular Activation (*)

M. Peitsch, R. Solari, A. Proudfoot, 1995, The Journal of Biological Chemistry.

Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.

M. Peitsch, J. Herrero, G. Buell, 2001, Microbial drug resistance.

Spatial Orientation of the α and βc Receptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs*

M. Peitsch, M. Edgerton, I. Uings, 1997, The Journal of Biological Chemistry.

In vitro testing of salt coating of fabrics as a potential antiviral agent in reusable face masks

M. Peitsch, J. Hoeng, S. Lebrun, 2022, Scientific Reports.

The carboxy-terminal region of human interleukin-5 is essential for maintenance of tertiary structure but not for dimerization

M. Peitsch, S. Brown, R. Solari, 1996, Journal of protein chemistry.

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice

M. Peitsch, K. Luettich, J. Hoeng, 2022, Journal of applied toxicology : JAT.

Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice

M. Peitsch, A. Sewer, K. Luettich, 1984, The Journal of experimental medicine.

Research Models of Neurodegenerative Diseases: Major Considerations for Translatability

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei.

M. Peitsch, H. Macdonald, J. Tschopp, 1992, Biochemical and biophysical research communications.

M. Peitsch, C. Borner, J. Tschopp, 1993, Trends in biochemical sciences.

Systems biology reveals anatabine to be an NRF2 activator

Dimitris E. Messinis, Rémi H. J. Dulize, M. Peitsch, 2022, Frontiers in Pharmacology.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

M. Peitsch, J. Hoeng, S. Boué, 2015, Inflammation Research.

Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death).

M. Peitsch, M. Irmler, F. Rauch, 1994, European journal of cell biology.

Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death.

M. Peitsch, J. Tschopp, R. Loos, 1993, European journal of cell biology.

Human CD40 ligand: molecular cloning, cellular distribution and regulation of IgE synthesis.

M. Peitsch, J. Bonnefoy, G. Mazzei, 1994, Research in immunology.

l spectrum of X-linked hyper-IgM syndrome

M. Peitsch, Lennart Hammarstrom, A. Finn, 2004 .

Asp-49 is not an absolute prerequisite for the enzymic activity of low-M(r) phospholipases A2: purification, characterization and computer modelling of an enzymically active Ser-49 phospholipase A2, ecarpholin S, from the venom of Echis carinatus sochureki (saw-scaled viper).

M. Peitsch, T. Wells, K. Clemetson, 1996, The Biochemical journal.

The UltraLink: An Expert System for Contextual Hyperlinking in Knowledge Management

Martin Romacker, Manuel C. Peitsch, Therese Vachon, 2006 .

SWISS-MODEL: an automated protein homology-modeling server

Manuel C. Peitsch, Torsten Schwede, Nicolas Guex, 2003, Nucleic Acids Res..

Assembly of macromolecular pores by immune defense systems.

M. Peitsch, J. Tschopp, J. Tschopp, 1991, Current opinion in cell biology.

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.

M. Peitsch, S. Antonarakis, C. Rossier, 1997, Genomics.

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification

Ajay K. Royyuru, Thomas Bonk, Pablo Meyer, 2012, Bioinform..

Hydrophobic C-terminal amino acids in the beta-subunit are involved in assembly with the alpha-subunit of Na,K-ATPase.

M. Peitsch, K. Geering, P. Béguin, 1993, Biochemistry.

Embracing Transparency Through Data Sharing

Julia Hoeng, Stéphanie Boué, Michael Byrne, 2018, International journal of toxicology.

Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties.

M. Peitsch, A. Mazurov, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective

Torsten Schwede, Nicolas Guex, Manuel C Peitsch, 2009, Electrophoresis.

Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.

M. Peitsch, C. Power, S. Alouani, 1997, European journal of biochemistry.

Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds

M. Peitsch, K. Luettich, J. Hoeng, 2021, Frontiers in Pharmacology.

A purification method for apolipoprotein A-I and A-II.

