M. Wick

发表

Chemoproteomics as a basis for post-genomic drug discovery.

P. Beroza, H. Villar, M. Wick, 2002, Drug discovery today.

CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation*

A Joly, N S Gray, P G Schultz, 1997, The Journal of Biological Chemistry.

Preclinical studies with platelet-activating factor antagonists in models of septic shock.

M. Wick, S. Kerwar, S. Dejoy, 1993, International journal of antimicrobial agents.

Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

P. Beroza, H. Villar, M. Wick, 2004, Journal of medicinal chemistry.

Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model.

Zvia Agur, David Sidransky, M. Wick, 2008, Cancer research.

Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.

M. Wick, R. Moran, A. Rosowsky, 1986, Biochemical pharmacology.

A New Structural Class of Proteasome Inhibitors that Prevent NF-κB Activation

M. Wick, A. Joly, S. Kerwar, 1998 .

A new structural class of proteasome inhibitors that prevent NF-kappa B activation.

M. Wick, A. Joly, S. Kerwar, 1998, Biochemical pharmacology.

HIV Type 1 Protease Activation of NF-κB within T Lymphoid Cells

M. Wick, R. Byrn, Z. Nan, 1995 .

L-dopa: selective toxicity for melanoma cells in vitro.

M. Wick, E. Frei, L. Byers, 1977, Science.

Dopamine: a novel antitumor agent active against B-16 melanoma in vivo.

M. Wick, 1978, The Journal of investigative dermatology.

Reduction of streptozotocin toxicity by 3-O-methyl-D-glucose with enhancement of antitumor activity in murine L1210 leukemia.

M. Wick, A. Rossini, D. Glynn, 1977, Cancer research.

Attenuation of interleukin 2-induced pulmonary vascular leak syndrome by low doses of oral methotrexate.

M. Wick, S. Kerwar, S. Schow, 1995, Cancer research.

Levodopa and dopamine analogs as DNA polymerase inhibitors and antitumor agents in human melanoma.

M. Wick, 1980, Cancer research.

Levodopa/dopamine analogs as inhibitors of DNA synthesis in human melanoma cells.

M. Wick, 1989, The Journal of investigative dermatology.

Melanoma cytotoxicity of buthionine sulfoximine (BSO) alone and in combination with 3,4-dihydroxybenzylamine and melphalan.

M. Wick, G. Fitzgerald, J. Prezioso, 1992, The Journal of investigative dermatology.

Reductionof StreptozotocinToxicity by 3-O-Methyl-D-glucose with Enhancementof AntitumorActivity in Murine L1210 Leukemia1

M. Wick, A. Rossini, D. Glynn, 1977 .

Bronchorrhea responsive to aerosolized atropine.

M. Wick, R. Ingram, 1976, JAMA.

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

M. Wick, A. Joly, R. Lum, 1998, Bioorganic & Medicinal Chemistry Letters.

Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2.

M. Wick, R. Paxton, S. Kerwar, 1995, Cellular immunology.

Effects of tyrosinase activity on the cytotoxicity of 3,4-dihydroxybenzylamine and buthionine sulfoximine in human melanoma cells.

M. Wick, G. Fitzgerald, J. Prezioso, 1989, Pigment cell research.

Methotrexate analogues--XVII. Antitumor activity of 4-amino-4-deoxy-N10-methylpteroyl-D,L-homocysteic acid and its dual inhibition of dihydrofolate reductase and folyl polyglutamate synthetase.

M. Wick, R. Moran, A. Rosowsky, 1984, Biochemical pharmacology.

Synthesis and in vivo antitumor activity of potential 5-fluorouracil prodrugs.

M. Wick, S. H. Kim, A. Rosowsky, 1982, Journal of medicinal chemistry.

Effect of high‐dose thymidine infusions in patients with mycosis fungoides

M. Wick, D. Kufe, P. Major, 1981, Cancer.

Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.

M. Wick, A. Rosowsky, J. Freisheim, 1983, Journal of medicinal chemistry.

Synthesis and biological activity of L-5-deazafolic acid and L-5-deazaaminopterin: synthetic strategies to 5-deazapteridines

M. Wick, G. P. Beardsley, A. Rosowsky, 1983 .

CHAPTER 29 – Preclinical Drug Development

M. Wick, C. Takimoto, 2007 .

3,4-Dihydroxybenzylamine: an improved dopamine analog cytotoxic for melanoma cells in part through oxidation products inhibitory to dna polymerase.

M. Wick, G. Fitzgerald, 1983, The Journal of investigative dermatology.

An experimental approach to the chemotherapy of melanoma.

