P. Toutain

发表

Comparative pharmacokinetics of doramectin and ivermectin in cattle.

P. Toutain, D. Upson, T. Terhune, 1997, Veterinary parasitology.

Blood clearance of the prion protein introduced by intravenous route in sheep is influenced by host genetic and physiopathologic factors

P. Toutain, V. Gayrard, G. Tabouret, 2008, Transfusion.

In vitro Degradation of Antimicrobials during Use of Broth Microdilution Method Can Increase the Measured Minimal Inhibitory and Minimal Bactericidal Concentrations

P. Toutain, E. Lallemand, M. Lacroix, 2016, Front. Microbiol..

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed‐effects to characterize and quantify variability in drug pharmacokinetics

P. Toutain, R. Gehring, D. Concordet, 2018, Journal of veterinary pharmacology and therapeutics.

The pharmacokinetic/pharmacodynamic paradigm for antimicrobial drugs in veterinary medicine: Recent advances and critical appraisal.

P. Toutain, J. Turnidge, P. Lees, 2020, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetics of tiludronate in horses: A field population study

P. Toutain, M. Popot, M. Jacobs, 2018, Equine veterinary journal.

Optimization of Antimicrobial Treatment to Minimize Resistance Selection.

P. Toutain, J. E. Olsen, L. Guardabassi, 2018, Microbiology spectrum.

En Route towards European Clinical Breakpoints for Veterinary Antimicrobial Susceptibility Testing: A Position Paper Explaining the VetCAST Approach

P. Toutain, P. Lees, D. Mevius, 2017, Front. Microbiol..

Use of Monte Carlo simulation to determine pharmacodynamic cutoffs of amoxicillin to establish a breakpoint for antimicrobial susceptibility testing in pigs.

P. Toutain, P. de Backer, S. Croubels, 2014, American journal of veterinary research.

The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics.

P. Toutain, J. D. Del Castillo, A. Bousquet-Mélou, 2002, Research in veterinary science.

Optimizing ciprofloxacin dosing in intensive care unit patients through the use of population pharmacokinetic-pharmacodynamic analysis and Monte Carlo simulations.

P. Toutain, G. Houin, C. Laffont, 2011, The Journal of antimicrobial chemotherapy.

Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida

P. Toutain, P. Lees, L. Pelligand, 2015, Journal of veterinary pharmacology and therapeutics.

Implementing Precision Antimicrobial Therapy for the Treatment of Bovine Respiratory Disease: Current Limitations and Perspectives

P. Toutain, S. Assié, F. El Garch, 2017, Front. Vet. Sci..

Intra- vs intermuscular injections in swine.

P. Toutain, H. Combrisson, P. Houpert, 1993, Veterinary research.

Plasma clearance.

P. Toutain, A. Bousquet-Mélou, 2004, Journal of veterinary pharmacology and therapeutics.

Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility

P. Toutain, M. Hedeland, U. Bondesson, 2021, BMC Veterinary Research.

Veterinary medicines and competition animals: the question of medication versus doping control.

P. Toutain, 2010, Handbook of experimental pharmacology.

Infection-stage adjusted dose of beta-lactams for parsimonious and efficient antibiotic treatments: A Pasteurella multocida experimental pneumonia in mice

P. Toutain, M. Lacroix, A. Ferran, 2017, PloS one.

Angiotensin-converting enzyme inhibitors in the therapy of renal diseases.

P. Toutain, H. Lefebvre, P. Toutain, 2004, Journal of veterinary pharmacology and therapeutics.

Determination of the pharmacokinetic-pharmacodynamic cut-off values of marbofloxacin in horses to support the establishment of a clinical breakpoint for antimicrobial susceptibility testing.

P. Toutain, M. Schneider, F. El Garch, 2020, Equine veterinary journal.

VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle

P. Toutain, P. Lees, P. Sidhu, 2019, Front. Microbiol..

Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling.

H. A. Haga, P. Toutain, T. E. Horsberg, 2011, Journal of veterinary pharmacology and therapeutics.

Evaluating a tylosin dosage regimen for treatment of Staphylococcus delphini infection in mink (Neovison vison): a pharmacokinetic-pharmacodynamic approach

P. Toutain, H. Frandsen, T. Struve, 2021, Veterinary Research.

Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media

P. Toutain, J. Standing, A. Mead, 2018, Journal of veterinary pharmacology and therapeutics.

A comprehensive model for enrofloxacin to ciprofloxacin transformation and disposition in dog.

P. Toutain, C. Cester, 1997, Journal of pharmaceutical sciences.

P. Toutain, D. Bibbal, A. Bousquet-Mélou, 2009, Applied and Environmental Microbiology.

Drug Selection and Optimization of Dosage Schedules To Minimize Antimicrobial Resistance

P. Toutain, D. Concordet, P. Lees, 2019, Antimicrobial Resistance in Bacteria of Animal Origin.

Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model

P. Toutain, F. El Garch, F. Woehrlé, 2018, Front. Microbiol..

A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle.

M. Alvinerie, P. Toutain, J. Fink-Gremmels, 2003, Veterinary research.

Bisphenol A in Thermal Paper Receipts: Taylor et al. Respond

P. Toutain, P. Hunt, Julia A. Taylor, 2012, Environmental Health Perspectives.

Characterization of the contribution of buccal absorption to internal exposure to bisphenol A through the diet.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Holding Thermal Receipt Paper and Eating Food after Using Hand Sanitizer Results in High Serum Bioactive and Urine Total Levels of Bisphenol A (BPA)

P. Toutain, Julia A. Taylor, M. Ellersieck, 2014, PloS one.

Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures.