M. Peitsch, P. Lerch, H. Heiniger, 1989, Analytical biochemistry.

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

M. Peitsch, J. Hoeng, N. Ivanov, 2022, The AAPS Journal.

Toxicological Assessment of Flavor Ingredients in E-Vapor Products

M. Peitsch, J. Hoeng, Davide Sciuscio, 2022, Frontiers in Toxicology.

Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

M. Peitsch, J. Tschopp, C. Heusser, 1989, Nature.

Differential effects of alkaloids on memory in rodents

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Scientific Reports.

Systems Toxicology: From Basic Research to Risk Assessment

Manuel C. Peitsch, Alan R. Boobis, Julia Hoeng, 2014, Chemical research in toxicology.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Computational Systems Toxicology

Manuel C. Peitsch, Julia Hoeng, M. Peitsch, 2015, Methods in Pharmacology and Toxicology.

The first lipocalin with enzymatic activity.

M C Peitsch, M S Boguski, M. Peitsch, 1991, Trends in biochemical sciences.

An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes

M. Peitsch, P. Vulto, J. Hoeng, 2020, SLAS technology.

Protein Modeling by E-mail

Manuel C. Peitsch, M. Peitsch, 1995, Bio/Technology.

Computational Epigenomics: From Fundamental Research to Disease Prediction and Risk Assessment

Manuel C. Peitsch, Julia Hoeng, Florian Martin, 2019, Computational Biology.

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke.

M. Peitsch, J. Hoeng, N. Ivanov, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data

Rémi H. J. Dulize, M. Peitsch, K. Luettich, 2021, Frontiers in Toxicology.

Effects of cigarette smoke exposure on a mouse model of multiple sclerosis

M. Peitsch, K. Luettich, J. Hoeng, 2022, Toxicology reports.

Effects of plant alkaloids on mitochondrial bioenergetic parameters.

M. Peitsch, B. Titz, J. Hoeng, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model

M. Peitsch, J. Hoeng, B. Titz, 2021, Journal of applied toxicology : JAT.

A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

M. Peitsch, Ashutosh Kumar, J. Hoeng, 2021, Toxicology Research and Application.

Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke.

M. Peitsch, J. Hoeng, S. Boué, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Characterization of Fas (Apo-1, CD95)-Fas Ligand Interaction*

Manuel C. Peitsch, Pascal Schneider, M. Peitsch, 1997, The Journal of Biological Chemistry.

Residual Risk of Nicotine

M. Peitsch, K. Luettich, J. Szostak, 2021 .

Systems pharmacology investigation of mechanism of action of nutraceuticals

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2021 .

Assessment of ENDPs in Animal Models of Disease

M. Peitsch, K. Luettich, J. Hoeng, 2021 .

Characterization of the non-functional Fas ligand of gld mice.

M C Peitsch, M. Peitsch, J. Tschopp, 1995, International immunology.

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

M. Peitsch, J. Hoeng, S. Boué, 2016, Journal of Translational Medicine.

Systems Toxicology: Real World Applications and Opportunities

Gary R. Mirams, Imran Shah, Paul Jennings, 2017, Chemical research in toxicology.

bronchial epithelium from human smokers cigarette smoke at the air-liquid interface resemble Human bronchial epithelial cells exposed in vitro to

M. Peitsch, V. Belcastro, A. Sewer, 2013 .

The COVID-19 PHARMACOME: Rational Selection of Drug Repurposing Candidates from Multimodal Knowledge Harmonization

Martin Hofmann-Apitius, Andrea Zaliani, Reagon Karki, 2020, bioRxiv.

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

Erhan Bilal, Pablo Meyer, Raquel Norel, 2014, Bioinform..

A new function for an old enzyme: the role of DNase I in apoptosis.

