J. Whisstock

James C. Whisstock, Maria Garcia de la Banda, Sarah E. Boyd, 2004, Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004..

Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens

Robert J. Moore, Robert J. Moore, J. Whisstock, 2013, mBio.

Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.

J. Whisstock, A. Bujotzek, M. Nold, 2021, Cell chemical biology.

The MACPF/CDC family of pore-forming toxins

Ashley M Buckle, James C Whisstock, Ruby H P Law, 2008, Cellular microbiology.

Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase

J. Whisstock, B. Kobe, Blagojce Jovcevski, 2015, PloS one.

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

A M Lesk, J. Whisstock, A. Lesk, 2000, Genome research.

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster

J. Whisstock, R. Law, C. Warr, 2014, BMC Structural Biology.

The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

J. Whisstock, J. Irving, D. Lomas, 2001, The Journal of Biological Chemistry.

Importance of the P4′ Residue in Human Granzyme B Inhibitors and Substrates Revealed by Scanning Mutagenesis of the Proteinase Inhibitor 9 Reactive Center Loop*

J. Whisstock, P. Bird, P. Thompson, 2001, The Journal of Biological Chemistry.

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Paul J Conroy, James C Whisstock, J. Whisstock, 2013, Trends in Biotechnology.

Serpins Flex Their Muscle

James C Whisstock, Dion Kaiserman, Stephen P Bottomley, 2010, The Journal of Biological Chemistry.

Prediction of the Immunodominant Epitope of the Pyruvate Dehydrogenase Complex E2 in Primary Biliary Cirrhosis Using Phage Display

J. Whisstock, M. Rowley, M. Scealy, 2000, The Journal of Immunology.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Helen R Saibil, Olivia Susanto, James C Whisstock, 2013, Blood.

Characterising the Subsite Specificity of Urokinase‐Type Plasminogen Activator and Tissue‐Type Plasminogen Activator using a Sequence‐Defined Peptide Aldehyde Library

J. Whisstock, D. Craik, R. Law, 2018, Chembiochem : a European journal of chemical biology.

Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis.

J. Whisstock, T. Beddoe, J. Rossjohn, 2006, Journal of molecular biology.

Brentuximab vedotin in T-cell lymphoma

J. Whisstock, H. Prince, M. Dickinson, 2019, Expert review of hematology.

Use of synthetic peptides to delineate discontinuous sequence regions involved in epitope sites of the thyrotropin β-subunit

J. Whisstock, M. Hearn, P. Thompson, 2006, Letters in Peptide Science.

Characterization of epitope regions of thyrotropin beta-subunit recognized by the monoclonal antibodies mAb279 and mAb299: a chimeric peptide approach.

J. Whisstock, M. Hearn, P. Thompson, 2008, The journal of peptide research : official journal of the American Peptide Society.

The molecular basis for perforin oligomerization and transmembrane pore assembly.

J. Whisstock, H. Saibil, J. Trapani, 2009, Immunity.

Requirement of leucine-rich repeats of glycoprotein (GP) Ibalpha for shear-dependent and static binding of von Willebrand factor to the platelet membrane GP Ib-IX-V complex.

J. Whisstock, L. McIntire, D. Kenny, 2000, Blood.

SH3 domains in prokaryotes.

A M Lesk, J. Whisstock, A. Lesk, 1999, Trends in biochemical sciences.

Serpins in prokaryotes.

Arthur M Lesk, James C Whisstock, Robert N Pike, 2002, Molecular biology and evolution.

Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like

J. Whisstock, C. Warr, R. Burke, 2016, Genetics.

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

James C. Whisstock, Maya Topf, Tom T. Caradoc-Davies, 2015, PLoS biology.

X‐ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation

J. Whisstock, J. Irving, S. Bottomley, 2006, The EMBO journal.

Role of the M-loop and Reactive Center Loop Domains in the Folding and Bridging of Nucleosome Arrays by MENT*

J. Whisstock, Tatiana Nikitina, S. Grigoryev, 2003, Journal of Biological Chemistry.

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome*

J. Whisstock, R. Pike, P. Wilmann, 2013, The Journal of Biological Chemistry.

Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?

