D. Botstein

发表

Gene Ontology: tool for the unification of biology

M. Ashburner, C. Ball, J. Blake, 2000, Nature Genetics.

Singular value decomposition for genome-wide expression data processing and modeling.

D. Botstein, P. Brown, O. Alter, 2000, Proceedings of the National Academy of Sciences of the United States of America.

DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli.

D. Botstein, A. Khodursky, B. Peter, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.

Michael Ruogu Zhang, D. Botstein, G. Sherlock, 1998, Molecular biology of the cell.

Cluster analysis and display of genome-wide expression patterns.

D. Botstein, P. Brown, P. Spellman, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Missing value estimation methods for DNA microarrays

Russ B. Altman, Robert Tibshirani, David Botstein, 2001, Bioinform..

'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns

Ash A. Alizadeh, R. Tibshirani, T. Hastie, 2000, Genome Biology.

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Ash A. Alizadeh, R. Tibshirani, D. Botstein, 2000, Nature.

The transcriptional program of sporulation in budding yeast.

D. Botstein, P. Brown, M. Eisen, 1998, Science.

Genomic expression programs in the response of yeast cells to environmental changes.

D. Botstein, P. Brown, P. Spellman, 2000, Molecular biology of the cell.

Systematic variation in gene expression patterns in human cancer cell lines

Christian A. Rees, D. Botstein, P. Brown, 2000, Nature Genetics.

Diversity of gene expression in adenocarcinoma of the lung

D. Botstein, P. Brown, O. Troyanskaya, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

R. Tibshirani, T. Hastie, D. Botstein, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The transcriptional program in the response of human fibroblasts to serum.

D. Botstein, P. Brown, V. Iyer, 1999, Science.

Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data

D. Pe’er, D. Koller, N. Friedman, 2003, Nature Genetics.

A gene expression database for the molecular pharmacology of cancer

D. Botstein, P. Brown, M. Eisen, 2000, Nature Genetics.

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.

Christian A. Rees, D. Botstein, P. Brown, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Missing Value Estimation

D. Botstein, O. Troyanskaya, R. Altman, 2003 .

Clustering methods for the analysis of DNA microarray data

R. Tibshirani, T. Hastie, D. Botstein, 1999 .

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

Ash A. Alizadeh, D. Botstein, P. Brown, 1999, Nature Genetics.

Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth

D. Botstein, P. Brown, P. Spellman, 2000, Nature.

Repeated observation of breast tumor subtypes in independent gene expression data sets

R. Tibshirani, T. Hastie, A. Nobel, 2003, Proceedings of the National Academy of Sciences of the United States of America.

implications Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical

R. Tibshirani, D. Botstein, P. Brown, 2001 .

Di erent types of di use large b-cell lymphoma identi ed by gene expression pro ling

Ash A. Alizadeh, R. Tibshirani, D. Botstein, 2000 .

A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae)

A. Owen, D. Botstein, K. Dolinski, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

T. Ideker, D. Botstein, K. Dolinski, 2006, Journal of biology.

Saccharomyces Genome Database.

C. Ball, D. Botstein, J. Cherry, 2002, Methods in enzymology.

Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes.

Ash A. Alizadeh, R. Tibshirani, D. Botstein, 2004, The New England journal of medicine.

Supervised harvesting of expression trees

R. Tibshirani, T. Hastie, D. Botstein, 2001, Genome Biology.

Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF

D. Botstein, P. Brown, V. Iyer, 2001, Nature.

Metabolic cycling without cell division cycling in respiring yeast

D. Botstein, A. Caudy, N. Slavov, 2011, Proceedings of the National Academy of Sciences.

Monitoring Editor

D. Botstein, E. Airoldi, A. van Oudenaarden, 2011 .

Fast-acting and Nearly Gratuitous Induction of Gene Expression and Protein Depletion in Saccharomyces Cerevisiae Graduate Program in Quantitative and Computational Biology, And

Megan N. McClean, D. Botstein, M. J. Hickman, 2022 .

Coupling among growth rate response, metabolic cycle, and cell division cycle in yeast

D. Botstein, N. Slavov, 2011, Molecular biology of the cell.

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

E. Lander, D. Botstein, 1989, Genetics.

Yeast: an experimental organism for modern biology.

D. Botstein, G. Fink, 1988, Science.

Systematic changes in gene expression patterns following adaptive evolution in yeast.

D. Botstein, P. Brown, R. Rosenzweig, 1999, Proceedings of the National Academy of Sciences of the United States of America.

For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group

D. Botstein, G. Sherlock, R. West, 2022 .

Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms

D. Botstein, P. Brown, O. Alter, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Identification of genes periodically expressed in the human cell cycle and their expression in tumors.

C. Ball, D. Botstein, J. Matese, 2002, Molecular biology of the cell.

Gene expression patterns in human liver cancers.

D. Botstein, P. Brown, S. Dudoit, 2002, Molecular biology of the cell.

Variation in gene expression patterns in human gastric cancers.

D. Botstein, P. Brown, O. Troyanskaya, 2003, Molecular biology of the cell.

Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.

D. Botstein, P. Brown, S. Elledge, 2001, Molecular biology of the cell.

Pervasive Genetic Hitchhiking and Clonal Interference in 40 Evolving Yeast Populations

Michael M. Desai, D. Botstein, G. Weinstock, 2013, Nature.

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

D. Botstein, N. Risch, 2003, Nature Genetics.

The cost of gene expression underlies a fitness trade-off in yeast

D. Botstein, A. Murray, G. I. Lang, 2009, Proceedings of the National Academy of Sciences.

Comparing whole genomes using DNA microarrays

Maitreya J. Dunham, D. Botstein, D. Gresham, 2008, Nature Reviews Genetics.

Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays

Ash A. Alizadeh, Christian A. Rees, D. Botstein, 1999, Nature Genetics.

Organization of the SUC gene family in Saccharomyces

D. Botstein, M. Carlson, D. Botstein, 1983, Molecular and cellular biology.

Gene expression profiling identifies clinically relevant subtypes of prostate cancer.

R. Tibshirani, D. Botstein, P. Brown, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.

D. Botstein, P. Brown, M. Berger, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Overview of the Alliance for Cellular Signaling

Temple F. Smith, D. Botstein, A. Arkin, 2002, Nature.

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

D. Botstein, R. W. Davis, M. Skolnick, 1980, American journal of human genetics.

Module Networks : Discovering Regulatory Modules and their Condition Specific Regulators from Gene Expression Data

D. Pe’er, D. Koller, N. Friedman, 2003 .

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

Christian A. Rees, R. Tibshirani, D. Botstein, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.

D. Botstein, P. Brown, R. Palmiter, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Comparison of the complete protein sets of worm and yeast: orthology and divergence.

Temple F. Smith, T. Smith, C. Ball, 1998, Science.

Plasmid construction by homologous recombination in yeast.

D. Botstein, H. Ma, S. Kunes, 1987, Gene.

Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children.

E S Lander, D Botstein, E. Lander, 1987, Science.

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

David Botstein, Ash A. Alizadeh, Richard Simon, 2001, The Journal of experimental medicine.

Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast.

Matthew J. Brauer, D. Botstein, J. Matese, 2008, Molecular biology of the cell.

Minor Isozymes Tailor Yeast Metabolism to Carbon Availability

Patrick H. Bradley, D. Botstein, O. Troyanskaya, 2018, mSystems.

Minor Isozymes Tailor Yeast Metabolism to Carbon Availability

Patrick H. Bradley, D. Botstein, O. Troyanskaya, 2018, mSystems.

Extensive Regulation of Metabolism and Growth during the Cell Division Cycle

D. Botstein, A. Caudy, N. Slavov, 2014, bioRxiv.

Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae

David Botstein, R. Scott McIsaac, Kirsten R. Benjamin, 2014, Nucleic acids research.

Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast

Benjamin L. Oakes, D. Botstein, M. Noyes, 2012, Nucleic acids research.

Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes

David Botstein, D. Botstein, David C. Hess, 2013, Proceedings of the National Academy of Sciences.

Decoupling nutrient signaling from growth rate causes aerobic glycolysis and deregulation of cell size and gene expression

D. Botstein, N. Slavov, 2013, Molecular biology of the cell.

Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway

David Botstein, Harmen J. Bussemaker, R. Scott McIsaac, 2012, Molecular biology of the cell.

Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases DNA Damage, and Selectively Sensitizes Cells to Agents With Diverse Mechanisms of Action

Brian E Snydsman, D. Botstein, C. W. Moore, 2012, G3: Genes | Genomes | Genetics.

System-Level Analysis of Genes and Functions Affecting Survival During Nutrient Starvation in Saccharomyces cerevisiae

David Botstein, John D. Storey, David Gresham, 2011, Genetics.

Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations

Patrick H. Bradley, D. Botstein, J. Rabinowitz, 2010, Molecular biology of the cell.

Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate

David Botstein, Robert H Singer, Nikolai Slavov, 2010, Proceedings of the National Academy of Sciences.

Universality, specificity and regulation of S. cerevisiae growth rate response in different carbon s

D. Botstein, N. Slavov, 2010 .

Slow Growth Induces Heat-shock Resistance in Normal and Respiratory-deficient Yeast

Matthew J. Brauer, D. Botstein, M. Brauer, 2022 .

Influence of genotype and nutrition on survival and metabolism of starving yeast

David Botstein, Viktor M Boer, D. Botstein, 2008, Proceedings of the National Academy of Sciences.

The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast

David Botstein, David Gresham, Maitreya J. Dunham, 2008, PLoS genetics.

Nutritional homeostasis in batch and steady-state culture of yeast.

David Botstein, Matthew J. Brauer, Matthew J Brauer, 2004, Molecular biology of the cell.

Homeostatic adjustment and metabolic remodeling in glucose-limited yeast cultures.

Kara Dolinski, David Botstein, Matthew J. Brauer, 2005, Molecular biology of the cell.

Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c-myc and its regulated genes

David Botstein, Ash A. Alizadeh, Maximilian Diehn, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

Ash A. Alizadeh, Howard Y. Chang, D. Botstein, 2004, PLoS biology.

Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation.

Emmitt R. Jolly, D. Botstein, J. Cherry, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

David Botstein, D. Botstein, M. Carlson, 1982, Cell.

A gene required for the separation of chromosomes on the spindle apparatus in yeast

D. Botstein, James H. Thomas, 1986, Cell.

Recurated protein interaction datasets

Michael S. Livstone, D. Botstein, K. Dolinski, 2009, Nature Methods.

Orthology and functional conservation in eukaryotes.

D. Botstein, K. Dolinski, 2007, Annual review of genetics.

Systems-level analysis of mechanisms regulating yeast metabolic flux

John D. Storey, David H Perlman, D. Botstein, 2016, Science.

Ammonium Toxicity and Potassium Limitation in Yeast

D. Botstein, David C. Hess, J. Rabinowitz, 2006, PLoS biology.

Expression array technology in the diagnosis and treatment of breast cancer.

D. Botstein, S. Jeffrey, A. Børresen-Dale, 2002, Molecular interventions.

Yeast: An Experimental Organism for 21st Century Biology

D. Botstein, G. Fink, 2011, Genetics.

Genetic Variation and the Fate of Beneficial Mutations in Asexual Populations

Michael M. Desai, D. Botstein, G. I. Lang, 2011, Genetics.

The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes.

Ash A. Alizadeh, D. Botstein, P. Brown, 1999, Cold Spring Harbor symposia on quantitative biology.

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

Ash A. Alizadeh, D. Botstein, P. Brown, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Stereotyped and specific gene expression programs in human innate immune responses to bacteria

Ash A. Alizadeh, D. Botstein, P. Brown, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A common language for physical mapping of the human genome.

L. Hood, D. Botstein, M. Olson, 1989, Science.

Propagation of some human DNA sequences in bacteriophage lambda vectors requires mutant Escherichia coli hosts.

D. Botstein, A. Wyman, L. B. Wolfe, 1985, Proceedings of the National Academy of Sciences of the United States of America.

A genetic linkage map of the human genome

M. Daly, E. Lander, D. Botstein, 1987, Cell.

Genetic and physical maps of Saccharomyces cerevisiae.

C. Ball, D. Botstein, J. Cherry, 1997, Nature.

Introductory Science and Mathematics Education for 21st-Century Biologists

W. Bialek, D. Botstein, 2004, Science.

A rapid, efficient method for isolating DNA from yeast.

D. Botstein, W. L. Fangman, C. Holm, 1986, Gene.

A DNA microarray survey of gene expression in normal human tissues

D. Botstein, P. Brown, M. van de Rijn, 2005, Genome Biology.

Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

D. Botstein, A. Addington, V. Willour, 2003, Molecular Psychiatry.

D. Botstein, R. West, P. Brown, 2022 .

Genetic approaches to the analysis of microbial development.

D. Botstein, R. Maurer, 1982, Annual review of genetics.

Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer

A. Nobel, D. Botstein, C. Fan, 2006, Molecular Cancer Therapeutics.

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

D. Botstein, G. Giaever, B. Andrews, 2009, Nature Biotechnology.

Mutants of yeast defective in sucrose utilization.

D. Botstein, M. Carlson, B. Osmond, 1981, Genetics.

Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae *

D. Botstein, P. Brown, A. Gasch, 2002, The Journal of Biological Chemistry.

Conservation of the metabolomic response to starvation across two divergent microbes

Matthew J. Brauer, D. Botstein, M. Brauer, 2006, Proceedings of the National Academy of Sciences.

Back to the future: education for systems-level biologists

D. Botstein, N. Wingreen, 2006, Nature Reviews Molecular Cell Biology.

Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells.

David Botstein, Hongjuan Zhao, James D Brooks, 2003, Molecular biology of the cell.

Imputing Missing Data for Gene Expression Arrays

Trevor Hastie, Robert Tibshirani, David Botstein, 2001 .

Strategies and applications of in vitro mutagenesis.

D Botstein, D. Botstein, D. Shortle, 1985, Science.

Genome-wide Analysis of Gene Expression Regulated by the Calcineurin / Crz 1 p Signaling Pathway in Saccharomyces cerevisiae *

D. Botstein, P. Brown, A. Gasch, 2002 .

Control of lysogenization by phage P22. I. The P22 cro gene.

D. Botstein, F. Winston, 1981, Journal of molecular biology.

A New System for Comparative Functional Genomics of Saccharomyces Yeasts

Manuel Llinás, David Botstein, Yuanfang Guan, 2013, Genetics.

Gene expression patterns in ovarian carcinomas.

Trevor Hastie, Robert Tibshirani, David Botstein, 2003, Molecular biology of the cell.

Variation in gene expression patterns in follicular lymphoma and the response to rituximab

David Botstein, Olga G. Troyanskaya, Patrick O. Brown, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association

David Botstein, Patrick O. Brown, D. Botstein, 2001, Nature Genetics.

Endothelial cell diversity revealed by global expression profiling

David Botstein, Howard Y. Chang, Guttorm Haraldsen, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A THEORY OF MODULAR EVOLUTION FOR BACTERIOPHAGES *

D. Botstein, 1980, Annals of the New York Academy of Sciences.

Genome-Wide Analysis of Nucleotide-Level Variation in Commonly Used Saccharomyces cerevisiae Strains

Kara Dolinski, David Botstein, Leonid Kruglyak, 2007, PloS one.

Suppressors of yeast actin mutations.

D Botstein, D. Botstein, P. Novick, 1989, Genetics.

Dissemination of an antibiotic resistance plasmid in hospital patient flora

D Botstein, D G Ross, D. Botstein, 1980, Antimicrobial Agents and Chemotherapy.

Packaging of an oversize transducing genome by Salmonella phage P22.

D. Botstein, B. Tye, R. K. Chan, 1974, Journal of molecular biology.

Visualization of receptor-mediated endocytosis in yeast.

D. Botstein, J. Mulholland, M. Zerial, 1999, Molecular biology of the cell.

Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.

N R Cozzarelli, D Botstein, D. Botstein, 2000, Proceedings of the National Academy of Sciences of the United States of America.

BMC Genomics BioMed Central Methodology article Universal Reference RNA as a standard for microarray experiments

David Botstein, Alexey Novoradovsky, Charles M Perou, 2004 .

Subcellular localization of yeast CDC46 varies with the cell cycle.

D. Botstein, K. Hennessy, C. D. Clark, 1990, Genes & development.

Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress.

David Botstein, Michael Shapira, Eran Segal, 2004, Molecular biology of the cell.

Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics.

