J. Irving

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Protein structural alignments and functional genomics

J. Whisstock, A. Lesk, J. Irving, 2001, Proteins.

Functional insights from the distribution and role of homopeptide repeat-containing proteins.

J. Whisstock, A. Lesk, J. Irving, 2005, Genome research.

Smoothing a rugged protein folding landscape by sequence-based redesign

Geoffrey I. Webb, J. Whisstock, J. Irving, 2016, Scientific Reports.

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

J. Whisstock, J. Irving, A. Buckle, 2009, Proceedings of the National Academy of Sciences of the United States of America.

The Evolution of Enzyme Specificity in Fasciola spp.

J. Whisstock, J. Irving, P. Smooker, 2003, Journal of Molecular Evolution.

Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.

J. Whisstock, J. Irving, L. Juliano, 2000, Biochemistry.

Targeting serpins in high-throughput and structure-based drug design.

J. Irving, J. Christodoulou, I. Nobeli, 2011, Methods in enzymology.

The serpinopathies studying serpin polymerization in vivo.

J. Irving, D. Lomas, B. Gooptu, 2011, Methods in enzymology.

Unravelling the twists and turns of the serpinopathies

J. Irving, D. Lomas, S. Marciniak, 2011, The FEBS journal.

The molecular species responsible for α1‐antitrypsin deficiency are suppressed by a small molecule chaperone

J. Irving, D. Lomas, A. Fra, 2020, The FEBS journal.

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4*

J. Whisstock, J. Irving, M. Gunzburg, 2013, The Journal of Biological Chemistry.

Computational analysis of evolution and conservation in a protein superfamily.

J. Whisstock, J. Irving, D. J. Askew, 2004, Methods.

The Murine Orthologue of Human Antichymotrypsin

J. Whisstock, J. Irving, S. Bottomley, 2005, Journal of Biological Chemistry.

High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin

J. Irving, D. Lomas, J. Christodoulou, 2020, Nature Communications.

Serpinopathies

J. Irving, B. Gooptu, D. Lomas, 2019, α1-Antitrypsin Deficiency.

Electrophoresis- and FRET-Based Measures of Serpin Polymerization.

Anwen E. Brown, J. Irving, I. Haq, 2017, Methods in molecular biology.

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

J. Irving, D. Lomas, E. Miranda, 2015, The Biochemical journal.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

J. Irving, Zhengrong Zhu, D. Lomas, 2021, Bioorganic & medicinal chemistry letters.

In Vitro Approaches for the Assessment of Serpin Polymerization.

J. Irving, D. Lomas, Emma L. K. Elliston, 2018, Methods in molecular biology.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

J. Irving, D. Lomas, G. Lukács, 2022, Cellular and Molecular Life Sciences.

Role of the α-Helix 163-170 in Factor Xa Catalytic Activity*

J. Irving, O. Christophe, G. Chérel, 2007, Journal of Biological Chemistry.

Functional role of cell surface integrins on human trophoblast cell migration: regulation by TGF-beta, IGF-II, and IGFBP-1.

J. Irving, P. Lala, 1995, Experimental cell research.

Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation

J. Irving, V. Chudasama, A. Chrzastek, 2022, Chemical science.

Conformational Change in the Chromatin Remodelling Protein MENT

J. Whisstock, J. Irving, S. Bottomley, 2009, PloS one.

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites.

J. Irving, M. Bogyo, R. Law, 2009, The international journal of biochemistry & cell biology.

For the record: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica

J. Whisstock, J. Irving, P. Smooker, 2000, Protein science : a publication of the Protein Society.

Peptide mimotopes selected with HIV‐1‐blocking monoclonal antibodies against CCR5 represent motifs specific for HIV‐1 entry

J. Irving, U. Dietrich, C. Königs, 2007, Immunology and cell biology.

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

A M Lesk, J. Whisstock, A. Lesk, 2000, Genome research.

The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

J. Whisstock, J. Irving, D. Lomas, 2001, The Journal of Biological Chemistry.

Characteristics of trophoblast cells migrating from first trimester chorionic villus explants and propagated in culture.

J. Irving, V. Han, C. Graham, 1995, Placenta.

Decidua-derived IGFBP-1 stimulates human intermediate trophoblast migration by binding to the α5β1 integrin subunits

J. Irving, P. Lala, 1994 .

Characteristics of first trimester normal human trophoblast cells propagated in culture

J. Irving, V. Han, K. McCrae, 1993 .

Scaling Concepts in Serpin Polymer Physics

J. Irving, D. Lomas, V. Martorana, 2021, Materials.

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes.

J. Irving, D. Lomas, R. Kitsis, 2021, Developmental cell.

Serpins in prokaryotes.

Arthur M Lesk, James C Whisstock, Robert N Pike, 2002, Molecular biology and evolution.

X‐ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation

J. Whisstock, J. Irving, S. Bottomley, 2006, The EMBO journal.

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.

J. Whisstock, J. Irving, S. Bottomley, 2002, Biochemistry.

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

J. Whisstock, J. Irving, David Miller, 2002, Biochemistry.

Cloning and Expression of the Major SecretedCathepsin B-Like Protein from Juvenile Fasciola hepatica andAnalysis of Immunogenicity following Liver FlukeInfection

J. Whisstock, J. Irving, R. Law, 2003, Infection and Immunity.

Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody

J. Irving, G. Alexander, D. Lomas, 2015, The international journal of biochemistry & cell biology.

olymerisation using a novel monoclonal antibody

J. Irving, K. Burling, J. Pérezc, 2014 .

Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

J. Whisstock, A. Lesk, J. Irving, 2000, Genome Research.

Structural mechanisms of inactivation in scabies mite serine protease paralogues.