J. Whisstock, C. Warr, E. Duncan, 2014, Current opinion in insect science.

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.

J. Whisstock, J. Irving, S. Bottomley, 2002, Biochemistry.

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

J. Whisstock, J. Irving, David Miller, 2002, Biochemistry.

Subunit γ-Green Fluorescent Protein Fusions Are Functionally Incorporated into Mitochondrial F1F0-ATP Synthase, Arguing Against a Rigid Cap Structure at the Top of F1 *

J. Whisstock, M. Prescott, P. Nagley, 2002, The Journal of Biological Chemistry.

Perforin and granzymes: function, dysfunction and human pathology

James C. Whisstock, J. Whisstock, J. Trapani, 2015, Nature Reviews Immunology.

Structure of the P-Rex1:Rac1 Complex 1 The P-Rex1:Rac1 Complex Reveals the Structural Basis of Rac1 Activation in Breast Cancer Cells

J. Whisstock, C. Mitchell, L. Ooms, 2017 .

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells*

J. Whisstock, C. Mitchell, L. Ooms, 2015, The Journal of Biological Chemistry.

The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease

J. Whisstock, C. Bayly-Jones, H. Venugopal, 2021, bioRxiv.

The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1

J. Whisstock, C. Bayly-Jones, H. Venugopal, 2021, Nature Structural & Molecular Biology.

The major human and mouse granzymes are structurally and functionally divergent

James C. Whisstock, Philip E. Thompson, Dion Kaiserman, 2006, The Journal of cell biology.

Maspin is not required for embryonic development or tumour suppression

J. Whisstock, R. Law, P. Bird, 2014, Nature Communications.

Perforin: structure, function, and role in human immunopathology

J. Whisstock, J. Trapani, Katherine Baran, 2010, Immunological reviews.

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Cyril F. Reboul, J. Whisstock, S. Panjikar, 2015, Proceedings of the National Academy of Sciences.

Cloning and Expression of the Major SecretedCathepsin B-Like Protein from Juvenile Fasciola hepatica andAnalysis of Immunogenicity following Liver FlukeInfection

J. Whisstock, J. Irving, R. Law, 2003, Infection and Immunity.

Real-time visualization of perforin nanopore assembly.

J. Whisstock, H. Saibil, J. Trapani, 2017, Nature nanotechnology.

An atlas of serpin conformations.

J. Whisstock, A. Lesk, R. Skinner, 1998, Trends in biochemical sciences.

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

J. Whisstock, A. Lesk, R. Carrell, 2000, Journal of molecular biology.

Mapping the binding site of C1-inhibitor for polyanion cofactors.

J. Whisstock, R. Pike, L. Hor, 2020, Molecular Immunology.

IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.

J. Whisstock, M. D. de Veer, S. Ralph, 1998, Genomics.

Molecular basis of α1‐antitrypsin deficiency revealed by the structure of a domain‐swapped trimer

James C Whisstock, J. Whisstock, J. Huntington, 2011, EMBO reports.

Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

J. Whisstock, A. Lesk, J. Irving, 2000, Genome Research.

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Woldeamanuel A. Birru, J. Whisstock, J. Dalton, 2010, Proceedings of the National Academy of Sciences.

Structural mechanisms of inactivation in scabies mite serine protease paralogues.

J. Whisstock, J. Irving, A. Buckle, 2009, Journal of molecular biology.

A Mechanism for Hereditary Angioedema Caused by a Lysine311 to Glutamic Acid Substitution in Plasminogen.

J. Whisstock, R. Law, E. Feener, 2022, Blood.

Identification of a Novel Domain in Two Mammalian Inositol-polyphosphate 5-Phosphatases That Mediates Membrane Ruffle Localization

J. Whisstock, C. Mitchell, M. Prescott, 2003, The Journal of Biological Chemistry.

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Olivia Susanto, James C Whisstock, Hideo Yagita, 2011, Immunity.