D Botstein, D. Botstein, N. Kleckner, 1977, Journal of molecular biology.

Different gene expression patterns in invasive lobular and ductal carcinomas of the breast.

David Botstein, Hongjuan Zhao, Anita Langerød, 2004, Molecular biology of the cell.

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.

D. Botstein, A. Levine, C. Watanabe, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Extrachromosomal circular DNA is common in yeast

David Botstein, Birgitte Regenberg, D. Botstein, 2015, Proceedings of the National Academy of Sciences.

Of Genes and Genomes

D Botstein, D. Botstein, 1999, Annals of the New York Academy of Sciences.

Genetic footprinting: a genomic strategy for determining a gene's function given its sequence.

D Botstein, D. Botstein, P. Brown, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae.

D. Botstein, C. Walsh, H. Ma, 1989, Molecular and cellular biology.

cancer clinical treatment response in locally advanced breast Gene expression profiles do not consistently predict the

A. Nobel, D. Botstein, C. Fan, 2011 .

Evidence for posttranslational translocation of β-lactamase across the bacterial inner membrane

D. Botstein, D. Koshland, 1982, Cell.

The Saccharomyces Genome Database provides comprehensive information about the biology of S. cerevisiae and tools for studies in comparative genomics

Kara Dolinski, David Botstein, Edith D. Wong, 2007 .

Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae.

David Botstein, Janos Demeter, D. Botstein, 2003, Molecular biology of the cell.

Structure and assembly of the capsid of bacteriophage P22.

D. Botstein, J. King, S. Casjens, 1976, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase

D. Botstein, T. Palzkill, 1992, Journal of bacteriology.

Specificity of insertion by the translocatable tetracycline-resistance element Tn10.

D. Botstein, N. Kleckner, D. A. Steele, 1979, Genetics.

Inversions and deletions of the Salmonella chromosome generated by the translocatable tetracycline resistance element Tn10.

D. Botstein, N. Kleckner, K. Reichardt, 1979, Journal of molecular biology.

Alignment of partial denaturation maps of circularly permuted DNA by computer.

D. Botstein, B. Tye, M. Eden, 1974, Journal of molecular biology.

The future of humans as model organisms

R. Collins, D. Botstein, R. Califf, 2018, Science.

Gene Shaving: a new class of clustering methods for expression arrays

Trevor Hastie, Robert Tibshirani, David Botstein, 2000 .

Correction: A DNA microarray survey of gene expression in normal human tissues

D. Botstein, P. Brown, M. van de Rijn, 2005, Genome Biology.

genome sequence Changing perspectives in yeast research nearly a decade after the

D. Botstein, K. Dolinski, D. Botstein, 2008 .

The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response Running title: The role of HSF1 in the heat shock response

D. Botstein, J. Murray, N. Trinklein, 2003 .

Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter

D. Botstein, J. Rabinowitz, Ariel Schieler, 2015, Proceedings of the National Academy of Sciences.

ISOLATION AND CHARACTERIZATION OF MUTATIONS IN T H E @-TUBULIN GENE OF SACCHAROMYCES CEREVISIAE

D. Botstein, '. NORMAF.NEFF, 2003 .

Molecular portraits of human breast tumours

Christian A. Rees, D. Botstein, P. Brown, 2000, Nature.

The ras-like yeast YPT1 gene is itself essential for growth, sporulation, and starvation response.

D. Botstein, N. Segev, 1987, Molecular and cellular biology.

Diverse effects of beta-tubulin mutations on microtubule formation and function

D. Botstein, J. Thomas, James H. Thomas, 1988, The Journal of cell biology.

Accumulation of Recessive Lethal Mutations in Saccharomyces cerevisiae mlh1 Mismatch Repair Mutants Is Not Associated With Gross Chromosomal Rearrangements

D. Botstein, D. Gresham, E. Alani, 2006, Genetics.

Yeast proteins associated with microtubules in vitro and in vivo.

D. Botstein, G. Barnes, K. Louie, 1992, Molecular biology of the cell.

Statement on use of DNA testing for presymptomatic identification of cancer risk. National Advisory Council for Human Genome Research.

Lloyd M. Smith, J. R. Cox, D. Botstein, 1994, JAMA.

The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin.

R. Olshen, D. Botstein, D. Cox, 2001, American journal of hypertension.

Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas.

Ash A. Alizadeh, D Botstein, M B Eisen, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The Princeton Protein Orthology Database (P-POD): A Comparative Genomics Analysis Tool for Biologists

Samuel V. Angiuoli, O. White, D. Botstein, 1997, PloS one.

Regulation of HIS4-lacZ fusions in Saccharomyces cerevisiae

D. Botstein, G. Fink, S. Silverman, 1982, Molecular and cellular biology.

Genomicampli ® cationof a decoy receptor for Fas ligand in lungandcoloncancer

D. Botstein, D. Lawrence, K. Hillan, 2022 .

Erratum: Diversity of gene expression in adenocarcinoma of the lung (Proceedings of the National Academy of Sciences of the United States of America (2001) 98 (13784-13789))

Russ B. Altman, David Botstein, Olga G. Troyanskaya, 2002 .

ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes

D. Botstein, T. Stearns, R. Kahn, 1990, Molecular and cellular biology.

Isolation and characterization of mutations in the HXK2 gene of Saccharomyces cerevisiae

D. Botstein, C. Walsh, H. Ma, 1989, Molecular and cellular biology.

Intragenic revertants of yeast invertase variants with secretion-defective leader sequences

D. Botstein, D. Preuss, '. Daphnepreuss, 1989, Molecular and cellular biology.

Transformation of yeast with linearized plasmid DNA. Formation of inverted dimers and recombinant plasmid products.

D. Botstein, S. Kunes, M. Fox, 1985, Journal of molecular biology.

The secreted form of invertase in Saccharomyces cerevisiae is synthesized from mRNA encoding a signal sequence

D. Botstein, R. Taussig, M. Carlson, 1983, Molecular and cellular biology.

Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast.

D. Botstein, K. Anders, 2001, Molecular biology of the cell.

Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli.

D. Botstein, F. Lacroute, M. Bach, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Host/vector interactions which affect the viability of recombinant phage lambda clones.

D. Botstein, K. Wertman, A. Wyman, 1986, Gene.

Nomenclature of transposable elements in prokaryotes.

D. Botstein, P. Starlinger, W. Szybalski, 1979, Plasmid.

Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin.

D. Botstein, J. Spudich, D. Drubin, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Efficiency and diversity of protein localization by random signal sequences

D. Botstein, C. Kaiser, D. Botstein, 1990, Molecular and cellular biology.

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

D. Botstein, M. Carlson, M. Carlson, 1982, Cell.

Novel insights from a multiomics dissection of the Hayflick limit

David R. Kelley, David G Hendrickson, D. Botstein, 2022, eLife.

The Princeton Protein Orthology Database (P-POD): A Comparative Genomics Analysis Tool for Biologists

Kara Dolinski, David Botstein, Rose Oughtred, 2007, PloS one.

P-POD, The Princeton Protein Orthology Database, as a Tool for Identifying Gene Function

D. Botstein, K. Dolinski, R. Oughtred, 2009 .

Exploring the new world of the genome with DNA microarrays

D. Botstein, P. Brown, 1999, Nature Genetics.

Planning the Genome Institute's Future

D. Botstein, A. Chakravarti, E. Clayton, 2003, Science.

Substitution of tyrosine for either cysteine in beta-lactamase prevents release from the membrane during secretion.

D. Botstein, J. Mulholland, R. Fitts, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Yeast actin cytoskeleton mutants accumulate a new class of Golgi-derived secretary vesicle.

D. Botstein, J. Mulholland, H. Riezman, 1997, Molecular biology of the cell.

IV. Yeast sequencing reports. Nucleotide sequence of the SAC2 gene of Saccharomyces cerevisiae

D. Botstein, A. Lee, E. Chen, 1994 .

Synapsis-mediated fusion of free DNA ends forms inverted dimer plasmids in yeast.

D. Botstein, S. Kunes, M. Fox, 1990, Genetics.

DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage

D. Botstein, T. Stearns, C. Holm, 1989, Molecular and cellular biology.

Insertions of up to 17 amino acids into a region of alpha-tubulin do not disrupt function in vivo

D. Botstein, P. Schatz, F. Solomon, 1987, Molecular and cellular biology.

Ordered Linear Tetrads Are Produced by the Sporulation of Newly Formed Zygotes of Saccharomyces cerevisiae.