P. Toutain, P. Hunt, Julia A. Taylor, 2014, Reproductive toxicology.

High Bioavailability of Bisphenol A from Sublingual Exposure

P. Toutain, V. Gayrard, N. Picard-Hagen, 2013, Environmental health perspectives.

Comparison of Serum Bisphenol A Concentrations in Mice Exposed to Bisphenol A through the Diet versus Oral Bolus Exposure

P. Toutain, M. Ellersieck, K. Kannan, 2011, Environmental health perspectives.

Estrogenicity of bisphenol a: a concentration-effect relationship on luteinizing hormone secretion in a sensitive model of prepubertal lamb.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Nonsteroidal anti-inflammatory agents: Species differences in pharmacodynamics

P. Toutain, Y. Ruckebusch, 1983, Veterinary Research Communications.

Emergence of Resistant Klebsiella pneumoniae in the Intestinal Tract during Successful Treatment of Klebsiella pneumoniae Lung Infection in Rats

P. Toutain, M. Laurentie, P. Sanders, 2010, Antimicrobial Agents and Chemotherapy.

Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats . 2 3 Running Title : Intestinal Impact of Fluoroquinolones 4 5 6

P. Toutain, M. Laurentie, P. Sanders, 2010 .

Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy

P. Toutain, D. Concordet, V. Laroute, 2002 .

The 2012 Antimicrobial Agents in Veterinary Medicine : exploring the consequences of antimicrobial drug use : a 3-D approach 1

P. Toutain, P. Silley, C. Cerniglia, 2017 .

Workshop report: the 2012 antimicrobial agents in veterinary medicine: exploring the consequences of antimicrobial drug use: a 3-D approach.

P. Toutain, P. Silley, C. Cerniglia, 2014, Journal of veterinary pharmacology and therapeutics.

Persistence and prevalence of pathogenic and extended-spectrum beta-lactamase-producing Escherichia coli in municipal wastewater treatment plant receiving slaughterhouse wastewater.

P. Toutain, É. Oswald, H. Brugère, 2013, Water research.

Simultaneous quantification of bisphenol A and its glucuronide metabolite (BPA-G) in plasma and urine: applicability to toxicokinetic investigations.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2011, Talanta.

Disposition of creatine kinase activity in dog plasma following intravenous and intramuscular injection of skeletal muscle homogenates.

P. Toutain, H. Lefebvre, P. Toutain, 1995, Journal of veterinary pharmacology and therapeutics.

Comment on “In Vitro Effects of Bisphenol A β-D-Glucuronide (BPA-G) on Adipogenesis in Human and Murine Preadipocytes”

P. Toutain, V. Gayrard, N. Picard-Hagen, 2015, Environmental health perspectives.

Conjugation and Deconjugation Reactions within the Fetoplacental Compartment in a Sheep Model: A Key Factor Determining Bisphenol A Fetal Exposure

P. Toutain, V. Gayrard, D. Zalko, 2015, Drug Metabolism and Disposition.

A nonlabeled method to evaluate cortisol production rate by modeling plasma CBG-free cortisol disposition.

M. Alvinerie, P. Toutain, V. Gayrard, 2001, American journal of physiology. Endocrinology and metabolism.

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.

P. Toutain, J. Elliott, P. Lees, 2014, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation.

P. Toutain, J. Elliott, P. Lees, 2012, Journal of veterinary pharmacology and therapeutics.

Influence of Inoculum Size and Marbofloxacin Plasma Exposure on the Amplification of Resistant Subpopulations of Klebsiella pneumoniae in a Rat Lung Infection Model

P. Toutain, M. Laurentie, P. Sanders, 2009, Antimicrobial Agents and Chemotherapy.

PHARMACOKINETICS AND PHARMACODYNAMICS OF MAVACOXIB IN THE DOG

P. Toutain, T. Kubiak, M. Krautmann, 2009 .

Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat

P. Toutain, J. Giraudel, V. Laroute, 2005, British journal of pharmacology.

COMPARATIVE KINETICS OF TWO ORALLY ADMINISTERED FLUOROQUINOLONES IN DOG : ENROFLOXACIN VERSUS MARBOFLOXACIN

P. Toutain, M. Schneider, C. Cester, 1996 .

Pharmacokinetics of meloxicam in plasma and urine of horses.

P. Toutain, V. Laroute, M. Popot, 2004, American journal of veterinary research.

Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis.

P. Toutain, D. Concordet, A. Regnier, 2008, American journal of veterinary research.

Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine.

P. Toutain, P. Lees, 2004, Journal of veterinary pharmacology and therapeutics.

Angiotensin-converting enzyme inhibitors in veterinary medicine.

P. Toutain, S. A. Brown, V. Chetboul, 2007, Current pharmaceutical design.

An in vivo model for pharmacokinetic studies in the kidney.

P. Toutain, B. Périquet, G. Larrieu, 1985, Journal of pharmacological methods.

Interindividual variability in plasma concentrations after systemic exposure of swine to dietary doxycycline supplied with and without paracetamol: a population pharmacokinetic approach.

P. Toutain, D. Concordet, J. D. Del Castillo, 2006, Journal of animal science.

Use of plasma creatine kinase pharmacokinetics to estimate the amount of excercise-induced muscle damage in Beagles.

P. Toutain, V. Laroute, G. Chanoit, 2001, American Journal of Veterinary Research.

Cortisol disposition and production rate in horses during rest and exercise.

M. Alvinerie, P. Toutain, V. Gayrard, 1996, The American journal of physiology.

PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology.

P. Toutain, J. Giraudel, P. Lees, 2004, Journal of veterinary pharmacology and therapeutics.

Plasma prion protein and creatinine levels in dogs with renal deficiency

P. Toutain, V. Gayrard, N. Picard-Hagen, 2008 .

The pharmacokinetics of xylazine hydrochloride: an interspecific study.

M. Alvinerie, P. Toutain, R. Garcia-Villar, 1981, Journal of veterinary pharmacology and therapeutics.

Urinary Cortisol excretion in the resting and exercising horse

M. Alvinerie, P. Toutain, V. Laroute, 2010 .

Pharmacokinetics of marbofloxacin in horses.