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

J. Whisstock, J. Trapani, I. Voskoboinik, 2009, Proceedings of the National Academy of Sciences.

PhosContext2vec: a distributed representation of residue-level sequence contexts and its application to general and kinase-specific phosphorylation site prediction

Jiangning Song, Campbell Wilson, Ying Xu, 2018, Scientific Reports.

EGM: encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes

Geoffrey I. Webb, Jiangning Song, Arun Siddharth Konagurthu, 2010, Bioinform..

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis

J. Whisstock, J. Irving, P. Bird, 2004, Cellular and Molecular Life Sciences CMLS.

Progressive Multiple Alignment Using Sequence Triplet Optimizations and Three-residue Exchange Costs

Peter J. Stuckey, Arun Siddharth Konagurthu, James C. Whisstock, 2004, J. Bioinform. Comput. Biol..

Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity

J. Whisstock, M. Layton, P. Majerus, 2001, Proceedings of the National Academy of Sciences of the United States of America.

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

J. Whisstock, D. Tscharke, G. Ramm, 2017, Oncotarget.

Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing

J. Whisstock, C. Warr, T. K. Johnson, 2013, Proceedings of the National Academy of Sciences.

The REFOLD database: a tool for the optimization of protein expression and refolding

James C. Whisstock, Ashley M. Buckle, Abdullah A. Amin, 2005, Nucleic Acids Res..

Automatic generation of protein structure cartoons with Pro-origami

Peter J. Stuckey, James C. Whisstock, Michael Wybrow, 2011, Bioinform..

The Structure and Function of Catalytic Domains Within Inositol Polyphosphate 5‐Phosphatases

J. Whisstock, R. Gurung, F. Wiradjaja, 2002, IUBMB life.

Display in Primary Biliary Cirrhosis Using Phage of the Pyruvate Dehydrogenase Complex E 2 Prediction of the Immunodominant Epitope

Mackay, J. Whisstock, M. Rowley, 2000 .

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

J. Whisstock, J. Trapani, P. Bird, 2012, BMC Evolutionary Biology.

Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

Samantha J. Stehbens, J. Whisstock, P. Pollock, 2020, Theranostics.

Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

J. Whisstock, J. Trapani, A. Brennan, 2017, EMBO reports.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

J. Whisstock, H. Saibil, J. Trapani, 2018, Cell Death & Differentiation.

GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome

Geoffrey I. Webb, Jiangning Song, James C. Whisstock, 2015, Bioinform..

PhosTransfer: A Deep Transfer Learning Framework for Kinase-Specific Phosphorylation Site Prediction in Hierarchy

James C. Whisstock, Campbell Wilson, Tatiana T. Marquez-Lago, 2020, PAKDD.

Leucine-rich Repeats 2-4 (Leu60-Glu128) of Platelet Glycoprotein Ibα Regulate Shear-dependent Cell Adhesion to von Willebrand Factor*

J. Whisstock, S. Jackson, S. Cranmer, 2006, Journal of Biological Chemistry.

Crystallography of serpins and serpin complexes.

J. Whisstock, M. Dunstone, 2011, Methods in enzymology.

Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like

J. Whisstock, C. Warr, T. K. Johnson, 2014, Nature Communications.

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

J. Whisstock, J. Dalton, G. Salvesen, 2012, PloS one.

Inhibitory Activity of a Heterochromatin-associated Serpin (MENT) against Papain-like Cysteine Proteinases Affects Chromatin Structure and Blocks Cell Proliferation*

J. Whisstock, J. Irving, S. Bottomley, 2002, The Journal of Biological Chemistry.

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification

J. Whisstock, B. Hoogenboom, S. Pang, 2019, bioRxiv.

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

J. Whisstock, R. Law, I. Voskoboinik, 2010, Tissue antigens.

The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix*

J. Whisstock, J. Irving, S. Bottomley, 2005, Journal of Biological Chemistry.

Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1

J. Whisstock, H. Elmlund, C. Mitchell, 2021, Science Signaling.

Structural analysis of the PTEN:P-Rex2 signalling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1

J. Whisstock, H. Elmlund, C. Mitchell, 2020, bioRxiv.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

J. Whisstock, C. Garlanda, A. Mantovani, 2015, Nature Immunology.

TcpA from the Clostridiumperfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins.