M. Peitsch, H. Mannherz, R. Paddenberg, 1995, Current topics in microbiology and immunology.

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Systems Biology: Methods and Applications

M. Peitsch, A. Sewer, J. Hoeng, 2017 .

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

M. Peitsch, J. Hoeng, S. Boué, 2016, Journal of Translational Medicine.

A genome-based approach for the identification of essential bacterial genes

Manuel Peitsch, M. Peitsch, H. Loferer, 1998, Nature Biotechnology.

The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and Expressed Sequence Tag Databases

M. Peitsch, T. Wells, 1997, Journal of leukocyte biology.

Selectivity and antagonism of chemokine receptors

M. Peitsch, R. Cooke, C. Chung, 1996, Journal of leukocyte biology.

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

M. Peitsch, J. Hoeng, K. Koshibu, 2019, Toxicology reports.

Analysis of Proteomic Data for Toxicological Applications

Manuel C. Peitsch, Bjoern Titz, Thomas Schneider, 2015 .

Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish

M. Peitsch, E. Levin, J. Hoeng, 2021, Pharmacology Biochemistry and Behavior.

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

M. Peitsch, A. Sewer, K. Luettich, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

M. Peitsch, J. Hoeng, Davide Sciuscio, 2020, Archives of Toxicology.

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

Julia Hoeng, Emilija Veljkovic, Manuel C Peitsch, 2016, Regulatory toxicology and pharmacology : RTP.

Systems biology approach highlights mechanistic differences between Crohn’s disease and ulcerative colitis

M. Peitsch, J. Hoeng, Sylvain Gubian, 2021, Scientific Reports.

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Amino acid sequence of the alpha subunit and computer modelling of the alpha and beta subunits of echicetin from the venom of Echis carinatus (saw-scaled viper).

M. Peitsch, T. Wells, K. Clemetson, 1997, The Biochemical journal.

A Systems-Based Approach to Toxicity Testing

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2021 .

Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States

M. Peitsch, M. Talikka, H. Yepiskoposyan, 2022, International journal of inflammation.

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.

M C Peitsch, C V Jongeneel, M. Peitsch, 1993, International immunology.

c-kit Activating Mutations and Mast Cell Proliferation in Human Leukemia

M. Peitsch, A. Fischer, W. Friedrich, 2017 .

New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.

A Bairoch, M C Peitsch, N. Guex, 1998, Genome research.

Mapping regions of Gαq interacting with PLCβ1 using multiple overlapping synthetic peptides

M. Peitsch, S. Arkinstall, K. Maundrell, 1995 .

MDB: a database system utilizing automatic construction of modules and STAR-derived universal language

Manuel C. Peitsch, Alexei A. Adzhubei, Eugenia Migliavacca, 2001, Bioinform..

Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family.

M. Peitsch, J. Haefliger, D. Jenne, 1991, Molecular immunology.

The clove (Syzygium aromaticum) genome provides insights into the eugenol biosynthesis pathway

M. Peitsch, G. Glauser, N. Ivanov, 2022, Communications Biology.

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

Yang Xiang, Manuel C. Peitsch, Julia Hoeng, 2014, BMC Bioinformatics.

Chapter 10 Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2017 .

[5] Granzyme B

M. Peitsch, J. Tschopp, 1994 .

Clinical Assessment of ENDPs

M. Peitsch, M. Peck, C. Haziza, 2021 .

Pre-malignant processes of smoking-induced lung adenocarcinoma development: A conceptual biological model

M. Peitsch, F. Tobin, J. Hoeng, 2013 .

Semi-Automated Curation Allows Causal Network Model Building for the Quantification of Age-Dependent Plaque Progression in ApoE−/− Mouse

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2016, Gene regulation and systems biology.

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Manuel C. Peitsch, Ashraf Elamin, Julia Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes.

M. Peitsch, J. Hoeng, S. Frentzel, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

M. Peitsch, J. Hoeng, S. Frentzel, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The SIB Swiss Institute of Bioinformatics’ resources: focus on curated databases

Oliver Horlacher, Damian Szklarczyk, Christian von Mering, 2015, Nucleic Acids Res..

Toxicological Assessment of ENDPs In Vivo

M. Peitsch, S. Boué, B. Phillips, 2021 .

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product.

