J. Caldwell

发表

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

R. König, Yingyao Zhou, D. Elleder, 2008, Cell.

PDX1, a Cellular Homeoprotein, Binds to and Regulates the Activity of Human Cytomegalovirus Immediate Early Promoter*

J. Caldwell, S. Chanda, S. Chao, 2004, Journal of Biological Chemistry.

Cancer cell-based genomic and small molecule screens.

J. Caldwell, Jeremy S Caldwell, 2007, Advances in cancer research.

Genome-scale functional profiling of the mammalian AP-1 signaling pathway

Frederick J. King, J. Caldwell, A. Orth, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.

Yi Liu, Nathanael Gray, Scott A Lesley, 2005, Bioorganic & medicinal chemistry letters.

Identification of Small Molecule and Genetic Modulators of AON-Induced Dystrophin Exon Skipping by High-Throughput Screening

Paul W Anderson, Yingyao Zhou, Buu P. Tu, 2009, PloS one.

Tips A time-resolved fluorescence resonance energy transfer-based assay for DEN 1 peptidase activity

J. Caldwell, I. H. Engels, A. Brinker, 2009 .

Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles

J. Caldwell, S. Lesley, A. Kreusch, 2005 .

Identification and Characterization of a Small Molecule Antagonist of Human VPAC2 Receptor

J. Caldwell, A. Chu, Y. Chen, 2010, Molecular Pharmacology.

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).

Andrew G. Spencer, J. Caldwell, D. Charmot, 2018, Journal of medicinal chemistry.

Fulfilling the promise: drug discovery in the post-genomic era.

Sumit K Chanda, J. Caldwell, S. Chanda, 2003, Drug discovery today.

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice

J. Caldwell, A. King, J. Jacobs, 2017, Journal of cardiovascular pharmacology and therapeutics.

In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.

Susan E. Cellitti, J. Caldwell, P. Schultz, 2008, Journal of the American Chemical Society.

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

J. Caldwell, T. Knöpfel, C. Wagner, 2018, Science Translational Medicine.

4-Aminopyrimidines as novel HIV-1 inhibitors.

J. Caldwell, K. Kuhen, Yun He, 2007, Bioorganic & Medicinal Chemistry Letters.

Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.

J. Caldwell, K. Kuhen, B. Bursulaya, 2006, Bioorganic & medicinal chemistry letters.

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.

Paul S Mischel, Timothy F Cloughesy, Joseph A Loo, 2009, Cancer research.

Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I.

J. Caldwell, K. Kuhen, B. Bursulaya, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.

J. Caldwell, K. Kuhen, B. Bursulaya, 2006, Bioorganic & medicinal chemistry letters.

Design, Synthesis and Biological Evaluations of Novel Oxindoles as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. Part 1.

J. Caldwell, K. Kuhen, B. Bursulaya, 2006 .

Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.

J. Caldwell, K. Kuhen, H. Yin, 2006, Bioorganic & medicinal chemistry letters.

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

J. Caldwell, D. Nguyen, H. Yin, 2009, Journal of Biological Chemistry.

3.01 – Genomics

J. Caldwell, 2007 .

Fyn and Src are Effectors of Oncogenic EGFR Signaling in Glioblastoma Patients

J. Caldwell, S. Nelson, C. James, 2009 .

Identification of p53 regulators by genome-wide functional analysis.

J. Caldwell, S. Chanda, P. Schultz, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Human Cep192 Is Required for Mitotic Centrosome and Spindle Assembly

J. Caldwell, S. Chanda, D. Rines, 2007, Current Biology.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

J. Caldwell, A. King, D. Dragoli, 2019, American journal of physiology. Gastrointestinal and liver physiology.

Identification of Homeodomain Proteins, PBX1 and PREP1, Involved in the Transcription of Murine Leukemia Virus

J. Caldwell, S. Chanda, N. Gray, 2003, Molecular and Cellular Biology.

HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1

J. Caldwell, I. H. Engels, A. Brinker, 2010, Current chemical genomics.

Ontology recapitulates physiology.

J. Caldwell, 2003, Chemistry & biology.

Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes.

J. Caldwell, Z. Klase, F. Kashanchi, 2007, Virology.

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.

J. Caldwell, N. Gray, T. Honda, 2006, Bioorganic & medicinal chemistry letters.

Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.

J. Caldwell, F. Moatamed, Jimin Xu, 2003, The Journal of clinical endocrinology and metabolism.

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.

J. Caldwell, N. Gray, O. Ohmori, 2006, Bioorganic & medicinal chemistry letters.

An efficient rapid system for profiling the cellular activities of molecular libraries.

Andrew I Su, Yingyao Zhou, Peter G Schultz, 2006, Proceedings of the National Academy of Sciences of the United States of America.

An intracellular conformational sensor assay for Abl T315I.

J. Caldwell, A. Brinker, Shulin Han, 2009, Analytical biochemistry.

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

Peter G. Schultz, Yingyao Zhou, Elizabeth A. Winzeler, 2008, Proceedings of the National Academy of Sciences.

Parsimonious discovery of synergistic drug combinations.

Marc Ferrer, Matthew Tudor, Jing Li, 2011, ACS chemical biology.

“UnPAKing” Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV Infection

J. Caldwell, K. Kuhen, D. Nguyen, 2006, Journal of Virology.

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform

J. Caldwell, D. Charmot, A. King, 2017, Stem cell reports.

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.

Paul W Anderson, Richard E Trager, J. Caldwell, 2009, Analytical biochemistry.

Human Cep 192 Is Required and Spindle Assembly

Daniel R. Rines, Sumit K. Chanda, Jeremy S. Caldwell, 2022 .

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells

Serge Batalov, Yingyao Zhou, Mischa Reinhardt, 2008, Genome Biology.

Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.

Scott A Lesley, Andreas Kreusch, Yun He, 2005, Bioorganic & medicinal chemistry letters.

Homogeneous High-Throughput Screening Assays for HIV-1 Integrase 3β-Processing and Strand Transfer Activities

J. Caldwell, K. Kuhen, S. Lesley, 2005, Journal of biomolecular screening.

Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening.

Yingyao Zhou, J. Caldwell, K. Kuhen, 2007, Virology.

A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors.

J. Caldwell, H. Klock, A. Brinker, 2004, Analytical biochemistry.

Cellular Ser/Thr-Kinase Assays Using Generic Peptide Substrates

Paul W Anderson, J. Caldwell, A. Orth, 2008, Current chemical genomics.

A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.

Truc Huynh, J. Caldwell, I. H. Engels, 2009, Analytical biochemistry.

Tenapanor Reduces IBS Pain Through Inhibition of TRPV1-Dependent Neuronal Hyperexcitability In vivo: 484

J. Caldwell, P. Pasricha, A. King, 2017 .

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

J. Caldwell, D. Mochly‐Rosen, L. Jamieson, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Learning from the Data: Mining of Large High-Throughput Screening Databases

Yun He, Yingyao Zhou, S. Frank Yan, 2006, J. Chem. Inf. Model..

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

J. Caldwell, A. King, D. Dragoli, 2019, American journal of physiology. Gastrointestinal and liver physiology.