J. Whisstock, D. Traore, J. Rood, 2023, Structure.

Glycoprotein Ib-IX-V.

J. Whisstock, M. Berndt, R. Andrews, 2003, The international journal of biochemistry & cell biology.

Maternal Torso-Like Coordinates Tissue Folding During Drosophila Gastrulation

J. Whisstock, C. Warr, T. K. Johnson, 2017, Genetics.

Evolution and classification of the serpin superfamily

James C. Whisstock, Dion Kaiserman, Lisa D. Cabrita, 2007 .

Conservation within the myosin motor domain: implications for structure and function.

J. Whisstock, I. Rayment, M. Cope, 1996, Structure.

The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens.

J. Whisstock, S. McGowan, J. K. Cheung, 2002, Journal of molecular biology.

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini

James C. Whisstock, Coral G. Warr, J. Whisstock, 2015, Nature Communications.

MUSTANG-MR Structural Sieving Server: Applications in Protein Structural Analysis and Crystallography

Peter J. Stuckey, James C. Whisstock, Arthur M. Lesk, 2010, PloS one.

Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders

J. Whisstock, P. Bird, Susan R. Berkowicz, 2016, Front. Behav. Neurosci..

Brinp1−/− mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

J. Whisstock, N. Borg, P. Bird, 2016, Molecular Autism.

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

J. Whisstock, A. Buckle, G. Fenalti, 2012, Bioscience reports.

The High Resolution Crystal Structure of a Native Thermostable Serpin Reveals the Complex Mechanism Underpinning the Stressed to Relaxed Transition*

Lisa D. Cabrita, J. Whisstock, A. Lesk, 2005, Journal of Biological Chemistry.

Mutagenesis of the dengue virus type 2 NS3 proteinase and the production of growth-restricted virus.

J. Whisstock, A. Davidson, P. J. Wright, 2001, The Journal of general virology.

Perforin-A key (shaped) weapon in the immunological arsenal.

J. Whisstock, B. Spicer, R. Law, 2017, Seminars in cell & developmental biology.

Serpins. A mechanistic class of their own.

J. Whisstock, S. Bottomley, P. C. Hopkins, 1997, Advances in experimental medicine and biology.

The Yeast Inositol Polyphosphate 5-Phosphatase Inp54p Localizes to the Endoplasmic Reticulum via a C-terminal Hydrophobic Anchoring Tail

J. Whisstock, J. Sambrook, M. Gething, 2001, The Journal of Biological Chemistry.

The N terminus of the serpin, tengpin, functions to trap the metastable native state

Lisa D. Cabrita, J. Whisstock, J. Irving, 2007, EMBO reports.

Helical ultrastructure of the oncogenic metalloprotease meprin α in complex with a small molecule hydroxamate inhibitor

J. Whisstock, A. de Marco, C. Bayly-Jones, 2022, bioRxiv.

Serpins: Finely Balanced Conformational Traps

J. Whisstock, J. Irving, S. Bottomley, 2002, IUBMB life.

Drosophila macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2

J. Whisstock, C. Warr, T. K. Johnson, 2020, bioRxiv.

The human serpin proteinase inhibitor‐9 self‐associates at physiological temperatures

J. Whisstock, S. Bottomley, P. Bird, 2004, Protein science : a publication of the Protein Society.

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.

J. Whisstock, J. Irving, P. Bird, 2003, Biochemistry.

DNA Accelerates the Inhibition of Human Cathepsin V by Serpins*

J. Whisstock, J. Irving, S. Bottomley, 2007, Journal of Biological Chemistry.

SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.

J. Whisstock, P. Bird, Jiuru Sun, 2007, Journal of biochemistry.

Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

J. Whisstock, C. O. Kamlin, A. Malhotra, 2020, Nature Communications.

A structural basis for loop C-sheet polymerization in serpins.

