D. Lockhart

发表

A genome-wide transcriptional analysis of the mitotic cell cycle.

Ronald W. Davis, R. J. Cho, M. Campbell, 1998, Molecular cell.

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer.

D. Lockhart, J. Welsh, L. Sapinoso, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mitotic misregulation and human aging.

D. Lockhart, D. Ly, R. Lerner, 2000, Science.

Genomics, gene expression and DNA arrays

E. Winzeler, D. Lockhart, 2000, Nature.

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.

Ronald W. Davis, J. Hegemann, P. Philippsen, 1999, Science.

RNA expression analysis using a 30 base pair resolution Escherichia coli genome array

G. Church, D. Lockhart, F. Blattner, 2000, Nature Biotechnology.

Accessing Genetic Information with High-Density DNA Arrays

James L. Winkler, S. P. Fodor, D. Lockhart, 1996, Science.

Genome-wide expression monitoring in Saccharomyces cerevisiae

L. Wodicka, D. Lockhart, M. Mittmann, 1997, Nature Biotechnology.

High density synthetic oligonucleotide arrays

S. P. Fodor, D. Lockhart, T. Gingeras, 1999, Nature Genetics.

Functional Genomics

D. Lockhart, S. Fields, Y. Kohara, 1999, Springer Netherlands.

Expression monitoring by hybridization to high-density oligonucleotide arrays

D. Lockhart, M. Chee, M. Mittmann, 1996, Nature Biotechnology.

A small molecule–kinase interaction map for clinical kinase inhibitors

L. Wodicka, D. Lockhart, P. Zarrinkar, 2005, Nature Biotechnology.

Elevated gene expression levels distinguish human from non-human primate brains

Matthew A. Zapala, D. Geschwind, D. Lockhart, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Regional and strain-specific gene expression mapping in the adult mouse brain.

L. Wodicka, D. Lockhart, R. Sandberg, 2000, Proceedings of the National Academy of Sciences of the United States of America.

DNA arrays and neurobiology — what's new and what's next?

D. Lockhart, C. Barlow, 2002, Current Opinion in Neurobiology.

Expressing what's on your mind: DNA arrays and the brain

David J. Lockhart, Carrolee Barlow, D. Lockhart, 2001, Nature Reviews Neuroscience.

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

Peter Walter, Jonathan S Weissman, L. Wodicka, 2000, Cell.

Replication dynamics of the yeast genome.

Ronald W. Davis, L Wodicka, D J Lockhart, 2001, Science.

Effects of environmental enrichment on gene expression in the brain.

D. Lockhart, P. Schultz, C. Rampon, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APPE693Q mice through reduction of ganglioside-bound Aβ

D. Lockhart, W. Klein, M. Ehrlich, 2014, Molecular Psychiatry.

Calculation of electrostatic effects at the amino terminus of an alpha helix.

B Honig, D J Lockhart, D. Lockhart, 1994, Biophysical journal.

Direct allelic variation scanning of the yeast genome.

Daniel R. Richards, M J McCullough, L Wodicka, 1998, Science.

Parallel identification of new genes in Saccharomyces cerevisiae.

John R Yates, Michael P Washburn, E. Winzeler, 2002, Genome research.

Electrostatic screening of charge and dipole interactions with the helix backbone.

P S Kim, D J Lockhart, P. S. Kim, 1993, Science.

Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays.

A Chakravarti, D J Lockhart, D. Lockhart, 2000, Genome research.

Arrays of arrays for high-throughput gene expression profiling.

D J Lockhart, D. Lockhart, D. Stern, 2001, Genome research.

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy

D. Lockhart, M. Chesselet, J. Flanagan, 2014, Neurotherapeutics.

Risk of Death in Heart Disease is Associated With Elevated Urinary Globotriaosylceramide

D. Lockhart, R. Schiffmann, Matthew R. G. Taylor, 2014, Journal of the American Heart Association.

Internal stark effect measurement of the electric field at the amino terminus of an alpha helix.

P S Kim, D J Lockhart, P. S. Kim, 1992, Science.

Tuning a three-component reaction for trapping kinase substrate complexes.

Dustin J Maly, D. Lockhart, P. Zarrinkar, 2008, Journal of the American Chemical Society.

Electric field effects on the initial electron-transfer kinetics in bacterial photosynthetic reaction centers

D. Lockhart, S. Boxer, C. Kirmaier, 1990 .

Functional Genomics

D. Lockhart, S. Fields, Y. Kohara, 2002, Springer Netherlands.

Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-β Peptide

J. Buxbaum, D. Lockhart, S. Gandy, 2012, The Journal of Neuroscience.

Mechanism of Charge Separation in Photosynthetic Reaction Centers: Electric Field Effects on the Initial Electron Transfer Kinetics

D. Lockhart, S. Boxer, C. Kirmaier, 1990 .

Reversible photochemical holeburning in Rhodopseudomonas viridis reaction centers

Thomas R. Middendorf, D. Lockhart, S. Boxer, 1986 .