D. Botstein, J. Thomas, J. Thomas, 1987, Genetics.

Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins

D. Botstein, P. Schatz, F. Solomon, 1986, Molecular and cellular biology.

Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins

D. Botstein, P. Schatz, L. Pillus, 1986, Molecular and cellular biology.

A rapid chromosome-mapping method for cloned fragments of yeast DNA.

D. Botstein, S. C. Falco, S. Falco, 1983, Genetics.

Isolation and characterization of conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae.

D. Botstein, P. Schatz, F. Solomon, 1988, Genetics.

GENETIC ANALYSIS OF THE CYTOSKELETON YEAST

D. Botstein, M. Hoyt, T. Huffaker, 1987 .

Lethal disruption of the yeast actin gene by integrative DNA transformation.

D. Botstein, D. Shortle, J. Haber, 1982, Science.

The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae

D. Botstein, C. Walsh, H. Ma, 1989 .

Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression

D. Botstein, H. Ma, D. Botstein, 1986, Molecular and cellular biology.

Determination of the order of gene function in the yeast nuclear division pathway using cs and ts mutants.

D. Botstein, D. Moir, 1982, Genetics.

Regional specificity of illegitimate recombination associated with the translocatable ampicillin-resistance element Tn1.

D. Botstein, G. Weinstock, 1979, Cold Spring Harbor Symposia on Quantitative Biology.

Genetic evidence for a silent SUC gene in yeast.

D. Botstein, M. Carlson, B. Osmond, 1981, Genetics.

SUC genes of yeast: a dispersed gene family.

D. Botstein, M. Carlson, B. Osmond, 1981, Cold Spring Harbor symposia on quantitative biology.

Two alanine racemase genes in Salmonella typhimurium that differ in structure and function

D. Botstein, S. Wasserman, C. Walsh, 1983, Journal of bacteriology.

TwoAlanine Racemase GenesinSalmonella typhimurium ThatDiffer inStructure andFunction

D. Botstein, 1983 .

GENETIC ANALYSIS OF DNA REPLICATION IN SALMONELLA TYPHIMURIUM

D. Botstein, R. Maurer, B. Osmond, 1981 .

Genetics of bacteriophage P22. IV. Correlation of genetic and physical map using translocatable drug-resistance elements.

D. Botstein, G. Weinstock, 1980, Virology.

Superinfection exclusion by P22 prophage in lysogens of Salmonella typhimurium. IV. Genetics and physiology of sieB exclusion.

D. Botstein, M. Susskind, A. Wright, 1974, Virology.

Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. I. Transduction of R factor 222 by phage P22.

D. Botstein, T. Watanabe, R. K. Chan, 1972, Virology.

Diverse effects of mutations in the signal sequence on the secretion of β-lactamase in Salmonella typhimurium

D. Botstein, R. Sauer, D. Koshland, 1982, Cell.

An early regulatory gene of Salmonella phage P22 analogous to gene N of coliphage lambda.

D. Botstein, S. Hilliker, 1975, Virology.

Superinfection exclusion by P22 prophage in lysogens of Salmonella typhimurium. III. Failure of superinfecting phage DNA to enter sieA+ lysogens.

D. Botstein, M. Susskind, A. Wright, 1974, Virology.

The ends of Tn10 are not IS3

D. Botstein, N. Kleckner, D. Ross, 1979, Journal of bacteriology.

P22 morphogenesis. II: Mechanism of DNA encapsulation.

D. Botstein, B. Tye, 1974, Journal of supramolecular structure.

Functional interchangeability of DNA replication genes in Salmonella typhimurium and Escherichia coli demonstrated by a general complementation procedure.

D. Botstein, R. Maurer, B. Osmond, 1984, Genetics.

Genetic Analysis of Cytoskeletal Protein Function in Yeast

D. Botstein, J. Thomas, James H. Thomas, 1984 .

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

D. Botstein, C. S. Chan, Clarence S M Chad, 1993, Genetics.

GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.

D. Baker, D. Botstein, R. Schekman, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Identification of clinically distinct types of diffuse large B-cell lymphoma based on gene expressio

Robert Tibshirani, David Botstein, Li Yang, 2000 .

Genetic mapping of mutations in a highly radiation-resistant mutant of Salmonella typhimurium LT2

D. Botstein, A. Sinskey, S. Ibe, 1982, Journal of bacteriology.

Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map.

E S Lander, D Botstein, E. Lander, 1986, Cold Spring Harbor symposia on quantitative biology.

Insertions of up to 17 amino acids into a region of alpha-tubulin do not disrupt function in vivo

D. Botstein, P. Schatz, F. Solomon, 1987, Molecular and Cellular Biology.

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

D. Botstein, D. Lawrence, K. Hillan, 1998, Nature.

Deoxyribonucleic Acid Repair in a Highly Radiation-Resistant Strain of Salmonella typhimurium

D. Botstein, A. Sinskey, R. Davies, 1973, Journal of bacteriology.

Genetics of bacteriophage P22. III. The late operon.

D. Botstein, G. Weinstock, P. Riggs, 1980, Virology.

Efficiency andDiversity ofProtein Localization by RandomSignal Sequences

D. Botstein, 1990 .

Ira Herskowitz: 1946-2003.

D. Botstein, 2004, Genetics.

CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences.

D. Botstein, B. Tye, K. Hennessy, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Genetic variation in the human urea transporter-2 is associated with variation in blood pressure.

R. Olshen, D. Botstein, D. Cox, 2001, Human molecular genetics.

Purification and properties of proteins essential to DNA encapsulation by phage P22.

D. Botstein, A. Poteete, 1979, Virology.

Conditional lethality of a yeast strain expressing human RHOA in place of RHO1.

D. Botstein, Y. Anraku, Y. Ohya, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Requirement of yeast fimbrin for actin organization and morphogenesis in vivo

D. Botstein, D. Drubin, A. Adams, 1991, Nature.

Probing beta-lactamase structure and function using random replacement mutagenesis.

D. Botstein, T. Palzkill, 1992, Proteins.

Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p.

D. Botstein, Y. Anraku, Y. Ohya, 1993, Molecular biology of the cell.

The Harvey lectures, Series 82

D. Botstein, H. Lodish, T. Cech, 1988 .

Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene.

D. Botstein, D. Shortle, P. Novick, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Phylogenetic Portrait of the S. cerevisiae Functional Genome

Patrick H. Bradley, D. Botstein, J. Matese, 2013 .

Global analysis of the yeast knockout phenome

Christie S. Chang, Jennifer M. Rust, D. Botstein, 2022, bioRxiv.

Secretion of beta-lactamase requires the carboxy end of the protein

D. Botstein, D. Koshland, 1980, Cell.

Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans.

David Botstein, Tina Hernandez-Boussard, David Siegmund, 2003, The American journal of pathology.

Encapsulation of phage P22 DNA in vitro.

D. Botstein, A. Poteete, V. Jarvik, 1979, Virology.

Anecdotal, Historical and Critical Commentaries on Genetics

D. Botstein, I. Herskowitz, 2004 .

Systematic structure-function analysis of the small GTPase Arf1 in yeast.

D. Botstein, T. Stearns, Eleanor S Click, 2002, Molecular biology of the cell.

Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function.

D Botstein, D. Botstein, T. Stearns, 1990, Genetics.

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

D. Botstein, J. Mulholland, N. Segev, 1988, Cell.

Many random sequences functionally replace the secretion signal sequence of yeast invertase.

D Botstein, D. Botstein, C. Kaiser, 1987, Science.

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.

D. Botstein, G. Fink, J. Thomas, 1987, Gene.

Secretion-defective mutations in the signal sequence for Saccharomyces cerevisiae invertase

D Botstein, D. Botstein, C. Kaiser, 1986, Molecular and cellular biology.

Phenotypic Analysis of Temperature-sensitive Yeast Actin Mutants

David Botstein, Peter Novick, D. Botstein, 2022 .

Structure and function of the yeast URA3 gene. Differentially regulated expression of hybrid beta-galactosidase from overlapping coding sequences in yeast.