P. Toutain, M. Schneider, S. Bernard, 2010, Equine veterinary journal.

Measurement of glomerular filtration rate and effective renal plasma flow in the conscious beagle dog by single intravenous bolus of iohexol and p-aminohippuric acid.

P. Toutain, V. Laroute, H. Lefebvre, 1999, Journal of pharmacological and toxicological methods.

Effects of renal impairment on the disposition of orally administered enalapril, benazepril, and their active metabolites.

P. Toutain, D. Concordet, V. Laroute, 1999, Journal of veterinary internal medicine.

Pharmacokinetics of a recombinant bovine growth hormone and pituitary bovine growth hormone in lactating dairy cows.

P. Toutain, D. Schams, M. Laurentie, 1993, Journal of animal science.

Mixing of Shiga toxin-producing and enteropathogenic Escherichia coli in a wastewater treatment plant receiving city and slaughterhouse wastewater.

P. Toutain, É. Oswald, H. Brugère, 2017, International journal of hygiene and environmental health.

P. Toutain, D. Bibbal, A. Bousquet-Mélou, 2017 .

Creatine kinase in the dog: A review

P. Toutain, M. Aktaş, H. Lefebvre, 2005, Veterinary Research Communications.

A non-invasive and quantitative method for the study of tissue injury caused by intramuscular injection of drugs in horses.

M. Alvinerie, P. Toutain, H. Lefebvre, 1995, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves.

P. Toutain, P. Lees, P. Sidhu, 2011, Journal of veterinary pharmacology and therapeutics.

Antibiotic treatment of animals--a different approach to rational dosing.

P. Toutain, 2003, Veterinary journal.

Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf

P. Toutain, P. Lees, L. Pelligand, 2017, Journal of veterinary pharmacology and therapeutics.

Enantioselectivity of the enterohepatic recycling of carprofen in the dog.

P. Toutain, F. Garnier, N. Priymenko, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib

P. Toutain, J. Giraudel, J. Elliott, 2022, Journal of veterinary pharmacology and therapeutics.

Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib.

P. Toutain, J. Giraudel, P. Lees, 2009, Journal of veterinary pharmacology and therapeutics.

Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats.

P. Toutain, J. Giraudel, P. Lees, 2005, American journal of veterinary research.

Creatine kinase in dog plasma: preanalytical factors of variation, reference values and diagnostic significance.

P. Toutain, D. Concordet, H. Lefebvre, 1994, Research in veterinary science.

Development and validation of a new model of inflammation in the cat and selection of surrogate endpoints for testing anti-inflammatory drugs.

P. Toutain, J. Giraudel, P. Lees, 2005, Journal of veterinary pharmacology and therapeutics.

Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling.

M. Alvinerie, P. Toutain, C. Legrand, 1994, Journal of veterinary pharmacology and therapeutics.

In vitro inhibition of natural-killer-mediated lysis by chromatin fragments

P. Toutain, H. Benoist, G. Fournié, 1994, Cancer Immunology, Immunotherapy.

Pharmacokinetics, Distribution, Bioavailability, and Relationship to Antibiotic Residues

P. Toutain, P. Lees, 2011 .

A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie

P. Toutain, V. Gayrard, O. Andréoletti, 2005, British journal of pharmacology.

Maternal and fetal exposure to bisphenol a is associated with alterations of thyroid function in pregnant ewes and their newborn lambs.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2013, Endocrinology.

Synovial fluid and plasma kinetics of methylprednisolone and methylprednisolone acetate in horses following intra-articular administration of methylprednisolone acetate.

M. Alvinerie, P. Toutain, A. Autefage, 1986, Equine veterinary journal.

Circadian profile and production rate of melatonin in the cow.

P. Toutain, M. Laurentie, J. Ravault, 1990, Domestic animal endocrinology.

Instantaneous secretion rate of growth hormone in lambs: relationships with sleep, food intake, and posture.

P. Toutain, M. Laurentie, P. Marnet, 1989, Endocrinology.

Diurnal and episodic variations of plasma hydrocortisone concentrations in horses.

M. Alvinerie, P. Toutain, A. Autefage, 1988, Domestic animal endocrinology.

Dynamic interactions between cephalexin and macrophages on different Staphylococcus aureus inoculum sizes: a tripartite in vitro model

P. Toutain, E. Lallemand, S. Boullier, 2021, BMC Veterinary Research.

European Conference on Comparative Clinical Pathology (ECCP 95)

P. Toutain, V. Laroute, H. Lefebvre, 2004, Comparative Haematology International.

A new LC/MS method for specific determination of human systemic exposure to bisphenol A, F and S through their metabolites: Application to cord blood samples.

P. Toutain, V. Gayrard, A. Berrebi, 2021, Environment international.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2020, Environment international.

Microsoft Word-48080291-file00

P. Toutain, V. Gayrard, D. Zalko, 2015 .

Bisphenol A Disposition in the Sheep Maternal-Placental-Fetal Unit: Mechanisms Determining Fetal Internal Exposure1

P. Toutain, V. Gayrard, N. Picard-Hagen, 2013, Biology of reproduction.

Pharmacokinetic and pharmacodynamic parameters of ramipril and ramiprilat in healthy dogs and dogs with reduced glomerular filtration rate.

P. Toutain, E. Jeunesse, V. Laroute, 2006, Journal of veterinary internal medicine.

Increased GH secretion in scrapie, a prion-associated neurodegenerative disease, is not due to suppressed IGF-1 negative feedback.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2009, Domestic animal endocrinology.

Pharmacokinetic/Pharmacodynamic Analysis of the Influence of Inoculum Size on the Selection of Resistance in Escherichia coli by a Quinolone in a Mouse Thigh Bacterial Infection Model

P. Toutain, A. Ferran, A. Bousquet-Mélou, 2009, Antimicrobial Agents and Chemotherapy.

Impact of Low and High Doses of Marbofloxacin on the Selection of Resistant Enterobacteriaceae in the Commensal Gut Flora of Young Cattle: Discussion of Data from 2 Study Populations.