Photochemical hole-burning in photosynthetic reaction centers

Thomas R. Middendorf, D. Lockhart, S. Boxer, 1986 .

Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression.

D. Lockhart, M. Miles, C. Hodge, 2000, Molecular pharmacology.

Response to Molecule–kinase interaction map

D. Lockhart, P. Zarrinkar, D. K. Treiber, 2005, Nature Biotechnology.

Arrays of arrays for high-throughput gene expression profiling.

D. Lockhart, D. Stern, J. Welsh, 2001, Genome research.

Software and methods for oligonucleotide and cDNA array data analysis

Matthew A. Zapala, D. Lockhart, D. J. Lockhart, 2002, Genome Biology.

Safety and pharmacodynamic effects of a pharmacological chaperone on α-galactosidase A activity and globotriaosylceramide clearance in Fabry disease: report from two phase 2 clinical studies

D. Lockhart, A. Mehta, R. Giugliani, 2012, Orphanet Journal of Rare Diseases.

Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase

D. Lockhart, J. Flanagan, C. Barlow, 2015, PloS one.

Migalastat HCl Reduces Globotriaosylsphingosine (Lyso-Gb3) in Fabry Transgenic Mice and in the Plasma of Fabry Patients

D. Lockhart, A. Mehta, R. Giugliani, 2013, PloS one.

Duvoglustat HCl Increases Systemic and Tissue Exposure of Active Acid α-Glucosidase in Pompe Patients Co-administered with Alglucosidase α

D. Lockhart, B. Byrne, J. Flanagan, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Structure‐based analysis of the initial electron transfer step in bacterial photosynthesis: Electric field induced fluorescence anisotropy

D. Lockhart, S. Boxer, R. Goldstein, 1988 .

Photochemical Holeburning and Stark Spectroscopy of Photosynthetic Reaction Centers

D. Lockhart, S. Boxer, Thomas R Middendorf, 1987 .

Reply to BIRB-796 is not an effective ABL(T315I) inhibitor

D. Lockhart, P. Zarrinkar, D. K. Treiber, 2005, Nature Biotechnology.

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

S H Kim, N S Gray, L Wodicka, 1998, Science.

Mutation detection by ligation to complete n-mer DNA arrays.

K. Gunderson, D. Lockhart, M. Chee, 1998, Genome research.

Excited states, electron-transfer reactions, and intermediates in bacterial photosynthetic reaction centers

D. Lockhart, S. Boxer, R. Goldstein, 1989 .

Electric field modulation of the fluorescence from Rhodobacter sphaeroides reaction centers

D. Lockhart, S. Boxer, 1988 .

Stark effect spectroscopy of Rhodobacter sphaeroides and Rhodopseudomonas viridis reaction centers.

D. Lockhart, S. Boxer, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Magnitude and direction of the change in dipole moment associated with excitation of the primary electron donor in Rhodopseudomonas sphaeroides reaction centers

D. Lockhart, S. Boxer, 1987 .

Detecting genetic variation in microarray expression data.

Mario Cáceres, Ondrej Libiger, Nicholas J Schork, 2007, Genome research.

DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies

Eric E Schadt, Ondrej Libiger, Nicholas J Schork, 2007, Genome Biology.

Electric field effects on emission line shapes when electron transfer competes with emission: an example from photosynthetic reaction centers

D. Lockhart, S. Boxer, S. Franzen, 1991 .

Glucosylceramide Quantitation in Normal and Glucocerebrosidase-Deficient Mouse Brain and Human Cell Lines

D. Lockhart, R. Khanna, N. Brignol, 2012 .

Co-administration With the Pharmacological Chaperone AT1001 Increases Recombinant Human α-Galactosidase A Tissue Uptake and Improves Substrate Reduction in Fabry Mice

D. Lockhart, J. Flanagan, Y. Lun, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

The pharmacological chaperone 1-deoxygalactonojirimycin increases α-galactosidase A levels in Fabry patient cell lines

D. Lockhart, J. Flanagan, R. Desnick, 2009, Journal of Inherited Metabolic Disease.

Electric Field Effects on the Quantum Yields and Kinetics of Fluorescence and Transient Intermediates in Bacterial Reaction Centers

D. Lockhart, S. Boxer, J. Stocker, 1992 .

Mechanisms of aging in senescence-accelerated mice

Shigeo Yoshida, Anand Swaroop, Robert Helton, 2005, Genome Biology.