D. Botstein, M. Rose, 1983, Journal of molecular biology.

Isolation of the β-tubulin gene from yeast and demonstration of its essential function in vivo

D. Botstein, James H. Thomas, N. Neff, 1983, Cell.

Genetic properties of chromosomally integrated 2μ plasmid DNA in yeast

D. Botstein, J. Broach, S. C. Falco, 1982, Cell.

Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments.

D. Botstein, R. W. Davis, K. Struhl, 1979, Gene.

Advanced bacterial genetics

D. Botstein, J. Roth, Ronald W. Davis, 1980 .

High-throughput genotyping with single nucleotide polymorphisms.

N Risch, D Botstein, R. Olshen, 2001, Genome research.

Cluster analysis and display of genome-wide expression patterns.

D. Botstein, P. Brown, P. Spellman, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structure-function relationships in yeast tubulins.

D. Botstein, K. Anders, E. Nogales, 2000, Molecular biology of the cell.

Diverse essential functions revealed by complementing yeast calmodulin mutants.

D. Botstein, Y. Ohya, 1994, Science.

Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae

David Botstein, Patrick O. Brown, Maitreya J. Dunham, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Identification of functional connections between calmodulin and the yeast actin cytoskeleton.

D. Botstein, Y. Ohya, M. Sekiya-Kawasaki, 1998, Genetics.

Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene.

D Botstein, D. Botstein, Y. Ohya, 1994, Genetics.

DNA Topoisomerase II MustActatMitosis ToPrevent Nondisjunction andChromosome Breakage

D. Botstein, T. Stearns, C. Holm, 1989 .

DNA topoisomerase II is required at the time of mitosis in yeast

D. Botstein, T. Goto, C. Holm, 1985, Cell.

Gene Ontology Consortium: The Gene Ontology (GO) database and informatics resource

B Marshall, Eurie L. Hong, Chandra L. Theesfeld, 2004, Nucleic Acids Res..

Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane

D. Botstein, J. Mulholland, D. Drubin, 1994, The Journal of cell biology.

Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I

David Botstein, David G. Drubin, D. Botstein, 1990, Nature.

Isolation and Characterization of Mutations in the β-Tubulin Gene of SACCHAROMYCES CEREVISIAE

D. Botstein, J. Thomas, N. Neff, 1985 .

Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms.

E. Lander, D. Botstein, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and characterization of mutations in the beta-tubulin gene of Saccharomyces cerevisiae.

D. Botstein, J. Thomas, N. Neff, 1985, Genetics.

Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins.

D. Botstein, P. Schatz, L. Pillus, 1986, Molecular and cellular biology.

Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins.

D. Botstein, P. Schatz, F. Solomon, 1986, Molecular and cellular biology.

Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins.

D. Botstein, J. Jarvik, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Genetic analysis of the yeast cytoskeleton.

D. Botstein, M. Hoyt, T. Huffaker, 1987, Annual review of genetics.

Movement of yeast cortical actin cytoskeleton visualized in vivo.

D. Botstein, T. Doyle, D. Botstein, 1996, Proceedings of the National Academy of Sciences of the United States of America.

GO: : TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes

David Botstein, Shuai Weng, J. Michael Cherry, 2004, Bioinform..

Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD)

Kara Dolinski, David Botstein, Marek S. Skrzypek, 2004, Nucleic Acids Res..

Diversity, topographic differentiation, and positional memory in human fibroblasts

David Botstein, Sandrine Dudoit, Howard Y. Chang, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A recombination function essential to the growth of bacteriophage P22.

D. Botstein, M. Matz, 1970, Journal of molecular biology.

Non-random circular permutation of phage P22 DNA.

D Botstein, D. Botstein, B. Tye, 1974, Journal of molecular biology.

Mechanism of head assembly and DNA encapsulation in Salmonella phage p22. I. Genes, proteins, structures and DNA maturation.

D. Botstein, J. King, C. Waddell, 1973, Journal of molecular biology.

Systemic and cell type-specific gene expression patterns in scleroderma skin

David Botstein, John Isaac Murray, Olga G Troyanskaya, 2003, Proceedings of the National Academy of Sciences of the United States of America.

High resolution analysis of functional determinants on human tissue-type plasminogen activator.

D. Botstein, B. Keyt, L. Presta, 1991, The Journal of biological chemistry.

SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data

David Botstein, Ash A. Alizadeh, Gail Binkley, 2003, Nucleic Acids Res..

Catabolic alanine racemase from Salmonella typhimurium: DNA sequence, enzyme purification, and characterization.

D. Botstein, S. Wasserman, C. Walsh, 1984, Biochemistry.

A deletion map of the human Y chromosome based on DNA hybridization.

D. Botstein, J. Weissenbach, L. Brown, 1986, American journal of human genetics.

Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes.

D. Botstein, D. Page, U. Francke, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin

David R. Kelley, David G Hendrickson, D. Botstein, 2021, bioRxiv.

Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy.

D. Botstein, J. Mulholland, N. Segev, 1992, Molecular biology of the cell.

Homologous Recombination between Episomal Plasmids and Chromosomes in Yeast.

D. Botstein, S. C. Falco, M. Rose, 1983, Genetics.

Gene Ontology annotations at SGD: new data sources and annotation methods

Kara Dolinski, David Botstein, Edith D. Wong, 2007, Nucleic Acids Res..

SGD: Saccharomyces Genome Database

David Botstein, Shuai Weng, J. Michael Cherry, 1998, Nucleic Acids Res..

Evolution of the Lambdoid Phages

D. Botstein, A. Campbell, 1983 .

Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae.

D. Botstein, P. Brown, A. Gasch, 2000, Cold Spring Harbor symposia on quantitative biology.

Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway

David Botstein, Harmen J. Bussemaker, R. Scott McIsaac, 2012, Molecular biology of the cell.

R. Tibshirani, D. Botstein, C. Perou, 2022 .

Genome-Wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray

Maitreya J. Dunham, D. Botstein, S. Pratt, 2006, Science.

A manic depressive history

D. Botstein, N. Risch, 1996, Nature Genetics.

Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect.

D. Botstein, F. McMahon, S. Folstein, 1995, American journal of human genetics.

Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution

D. Botstein, D. Page, M. Harper, 1984, Nature.

Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.

D. Botstein, T. Petes, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Expanded protein information at SGD: new pages and proteome browser

Kara Dolinski, David Botstein, Marek S. Skrzypek, 2006, Nucleic Acids Res..

Saccharomyces cerevisiae S288C genome annotation: a working hypothesis

Kara Dolinski, David Botstein, Eurie L. Hong, 2006, Yeast.

The Gene Ontology Consortium

M. Ashburner, C. Ball, J. Blake, 2000 .

The Gene Ontology in 2010: extensions and refinements

Giorgio Valle, Juancarlos Chan, Paul W. Sternberg, 2009, Nucleic Acids Res..

Desferrioxamine-mediated Iron Uptake in Saccharomyces cerevisiae

D Botstein, D. Botstein, P. Brown, 2000, The Journal of Biological Chemistry.

Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations.

R. Olshen, D. Botstein, D. Cox, 2000, American journal of hypertension.

Segment-directed mutagenesis: construction in vitro of point mutations limited to a small predetermined region of a circular DNA molecule.

D. Botstein, G. Weinstock, D. Shortle, 1980, Proceedings of the National Academy of Sciences of the United States of America.

BIM1 encodes a microtubule-binding protein in yeast.

D. Botstein, K. Richards, Katja Schwartz, 1997, Molecular biology of the cell.

Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting

D Botstein, D. Botstein, P. Brown, 1996, Science.

Rapid Synthesis and Screening of Chemically Activated Transcription Factors with GFP-based Reporters

Benjamin L. Oakes, D. Botstein, M. Noyes, 2013, Journal of visualized experiments : JoVE.

The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response.

David Botstein, Richard M Myers, D. Botstein, 2003, Molecular biology of the cell.

Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.

Kevin S. Smith, S. Chanda, D. Botstein, 2003, Molecular cell.

Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeast.

D. Botstein, M. Rose, 1983, Methods in enzymology.

The Stanford Microarray Database: data access and quality assessment tools

David Botstein, Gail Binkley, Gavin Sherlock, 2003, Nucleic Acids Res..

A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast.

D Botstein, D. Botstein, M. Carlson, 1984, Genetics.