Julia Hoeng, Carole Mathis, Manuel C Peitsch, 2016, ALTEX.

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

Jennifer Park, Manuel C. Peitsch, Carine Poussin, 2011, BMC Systems Biology.

Developing Network-Based Systems Toxicology by Combining Transcriptomics Data with Literature Mining and Multiscale Quantitative Modeling

Julia Hoeng, Marja Talikka, Florian Martin, 2018, Bioinformatics in the Era of Post Genomics and Big Data.

Quantifying the Biological Impact of Active Substances Using Causal Network Models

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2015 .

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

M. Peitsch, J. Hoeng, Sylvain Gubian, 2021, Frontiers in Genetics.

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

M. Peitsch, A. Sewer, A. Hengstermann, 2014, BMC Research Notes.

Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative.

M. Peitsch, P. Romero, C. Jongeneel, 1995, Immunity.

Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement.

M. Peitsch, J. Tschopp, T. Kovacsovics, 1987, Journal of immunology.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

M. Peitsch, S. Gebel, J. Hoeng, 2014, Journal of Translational Medicine.

Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish.

M. Peitsch, V. Belcastro, J. Hoeng, 2020, Chemical research in toxicology.

Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin.

M. Peitsch, J. Maizel, J. Brunner, 1990, Molecular immunology.

alpha 1 but not alpha 2 or alpha 3 isoforms of Na,K-ATPase are efficiently phosphorylated in a novel protein kinase C motif.

M. Peitsch, K. Geering, P. Béguin, 1996, Biochemistry.

Functional characterisation of serum DNase I in MRL-lpr/lpr mice.

M. Peitsch, T. Hesterkamp, J. Tschopp, 1992, Biochemical and Biophysical Research Communications - BBRC.

From proteomics to systems biology of bacterial pathogens: Approaches, tools, and applications

Manuel C Peitsch, Uwe Plikat, Jan van Oostrum, 2007, Proteomics.

Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.

M. Peitsch, J. Hoeng, S. Boué, 2013, Toxicology.

Identification of novel chemokines from expressed sequence tag databases.

M. Peitsch, T. Wells, 2000, Methods in molecular biology.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Scientific Reports.

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy.

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Journal of Natural Products.

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

Jennifer Park, Manuel C. Peitsch, William Hayes, 2015, Database J. Biol. Databases Curation.

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2012, BMC Systems Biology.

A framework for in vitro systems toxicology assessment of e-liquids

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2016, Toxicology mechanisms and methods.

Comparative molecular modelling of the Fas-ligand and other members of the TNF family.

M C Peitsch, M. Peitsch, J. Tschopp, 1995, Molecular immunology.

Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)

Juliane Fluck, Manuel C. Peitsch, Reagon Karki, 2016, Database J. Biol. Databases Curation.

The Swiss-3DImage collection and PDB-Browser on the World-Wide Web.

M C Peitsch, J L Sussman, T N Wells, 1995, Trends in biochemical sciences.

Toxicological Assessment In Vitro

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2021 .

Translational Models for ENDP Assessment

M. Peitsch, J. Hoeng, B. Titz, 2021 .

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.

Julia Hoeng, Manuel C Peitsch, Jenny Ho, 2016, Regulatory toxicology and pharmacology : RTP.

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, BioMed research international.

Physiological and biological characterization of smokers with and without COPD

M. Peitsch, K. Luettich, J. Hoeng, 2018, F1000Research.

Data of physiological measurements and quality of life in subjects with mild to moderate COPD compared to asymptomatic current smokers, former smokers and never-smokers.

M. Peitsch, K. Luettich, J. Hoeng, 2017, F1000Research.

Systems toxicology meta-analysis—From aerosol exposure to nanotoxicology

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2019, Current Opinion in Toxicology.

Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols

M. Peitsch, A. Mazurov, J. Hoeng, 2022, Journal of the American Society for Mass Spectrometry.

A crowd-sourcing approach for the construction of species-specific cell signaling networks

Theodore Sakellaropoulos, Erhan Bilal, Pablo Meyer, 2014, Bioinform..

Genomic organisation and expression of mouse deoxyribonuclease I.

M. Peitsch, L. French, M. Irmler, 1995, Biochemical and biophysical research communications.

Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.

M. Peitsch, J. Hoeng, Yanfang Ren, 2019, Quintessence international.

Automated protein modelling--the proteome in 3D.

M C Peitsch, N. Guex, M. Peitsch, 2000, Pharmacogenomics.

About the use of protein models

Manuel C. Peitsch, M. Peitsch, 2002, Bioinform..

Protein structure computing in the genomic era.

M C Peitsch, Alexander V. Diemand, N. Guex, 2000, Research in microbiology.

Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract

M. Peitsch, J. Hoeng, J. Szostak, 2021, Frontiers in Microbiology.

M. Peitsch, J. Hoeng, S. Boué, 2021 .

Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies.

M. Peitsch, J. Hoeng, B. Titz, 2020, Life sciences.

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

Manuel C. Peitsch, Kim Ekroos, Ashraf Elamin, 2016, Scientific Data.

Modulation of the Hepatic Lipidome and Transcriptome of Apoe-/- Mice in Response to Smoking Cessation

Manuel C. Peitsch, Julia Hoeng, Stéphanie Boué, 2013 .

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

M. Peitsch, B. Titz, A. Sewer, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx00152e

Julia Hoeng, Carole Mathis, Manuel C Peitsch, 2017, Toxicology research.

Advancing Risk Assessment through the Application of Systems Toxicology

Manuel C. Peitsch, A. Wallace Hayes, André Kleensang, 2016, Toxicological research.

A lung/liver-on-a-chip platform for acute and chronic toxicity studies.

Julia Hoeng, Manuel C Peitsch, Diego Marescotti, 2018, Lab on a chip.

Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract

Miroslav Jicha, Frantisek Lizal, Miloslav Belka, 2017, Inhalation toxicology.

A network-based approach to quantifying the impact of biologically active substances.

Julia Hoeng, Manuel C Peitsch, Dexter Pratt, 2012, Drug discovery today.

Long term exposure to cigarette smoke impacts genes involved in cardiac muscle structure and function in Apoe−/− mouse while exposure to the aerosol does not

M. Peitsch, J. Hoeng, S. Boué, 2016 .

Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery.

M. Peitsch, J. Hoeng, S. Boué, 2015, Current drug discovery technologies.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

M. Peitsch, J. Hoeng, S. Boué, 2015, Inflammation Research.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

Carine Poussin, Julia Hoeng, Stephan Gebel, 2014, Journal of Translational Medicine.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

Julia Hoeng, Stephan Gebel, Marja Talikka, 2013, Toxicology and applied pharmacology.

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

Julia Hoeng, Stephan Gebel, Manuel C Peitsch, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The Apoe -/- Mouse PhysioLab ® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe -/- Mouse

Manuel C. Peitsch, Julia Hoeng, Caitlin A. Bever, 2012 .

Applying Systems Toxicology Methods to Drug Safety

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2019 .

The Difference between IQOS and Continued Smoking Response to the article entitled “PMI’s own in vivo clinical data on biomarkers of potential harm in Americans show that IQOS is not detectably different from conventional cigarettes,” by Stanton

Stanton, M. Peitsch, P. Vanscheeuwijck, 2018 .

A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2)

M. Peitsch, J. Hoeng, N. Ivanov, 2019, Front. Pharmacol..

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2015, Journal of visualized experiments : JoVE.

An in vitro evaluation of e-vapor products: The contributions of chemical adulteration, concentration, and device power.

M. Peitsch, J. Hoeng, A. Iskandar, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Toxicology reports.

Organs-on-a-chip

Manuel C. Peitsch, Julia Hoeng, Karsta Luettich, 2017 .

A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures.