P. Toutain, H. Seegers, S. Assié, 2017, Foodborne pathogens and disease.

Effect of experimental renal impairment on disposition of marbofloxacin and its metabolites in the dog.

P. Toutain, M. Schneider, V. Laroute, 1998, Journal of veterinary pharmacology and therapeutics.

The effect of experimental renal failure on tolfenamic acid disposition in the dog.

M. Alvinerie, P. Toutain, M. Schneider, 1997, Biopharmaceutics & drug disposition.

DRUG PRESCRIPTION IN RENAL-IMPAIRED DOGS

P. Toutain, H. Lefebvre, J. Braun, 1996 .

Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review.

P. Toutain, J. Elliott, P. Lees, 2015, Journal of veterinary pharmacology and therapeutics.

Rebuttal to the reaction of the EGGVP to the review article 'the consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: the need for new antibiotics'.

P. Toutain, A. Bousquet-Mélou, 2014, Journal of veterinary pharmacology and therapeutics.

Comparison of standardised versus non-standardised methods for testing the in vitro potency of oxytetracycline against Mannheimia haemolytica and Pasteurella multocida.

P. Toutain, P. Lees, L. Pelligand, 2016, The Veterinary Journal.

Pharmacokinetic/pharmacodynamic integration and modelling of amoxicillin for the calf pathogens Mannheimia haemolytica and Pasteurella multocida.

P. Toutain, P. Lees, M. Lacroix, 2015, Journal of veterinary pharmacology and therapeutics.

WS03 Minimising antimicrobial resistance through rational design of dosing schedules: a role for pre‐clinical PK‐PD modelling?

P. Toutain, P. Lees, F. Aliabadi, 2006 .

Pharmacokinetic/pharmacodynamic assessment of the effects of parenteral administration of a fluoroquinolone on the intestinal microbiota: comparison of bactericidal activity at the gut versus the systemic level in a pig model.

P. Toutain, Marc Schneider, M. Laurentie, 2013, International journal of antimicrobial agents.

Competitive binding to plasma thyroid hormone transport proteins and thyroid disruption by phenylbutazone used as a probe.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2011, General and comparative endocrinology.

Pharmacokinetics of methylprednisolone succinate, methylprednisolone, and lidocaine in the normal dog and during hemorrhagic shock.

M. Alvinerie, P. Toutain, A. Autefage, 1987, Journal of pharmaceutical sciences.

Comparative benzylpenicillin pharmacokinetics in the dromedary Camelus dromedarius and in sheep.

P. Toutain, M. Oukessou, J. Hossaini, 1990, Journal of veterinary pharmacology and therapeutics.

Low or High Doses of Cefquinome Targeting Low or High Bacterial Inocula Cure Klebsiella pneumoniae Lung Infections but Differentially Impact the Levels of Antibiotic Resistance in Fecal Flora

P. Toutain, M. Laurentie, J. Henri, 2014, Antimicrobial Agents and Chemotherapy.

but differentially impact the levels of antibiotic resistance in

P. Toutain, M. Laurentie, Jérôme, 2014 .

Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2022, Environment international.

Development of an on-line solid phase extraction ultra-high-performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: Applicability to toxicokinetic investigations.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2017, Journal of chromatography. A.

Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs

P. Toutain, V. Gayrard, N. Picard-Hagen, 2019, Environmental health perspectives.

Plasma terminal half-life.

P. Toutain, P L Toutain, A. Bousquet-Mélou, 2004, Journal of veterinary pharmacology and therapeutics.

Simultaneous and minimally invasive assessment of muscle tolerance and bioavailability of different volumes of an intramuscular formulation in the same animals.

P. Toutain, V. Laroute, H. Lefebvre, 2006, Journal of animal science.

Validation of an automated technique for the measurement of glutathione S-transferase in plasma of sheep

P. Galtier, P. Toutain, J. Braun, 1996 .

In vivo non-invasive quantification of muscle damage following a single intramuscular injection of phenylbutazone in sheep.

P. Toutain, H. Lefebvre, P. Houpert, 1995, Veterinary and human toxicology.

Use of a pharmacokinetic/pharmacodynamic approach in the cat to determine a dosage regimen for the COX-2 selective drug robenacoxib.

P. Toutain, J. Giraudel, E. Jeunesse, 2009, Journal of Veterinary Pharmacology and Therapeutics.

Comparative incidence of experimental fascioliasis on corticosteroid pharmacokinetics in sheep.

P. Galtier, M. Alvinerie, P. Toutain, 1989, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Florfenicol concentrations in ovine tear fluid following intramuscular and subcutaneous administration and comparison with the minimum inhibitory concentrations against mycoplasmal strains potentially involved in infectious keratoconjunctivitis.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2013, American journal of veterinary research.

Is the mechanisms of fipronil-induced thyroid disruption specific of the rat: Re-evaluation of fipronil thyroid toxicity in sheep?

P. Toutain, V. Gayrard, N. Picard-Hagen, 2010, Toxicology letters.

Non-invasive and quantitative evaluation of post-injection muscle damage by pharmacokinetic analysis of creatine kinase release.

P. Toutain, V. Laroute, H. Lefebvre, 1996, Veterinary research.

Clinical enzymology for the assessment of organ damage: Interspecific differences

P. Toutain, H. Lefebvre, J. Braun, 1993, Comparative Haematology International.

Non-invasive quantification of organ damage

P. Toutain, V. Laroute, H. Lefebvre, 1995, Comparative Haematology International.

In vivo pharmacological characterization of alpha adrenergic receptors in sheep myometrium and their physiological meaning.