[9] Construction and use of gene fusions to lacZ (β-galactosidase) that are expressed in yeast

D. Botstein, M. Rose, 1983 .

Role of thioredoxin reductase in the Yap1p‐dependent response to oxidative stress in Saccharomyces cerevisiae

D. Botstein, P. Brown, A. Gasch, 2001, Molecular microbiology.

The Gene Ontology project in 2008

Giorgio Valle, Kimberly Van Auken, Paul W. Sternberg, 2007, Nucleic Acids Res..

Predicting Cellular Growth from Gene Expression Signatures

Edoardo M. Airoldi, David Botstein, Olga G. Troyanskaya, 2009, PLoS Comput. Biol..

A genome-scale yeast library with inducible expression of individual genes

D. Botstein, B. Andrews, H. Friesen, 2020, bioRxiv.

1989 Allen Award address: the American Society of Human Genetics annual meeting, Baltimore.

D. Botstein, David Botstein, 1990, American journal of human genetics.

Identification of more than 500 RFLPs by screening random genomic clones.

D. Botstein, C. Helms, D. Barker, 1988, American journal of human genetics.

Diverse and specific gene expression responses to stresses in cultured human cells.

David Botstein, Richard M Myers, John Isaac Murray, 2004, Molecular biology of the cell.

Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus

D. Botstein, B. Regenberg, D. Gresham, 2010, Proceedings of the National Academy of Sciences.

Properties of hybrids between Salmonella phage P22 and coliphage λ

D. Botstein, I. Herskowitz, 1974, Nature.

Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae.

D Botstein, D. Botstein, T. Stearns, 1988, Genetics.

Misfolded Proteins Are Competent to Mediate a Subset of the Responses to Heat Shock in Saccharomyces cerevisiae * 210

G. Petsko, D. Botstein, C. Kao, 2002, The Journal of Biological Chemistry.

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells.

David Botstein, Birgitte Regenberg, D. Botstein, 2016, Journal of visualized experiments : JoVE.

Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.

D. Botstein, J. Mulholland, J. Pringle, 1997, Molecular biology of the cell.

Basic References

Ash A. Alizadeh, R. Tibshirani, D. Botstein, 2022 .

Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

Rui Li, David Botstein, Olga G. Troyanskaya, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Three Cell Wall Mannoproteins Facilitate the Uptake of Iron in Saccharomyces cerevisiae *

D Botstein, D. Botstein, P. Brown, 2001, The Journal of Biological Chemistry.

Microarrays in primary breast cancer--lessons from chemotherapy studies.

D. Botstein, C. Perou, T. Sørlie, 2001, Endocrine-related cancer.

The Stanford Microarray Database

David Botstein, Paul T. Spellman, Shuai Weng, 2001, Nucleic Acids Res..

Large-scale identification of secreted and membrane-associated gene products using DNA microarrays

D. Botstein, P. Brown, M. Eisen, 1999, Nature Genetics.

Fully Phased Sequence of a Diploid Human Genome Determined de Novo from the DNA of a Single Individual

D. Botstein, V. Jojic, P. Peluso, 2020, G3.

Defining protein interactions with yeast actin in vivo

David Botstein, D. Botstein, D. Amberg, 1995, Nature Structural Biology.

Challenges in developing a molecular characterization of cancer.

David Botstein, Jonathan R Pollack, D. Botstein, 2002, Seminars in oncology.

Nonparametric methods for identifying differentially expressed genes in microarray data

Russ B. Altman, David Botstein, Olga G. Troyanskaya, 2002, Bioinform..

A method for detecting and correcting feature misidentification on expression microarrays

D. Botstein, P. Brown, M. Diehn, 2004, BMC Genomics.

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.

D. Botstein, M. Willingham, T. Stearns, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Principles and Practice of Recombinant DNA Research with Yeast

David Botstein, D. Botstein, Ronald W. Davis, 1982 .

Superinfection exclusion by λ prophage in lysogens ofSalmonella typhimurium

D. Botstein, M. Susskind, 1971 .

Superinfection exclusion by P22 prophage in lysogens of Salmonella typhimurium. 1. Exclusion of generalized transducing particles.

D. Botstein, J. Ebel-Tsipis, 1971, Virology.

Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants

David G Hendrickson, D. Botstein, R. McIsaac, 2021, Molecular biology of the cell.

Genetic variation in aldosterone synthase predicts plasma glucose levels

David Botstein, Richard A. Olshen, Low-Tone Ho, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification of alterations in DNA copy number in host stromal cells during tumor progression

David Botstein, Robert Lucito, Michael Wigler, 2006, Proceedings of the National Academy of Sciences.

254 exonucleolytic degradation of single and double-stranded DNA , low-level endonucleolytic cleavage of single-stranded DNA

D. Botstein, K. Wertman, A. Wyman, 1986 .

Saccharomyces Genome Database provides tools to survey gene expression and functional analysis data

Kara Dolinski, David Botstein, Midori A. Harris, 2001, Nucleic Acids Res..

EXPLORATORY SCREENING OF GENES AND CLUSTERS FROM MICROARRAY EXPERIMENTS

Robert Tibshirani, David Botstein, Michael B. Eisen, 2002 .

Genome-Scale Identification of Membrane-Associated Human mRNAs

D. Botstein, P. Brown, M. Diehn, 2006, PLoS genetics.

Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure

Kara Dolinski, David Botstein, Midori A. Harris, 1999, Nucleic Acids Res..

The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase.

D. Botstein, J. Mulholland, B. Roberts, 1992, The Journal of biological chemistry.

A group of interacting yeast DNA replication genes.

D. Botstein, E. Chen, Angela L. Lee, 1991, Genes & development.

Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies.

D. Botstein, D. Moir, B. Osmond, 1982, Genetics.

Saccharomyces genome database: Underlying principles and organisation

Kara Dolinski, David Botstein, Shuai Weng, 2004, Briefings Bioinform..

T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression

David Botstein, Ash A. Alizadeh, Maximilian Diehn, 2003, PLoS biology.

Genetics of bacteriophage P22. II. Gene order and gene function.

D. Botstein, R. K. Chan, C. Waddell, 1972, Virology.

Genetics of bacteriophage P22. I. Isolation of prophage deletions which affect immunity to superinfection.

D. Botstein, R. K. Chan, 1972, Virology.

Genetic footprinting and functional maps of the yeast genome

D. Botstein, P. Brown, T. Ferea, 1999 .

Structure and function of the yeast URA3 gene: expression in Escherichia coli.

D. Botstein, M. Rose, P. Grisafi, 1984, Gene.

A locus for Fanconi anemia on 16q determined by homozygosity mapping.

E. Lander, D. Botstein, J. Weissenbach, 1996, American journal of human genetics.

Simple Mendelian inheritance of the repeating yeast ribosomal DNA genes.

D. Botstein, T. Petes, L. Hereford, 1978, Cold Spring Harbor Symposia on Quantitative Biology.

Yeast suppressors of UAA and UAG nonsense codons work efficiently in vitro via tRNA

D. Botstein, G. Fink, R. Gesteland, 1976, Cell.

Molecular genetics of bacteriophage P22

D. Botstein, M. Susskind, 1978 .

A systematic approach to reconstructing transcription networks in Saccharomyces cerevisiae

David Botstein, J Michael Cherry, Wei Wang, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Molecular linguistics: extracting information from gene and protein sequences.

J M Cherry, D Botstein, D. Botstein, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms

Kara Dolinski, David Botstein, Shuai Weng, 2004, Nucleic Acids Res..

Genome Snapshot: a new resource at the Saccharomyces Genome Database (SGD) presenting an overview of the Saccharomyces cerevisiae genome

Kara Dolinski, David Botstein, Marek S. Skrzypek, 2005, Nucleic Acids Res..

RERG Is a Novel ras-related, Estrogen-regulated and Growth-inhibitory Gene in Breast Cancer*

David Botstein, Charles M. Perou, Patrick O. Brown, 2001, The Journal of Biological Chemistry.

Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes

D. Botstein, L. Kruglyak, D. B. Gordon, 2010, Proceedings of the National Academy of Sciences.

A Test of the Coordinated Expression Hypothesis for the Origin and Maintenance of the GAL Cluster in Yeast

David Botstein, D. Botstein, G. I. Lang, 2011, PloS one.

Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source.

David Botstein, D. Botstein, M. Ronen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and analysis of recombinant DNA molecules containing yeast DNA.