Ashraf Elamin, Julia Hoeng, Carole Mathis, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

M. Peitsch, J. Hoeng, P. Leroy, 2014, Chemistry Central Journal.

The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure

Marcel Geertz, Julia Hoeng, Carole Mathis, 2014, International journal of toxicology.

Mitochondrial Network and Biogenesis in Response to Short and Long-Term Exposure of Human BEAS-2B Cells to Aerosol Extracts from the Tobacco Heating System 2.2.

M. Peitsch, K. Luettich, J. Hoeng, 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products

M. Peitsch, J. Hoeng, S. Boué, 2020 .

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

M. Peitsch, J. Hoeng, Davide Sciuscio, 2020, Archives of Toxicology.

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.

Ashraf Elamin, Julia Hoeng, Carole Mathis, 2016, Chemical research in toxicology.

Effects of Switching to a Heat-Not-Burn Tobacco Product on Biologically Relevant Biomarkers to Assess a Candidate Modified Risk Tobacco Product: A Randomized Trial

M. Peitsch, R. Weitkunat, A. Donelli, 2019, Cancer Epidemiology, Biomarkers & Prevention.

Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge

Mario Lauria, Preetam Nandy, Erhan Bilal, 2013, Bioinform..

Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes.

M. Peitsch, S. Maeder, 2017, JAMA internal medicine.

Systems Toxicology Approach to Unravel Early Indicators of Squamous Cell Carcinoma Rate in Rat Nasal Epithelium Induced by Formaldehyde Exposure

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2019, PACBB.

Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, Bioinformatics and biology insights.

Scientific Basis for Assessment of Electronic Nicotine Delivery Products

Manuel C. Peitsch, Julia Hoeng, Stéphanie Boué, 2021, Toxicological Evaluation of Electronic Nicotine Delivery Products.

CSEO – the Cigarette Smoke Exposure Ontology

Martin Hofmann-Apitius, Manuel C. Peitsch, Julia Hoeng, 2014, J. Biomed. Semant..

Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2021, Archives of Toxicology.

Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2023, International journal of molecular sciences.

Aerosol Filtration Testing of Fabrics for Development of Reusable Face Masks

M. Peitsch, Y. Tardy, J. Hoeng, 2021, Aerosol and Air Quality Research.

Toxicological Assessment of Flavors Used in E-vapor Products

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2021 .

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

M. Peitsch, J. Hoeng, S. Frentzel, 2016, Journal of visualized experiments : JoVE.

Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding

M. Peitsch, R. Martinez, A. Beck‐Sickinger, 1995, Molecular and Cellular Endocrinology.

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

M. Peitsch, J. Hoeng, F. Martin, 2020, BMC Genomics.

Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications

Yang Xiang, Jennifer Park, Manuel C. Peitsch, 2016, Gene regulation and systems biology.

Enhancement of COPD biological networks using a web-based collaboration interface.

Jennifer Park, Julia Hoeng, Marja Talikka, 2015, F1000Research.

Causal biological network models for reactive astrogliosis: a systems approach to neuroinflammation

M. Peitsch, Sylvain Gubian, M. Talikka, 2022, Scientific Reports.

The BEL information extraction workflow (BELIEF): evaluation in the BioCreative V BEL and IAT track

Juliane Fluck, Manuel C. Peitsch, Julia Hoeng, 2016, Database J. Biol. Databases Curation.

Construction of biological networks from unstructured information based on a semi-automated curation workflow

Juliane Fluck, Manuel C. Peitsch, Martin Hofmann-Apitius, 2015, Database J. Biol. Databases Curation.

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2019, Internal and Emergency Medicine.

A decade of Systems Biology: where are we and where are we going to?

Manuel C Peitsch, M. Peitsch, D. de Graaf, 2014, Drug discovery today.

A rapid and efficient method for the purification of the complement subcomponents C1r and C1s in zymogen form using fast protein chromatography.