P. Toutain, M. Laurentie, P. Marnet, 1987, Biology of reproduction.

Species differences in pharmacokinetics and pharmacodynamics.

Alain Bousquet-Mélou, Aude Ferran, P. Toutain, 2010, Handbook of experimental pharmacology.

Interspecies variations of corticosteroid-binding globulin parameters.

M. Alvinerie, P. Toutain, V. Gayrard, 1996, Domestic animal endocrinology.

Fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes.

P. Toutain, V. Gayrard, E. Perdu, 2009, Toxicology.

Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

Laura N. Vandenberg, John Peterson Myers, Frederick S vom Saal, 2014, Environmental Health.

A history of antimicrobial drugs in animals: Evolution and revolution.

P. Toutain, P. Lees, E. Giraud, 2020, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetic/pharmacodynamic approach to assess irrelevant plasma or urine drug concentrations in postcompetition samples for drug control in the horse.

P. Toutain, V. Lassourd, 2010, Equine veterinary journal.

Licking behaviour and environmental contamination arising from pour-on ivermectin for cattle.

M. Alvinerie, P. Toutain, C. Laffont, 2001, International journal for parasitology.

Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors.

P. Toutain, P L Toutain, H P Lefèbvre, 2004, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetic/pharmacodynamic modelling of the disposition and effect of benazepril and benazeprilat in cats.

P. Toutain, J. N. King, M. Maurer, 2003, Journal of veterinary pharmacology and therapeutics.

Plasma exogenous creatinine clearance test in dogs: comparison with other methods and proposed limited sampling strategy.

P. Toutain, D. Concordet, V. Laroute, 2002, Journal of veterinary internal medicine.

Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach.

P. Toutain, H. Lefebvre, J. N. King, 2000, The Journal of pharmacology and experimental therapeutics.

New insights on effect of kidney insufficiency on disposition of angiotensin-converting enzyme inhibitors: case of enalapril and benazepril in dogs.

P. Toutain, V. Laroute, H. Lefebvre, 2000, The Journal of pharmacology and experimental therapeutics.

Bioavailability and its assessment.

P. Toutain, A. Bousquet-Mélou, 2004, Journal of veterinary pharmacology and therapeutics.

A large potentiation effect of serum on the in vitro potency of tulathromycin against Mannheimia haemolytica and Pasteurella multocida

P. Toutain, P. Lees, L. Pelligand, 2017, Journal of veterinary pharmacology and therapeutics.

Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

M. Alvinerie, P. Toutain, E. Lallemand, 2007, Journal of veterinary pharmacology and therapeutics.

Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland.

J. D. Baggot, M. Alvinerie, P. Toutain, 1984, American journal of veterinary research.

Prednisolone binding to plasma proteins in domestic species.

M. Alvinerie, P. Toutain, G. Houin, 1988, Journal of pharmaceutical sciences.

Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses

P. Toutain, Kazuaki Matsumoto, H. Niwa, 2020, Equine veterinary journal.

In vivo quantification of muscle damage in dogs after general anaesthesia with halothane and propofol.

P. Toutain, H. Lefebvre, A. Autefage, 1997, The Journal of small animal practice.

Diagnostic microbiology in veterinary dermatology: present and future

P. Toutain, L. Guardabassi, E. Broens, 2017, Veterinary dermatology.

Pharmacokinetics and local tolerance of a long-acting oxytetracycline formulation in camels.

P. Toutain, M. Oukessou, V. Uccelli-Thomas, 1992, American Journal of Veterinary Research.

Pharmacokinetics of oxytetracycline in young cattle: comparison of conventional vs long-acting formulations.

P. Toutain, J. Raynaud, 1983, American journal of veterinary research.

The consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: the need for new antibiotics.

P. Toutain, A. Bousquet-Mélou, 2013, Journal of veterinary pharmacology and therapeutics.

The role of pharmacokinetics in veterinary drug residues.

P. Toutain, P. Lees, 2012, Drug testing and analysis.

Guidelines for Antimicrobial Use in Horses

P. Toutain, J. Weese, K. Baptiste, 2009 .

Population Pharmacokinetic Study of Cefazolin Used Prophylactically in Canine Surgery for Susceptibility Testing Breakpoint Determination

P. Toutain, F. Di Cesare, P. Cagnardi, 2018, Front. Pharmacol..

Impact of Three Ampicillin Dosage Regimens on Selection of Ampicillin Resistance in Enterobacteriaceae and Excretion of blaTEM Genes in Swine Feces

P. Toutain, O. Fayet, D. Bibbal, 2007, Applied and Environmental Microbiology.

The Pharmacodynamics of Antimicrobial Agents

P. Toutain, J. Turnidge, Marilyn N. Martinez, 2013 .

Challenges obtaining a biowaiver for topical veterinary dosage forms.

P. Toutain, M. Peyrou, N. Monteiro-Riviere, 2012, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetics and tissue uptake of D-alpha-tocopherol in sheep following a single intraperitoneal injection.

P. Toutain, M. Hidiroglou, E. Charmley, 1995, Journal of dairy science.

Volumes of distribution.

P. Toutain, P L Toutain, A. Bousquet-Mélou, 2004, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetics and pharmacodynamics of stereoisomeric drugs with particular reference to bioequivalence determination.

P. Toutain, P. Lees, R. P. Hunter, 2012, Journal of veterinary pharmacology and therapeutics.

Veterinary pharmacology: history, current status and future prospects.

P. Toutain, J. Fink-Gremmels, P. Lees, 2013, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetic profile and in vitro selective cyclooxygenase-2 inhibition by nimesulide in the dog.

P. Toutain, P L Toutain, T. Haak, 2001, Journal of veterinary pharmacology and therapeutics.

A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog.

P. Toutain, V. Laroute, T. Haak, 2001, Journal of veterinary pharmacology and therapeutics.

Electrical and mechanical activity of the cervix in the ewe during pregnancy and parturition.