D. Botstein, G. Fink, J. Broach, 1978, Gene.

Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast

D. Botstein, M. J. Hickman, R. McIsaac, 2011, Molecular biology of the cell.

NDC1: a nuclear periphery component required for yeast spindle pole body duplication

D. Botstein, M. Winey, M. Hoyt, 1993, The Journal of cell biology.

Multiple functions for actin during filamentous growth of Saccharomyces cerevisiae.

D. Botstein, G. Fink, T. Doyle, 1998, Molecular biology of the cell.

Changing perspectives in yeast research nearly a decade after the genome sequence.

Kara Dolinski, David Botstein, D. Botstein, 2005, Genome research.

Advanced Bacterial Genetics: A Manual for Genetic Engineering

D. Botstein, J. Roth, Ronald W. Davis, 1980 .

Gap misrepair mutagenesis: efficient site-directed induction of transition, transversion, and frameshift mutations in vitro.

D. Botstein, D. Shortle, S. Benkovic, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Single-stranded gaps as localized targets for in vitro mutagenesis.

D. Botstein, D. Shortle, 1982, Basic life sciences.

Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae

David Botstein, Fred Winston, D. Botstein, 2015, Genetics.

Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case

D. Botstein, L. Kruglyak, David C. Hess, 2013, G3: Genes, Genomes, Genetics.

The 15 N‐terminal amino acids of hexokinase II are not required for in vivo function: Analysis of a truncated form of hexokinase II in Saccharomyces cerevisiae

D. Botstein, C. Walsh, Hong Ma, 1989, Proteins.

Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda.

D. Botstein, N. Kleckner, D. Barker, 1978, Genetics.

A genome‐scale yeast library with inducible expression of individual genes

D. Botstein, B. Andrews, H. Friesen, 2021, Molecular systems biology.

Fine structure recombinational analysis of cloned genes using yeast transformation.

D. Botstein, H. Ma, S. Kunes, 1987, Genetics.

Specificity of genetic elements controlling regulation of early functions in temperate bacteriophages.

D. Botstein, S. Hilliker, D. Botstein, 1976, Journal of molecular biology.

Regional assignments of three polymorphic DNA segments on human chromosome 15

D. Botstein, D. Page, J. Trowsdale, 1986, Genetic epidemiology.

Regional specificity of illegitimate recombination by the translocatable ampicillin-resistance element Tn1 in the genome of phage P22.

D. Botstein, G. Weinstock, M. Susskind, 1979, Genetics.

Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate.

D. Botstein, T. Watanabe, R. K. Chan, 1972, Virology.

Molecular genetics of bacteriophage P22.

D. Botstein, M. Susskind, 1978, Microbiological reviews.

Mechanism of head assembly and DNA encapsulation in Salmonella phage P22. II. Morphogenetic pathway.

D. Botstein, J. King, E. Lenk, 1973, Journal of molecular biology.

Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes.

D. Botstein, T. Stearns, M. Hoyt, 1990, Molecular and cellular biology.

Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO)

Kara Dolinski, David Botstein, Midori A. Harris, 2002, Nucleic Acids Res..

Evaluating Gene Expression Dynamics Using Pairwise RNA FISH Data

David Botstein, Matthieu Wyart, Ned S. Wingreen, 2010, PLoS Comput. Biol..

Generalized transduction by bacteriophage P22 in Salmonella typhimurium. II. Mechanism of integration of transducing DNA.

D. Botstein, M. Fox, J. Ebel-Tsipis, 1972, Journal of molecular biology.

Transcription Termination and Regulation in Bacteriophages P22 and Lambda

Jeffrey W. Roberts, D. Botstein, S. Hilliker, 1976 .

Superinfection exclusion by P22 prophage in lysogens of Salmonella typhimurium. II. Genetic evidence for two exclusion systems.

D. Botstein, M. Susskind, A. Wright, 1971, Virology.

Mechanism of action of Salmonella phage P22 antirepressor.

D. Botstein, M. Susskind, 1975, Journal of molecular biology.

Integrating functional genomic information into the Saccharomyces Genome Database

Kara Dolinski, David Botstein, Midori A. Harris, 2000, Nucleic Acids Res..

Synthesis and maturation of phage P22 DNA. II. Properties of temperature-sensitive phage mutants defective in DNA metabolism.

D. Botstein, M. Levine, 1968, Journal of molecular biology.

A new yeast gene with a myosin-like heptad repeat structure

D. Botstein, E. Chen, R. Kölling, 1993, Molecular and General Genetics MGG.

TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae

D. Botstein, D. Koshland, P. Gibney, 2013, Molecular biology of the cell.

Yeast as a Model Organism

David Botstein, D. Botstein, S. Chervitz, 1997, Science.

Generalized transduction by phage P22 in Salmonella typhimurium. I. Molecular origin of transducing DNA.

D. Botstein, M. Fox, J. Ebel-Tsipis, 1972, Journal of molecular biology.

A genetic method for determining the order of events in a biological pathway.

D. Botstein, J. Jarvik, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Systematic Mutational Analysis of the Yeast Actl Gene

D. Botstein, D. Drubin, K. Wertman, 2022 .

Synthesis and maturation of phage P22 DNA. I. Identification of intermediates.

D. Botstein, 1968, Journal of molecular biology.

Nonsense suppressor mutants of bacteriophage T5.

D. Botstein, R. Bender, A. Macaluso, 1982, Virology.

Nomenclature of transposable elements in prokaryotes.

P Starlinger, D Botstein, W Szybalski, 1979, Gene.

Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition.

D. Botstein, N. Kleckner, B. Tye, 1975, Journal of molecular biology.

Dominant suppressors of yeast actin mutations that are reciprocally suppressed.

D. Botstein, A. Adams, D. Botstein, 1989, Genetics.

A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation.

D. Botstein, D. Drubin, A. Adams, 1989, Science.

Processing and modeling genome-wide expression data using singular value decomposition

David Botstein, Patrick O. Brown, Orly Alter, 2001, SPIE BiOS.

Recessive lethal amber suppressors in yeast.

D. Botstein, M. Brandriss, L. Soll, 1975, Genetics.

A Tn10-lacZ-kanR-URA3 gene fusion transposon for insertion mutagenesis and fusion analysis of yeast and bacterial genes.

D. Botstein, N. Kleckner, M. Hoyt, 1987, Genetics.

Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression

D. Botstein, D. Mecke, K. Fröhlich, 1991, The Journal of cell biology.

Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.

M. Daly, D. Botstein, F. McMahon, 2000, American journal of human genetics.

Dominant-Lethal α-Tubulin Mutants Defective in Microtubule Depolymerization in Yeast

D. Botstein, K. Anders, K. R. Anders, 2001 .

Saccharomyces Genome Database provides mutant phenotype data

Kara Dolinski, David Botstein, Edith D. Wong, 2009, Nucleic Acids Res..

Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4

D. Botstein, T. Stearns, B. Dunn, 1993, Nature.

Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.

D. Botstein, J. Rabinowitz, A. Yakunin, 2018, ACS chemical biology.

Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase

D. Botstein, T. Palzkill, 1992, Journal of bacteriology.

Consanguinity and heterogeneity: cystic fibrosis need not be homogeneous in Italy.

E. Lander, D. Botstein, 1986, American journal of human genetics.

Selection of functional signal peptide cleavage sites from a library of random sequences

D. Botstein, T. Palzkill, Q. Le, 1994, Journal of bacteriology.

Maize transposable elements: a story in four parts.

D. Botstein, N. Fedoroff, 1992 .

Simultaneous Profiling of DNA Accessibility and Gene Expression Dynamics with ATAC-Seq and RNA-Seq.

David G Hendrickson, D. Botstein, Ilya Soifer, 2018, Methods in molecular biology.

The molecular biology of color vision.

D. Botstein, 1986, Science.

A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.

R. Olshen, D. Botstein, D. Cox, 2002, American journal of human genetics.

Regulation of DNA replication during the yeast cell cycle.

D Botstein, D. Botstein, K. Hennessy, 1991, Cold Spring Harbor symposia on quantitative biology.

Saccharomyces Genome Database (SGD) provides biochemical and structural information for budding yeast proteins

Kara Dolinski, David Botstein, Shuai Weng, 2003, Nucleic Acids Res..

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

D. Botstein, J. Mulholland, M. Ziman, 1993, Molecular biology of the cell.

A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.