M. Peitsch, T. Kovacsovics, H. Isliker, 1988, Journal of immunological methods.

On Crowd-verification of Biological Networks

Raquel Norel, Kahn Rhrissorrakrai, Manuel C. Peitsch, 2013, Bioinformatics and biology insights.

Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein.

M. Peitsch, J. Tschopp, U. Hamann, 1993, Molecular immunology.

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

M. Peitsch, A. Sewer, K. Luettich, 2014, Interdisciplinary toxicology.

CSEO – the Cigarette Smoke Exposure Ontology

M. Peitsch, M. Hofmann-Apitius, J. Hoeng, 2014, J. Biomed. Semant..

Attention Deficit Hyperactivity Disorder in Children and Adults

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Tobacco Harm Reduction Concepts and Policy Approaches

M. Peitsch, M. Firestone, 2021 .

Is apolipoprotein D a mammalian bilin-binding protein?

M C Peitsch, M S Boguski, M. Peitsch, 1992, The New biologist.

sbv IMPROVER Diagnostic Signature Challenge

Yang Xiang, Erhan Bilal, Pablo Meyer, 2013 .

Covalent Homodimers of Murine Secretory Component Induced by Epitope Substitution Unravel the Capacity of the Polymeric Ig Receptor to Dimerize Noncovalently in the Absence of IgA Ligand*

M. Peitsch, C. Servis, P. Crottet, 1999, The Journal of Biological Chemistry.

Production of Valuable Compounds in Tobacco

M. Peitsch, N. Ivanov, S. Goepfert, 2020 .

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

M. Peitsch, J. Hoeng, F. Martin, 2020, BMC Genomics.

Automated modelling of the transmembrane region of G-protein coupled receptor by Swiss-model.

M C Peitsch, P Herzyk, T N Wells, 1996, Receptors & channels.

A protein conformational search space defined by secondary structure contacts.

M. Peitsch, F. Major, M. Parisien, 1998, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.

Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2013, Bioinformatics and biology insights.

Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration.

M. Peitsch, J. Hoeng, K. Koshibu, 2019, European journal of pharmacology.

Review of the article entitled “ Heat-Not-Burn Tobacco Cigarettes : Smoke by Any Other Name ” 1

M. Peitsch, S. Maeder, P. Morris, 2017 .

Large‐scale protein modelling and integration with the SWISS‐PROT and SWISS‐2DPAGE databases: The example of Escherichia coli

R D Appel, D F Hochstrasser, M C Peitsch, 1997, Electrophoresis.

GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology

Manuel C. Peitsch, Julia Hoeng, Florian Martin, 2019, Bioinform..

Whole genome profiling physical map and ancestral annotation of tobacco Hicks Broadleaf

Manuel C Peitsch, Florian Martin, Jan van Oeveren, 2013, The Plant journal : for cell and molecular biology.

A Pathogen-specific Epitope Inserted into Recombinant Secretory Immunoglobulin A Is Immunogenic by the Oral Route*

M. Peitsch, J. Kraehenbuhl, A. Phalipon, 1996, The Journal of Biological Chemistry.

Genome Size and Numbers of Biological Functions

Denis Noble, Ernest Feytmans, Manuel C. Peitsch, 2005, Trans. Comp. Sys. Biology.

Protein Structure Modeling and Docking at the Swiss Institute of Bioinformatics

Manuel C. Peitsch, Torsten Schwede, M. Peitsch, 2009 .

About the involvement of deoxyribonuclease I in apoptosis.

M. Peitsch, J. Tschopp, B. Polzar, 1994, Cell death and differentiation.

Conclusions and Outlook

M. Peitsch, J. Hoeng, 2021, Toxicological Evaluation of Electronic Nicotine Delivery Products.

The Molecular Basis of Selectivity Between CC and CXC Chemokines: The Possibility of Chemokine Antagonists as Anti‐inflammatory Agents

M. Peitsch, C. Chung, C. Power, 1996, Annals of the New York Academy of Sciences.

A mechanistic study of cigarette smoke-induced COPD in C57BL/6 mice: the impact of switching to pMRTP

M. Peitsch, J. Hoeng, B. Phillips, 2015 .

Passive Exposure to ENDP Aerosols

M. Peitsch, C. Haziza, Catherine G. Goujon-Ginglinger, 2021 .

Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Journal of Natural Medicines.

