C. Leslie

发表

Learning Regulatory Networks from Sparsely Sampled Time Series Expression Data

A. Kundaje, Omar Antar, C. Leslie, 2002 .

Profile-based string kernels for remote homology detection and motif extraction.

Y. Freund, C. Leslie, C. Leslie, 2005, Journal of bioinformatics and computational biology.

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

Martin L. Miller, Aly A. Khan, C. Sander, 2009, Nature Biotechnology.

Identifying remote protein homologs by network propagation

William Stafford Noble, J. Weston, C. Leslie, 2005, The FEBS journal.

Localization and function of cytosolic phospholipase A2alpha at the Golgi.

C. Leslie, M. Gelb, T. A. Gangelhoff, 2010, Biochimie.

Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis.

C. Leslie, M. Triggiani, M. Gelb, 2009, Biochimica et biophysica acta.

Computational methods to dissect gene regulatory networks in cancer

C. Leslie, H. Osmanbeyoglu, A. Iyer, 2017 .

Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2β) and Comparison with the Other cPLA2 Isoforms*

James G. Bollinger, C. Leslie, M. Gelb, 2010, The Journal of Biological Chemistry.

Properties and regulation of mammalian nonpancreatic phospholipase A2 enzymes

C. Leslie, 1996 .

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Sun Mi Park, Levi N. Naden, Steven K. Albanese, 2018, bioRxiv.

Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation

C. Leslie, John H. Evans, D. Fergus, 2002, BMC Biochemistry.

Predictive models of gene regulation

A. Kundaje, C. Leslie, 2008 .

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

Michel Sadelain, Frederic D Bushman, Manu Setty, 2011, Nature Biotechnology.

Role of cytosolic phospholipase A(2) in prostaglandin E(2) production by lung fibroblasts.

C. Leslie, J. Bonventre, R. Murphy, 2012, American journal of respiratory cell and molecular biology.

Intracellular Calcium Signals Regulating Cytosolic Phospholipase A2 Translocation to Internal Membranes* 210

C. Leslie, John H. Evans, A. Zweifach, 2001, The Journal of Biological Chemistry.

Regulation of Cytosolic Phospholipase A2 Activation and Cyclooxygenase 2 Expression in Macrophages by the β-Glucan Receptor*

C. Leslie, S. Akira, S. Gordon, 2006, Journal of Biological Chemistry.

Regulation of cytosolic phospholipase A2 phosphorylation and eicosanoid production by colony-stimulating factor 1.

C. Leslie, C. Rock, S. Jackowski, 1994, The Journal of biological chemistry.

COMPUTATIONAL BIOLOGY AND BIOINFORMATICS

Cigdem Demir, Alexander Schliep, John Hawkins, 2005 .

Regulation of arachidonic acid release and cytosolic Phospholipase A2 activation

C. Leslie, M. Gijón, M. Gijon, 1999, Journal of leukocyte biology.

Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.

C. Leslie, S. Gordon, P. Taylor, 2010, American journal of respiratory cell and molecular biology.

Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells.

C. Leslie, M. Gelb, L. Nallan, 2005, Journal of lipid research.

Macrophages stimulate DNA synthesis in rat alveolar type II cells.

C. Leslie, R. Mason, J. L. Cook, 1985, The American review of respiratory disease.

Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2α in Regulating Interfacial Kinetics and Binding and Cellular Function*

James G. Bollinger, C. Leslie, M. Gelb, 2009, Journal of Biological Chemistry.

cPLA 2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells

C. Leslie, K. Malik, Zoran Pavicevic, 2008 .

cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells Published, JLR Papers in Press, January 9, 2008.

C. Leslie, K. Malik, Zoran Pavicevic, 2008, Journal of Lipid Research.

Regulation ofthe specific release ofarachidonic acid by cytosolic phospholipase A 2

C. Leslie, 2004 .

Regulation of cytosolic phospholipase A(2) translocation.