M. Wick, 1980, The Journal of investigative dermatology.

Inhibition of clonogenic growth of melanoma cells by combination of melanocyte stimulating hormone and theophylline.

M. Wick, 1981, The Journal of investigative dermatology.

An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent.

M. Wick, T. Fitzpatrick, A. Sober, 1985, The Journal of investigative dermatology.

Polyhydroxylated phenylacrylic acid derivatives as new anti-tumor agents.

M. Wick, G. Fitzgerald, S. Hussoin, 1991, Journal of pharmaceutical sciences.

2,4-Dihydroxybenzylamine: a specific inhibitor of glutathione reductase.

M. Wick, G. Fitzgerald, M. S. Hussoin, 1991, Biochemical pharmacology.

Antitumor effects of biologic reducing agents related to 3,4-dihydroxybenzylamine: dihydroxybenzaldehyde, dihydroxybenzaldoxime, and dihydroxybenzonitrile.

M. Wick, G. Fitzgerald, 1987, Journal of pharmaceutical sciences.

Inhibition of transformation by levodopa-carbidopa in lymphocytes derived from patients with melanoma.

M. Wick, 1987, The Journal of investigative dermatology.

Sequential inhibitory effects of antitumor agents related to levodopa and dopamine upon DNA synthetic enzymes.

M. Wick, G. Fitzgerald, 1986, Biochemical pharmacology.

Inhibition of ribonucleotide reductase by antitumor agents related to levodopa and dopamine.

M. Wick, G. Fitzgerald, 1985, Biochemical pharmacology.

Inhibition of ribonucleotide reductase by naturally occurring quinols from spores of Agaricus bisporus.

M. Wick, A. Rosowsky, G. Fitzgerald, 1984, Biochemical and biophysical research communications.

Inhibition of reverse transcriptase by tyrosinase generated quinones related to levodopa and dopamine.

M. Wick, G. Fitzgerald, 1981, Chemico-biological interactions.

Synthesis and biologic evaluation of the dopamine analog N-acetyldopamine in experimental leukemia in mice.

M. Wick, A. Mui, 1981, Journal of the National Cancer Institute.

3,4-Dihydroxybenzylamine: a dopamine analog with enhanced antitumor activity against B16 melanoma.

M. Wick, 1979, Journal of the National Cancer Institute.

L‐DOPA METHYL ESTER AS A NEW ANTITUMOR AGENT

M. Wick, 1978 .

L-Dopa methyl ester as a new antitumour agent

M. Wick, 1977, Nature.

Selective incorporation of L-3,4-dihydroxyphenylalanine by S-91 Cloudman melanoma in vitro.

M. Wick, E. Frei, 1977, Cancer research.

The chemotherapy of malignant melanoma.

M. Wick, 1983, The Journal of investigative dermatology.

STRUCTURAL ANALOGS OF L-GLUTAMIC ACID Γ-(4-HYDROXYANILIDE) AND Γ-(3,4-DIHYDROXYANILIDE) AS POTENTIAL AGENTS AGAINST MELANOMA

M. Wick, S. H. Kim, A. Rosowsky, 1980 .

Structural analogues of L-glutamic Acid gamma-(4-hydroxyanilide) and gamma-(3,4-dihydroxyanilde) as potential agents against melanoma.

M. Wick, S. H. Kim, A. Rsoswsky, 1979, Journal of medicinal chemistry.

Enhancement of L-dopa incorporation into melanoma by dopa decarboxylase inhibition.

M. Wick, R. Kramer, M. Gorman, 1978, The Journal of investigative dermatology.

L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment.

M. Wick, 1978, Science.

Synthesis and antitumor activity of an acyclonucleoside derivative of 5-fluorouracil.

M. Wick, S. H. Kim, A. Rosowsky, 1981, Journal of medicinal chemistry.

A synthesis or indolizidines related to castanospermine and swainsonine.

M. Wick, R. Babine, S. Schow, 1993 .

Structure activity studies on pseudo-symmetrical HIV-1 protease inhibitors

M. Wick, R. Babine, S. Kerwar, 1993 .

Lipophilic 5'-(alkyl phosphate) esters of 1-beta-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs.

M. Wick, S. H. Kim, A. Rosowsky, 1982, Journal of medicinal chemistry.

Bowen's disease

M. Wick, Myung-Moo Lee, 1990, CA: a cancer journal for clinicians.

Bowen's disease

M. Wick, M. M. Lee, Myung-Moo Lee, 1990 .

Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.