P. Toutain, C. Hanzen, R. Garcia-Villar, 1983, Journal of reproduction and fertility.

Kinetic studies and production rate of equine (e) FSH in ovariectomized pony mares. Application to the determination of a dosage regimen for eFSH in a superovulation treatment.

P. Toutain, T. Magallon, D. Guillaume, 2004, The Journal of endocrinology.

Kinetic evaluation of muscle damage during exercise by calculation of amount of creatine kinase released.

P. Toutain, P. Toutain, J. Braun, 1994, The American journal of physiology.

Effect of water deprivation on absorption (oral, intramuscular) and disposition of ampicillin in sheep.

P. Toutain, M. Oukessou, 1992, Journal of veterinary pharmacology and therapeutics.

Distribution of material injected intramuscularly in dogs.

P. Toutain, A. Autefage, P. Fayolle, 1990, American journal of veterinary research.

Pharmacokinetics of dexamethasone and its effect on adrenal gland function in the dog.

M. Alvinerie, P. Toutain, Y. Ruckebusch, 1983, American journal of veterinary research.

A preclinical pharmacokinetic/pharmacodynamic approach to determine a dose of GnRH, for treatment of ovarian follicular cyst in cattle.

P. Toutain, J. Guyonnet, S. Monnoyer, 2004, Journal of veterinary pharmacology and therapeutics.

GRF treatment of late pregnant ewes alters maternal and fetal somatotropic axis activity.

P. Toutain, C. Goodyer, A. Bousquet-Mélou, 1991, The American journal of physiology.

Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest.

P. Toutain, J. Giraudel, P. Lees, 2004, Journal of veterinary pharmacology and therapeutics.

Pattern of electrical activity of the ovine uterus and cervix from mating to parturition.

P. Toutain, R. Garcia-Villar, Y. Ruckebusch, 1984, Journal of reproduction and fertility.

Simultaneous Pharmacokinetic–Pharmacodynamic Modeling

P. Toutain, J. Riviere, 2011 .

Fenprostalene in cattle: Evaluation of oxytocic effects in ovariectomized cows and abortion potential in a 100-day pregnant cow.

P. Toutain, M. Laurentie, P. Marnet, 1987, Theriogenology.

Pharmacokinetics, pharmacodynamics, metabolism, toxicology and residues of phenylbutazone in humans and horses.

P. Toutain, P. Lees, 2013, Veterinary journal.

Differential responsiveness to oxytocin of the uterus and cervix in the ovariectomized ewe

P. Toutain, R. Garcia-Villar, Y. Ruckebusch, 1984 .

Secretory profiles and production rate of growth hormone in ruminant lambs.

P. Toutain, M. Laurentie, P. Marnet, 1987, Reproduction, nutrition, developpement.

Influence of sources of dietary vitamin E on the maternal transfer of α-tocopherol to fetal and neonatal guinea pigs as determined by a stable isotopic technique

P. Toutain, N. Hidiroglou, R. Madère, 2003, British Journal of Nutrition.

Testosterone administration to mares: criteria for detection of testosterone abuse by analysis of metabolites in plasma and urine.

P. Toutain, Y. Bonnaire, L. Dehennin, 1995, Journal of analytical toxicology.

Absence of circadian rhythm in the disposition of melatonin in the cow

P. Toutain, D. Concordet, J. Ravault, 1993, Journal of pineal research.

Are regular activity episodes of the genital tract controlled by pulsatile releases of oxytocin?

P. Toutain, D. Schams, R. Garcia-Villar, 1983, Biology of reproduction.

Veterinary Pharmacology and Toxicology

P. Toutain, G. Koritz, Y. Ruckebusch, 1983, Springer Netherlands.

Small bowel motility and colonic transit are altered in dogs with moderate renal failure.

P. Toutain, D. Concordet, V. Laroute, 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

Should licking behavior be considered in the bioavailability evaluation of transdermal products?

J. Sallovitz, C. Lanusse, P. Toutain, 2012, Journal of veterinary pharmacology and therapeutics.

Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin.

M. Alvinerie, P. Toutain, A. Bousquet-Mélou, 2004, International journal for parasitology.

Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

M. Alvinerie, P. Toutain, G. Chanoit, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Free drug fraction vs free drug concentration: a matter of frequent confusion.

P. Toutain, P L Toutain, A Bousquet-Melou, 2002, Journal of veterinary pharmacology and therapeutics.

Medication control of flunixin in racing horses: Possible detection times using Monte Carlo simulations

P. Toutain, F. Sato, S. Nagata, 2021, Equine veterinary journal.

In vivo quantification of muscle damage in dogs after intramuscular administration of drugs.

P. Toutain, H. Lefebvre, J. Braun, 1995, The British veterinary journal.

Steroidal anti-inflammatory agents in the horse: pharmacokinetics and action on the adrenal gland

P. Toutain, R. Brandon, 1983 .

Acute Changes in Muscle Blood Flow and Concomitant Muscle Damage after an Intramuscular Administration

P. Toutain, I. Raymond-Letron, H. Lefebvre, 2005, Pharmaceutical Research.

A simple method for the quantitative evaluation of neuromuscular blockade in mice.

P. Toutain, J. Bach, H. Lefebvre, 1992, Journal of pharmacological and toxicological methods.

The Decline and Fall of Materia Medica and the Rise of Pharmacology and Therapeutics in Veterinary Medicine

P. Toutain, P. Lees, W. Bäumer, 2022, Frontiers in Veterinary Science.

A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients

J. Sutra, P. Toutain, A. Bousquet-Mélou, 2021, Frontiers in Pharmacology.

Title: Large Impact of obesity on the disposition of ivermectin, moxidectin and eprinomectin in a canine model: relevance for COVID-19 patients. Short running title: obesity and pharmacokinetics of ivermectin, moxidectin and eprinomectin Authors:

J. Sutra, P. Toutain, A. Bousquet-Mélou, 2021 .

Dominant plasmids carrying extended-spectrum β-lactamases blaCTX-M genes in genetically diverse Escherichia coli from slaughterhouse and urban wastewaters.