J. Whisstock, S. Bottomley, A. Buckle, 2008, Journal of molecular biology.

REFOLD: an analytical database of protein refolding methods.

Michelle K. M. Chow, J. Whisstock, S. Bottomley, 2006, Protein expression and purification.

Protease SFTI complex

J. Whisstock, D. Craik, T. Durek, 2019 .

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

J. Whisstock, M. Rowley, I. Mackay, 2008, Diabetes.

Mining folded proteomes in the era of accurate structure prediction

J. Whisstock, C. Bayly-Jones, 2021, bioRxiv.

Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin involved in virulence.

J. Whisstock, S. Bertagnoli, J. Guérin, 2001, The Journal of general virology.

A New Model for Pore Formation by Cholesterol-Dependent Cytolysins

James C. Whisstock, Cyril F. Reboul, Cyril F. Reboul, 2014, PLoS Comput. Biol..

Bioinformatics Discovery Note Structural Bioinformatics Predicting Giant Transmembrane Β-barrel Architecture

James C. Whisstock, Cyril F. Reboul, Khalid Mahmood, 2022 .

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice.

J. Whisstock, K. Rogers, R. Dinglasan, 2017, Cell reports.

Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway

J. Whisstock, C. Warr, T. K. Johnson, 2018, G3: Genes, Genomes, Genetics.

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

J. Whisstock, J. Dalton, A. Buckle, 2009, Proceedings of the National Academy of Sciences.

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

J. Whisstock, J. Stuckey, D. Lawrence, 2013, Proceedings of the National Academy of Sciences.

The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment.

Lisa D. Cabrita, J. Whisstock, J. Irving, 2003, Structure.

Probing the Unfolding Pathway of α1-Antitrypsin*

J. Whisstock, S. Bottomley, M. Gore, 1999, The Journal of Biological Chemistry.

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

J. Whisstock, M. Perugini, P. Conroy, 2017, Science Immunology.

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

J. Whisstock, D. Traore, S. Panjikar, 2018, Nature Communications.

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

J. Whisstock, D. Traore, J. Rood, 2016, Molecular microbiology.

Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding*

S. E. Stewart, J. Whisstock, J. Trapani, 2015, The Journal of Biological Chemistry.

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.

James McCluskey, James C Whisstock, Anthony W Purcell, 2003, Immunity.

Modeling of serpin‐protease complexes: Antithrombin‐thrombin, α1‐antitrypsin (358Met→Arg)‐thrombin, α1‐antitrypsin (358Met→Arg)‐trypsin, and antitrypsin‐elastase

J. Whisstock, A. Lesk, R. Carrell, 1996 .

Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met-->Arg)-thrombin, alpha 1-antitrypsin (358Met-->Arg)-trypsin, and antitrypsin-elastase.

J. Whisstock, A. Lesk, R. Carrell, 1996, Proteins.

The Perforin Pore Facilitates the Delivery of Cationic Cargos*

S. E. Stewart, J. Whisstock, J. Trapani, 2014, The Journal of Biological Chemistry.

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

J. Whisstock, J. Irving, H. O. D. op den Camp, 2008, Mycological research.

Pops: a Computational Tool for Modeling and Predicting Protease Specificity

James C. Whisstock, Maria Garcia de la Banda, Sarah E. Boyd, 2004, J. Bioinform. Comput. Biol..

Preferential Acquisition and Activation of Plasminogen Glycoform II by PAM Positive Group A Streptococcal Isolates.

J. Whisstock, J. McArthur, R. Law, 2015, Biochemistry.

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets.

J. Whisstock, R. Law, P. Conroy, 2017, Methods.

Molecular Modeling of the Seven Tandem Leucine-Rich Repeats within the Ligand-Binding Region of Platelet Glycoprotein Ibα

J. Whisstock, José A López, M. Berndt, 2002, Thrombosis and Haemostasis.

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence

J. Whisstock, N. Freitag, Bobbi Xayarath, 2011, Molecular microbiology.

SERPINB11 Is a New Noninhibitory Intracellular Serpin

J. Whisstock, D. Brömme, G. Silverman, 2007, Journal of Biological Chemistry.

Solution structure of VEK50 in the bound form with plasminogen kringle 2

J. Whisstock, R. Law, F. Castellino, 2019 .

Aeropin from the Extremophile Pyrobaculum aerophilum Bypasses the Serpin Misfolding Trap*

Lisa D. Cabrita, J. Whisstock, J. Irving, 2007, Journal of Biological Chemistry.

