V. Villeret

发表

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway.

B. Clantin, H. Hodak, E. Willery, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Computational characterization of the binding mode between oncoprotein Ets‐1 and DNA‐repair enzymes

V. Villeret, J. de Ruyck, M. Lensink, 2018, Proteins.

The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures.

N. Glansdorff, B. Clantin, V. Villeret, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Genes and enzymes involved in arginine and pyrimidine biosynthesis in psychrophilic Vibrio strains from the deep sea

N. Glansdorff, V. Villeret, J. Beeumen, 1999 .

Biochemical characterisation of ornithine carbamoyltransferase from Pyrococcus furiosus.

D. Gigot, N. Glansdorff, A. Piérard, 1997, European journal of biochemistry.

Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS

C. Locht, F. Jacob-Dubuisson, V. Villeret, 2015, PLoS pathogens.

Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling.

B. Clantin, F. Jacob-Dubuisson, V. Villeret, 2014, Biophysical journal.

Crystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis.

V. Villeret, J. Frère, J. V. Van Beeumen, 1999, Acta crystallographica. Section D, Biological crystallography.

The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners.

V. Villeret, P. Roblin, V. Receveur-Bréchot, 2013, Biochimica et biophysica acta.

Twenty years of Mediator complex structural studies

V. Villeret, D. Monté, A. Verger, 2019, Biochemical Society transactions.

Structural Insight into the Role of the PAS Domain for Signal Transduction in Sensor Kinase BvgS

B. Clantin, F. Jacob-Dubuisson, V. Villeret, 2021, Journal of Bacteriology.

Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucans.

B. Clantin, V. Villeret, I. Landrieu, 2004, Journal of molecular biology.

Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator.

C. Locht, V. Villeret, A. Baulard, 2010, ACS chemical biology.

NMR structure of the human Mediator MED25 ACID domain.

V. Villeret, D. Monté, Y. De Launoit, 2011, Journal of structural biology.

Structural aspects of the allosteric inhibition of fructose-1,6-bisphosphatase by AMP: the binding of both the substrate analogue 2,5-anhydro-D-glucitol 1,6-bisphosphate and catalytic metal ions monitored by X-ray crystallography.

V. Villeret, W. Lipscomb, Y. Zhang, 1995, Biochemistry.

Allosteric regulation in Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase revisited: association of concerted homotropic cooperative interactions and local heterotropic effects.

V. Villeret, C. Tricot, V. Stalon, 1998, Journal of molecular biology.

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis.

B. Clantin, H. Hodak, F. Jacob-Dubuisson, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray diffraction analysis of two extracytoplasmic solute receptors of the DctP family from Bordetella pertussis.

F. Jacob-Dubuisson, V. Villeret, R. Antoine, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex.

B. Clantin, V. Villeret, R. Wintjens, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Preliminary crystal structure determination of the alkaline protease from the Antarctic psychrophile pseudomonas aeruginosa

V. Villeret, J. Beeumen, C. Gerday, 1997, Protein science : a publication of the Protein Society.

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

E. Willery, C. Locht, V. Villeret, 2011, Nucleic acids research.

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.

V. Villeret, I. Landrieu, D. Monté, 2017, Journal of molecular biology.

Glycine 122 Is Essential for Cooperativity and Binding of Mg to Porcine Fructose-1,6-bisphosphatase (*)

V. Villeret, H. Fromm, Lirong Chen, 1995, The Journal of Biological Chemistry.

Purification of SUMO-1 modified IκBα and complex formation with NF-κB.

V. Villeret, C. Van Lint, Y. De Launoit, 2011, Protein expression and purification.

Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase.

V. Villeret, C. Erneux, F. Dewitte, 2007, Protein expression and purification.

Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1

V. Villeret, Arnaud J. Legrand, M. Aumercier, 2018, Bioscience, biotechnology, and biochemistry.

Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase.

V. Villeret, H. Fromm, W. Lipscomb, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches.

Olivier Sperandio, Bruno O Villoutreix, Nicolas Blondiaux, 2014, Journal of medicinal chemistry.

A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi.

V. Villeret, J. Frère, J. V. Van Beeumen, 2000, Structure.

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

Amit Singhal, Marc Aumercier, Florence Leroux, 2009, Nature Medicine.