Building an R&D chemical registration system

Manuel C. Peitsch, Aurélien Monge, Pavel Pospisil, 2012, Journal of Cheminformatics.

Structure and Bioactivity of Recombinant Human CTAP-III and NAP-2

M. Peitsch, J. Mermod, B. Allet, 1997, Journal of protein chemistry.

Large Scale Protein Modeling and Model Repository

Manuel C. Peitsch, M. Peitsch, 1997, ISMB.

BEL Networks Derived from Qualitative Translations of BioNLP Shared Task Annotations

Juliane Fluck, Manuel C. Peitsch, Martin Hofmann-Apitius, 2013, BioNLP@ACL.

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™)

M. Peitsch, S. Gebel, J. Hoeng, 2014, Gene regulation and systems biology.

Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

M. Peitsch, J. Hoeng, Davide Sciuscio, 2019, Inhalation toxicology.

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

M. Peitsch, A. Sewer, J. Hoeng, 2014, BMC Research Notes.

Design of a tobacco exon array with application to investigate the differential cadmium accumulation property in two tobacco varieties

Mario Stanke, Manuel C Peitsch, Florian Martin, 2012, BMC Genomics.

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

M. Peitsch, A. Sewer, J. Hoeng, 2014, BMC Bioinformatics.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Scientific Reports.

Systems toxicology assessment of repeated exposure to cigarette smoke and a potential modified-risk tobacco product aerosol on gingival organotypic cultures

M. Peitsch, A. Sewer, J. Hoeng, 2017 .

Docking for neglected diseases as community efforts

Manuel C. Peitsch, Torsten Schwede, Michael Podvinec, 2008 .

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

Michael B. Stadler, M. Peitsch, V. Belcastro, 2013, BMC Genomics.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

M. Peitsch, V. Belcastro, A. Sewer, 2013, Toxicology and applied pharmacology.

Antibody-independent activation of C1. I. Differences in the mechanism of C1 activation by nonimmune activators and by immune complexes: C1r-independent activation of C1s by cardiolipin vesicles.

M. Peitsch, T. Kovacsovics, H. Isliker, 1987, Journal of immunology.

Genomic impact of cigarette smoke, with application to three smoking-related diseases

M. J. Peck, M. Peitsch, J. Hoeng, 2012, Critical reviews in toxicology.

A lung/liver-on-a-chip platform for acute and chronic toxicity studies.

M. Peitsch, K. Luettich, J. Hoeng, 2018, Lab on a chip.

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product.

M. Peitsch, V. Belcastro, J. Hoeng, 2017, Chemical research in toxicology.

The SIB Swiss Institute of Bioinformatics’ resources: focus on curated databases

Joshua L. Payne, Christian J. A. Sigrist, Brian J. Stevenson, 2015, Nucleic Acids Res..

Imaging Science in Biochemistry

N. Guex, M. Peitsch, T. Schwede, 2002 .

The impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production

M. Peitsch, N. Sierro, J. Battey, 2018, BMC Genomics.

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Rémi H. J. Dulize, M. Peitsch, E. Masliah, 2023, Frontiers in neuroscience.

Nicotine flux and pharmacokinetics-based considerations for early assessment of nicotine delivery systems

M. Peitsch, E. Veljkovic, A. Kuczaj, 2024, Drug and alcohol dependence reports.

In Vitro Systems Toxicology Assessment of Nonflavored e-Cigarette Liquids in Primary Lung Epithelial Cells

MartinFlorian, Rémi H. J. Dulize, M. Peitsch, 2017 .

Large-Scale Comparative Protein Modelling

Manuel C. Peitsch, Nicolas Guex, N. Guex, 1997 .