C. Leslie, John H. Evans, D. Fergus, 2003, Advances in enzyme regulation.

Enzymatic Properties of Human Cytosolic Phospholipase A2γ*

C. Leslie, M. Ghosh, A. Stewart, 2002, The Journal of Biological Chemistry.

Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2*

C. Leslie, A. Bielawska, Y. Hannun, 2004, Journal of Biological Chemistry.

Heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells.

C. Leslie, J. Abraham, J. Shannon, 1997, American journal of respiratory cell and molecular biology.

Hepatocyte growth factor is a growth factor for rat alveolar type II cells.

C. Leslie, T. Nakamura, J. Rubin, 1994, American journal of respiratory cell and molecular biology.

Extracellular ATP-mediated Signaling for Survival in Hyperoxia-induced Oxidative Stress*

C. Leslie, Aftab Ahmad, Shama Ahmad, 2004, Journal of Biological Chemistry.

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A*

C. Leslie, R. Murphy, P. Henson, 2008, Journal of Biological Chemistry.

Activation of Cytosolic Phospholipase A2α in Resident Peritoneal Macrophages by Listeria monocytogenes Involves Listeriolysin O and TLR2*

C. Leslie, S. Akira, J. Bonventre, 2008, Journal of Biological Chemistry.

Neutrophils Regulate Tissue Neutrophilia in Inflammation via the Oxidant-modified Lipid Lysophosphatidylserine*

C. Leslie, J. Nick, R. Murphy, 2013, The Journal of Biological Chemistry.

Cytosolic Phospholipase A2 Is Required for Macrophage Arachidonic Acid Release by Agonists That Do and Do Not Mobilize Calcium

C. Leslie, J. Bonventre, M. Gijón, 2000, The Journal of Biological Chemistry.

Macrophage phospholipase A2 specific for sn-2-arachidonic acid.

C. Leslie, 1990, Methods in enzymology.

A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine.

C. Leslie, P. Henson, F. Alonso, 1986, Biochimica et biophysica acta.

Production of Growth Factor Activity for Fibroblasts by Human Monocyte‐Derived Macrophages

C. Leslie, P. Henson, R. A. Musson, 1984, Journal of leukocyte biology.

Heparin-binding growth factors stimulate DNA synthesis in rat alveolar type II cells.

C. Leslie, R. Mason, K. McCormick-Shannon, 1990, American journal of respiratory cell and molecular biology.

Stimulation of phospholipid and cholesterol ester synthesis by platelet-derived growth factor in normal and homozygous familial hypercholesterolemia human skin fibroblasts

C. Leslie, H. Antoniades, R. Geyer, 1982 .

Prostaglandins from Cytosolic Phospholipase A2α/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages*

C. Leslie, R. Murphy, Heejung Lee, 2016, The Journal of Biological Chemistry.

Pulmonary Surfactant Phosphatidylglycerol Inhibits Mycoplasma pneumoniae-stimulated Eicosanoid Production from Human and Mouse Macrophages*

C. Leslie, E. Chan, R. Murphy, 2011, The Journal of Biological Chemistry.

Role of Phosphorylation Sites and the C2 Domain in Regulation of Cytosolic Phospholipase A2

C. Leslie, A. Kaiser, M. Gijón, 1999, The Journal of cell biology.

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A*

C. Leslie, R. Murphy, P. Henson, 2008, Journal of Biological Chemistry.

Signaling via Macrophage G2A Enhances Efferocytosis of Dying Neutrophils by Augmentation of Rac Activity*

C. Leslie, J. Bonventre, R. Murphy, 2011, The Journal of Biological Chemistry.

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7.

C. Leslie, D. Voelker, P. Zelarney, 1988, Biochimica et biophysica acta.

Stimulation of DNA synthesis in cultured rat alveolar type II cells.

C. Leslie, R. Mason, P. Robinson, 1985, Experimental lung research.

Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling

C. Leslie, R. Murphy, D. Voelker, 2016, Journal of Lipid Research.

Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid.