P. Toutain, É. Oswald, H. Brugère, 2016, Environmental microbiology reports.

Effect of stage of oestrous cycle on tylosin disposition in genital tract secretions of cows.

P. Toutain, J. Ganière, C. Cester, 1993, Research in veterinary science.

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology.

P. Toutain, R. Gehring, M. Fink, 2013, Journal of veterinary pharmacology and therapeutics.

Longitudinal Analysis of Gene Expression in Porcine Skeletal Muscle After Post-Injection Local Injury

P. Toutain, A. Bonnet, M. Sancristobal, 2007, Pharmaceutical Research.

Antiretroviral unbound concentration during pregnancy: piece of interest in the puzzle?

P. Toutain, D. Metsu, P. Gandia, 2017, The Journal of antimicrobial chemotherapy.

Impact of three ampicillin dosage regimens on selection of ampicillin resistance in Enterobacteriaceae and excretion of bla 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 TEM genes in swine feces

P. Toutain, O. Fayet, D. Bibbal, 2010 .

AUC/MIC: a PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor?

P. Toutain, A. Bousquet-Mélou, Marilyn N. Martinez, 2007, The Journal of antimicrobial chemotherapy.

Céline M. Laffont, Patricia A. Hunt, P. Toutain, 2010, Environmental health perspectives.

Effect of premedication with acetylpromazine on the disposition kinetics of thiopental.

J. D. Baggot, M. Alvinerie, P. Toutain, 1984, Journal of veterinary pharmacology and therapeutics.

Application of pharmacological principles to dosage design of antimicrobial drugs

P. Toutain, École Nationale, P. Lees, 2015 .

Comparison of the reduction in the antibacterial potency of a fluoroquinolone conferred by a single mutation in the quinolone resistance-determining region or by the inoculum size effect.

P. Toutain, A. Ferran, A. Bousquet-Mélou, 2014, International journal of antimicrobial agents.

Comparison of the In vitro Activity of Five Antimicrobial Drugs against Staphylococcus pseudintermedius and Staphylococcus aureus Biofilms

P. Toutain, A. Ferran, A. Bousquet-Mélou, 2016, Front. Microbiol..

Bacterial Species-Specific Activity of a Fluoroquinolone against Two Closely Related Pasteurellaceae with Similar MICs: Differential In Vitro Inoculum Effects and In Vivo Efficacies

P. Toutain, F. El Garch, A. Ferran, 2015, PloS one.

Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus

P. Toutain, F. El Garch, F. Woehrlé, 2019, PloS one.

Validating an empiric sulfadiazine-trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink (Neovison vison).

P. Toutain, H. Frandsen, T. Struve, 2020, Journal of veterinary pharmacology and therapeutics.

The adrenocorticotropin stimulation test: contribution of a physiologically based model developed in horse for its interpretation in different pathophysiological situations encountered in man.

P. Toutain, N. Picard-Hagen, V. Laroute, 2006, Endocrinology.

Disposition of oxytetracycline in pigs after i.m. administration of two long-acting formulations.

P. Toutain, G. Gettinby, P. Lees, 2002, Journal of veterinary pharmacology and therapeutics.

Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2016, Environment international.

Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection.

P. Toutain, A. Ferran, A. Bousquet-Mélou, 2011, Veterinary microbiology.

Influence of Inoculum Size on the Selection of Resistant Mutants of Escherichia coli in Relation to Mutant Prevention Concentrations of Marbofloxacin

P. Toutain, A. Ferran, A. Bousquet-Mélou, 2007, Antimicrobial Agents and Chemotherapy.

Clinical, electroretinographic and histomorphometric evaluation of the retina in sheep with natural scrapie

P. Toutain, O. Andréoletti, F. Schelcher, 2011, BMC veterinary research.

Veterinary Medicine Needs New Green Antimicrobial Drugs

P. Toutain, P. Lees, A. Ferran, 2016, Front. Microbiol..

Benzylpenicillin kinetics in the ewe: influence of pregnancy and lactation.

P. Toutain, S. Benlamlih, M. Oukessou, 1990, Research in veterinary science.

Use of Mixture Dosing and Nonlinear Mixed Effect Modeling of Eight Environmental Contaminants in Rabbits to Improve Extrapolation Value of Toxicokinetic Data

P. Toutain, V. Gayrard, J. Antignac, 2021, Environmental health perspectives.

The withdrawal time estimation of veterinary drugs: a non-parametric approach.

P. Toutain, D. Concordet, P. Toutain, 1997, Journal of veterinary pharmacology and therapeutics.

Authors’ Reply to Castello-Bridoux et al.: “Comment on Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet, Pierre-Louis Toutain, Peggy Gandia, 2019, Clinical Pharmacokinetics.

Hydrocortisone secretion: production rate and pulse characterization by numerical deconvolution.

M. Alvinerie, P. Toutain, M. Laurentie, 1988, The American journal of physiology.

Dexamethasone concentrations in bovine blood plasma and milk after intravenous injection.

M. Alvinerie, P. Toutain, D. Tainturier, 1982, Journal of dairy science.

Dexamethasone in cattle: pharmacokinetics and action on the adrenal gland.

M. Alvinerie, P. Toutain, R. Brandon, 1982, Journal of veterinary pharmacology and therapeutics.

Prednisolone succinate and prednisolone acetate in cattle: pharmacokinetics and action on the adrenal gland.

M. Alvinerie, P. Toutain, G. Koritz, 1985, American journal of veterinary research.

Clinical evaluation of combined dexamethasone suppression/ACTH stimulation testing in dogs with hyperadrenocorticism, using HPLC for plasma cortisol determination.