Structural and phylogenetic relationships among plant and animal cystatins.

V. Villeret, R. Margis, E. Reis, 1998, Archives of biochemistry and biophysics.

Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases.

B. Clantin, V. Villeret, R. Wintjens, 2006, Journal of molecular biology.

Aspartate carbamoyltransferase from the thermoacidophilic archaeon Sulfolobus acidocaldarius. Cloning, sequence analysis, enzyme purification and characterization.

N. Glansdorff, V. Villeret, D. Charlier, 1999, European journal of biochemistry.

Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase

B. Clantin, V. Villeret, C. Tricot, 2001, The EMBO journal.

Kinetics and mechanisms of activation and inhibition of porcine liver fructose-1,6-bisphosphatase by monovalent cations.

V. Villeret, H. Fromm, W. Lipscomb, 1996, Biochemistry.

Crystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 A resolution.

V. Villeret, W. Lipscomb, Y. Zhang, 1995, Biochemistry.

Structure of the FhaC translocation pore: insights into transport across the bacterial membrane

B. Clantin, V. Villeret, 2008 .

Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold‐adapted proteases

V. Villeret, J. V. Van Beeumen, F. van Petegem, 2003, Proteins.

Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus.

V. Villeret, C. Tricot, V. Stalon, 1994, European journal of biochemistry.

The Level of Ets-1 Protein Is Regulated by Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Cancer Cells to Prevent DNA Damage

V. Villeret, Arnaud J. Legrand, H. Drobecq, 2013, PloS one.

Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage.

V. Villeret, B. Foveau, D. Tulasne, 2009, Cellular signalling.

X-ray structure of papaya chitinase reveals the substrate binding mode of glycosyl hydrolase family 19 chitinases.

B. Clantin, V. Villeret, R. Wintjens, 2008, Biochemistry.

1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26

V. Villeret, I. Landrieu, J. Baert, 2016, Biomolecular NMR Assignments.

1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26

V. Villeret, I. Landrieu, J. Baert, 2016, Biomolecular NMR assignments.

Deletion of Flagellin’s Hypervariable Region Abrogates Antibody-Mediated Neutralization and Systemic Activation of TLR5-Dependent Immunity1

V. Villeret, J. Sirard, M. Rumbo, 2008, The Journal of Immunology.

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25

V. Villeret, I. Landrieu, D. Monté, 2015, Nucleic acids research.

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members

V. Villeret, D. Monté, Y. De Launoit, 2013, Nucleic acids research.

Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo

V. Villeret, M. Boube, H. Bourbon, 2020, The Journal of Biological Chemistry.

Mediator complex subunit Med19 binds directly GATA DNA-binding zinc finger and functions with Med1 in GATA-driven gene regulation in vivo

V. Villeret, M. Boube, H. Bourbon, 2020, bioRxiv.

First structural insights into the TpsB/Omp85 superfamily

B. Clantin, F. Jacob-Dubuisson, V. Villeret, 2009, Biological chemistry.

Structure of the Membrane Protein FhaC: A Member of the Omp85-TpsB Transporter Superfamily

B. Clantin, C. Locht, F. Jacob-Dubuisson, 2007, Science.

Secretion signal of the filamentous haemagglutinin, a model two‐partner secretion substrate

B. Clantin, H. Hodak, E. Willery, 2006, Molecular microbiology.

Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily

B. Clantin, C. Locht, F. Jacob-Dubuisson, 2010, The FEBS journal.

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors.

C. Locht, V. Villeret, R. Wintjens, 2011, Journal of medicinal chemistry.

Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family.

V. Villeret, J. Frère, T. Prangé, 2000, Structure.

DNA Binding of the Cell Cycle Transcriptional Regulator GcrA Depends on N6-Adenosine Methylation in Caulobacter crescentus and Other Alphaproteobacteria

V. Villeret, E. Biondi, S. Mohapatra, 2013, PLoS genetics.

Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways.

A. Piérard, V. Villeret, D. Charlier, 1999, Journal of molecular biology.

Conserved Omp85 lid-lock structure and substrate recognition in FhaC

B. Clantin, F. Jacob-Dubuisson, V. Villeret, 2015, Nature Communications.

Preliminary structural studies of Escherichia coli isopentenyl diphosphate isomerase.