M. Wick, G. Fitzgerald, 1987, Journal of Investigative Dermatology.

The mechanism of differential sensitivity to methotrexate of normal and malignant human epidermal cells

M. Wick, J. Ratliff, G. Fitzgerald, 2004, Cancer Chemotherapy and Pharmacology.

A comparison of the effects of antitumor agents upon normal human epidermal keratinocytes and human squamous cell carcinoma.

M. Wick, G. Fitzgerald, W. M. Firestone, 1990, The Journal of investigative dermatology.

Reducing agents structurally related to catechols as inhibitors of DNA synthesis in mammalian cells.

M. Wick, 1987, The Journal of investigative dermatology.

13 – Skin Cancer

M. Wick, F. Hodi, P. Friedlander, 2010 .

Selective toxicity of 6-hydroxydopa for melanoma cells.

M. Wick, J. Ratliff, L. Byers, 1979, The Journal of investigative dermatology.

Levodopa and dopamine analogs: melanin precursors as antitumor agents in experimental human and murine leukemia.

M. Wick, 1979, Cancer treatment reports.

Antitumor effects of L-glutamic acid dihydroxyanilides against experimental melanoma.

M. Wick, A. Rosowsky, J. Ratliff, 1980, The Journal of investigative dermatology.

Therapeutic effect of dopamine infusion on human malignant melanoma.

M. Wick, 1982, Cancer treatment reports.

Levodopa therapy and malignant melanoma.

M. Wick, A. Sober, 1978, JAMA.

Levodopa and dopamine analogs: dihydroxy and trihydroxybenzylamines as novel quinol antitumor agents in experimental leukemia in vivo.

M. Wick, 1981, Cancer treatment reports.

LIPOPHILIC 5′‐ALKYL PHOSPHATE ESTERS OF 1‐β‐D‐ARABINOFURANOSYLCYTOSINE AND ITS N4‐ACYL AND 2,2′‐ANHYDRO‐3′‐O‐ACYL DERIVATIVES AS POTENTIAL PRODRUGS

M. Wick, S. H. Kim, A. Rosowsky, 1982 .

Studies on the effect of CL 306,293, a substituted quinoline carboxylic acid, on the clinical disease induced in mice with LP-BM5 virus.

M. Wick, S. Kerwar, S. Dejoy, 1993, Antiviral research.

Comparison of cellular protooncogene activation and transformation-related activity of human melanocytes and metastatic melanoma.

M. Wick, Z. Husain, G. Fitzgerald, 1990, The Journal of investigative dermatology.

Relationship of the eye uptake of N-isopropyl-p-(/sup 123/I)iodoamphetamine to melanin production

M. Wick, Holman Bl, T. Hill, 1984 .

The relationship of the eye uptake of N-isopropyl-p-[123I]iodoamphetamine to melanin production.

M. Wick, B. Holman, J. Wu, 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Natural resistance to methotrexate in human melanomas.

M. Wick, D. Kufe, H. Abelson, 1980, The Journal of investigative dermatology.

Synthesis and biological evaluation of a series of HIV-1 protease inhibitors

M. Wick, R. Babine, S. Kerwar, 1993 .

Clinical characteristics of early cutaneous melanoma

M S Blois, M C Mihm, M. S. Blois, 1980, Cancer.

Role of ultraviolet radiation in the induction of melanocytic tumors in hairless mice following 7,12-dimethylbenz(a)anthracene application and ultraviolet irradiation.

M. Wick, Z. Husain, T. Flotte, 1991, Cancer research.

A fluorescence assay for geranylgeranyl transferase type I.

M. Wick, S. Kerwar, S. Schow, 1995, Analytical biochemistry.

Proceedings of the United States-Japan Melanoma and Skin Cancer Seminar on the Biology and Comparative Features

M. Wick, 1989 .

Synthesis and activity of 2,6,9-trisubstituted purines

M. Wick, A. Joly, S. Kerwar, 1997 .

Methotrexate analogues. 14. Synthesis of new gamma-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents.

M. Wick, A. Rosowsky, R. Forsch, 1981, Journal of medicinal chemistry.

Levodopa and Melanoma-Reply

M. Wick, A. Sober, 1979 .

Ferritin in Iron Metabolism: Diagnosis of Anemias

M. Wick, P. Lehmann, W. Pinggera, 1996 .

Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model.

M. Wick, Z. Agur, D. Sidransky, 2008, Cancer research.

Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors

M. Wick, R. Babine, S. Kerwar, 1994 .

Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: A new theranostic method combining xenografted biopsies with a mathematical model (Cancer Research (November 1, 2008) 68 (9033-9040))

M. Wick, Z. Agur, D. Sidransky, 2008 .