C. Leslie, T. Nakamura, J. Rubin, 1996, The American journal of physiology.

Recent advances in the regulation of cytosolic phospholipase A(2).

C. Leslie, M. Gijón, D. M. Spencer, 2000, Advances in enzyme regulation.

Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-α/EGFR signaling

C. Leslie, Yoko Ito, R. Murphy, 2015, American journal of physiology. Lung cellular and molecular physiology.

Regulation of human PLD1 and PLD2 by calcium and protein kinase C.

C. Leslie, A. R. Siddiqi, G. Srajer, 2000, Biochimica et biophysica acta.

COPI acts in both vesicular and tubular transport

C. Leslie, A. Luini, D. Corda, 2011, Nature Cell Biology.

Suppression of Macrophage Eicosanoid Synthesis by Atherogenic Lipoproteins Is Profoundly Affected by Cholesterol-Fatty Acyl Esterification and the Niemann-Pick C Pathway of Lipid Trafficking*

C. Leslie, I. Tabas, A. R. Leventhal, 2004, Journal of Biological Chemistry.

Inferring protein structure with discriminative learning and network diffusion

C. Leslie, R. Kuang, 2006 .

Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2ζ in Mouse Lung Fibroblasts*

C. Leslie, M. Gelb, J. Bonventre, 2007, Journal of Biological Chemistry.

Receptor-mediated signal transduction in mononuclear phagocytes.

C. Leslie, D. Riches, P. Henson, 1988, Progress in allergy.

Novel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins.

C. Leslie, M. Willingham, J. O'flaherty, 2008, Biochimica et biophysica acta.

Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum.

C. Leslie, M. Gelb, Heejung Lee, 2016, Biochemical and biophysical research communications.

Functional characterization of mutations in inherited human cPLA₂ deficiency.

C. Leslie, M. Gelb, O. Boutaud, 2011, Biochemistry.

The development of an ELISA for group IVA phospholipase A2 in human red blood cells.

C. Leslie, D. Horrobin, A. Glen, 2015, Prostaglandins, leukotrienes, and essential fatty acids.

Enzymatic properties of human cytosolic phospholipase A(2)gamma.

C. Leslie, M. Ghosh, A. Stewart, 2002, The Journal of biological chemistry.

Role of Endogenously Derived Leukotrienes in the Regulation of Lysosomal Enzyme Expression in Macrophages Exposed to β 1,3‐Glucan

C. Leslie, D. Riches, P. Henson, 1991, Journal of leukocyte biology.

Kinetic properties of a high molecular mass arachidonoyl-hydrolyzing phospholipase A2 that exhibits lysophospholipase activity.

C. Leslie, 1991, The Journal of biological chemistry.

The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

C. Leslie, E. Krebs, R. Ross, 1997, The Journal of clinical investigation.

BindSpace: decoding transcription factor binding signals by large-scale joint embedding

Han Yuan, Meghana Kshirsagar, Yuheng Lu, 2018, bioRxiv.

Cellular Assays for Evaluating Calcium-Dependent Translocation of cPLA2α to Membrane.

C. Leslie, B. Yun, 2017, Methods in enzymology.

Cytosolic Phospholipase A2 Translocates to Forming Phagosomes during Phagocytosis of Zymosan in Macrophages*[boxs]

C. Leslie, M. Girotti, John H. Evans, 2004, Journal of Biological Chemistry.

The Cytosolic Phospholipase A2 Catalytic Domain Modulates Association and Residence Time at Golgi Membranes*

C. Leslie, John H. Evans, 2004, Journal of Biological Chemistry.

A pyrrolidine-based specific inhibitor of cytosolic phospholipase A(2)alpha blocks arachidonic acid release in a variety of mammalian cells.

C. Leslie, M. Gelb, J. Turk, 2001, Biochimica et biophysica acta.

Dealing with large diagonals in kernel matrices

Jason Weston, William Stafford Noble, Bernhard Schölkopf, 2003 .

Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection

C. Leslie, R. Murphy, A. Dakhama, 2016, BMC Immunology.

Anionic phospholipids stimulate an arachidonoyl-hydrolyzing phospholipase A2 from macrophages and reduce the calcium requirement for activity.

C. Leslie, J. Channon, J Y Channon, 1990, Biochimica et biophysica acta.

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Levi N. Naden, Steven K. Albanese, Derek S. Tan, 2018, bioRxiv.

High-resolution in vivo identification of miRNA targets by Halo-Enhanced Ago2 Pulldown

C. Leslie, J. Paulo, Yuheng Lu, 2019, bioRxiv.

Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

C. Leslie, M. Gelb, B. Cravatt, 2017, Biochemical and biophysical research communications.

Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation*

C. Leslie, M. Gelb, B. Cravatt, 2013, The Journal of Biological Chemistry.

Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β)

C. Leslie, M. Gelb, M. Ghosh, 2006, Journal of Biological Chemistry.

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation

Christina C. Leslie, Joseph V. Bonventre, C. Leslie, 2013, PloS one.

Pathways Regulating Cytosolic Phospholipase A2 Activation and Eicosanoid Production in Macrophages by Candida albicans

C. Leslie, S. Akira, P. Taylor, 2010, The Journal of Biological Chemistry.

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

C. Leslie, J. Côté, O. Abdel-Wahab, 2015, eLife.

1 Cross-talk between PRMT 1-mediated methylation and ubiquitylation on RBM 15 controls RNA splicing 1

C. Leslie, J. Côté, O. Abdel-Wahab, 2015 .

Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2.

C. Leslie, Christina C Leslie, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.

Michael G. Kharas, C. Leslie, S. Armstrong, 2019, Cell stem cell.

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Scott A. Shaffer, David R. Goodlett, Aaron Arvey, 2012, Nature Immunology.

Proliferation of rat alveolar epithelial cells in low density primary culture.

C. Leslie, J. Shannon, R. Mason, 1993, American journal of respiratory cell and molecular biology.

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

Michael G. Kharas, N. Hacohen, C. Leslie, 2015, The Journal of clinical investigation.

Combining integrated genomics and functional genomics to dissect the biology of a cancer‐associated, aberrant transcription factor, the ASPSCR1–TFE3 fusion oncoprotein

C. Leslie, A. Olshen, M. Ladanyi, 2013, The Journal of pathology.

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix

C. Leslie, S. Lowe, K. Manova-Todorova, 2021, Molecular oncology.

Properties of the Group IV phospholipase A2 family.

C. Leslie, S. Burchett, M. Ghosh, 2006, Progress in lipid research.

Properties and Regulation of Cytosolic Phospholipase A2 *

C. Leslie, 1997, The Journal of Biological Chemistry.

Regulation of phospholipase A2 activation by phosphorylation in mouse peritoneal macrophages.

C. Leslie, Z. Qiu, M. S. D. de Carvalho, 1993, The Journal of biological chemistry.

Regulation of arachidonic acid availability for eicosanoid production.

C. Leslie, 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

C. Leslie, J. Channon, J Y Channon, 1990, The Journal of biological chemistry.

Resolution of pulmonary inflammation.

C. Leslie, G. Larsen, P. Henson, 1984, Federation proceedings.

Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

C. Leslie, A. Arvey, Li Zhang, 2010, Biochemical and biophysical research communications.

Phospholipase A2IVα Regulates Phagocytosis Independent of Its Enzymatic Activity*

C. Leslie, D. Corda, P. Cossart, 2012, The Journal of Biological Chemistry.

Induction of macrophage lysosomal hydrolase synthesis and secretion by beta-1,3-glucan.

C. Leslie, D. Riches, P. Henson, 1986, Cellular immunology.

Cytosolic phospholipase A2: physiological function and role in disease

C. Leslie, Christina C Leslie, 2015, Journal of Lipid Research.

Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol.

C. Leslie, J. Bonventre, L. Yang, 2001, Journal of lipid research.

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

Gabriela Chiosis, Hatice U. Osmanbeyoglu, Petar Jelinic, 2018, Nature Communications.