B. Clantin, V. Villeret, C. Tricot, 2001, Acta crystallographica. Section D, Biological crystallography.

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae

Ahmed Haouz, Mohamed Chami, B. Clantin, 2016, Nature Communications.

Substrate recognition by the POTRA domains of TpsB transporter FhaC

B. Clantin, E. Willery, C. Locht, 2011, Molecular microbiology.

The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti

V. Villeret, A. Becker, E. Biondi, 2013, Molecular microbiology.

Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis.

V. Villeret, A. Baulard, F. Frénois, 2006, Tuberculosis.

Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis.

C. Locht, V. Villeret, A. Baulard, 2004, Molecular cell.

Structure of the secretion domain of HxuA from Haemophilus influenzae.

B. Clantin, V. Villeret, F. Dewitte, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation.

C. Locht, F. Jacob-Dubuisson, V. Villeret, 2006, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of Bordetella pertussis BugD solute receptor unveils the basis of ligand binding in a new family of periplasmic binding proteins.

C. Locht, F. Jacob-Dubuisson, V. Villeret, 2006, Journal of molecular biology.

Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family.

C. Locht, F. Jacob-Dubuisson, V. Villeret, 2007, Journal of molecular biology.

Ornithine carbamoyltransferase from Pyrococcus furiosus.

N. Glansdorff, B. Clantin, V. Villeret, 1998, Methods in enzymology.

Crystal structure of Pseudomonas aeruginosa catabolic ornithine transcarbamoylase at 3.0-A resolution: a different oligomeric organization in the transcarbamoylase family.

V. Villeret, C. Tricot, V. Stalon, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of the N-terminal transactivation domain of ERM modified by SUMO-1.

V. Villeret, C. Van Lint, D. Monté, 2010, Biochemical and biophysical research communications.

The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.

V. Villeret, F. Vandeput, X. Pesesse, 2006, Cellular signalling.

Probing the role of oligomerization in the high thermal stability of Pyrococcus furiosus ornithine carbamoyltransferase by site-specific mutants.

B. Clantin, V. Villeret, C. Tricot, 2001, European journal of biochemistry.

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.

C. Locht, V. Villeret, R. Wintjens, 2012, Journal of medicinal chemistry.

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors.

C. Locht, V. Villeret, A. Baulard, 2011, Journal of medicinal chemistry.

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.

B. Clantin, H. Hodak, F. Jacob-Dubuisson, 2010, Journal of structural biology.

Crystal structure of human Mediator subunit MED23

B. Clantin, V. Villeret, E. Pardon, 2018, Nature Communications.

Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily.

C. Locht, F. Jacob-Dubuisson, V. Villeret, 2007, Journal of molecular biology.

Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus

B. Clantin, V. Villeret, E. Biondi, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism

E. Willery, C. Locht, F. Jacob-Dubuisson, 2010, Proceedings of the National Academy of Sciences.

Linker insertion mutagenesis based on IS21 transposition: isolation of an AMP-insensitive variant of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa.

V. Villeret, C. Tricot, V. Stalon, 2000, Protein engineering.

Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Importance of the N-terminal region for dodecameric structure and homotropic carbamoylphosphate cooperativity.

D. Gigot, V. Villeret, D. Baker, 1996, European journal of biochemistry.

Methionine-321 in the C-terminal alpha-helix of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa is important for positive homotropic cooperativity.

V. Villeret, C. Tricot, V. Stalon, 1994, FEMS Microbiology Letters.

Poly(ADP-ribose) Polyremase-1 (PARP-1) Inhibition: A Promising Therapeutic Strategy for ETS-Expressing Tumours

V. Villeret, Arnaud J. Legrand, M. Aumercier, 2023, International journal of molecular sciences.

A Salmonella Type Three Secretion Effector/Chaperone Complex Adopts a Hexameric Ring-Like Structure

V. Villeret, P. Roblin, E. Biondi, 2014, Journal of bacteriology.

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors.

C. Locht, V. Villeret, A. Baulard, 2011, Journal of medicinal chemistry.