J. Whisstock, J. Irving, A. Buckle, 2009, Journal of molecular biology.

Phosphoproteins in stress-induced disease.

J. Irving, E. Healey, S. Marciniak, 2012, Progress in molecular biology and translational science.

The structural basis for Z α1-antitrypsin polymerization in the liver

J. Irving, E. Orlova, D. Lomas, 2020, Science Advances.

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis

J. Whisstock, J. Irving, P. Bird, 2004, Cellular and Molecular Life Sciences CMLS.

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity☆

J. Irving, D. Lomas, E. Speretta, 2013, Biochimica et biophysica acta.

Inhibitory Activity of a Heterochromatin-associated Serpin (MENT) against Papain-like Cysteine Proteinases Affects Chromatin Structure and Blocks Cell Proliferation*

J. Whisstock, J. Irving, S. Bottomley, 2002, Journal of Biological Chemistry.

Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25.

J. Irving, J. Ragoussis, P. Bird, 1999, Genomics.

The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix*

J. Whisstock, J. Irving, S. Bottomley, 2005, Journal of Biological Chemistry.

Evolution and classification of the serpin superfamily

James C. Whisstock, Dion Kaiserman, Lisa D. Cabrita, 2007 .

Characterisation of serpin polymers in vitro and in vivo.

Claire H. Michel, J. Irving, C. Robinson, 2011, Methods.

MUSTANG-MR Structural Sieving Server: Applications in Protein Structural Analysis and Crystallography

Peter J. Stuckey, James C. Whisstock, Arthur M. Lesk, 2010, PloS one.

The High Resolution Crystal Structure of a Native Thermostable Serpin Reveals the Complex Mechanism Underpinning the Stressed to Relaxed Transition*

Lisa D. Cabrita, J. Whisstock, A. Lesk, 2005, Journal of Biological Chemistry.

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

J. Irving, U. Dietrich, C. Königs, 2005, Journal of immunological methods.

The N terminus of the serpin, tengpin, functions to trap the metastable native state

Lisa D. Cabrita, J. Whisstock, J. Irving, 2007, EMBO reports.

Serpins: Finely Balanced Conformational Traps

J. Whisstock, J. Irving, S. Bottomley, 2002, IUBMB life.

The pathological Trento variant of alpha‐1‐antitrypsin (E75V) shows nonclassical behaviour during polymerization

J. Irving, D. Lomas, A. Fra, 2017, The FEBS journal.

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding

J. Irving, D. Lomas, G. Sivalingam, 2015, Protein science : a publication of the Protein Society.

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.

J. Whisstock, J. Irving, P. Bird, 2003, Biochemistry.

DNA Accelerates the Inhibition of Human Cathepsin V by Serpins*

J. Whisstock, J. Irving, S. Bottomley, 2007, Journal of Biological Chemistry.

Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis.

J. Irving, P. Bird, T. Ruzicka, 2001, DNA and cell biology.

Probing the folding pathway of a consensus serpin using single tryptophan mutants

J. Irving, S. Bottomley, Weiwen Dai, 2018, Scientific Reports.

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

J. Irving, D. Lomas, S. Marciniak, 2015, The FASEB Journal.

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

J. Irving, D. Lomas, Jennifer A. Dickens, 2014, The Biochemical journal.

The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment.

Lisa D. Cabrita, J. Whisstock, J. Irving, 2003, Structure.

Alpha1-Antitrypsin: Structure and Dynamics in Health, Disease and Drug Development

J. Irving, D. Lomas, B. Gooptu, 2017 .

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

J. Whisstock, J. Irving, H. O. D. op den Camp, 2008, Mycological research.

Interactions between N‐linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

J. Irving, D. Lomas, V. Martorana, 2015, The FEBS journal.

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.

J. Irving, D. Lomas, L. Dron, 2016, American journal of respiratory cell and molecular biology.

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant

J. Irving, D. Lomas, E. Miranda, 2021, International journal of molecular sciences.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

J. Irving, Zhengrong Zhu, D. Lomas, 2020, bioRxiv.

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin

J. Irving, D. Lomas, A. Fra, 2020, JCI insight.

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour

J. Irving, D. Lomas, E. Miranda, 2016, The Biochemical journal.

Aeropin from the Extremophile Pyrobaculum aerophilum Bypasses the Serpin Misfolding Trap*

Lisa D. Cabrita, J. Whisstock, J. Irving, 2007, Journal of Biological Chemistry.

Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion.

J. Irving, S. Price, Rosanna C. G. Smith, 2019, Metallomics : integrated biometal science.

Role of the alpha-helix 163-170 in factor Xa catalytic activity.

J. Irving, O. Christophe, G. Chérel, 2007, The Journal of biological chemistry.

THE MURINE ORTHOLOGUE OF HUMAN ANTICHYMOTRYPSIN: A STRUCTURAL PARADIGM FOR CLADE A3 SERPINS

J. Irving, J. Rossjohn, R. Law, 2005 .

Infection Immunogenicity following Liver Fluke and Analysis of Fasciola hepatica Juvenile Secreted Cathepsin B-Like Protein from Cloning and Expression of the Major

J. Irving, R. Law, P. Smooker, 2003 .

Serpins in the Caenorhabditis elegans genome

J. Whisstock, A. Lesk, J. Irving, 1999 .

Serpins in the Caenorhabditis elegans genome.

J. Whisstock, A. Lesk, J. Irving, 1999, Proteins.

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

J. Irving, D. Lomas, A. Fra, 2018, bioRxiv.

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

J. Whisstock, J. Irving, A. Buckle, 2009, Proceedings of the National Academy of Sciences.