Group IV Phospholipase A2α Controls the Formation of Inter-Cisternal Continuities Involved in Intra-Golgi Transport

C. Leslie, A. Luini, D. Corda, 2009, PLoS biology.

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

Michael G. Kharas, N. Hacohen, C. Leslie, 2014, The Journal of experimental medicine.

Group V Secretory Phospholipase A2 Translocates to the Phagosome after Zymosan Stimulation of Mouse Peritoneal Macrophages and Regulates Phagocytosis*

C. Leslie, J. Bonventre, V. Hsu, 2006, Journal of Biological Chemistry.

Pharmacology of Alveolar Type II Cells

C. Leslie, K. Sugahara, R. Mason, 1984 .

Regulation of cytosolic phospholipase A2α by hsp90 and a p54 kinase in okadaic acid‐stimulated macrophages

C. Leslie, M. Gelb, M. Gijón, 2008, Journal of leukocyte biology.

Bronchoalveolar lavage fluid from normal rats stimulates DNA synthesis in rat alveolar type II cells.

C. Leslie, R. Mason, K. McCormick-Shannon, 1989, The American review of respiratory disease.

Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.

C. Leslie, D. Murray, J. Falke, 2005, Molecular biology of the cell.

Hypertrophic alveolar type II cells from silica-treated rats are committed to DNA synthesis in vitro.

C. Leslie, A. Suwabe, R. Mason, 1990, American journal of respiratory cell and molecular biology.

Identification of Phosphorylation Sites of Human 85-kDa Cytosolic Phospholipase A Expressed in Insect Cells and Present in Human Monocytes (*)

C. Leslie, J. Yates, M. Gelb, 1996, The Journal of Biological Chemistry.

Assaying phospholipase A2 activity.

C. Leslie, M. Gelb, Michael H Gelb, 2004, Methods in molecular biology.

The Role of Calcium and Phosphorylation of Cytosolic Phospholipase A2 in Regulating Arachidonic Acid Release in Macrophages*

C. Leslie, M. Gijón, D. M. Spencer, 1998, The Journal of Biological Chemistry.

Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.

C. Leslie, Z. Qiu, 1994, The Journal of biological chemistry.

The 85-kDa, arachidonic acid-specific phospholipase A2 is expressed as an activated phosphoprotein in Sf9 cells.

C. Leslie, F. McCormack, M. S. D. de Carvalho, 1993, Archives of biochemistry and biophysics.

The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells.

C. Leslie, S. Gerber, D. Murray, 2003, Molecular biology of the cell.

Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages.

C. Leslie, D. M. Detty, 1986, The Biochemical journal.

Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.

C. Leslie, J. García-Sancho, A. Alonso, 1997, The Biochemical journal.

A machine learning approach predicts essential genes and pharmacological targets in cancer

Gaurav Pandey, Coryandar Gilvary, Neel Madhukar, 2019, bioRxiv.

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Sun Mi Park, Levi N. Naden, Steven K. Albanese, 2019, Nature Communications.

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

C. Leslie, C. Leslie, S. Lowe, 2019, Nature Communications.

Cytosolic phospholipase A2: physiological function and role in disease

C. Leslie, 2015, Journal of Lipid Research.

Machine Learning in Computational Biology

William Stafford Noble, C. Leslie, G. Rätsch, 2007, NIPS 2007.

High resolution models of transcription factor-DNA anities improve in vitro and in vivo binding predictions: supplementary methods

C. Leslie, P. Agius, A. Arvey, 2010 .

Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2α in Regulating Interfacial Kinetics and Binding and Cellular Function*

James G. Bollinger, C. Leslie, M. Gelb, 2009, Journal of Biological Chemistry.

Transcription factor Foxp3 and its protein partners form a complex regulatory network

C. Leslie, D. Goodlett, A. Rudensky, 2012, Nature Immunology.

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

Martin L. Miller, Aly A. Khan, C. Sander, 2009, Nature Biotechnology.