R. Olshen, D. Botstein, D. Cox, 2003, American journal of hypertension.

Manipulating yeast genome using plasmid vectors.

D. Botstein, T. Stearns, H. Ma, 1990, Methods in enzymology.

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.

W Ansorge, D Botstein, B. Barrell, 1997, Nature.

Biosynthetic alr alanine racemase from Salmonella typhimurium: DNA and protein sequence determination.

D. Botstein, C. Walsh, N. Galakatos, 1986, Biochemistry.

Genetic analysis of DNA replication in bacteria: dnaB mutations that suppress dnaC mutations and dnaQ mutations that suppress dnaE mutations in Salmonella typhimurium.

D. Botstein, R. Maurer, B. Osmond, 1984, Genetics.

Structure of the yeast endoplasmic reticulum: Localization of ER proteins using immunofluorescence and immunoelectron microscopy

D Botstein, D. Botstein, J. Mulholland, 1991, Yeast.

Probing Lymphocyte Biology by Genomic-Scale Gene Expression Analysis

David Botstein, Ash A. Alizadeh, Patrick O. Brown, 1998, Journal of Clinical Immunology.

Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function

D. Botstein, A. Petti, J. Rabinowitz, 2011, Proceedings of the National Academy of Sciences.

Immunoelectron microscopy of aldehyde-fixed yeast cells.

D. Botstein, J. Mulholland, 2002, Methods in enzymology.

1 The Yeast Cytoskeleton

D. Botstein, J. Mulholland, T. Stearns, 1997 .

Yeast actin-binding proteins: evidence for a role in morphogenesis

D Botstein, D. Botstein, D. Drubin, 1988, The Journal of cell biology.

A group of interacting yeast DNA replication genes.

D. Botstein, K. Hennessy, E. Chen, 1991, Genes & Development.

Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast.

D. Botstein, M. Rose, M. Casadaban, 1981, Proceedings of the National Academy of Sciences of the United States of America.

in Yeast Diverse Biological Functions of Small GTP-binding Proteins

D. Botstein, T. Stearns, N. Segev, 2008 .

Diverse biological functions of small GTP-binding proteins in yeast.

D. Botstein, T. Stearns, R. Kahn, 1988, Cold Spring Harbor symposia on quantitative biology.

Gene Ontology: a controlled vocabulary to describe the function, biological process and cellular location of gene products in genome databases

M. Ashburner, J. Blake, D. Botstein, 1999 .

Substitution of serine caused by a recessive lethal suppressor in yeast.

D. Botstein, M. Brandriss, J. Stewart, 1976, Journal of molecular biology.

Fusions of bacteriophage P22 late genes to the Escherichia coli lacZ gene

D. Botstein, P. Riggs, 1987, Journal of Virology.

Bacteriophage P22 gene 23 product acts preferentially in cis

D. Botstein, P. Riggs, 1987, Journal of Virology.

Characterization of amber and ochre suppressors in Salmonella typhimurium

D. Botstein, J. Miller, F. Winston, 1979, Journal of bacteriology.

A MODULAR THEORY OF VIRUS EVOLUTION

D. Botstein, 1980 .

Superinfection exclusion by lambda prophage in lysogens of Salmonella typhimurium.

D. Botstein, M. Susskind, 1980, Virology.

Directed mutagenesis with sodium bisulfite.

D. Botstein, D. Shortle, D. Botstein, 1983, Methods in enzymology.

Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast.

D. Botstein, W. Konigsberg, J. Swan, 1986, Nucleic acids research.

Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast

D. Botstein, S. Silverman, J. Rabinowitz, 2018, Molecular biology of the cell.

Phylogenetic Portrait of the Saccharomyces cerevisiae Functional Genome

Patrick H. Bradley, D. Botstein, J. Matese, 2013, G3: Genes, Genomes, Genetics.

Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11

D. Botstein, P. Brown, M. Diehn, 2002, BMC Immunology.

A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1

David G Hendrickson, D. Botstein, R. McIsaac, 2020, PloS one.

Nonrandom Mutagenesis of the Escherichia coli Genome by Nitrosoguanidine

D. Botstein, E. W. Jones, 1969, Journal of bacteriology.

Molecular sequence accuracy and the analysis of protein coding regions.

D J States, D Botstein, D. Botstein, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop.

D. Botstein, T. Palzkill, C. Clark, 1994, The Journal of biological chemistry.

Proposed Changes for NIH's Center for Scientific Review

D. Botstein, S. Oparil, S. Orkin, 1999, Science.

Gap misrepair mutagenesis: Efficie transition, transversion, and frame. (site-specific mutagenesis/base substitutions/DNA polymerase/fide

D. Botstein, D. Shortle, P. Grisafi, 2016 .

It's the Data!

David Botstein, D. Botstein, 2010, Molecular biology of the cell.

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

Ash A. Alizadeh, D. Botstein, P. Brown, 1999 .

References and Notes

D. Botstein, P. Brown, D. Lashkari, 2022 .

Why yeast?

D. Botstein, 1991, Hospital practice.

A faster-acting and more potent form of tissue plasminogen activator.

D. Botstein, B. Keyt, H. Nguyen, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Automating the construction of gene ontologies

Kara Dolinski, David Botstein, D. Botstein, 2013, Nature Biotechnology.

Lasker∼Koshland to Genetics Pioneer

D. Botstein, 2014, Cell.

Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming).

D. Botstein, C. Walsh, L. Zawadzke, 1988, Biochemistry.

Dna Microarray Analysis of Gene Expression in Response to Physiological and Genetic Changes That Affect Tryptophan Metabolism in Escherichia Coli

D. Botstein, A. Khodursky, B. Peter, 2022 .

Functional analysis reports. Precise gene disruption in Saccharomyces cerevisiae by double fusion polymerase chain reaction

D. Botstein, E. Beasley, D. Amberg, 1995, Yeast.

Probing β‐lactamase structure and function using random replacement mutagenesis

D. Botstein, T. Palzkill, 1992 .

Extracting information from protein sequences using random replacement mutagenesis

D. Botstein, T. Palzkill, 1991 .

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.

B. Dujon, J. Ballesta, N. Biteau, 1997, Nature.

Functional clustering of genes using microarray gene expression data

D. Botstein, P. Brown, P. Spellman, 1999, Nature Genetics.

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

Ash A. Alizadeh, D. Botstein, P. Brown, 2001, The Journal of experimental medicine.

Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes.

Ash A. Alizadeh, R. Tibshirani, D. Botstein, 2004, The New England journal of medicine.

Missing value estimation methods for DNA microarrays

R. Tibshirani, T. Hastie, D. Botstein, 2001, Bioinform..

Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children.

E. Lander, D. Botstein, 1987, Science.

Changing perspectives in yeast research nearly a decade after the genome sequence.

Kara Dolinski, David Botstein, D. Botstein, 2005, Genome research.

SGD: Saccharomyces Genome Database

C. Ball, D. Botstein, J. Cherry, 1998, Nucleic Acids Res..

Intermediates in the synthesis of phage P22 DNA.

D. Botstein, M. Levine, 1968, Cold Spring Harbor symposia on quantitative biology.

Systematic changes in gene expression patterns following adaptive evolution in yeast.

D. Botstein, P. Brown, T. Ferea, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology.

D. Botstein, R. Brent, E. Golemis, 1995, Molecular biology of the cell.

Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF

D. Botstein, P. Brown, V. Iyer, 2001, Nature.

Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure

C. Ball, D. Botstein, J. Cherry, 1999, Nucleic Acids Res..

System-Level Analysis of Genes and Functions Affecting Survival During Nutrient Starvation in Saccharomyces cerevisiae

John D. Storey, D. Botstein, A. Caudy, 2011, Genetics.

GeneXplorer: an interactive web application for microarray data visualization and analysis

David Botstein, Gavin Sherlock, Christian A. Rees, 2004, BMC Bioinformatics.

Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast

D. Botstein, R. McIsaac, S. Silverman, 2011, Molecular biology of the cell.

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells.

D. Botstein, Lance L. Parsons, Henrik D. Møller, 2016, Journal of visualized experiments : JoVE.

Expanding yeast knowledge online

C. Ball, D. Botstein, J. Cherry, 1998, Yeast.

Mutational analysis of the role of hydrophobic residues in the 338-348 helix on actin in actomyosin interactions.

D. Botstein, T. Doyle, E. Reisler, 1996, Biochemistry.