Coformulation of a Novel Human α-Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice

D. Lockhart, S. Sullivan, Y. Lun, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study

D. Lockhart, R. Schiffmann, C. Barlow, 2016, Journal of Medical Genetics.

The validation of pharmacogenetics for the identification of Fabry patients to be treated with migalastat

D. Lockhart, R. Schiffmann, C. Barlow, 2016, Genetics in Medicine.

Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat.

D. Lockhart, S. Packman, R. Schiffmann, 2016, The New England journal of medicine.

The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease.

D. Lockhart, R. Desnick, Y. Lun, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

A Pharmacogenetic Approach to Identify Mutant Forms of α-Galactosidase A that Respond to a Pharmacological Chaperone for Fabry Disease

D. Lockhart, R. Schiffmann, J. Flanagan, 2011, Human mutation.

Chipping away at complex behavior: Transcriptome/phenotype correlations in the mouse brain

D. Lockhart, C. Barlow, T. Carter, 2001, Physiology & Behavior.

Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays.

D J Lockhart, R. Mei, D. Lockhart, 2000, Genome research.

The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of β‐glucosidase

D. Lockhart, R. Schiffmann, Y. Lun, 2010, The FEBS journal.

Deciphering Molecular Circuitry Using High-Density DNA Arrays

D. Lockhart, T. Gingeras, M. Mittmann, 1998 .

Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

Daniel K. Treiber, John Kuriyan, David J. Lockhart, 2006, Cancer research.

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.

William Pao, Harold Varmus, Daniel K Treiber, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The Pharmacological Chaperone AT2220 Increases the Specific Activity and Lysosomal Delivery of Mutant Acid Alpha-Glucosidase, and Promotes Glycogen Reduction in a Transgenic Mouse Model of Pompe Disease

D. Lockhart, Y. Lun, B. Wustman, 2014, PloS one.

Transcriptional regulation and function during the human cell cycle

Ronald W. Davis, R. J. Cho, M. Campbell, 2001, Nature Genetics.

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Eric E. Schadt, David J. Lockhart, Inder M. Verma, 2005, Nature.

Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.

D. Lockhart, C. Barlow, C. Winrow, 2005, Human molecular genetics.

Quantifying DNA–protein interactions by double-stranded DNA arrays

Martha L. Bulyk, George M. Church, David J. Lockhart, 1999, Nature Biotechnology.

Myoseverin, a microtubule-binding molecule with novel cellular effects

Peter G. Schultz, David J. Lockhart, Young-Tae Chang, 2000, Nature Biotechnology.

Parallel analysis of genetic selections using whole genome oligonucleotide arrays.

L Wodicka, D J Lockhart, R. J. Cho, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Nonphotochemical holeburning in a protein matrix: Chlorophyllide in apomyoglobin

David J. Lockhart, David S. Gottfried, Thomas R. Middendorf, 1987 .

Adult mouse brain gene expression patterns bear an embryologic imprint.

Matthew A. Zapala, Carrolee Barlow, F. Bloom, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The Pharmacological Chaperone AT2220 Increases Recombinant Human Acid α-Glucosidase Uptake and Glycogen Reduction in a Mouse Model of Pompe Disease

D. Lockhart, J. Flanagan, Y. Lun, 2012, PloS one.

The pharmacological chaperone 1‐deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha‐glucosidase

D. Lockhart, J. Flanagan, M. Cubellis, 2009, Human mutation.

114. Pharmacological chaperone therapy for Gaucher disease: Mechanism of action, a survey of responsive mutations and phase I clinical trial results

P. Kaplan, P. Fernhoff, D. Lockhart, 2008 .

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy

D. Lockhart, M. Chesselet, J. Flanagan, 2014, Neurotherapeutics.

An Introduction to DNA Microarrays

Patrick McConnell, Kimberly S. Johnson, David J. Lockhart, 2002 .

DNA Chip Revolution

D. Lockhart, 2006 .

Genomic and Genetic Definition of a Functional Human Centromere

E. Winzeler, A. Conway, L. Wodicka, 2001, Science.

Genomics, gene expression and DNA arrays

E. Winzeler, D. Lockhart, 2000, Nature.

Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.

D. Lockhart, P. Zarrinkar, D. K. Treiber, 2009, Bioorganic & medicinal chemistry letters.

Phase 3 FACETS study of migalastat HCl for Fabry disease: post hoc GLA mutation-based identification of subjects likely to show a drug effect

D. Lockhart, C. Barlow, E. Benjamin, 2014 .

Software and methods for oligonucleotide and cDNA array data analysis

Matthew A. Zapala, Carrolee Barlow, D. Lockhart, 2002, Genome Biology.