Reconciling the Structural Attributes of Avian Antibodies*

James C. Whisstock, Paul J. Conroy, Stephen Hearty, 2014, The Journal of Biological Chemistry.

Design of Polarity-Dependent Immunosensors Based on the Structural Analysis of Engineered Antibodies.

J. Whisstock, R. Law, P. Conroy, 2023, ACS chemical biology.

Structural biology: Serpins' mystery solved

J. Whisstock, S. Bottomley, 2008, Nature.

eResearch Solutions for High Throughput Structural Biology

David Abramson, James C. Whisstock, Andrew E. Treloar, 2007, Third IEEE International Conference on e-Science and Grid Computing (e-Science 2007).

Automated cryo-lamella preparation for high-throughput in-situ structural biology

J. Whisstock, A. de Marco, H. Venugopal, 2019, bioRxiv.

Serpins in the Caenorhabditis elegans genome

J. Whisstock, A. Lesk, J. Irving, 1999 .

Serpins in the Caenorhabditis elegans genome.

J. Whisstock, A. Lesk, J. Irving, 1999, Proteins.

S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction*

Cyril F. Reboul, J. Whisstock, W. Wong, 2011, The Journal of Biological Chemistry.

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

J. Whisstock, S. Dalal, M. Klemba, 2011, Proceedings of the National Academy of Sciences.

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.

J. Whisstock, R. Law, P. Conroy, 2019, Blood advances.

The molecular basis for perforin oligomerization and transmembrane pore assembly.

J. Whisstock, H. Saibil, J. Trapani, 2009, Immunity.

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence

J. Whisstock, N. Freitag, Bobbi Xayarath, 2011, Molecular microbiology.

An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Letter.

J. Whisstock, P. Bird, 2017, Cancer research.

Defining the interaction of perforin with calcium and the phospholipid membrane.

J. Whisstock, J. Trapani, A. Brennan, 2013, The Biochemical journal.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

J. Whisstock, H. Saibil, J. Trapani, 2018, Cell Death & Differentiation.

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

J. Whisstock, J. Irving, A. Buckle, 2009, Proceedings of the National Academy of Sciences.

Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

J. Whisstock, J. Trapani, A. Brennan, 2017, EMBO reports.

Molecular Determinants of the Mechanism Underlying Acceleration of the Interaction between Antithrombin and Factor Xa by Heparin Pentasaccharide*

J. Whisstock, S. Bottomley, R. Pike, 2002, The Journal of Biological Chemistry.

Federated repositories of X-ray diffraction images.

Mark A. Bate, J. Whisstock, Jennifer L. Martin, 2008, Acta crystallographica. Section D, Biological crystallography.

Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site

J. Whisstock, Victor Yin, Vojtech Franc, 2023, Molecular & cellular proteomics : MCP.

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.

J. Whisstock, R. Law, F. Castellino, 2019, Journal of structural biology.

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram‐negative bacteria

J. Whisstock, C. Porter, J. Rood, 2012, Molecular microbiology.

Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus.

J. Whisstock, W. Wong, C. Porter, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Woldeamanuel A. Birru, J. Whisstock, A. Buckle, 2010, Proceedings of the National Academy of Sciences.

From the Cover: Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

J. Whisstock, J. Dalton, A. Buckle, 2009 .

Additional file 4: Figure S4. of Brinp1 −/− mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

J. Whisstock, N. Borg, P. Bird, 2016 .

Bioinformatics Discovery Note Structural Bioinformatics Predicting Giant Transmembrane Β-barrel Architecture

Cyril F. Reboul, J. Whisstock, M. Dunstone, 2022 .