M. Alvinerie, P. Toutain, A. Regnier, 1988, Zentralblatt fur Veterinarmedizin. Reihe A.

[Comparative pharmacokinetics of triclabendazole in camels and sheep].

P. Galtier, M. Alvinerie, P. Toutain, 1991, Revue d'Elevage et de Médecine Vétérinaire des Pays Tropicaux.

Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

P. Toutain, V. Gayrard, M. Lacroix, 2023, Journal of Veterinary Pharmacology and Therapeutics.

Route of administration and uterine response to oxytocin in the ewe.

P. Toutain, M. Laurentie, P. Marnet, 1986, Journal of Veterinary Pharmacology and Therapeutics.

Spontaneous motility of the cervix in cyclic and ovariectomized ewes and changes induced by exogenous hormones.

P. Toutain, J. Moré, R. Garcia-Villar, 1982, Journal of reproduction and fertility.

Relative oxytocic properties of fenprostalene compared with cloprostenol, prostaglandin F2 alpha, and oxytocin in the ovariectomized ewe.

P. Toutain, M. Laurentie, P. Marnet, 1985, American journal of veterinary research.

Comparative bioavailability between two routes of administration of florfenicol and flunixin in cattle

P. Toutain, M. Lacroix, Véronique Gayrard-Troy, 2011 .

Overestimation of the Predictive Value of Positives by the Usual Calculations of the Specificity of Diagnostic Tests

P. Toutain, D. Concordet, H. Lefebvre, 2000, Veterinary Research Communications.

Generation and processing of urinary and plasmatic metabolomic fingerprints to reveal an illegal administration of recombinant equine growth hormone from LC-HRMS measurements

P. Toutain, J. Antignac, G. Pinel, 2011, Metabolomics.

Evaluation and validation of an analytical approach for high-throughput metabolomic fingerprinting using direct introduction–high-resolution mass spectrometry: Applicability to classification of urine of scrapie-infected ewes

Véronique Gayrard, Estelle Rathahao-Paris, Sandra Alves, 2018, European journal of mass spectrometry.

Paw Inflammation Model in Dogs for Preclinical Pharmacokinetic/Pharmacodynamic Investigations of Nonsteroidal Anti-Inflammatory Drugs

P. Toutain, J. Giraudel, E. Jeunesse, 2011, Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetics of methylprednisolone, methylprednisolone sodium succinate, and methylprednisolone acetate in dogs.

M. Alvinerie, P. Toutain, G. Koritz, 1986, Journal of Pharmacy and Science.

Determination of methylprednisolone and methylprednisolone acetate in synovial fluid using high-performance liquid chromatography.

M. Alvinerie, P. Toutain, 1984, Journal of chromatography.

Prediction of human prenatal exposure to bisphenol A and bisphenol A glucuronide from an ovine semi-physiological toxicokinetic model

P. Toutain, V. Gayrard, N. Picard-Hagen, 2017, Scientific Reports.

Allometric scaling for predicting human clearance of bisphenol A.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2015, Toxicology and applied pharmacology.

Quantification of fipronil and its metabolite fipronil sulfone in rat plasma over a wide range of concentrations by LC/UV/MS.

P. Toutain, C. Viguié, M. Lacroix, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Toxicokinetics of bisphenol S in rats for predicting human bisphenol S clearance from allometric scaling.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2019, Toxicology and applied pharmacology.

Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2018, Environment international.

Interpreting Bisphenol A Absorption in the Canine Oral Cavity: Gayrard et al. Respond

P. Toutain, V. Gayrard, N. Picard-Hagen, 2013, Environmental health perspectives.

Metabolism of tritiated D-alpha-tocopherol and D-alpha-tocopheryl succinate in intraruminally dosed sheep.

P. Toutain, M. Hidiroglou, M. Ivan, 1994, Journal of animal science.

Pathologic study of an experimental canine arthritis induced with Complete Freund's Adjuvant.

P. Toutain, I. Oswald, T. Haak, 1996, Clinical and experimental rheumatology.

Sulfadimethoxine in giant freshwater prawns (Macrobrachium rosenbergii)

P. Toutain, S. Poapolathep, M. Giorgi, 2017, Journal of Veterinary Pharmacology and Therapeutics.

Assessment of alpha-2 adrenergic antagonists on the central nervous system using reticular contraction in sheep as a model.

P. Toutain, Y. Ruckebusch, M. Zingoni, 1982, The Journal of pharmacology and experimental therapeutics.

Simultaneous determination of corticosterone, hydrocortisone, and dexamethasone in dog plasma using high performance liquid chromatography.

M. Alvinerie, P. Toutain, 1982, Journal of Pharmacy and Science.

Cortisol concentrations in post competition horse urine: a French and British survey.

P. Toutain, P. Teale, D. Cowan, 1997, Equine veterinary journal.

In vivo and in vitro effects of three glucocorticoids on blood leukocyte chemotaxis in the dog.

M. Alvinerie, P. Toutain, J. Guelfi, 1985, Veterinary immunology and immunopathology.

Phenylbutazone in horses and man: Properties relevant to safety of humans consuming horse meat containing phenylbutazone and its metabolites

P. Toutain, P. Lees, 2013 .

Residue profile of phenylbutazone in the rabbit. A comparative evaluation by tissue kinetics prior to and post mortem

M. Alvinerie, P. Toutain, Y. Ruckebusch, 1980 .

New approaches to detect cortisol administration in the horse.

P. Toutain, V. Laroute, D. Cowan, 1999, Equine veterinary journal.

Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta.

P. Toutain, V. Gayrard, N. Picard-Hagen, 2019, Chemosphere.

Spiramycin concentrations in plasma and genital-tract secretions after intravenous administration in the ewe.

P. Toutain, M. Laurentie, R. Garcia-Villar, 1990, Journal of veterinary pharmacology and therapeutics.

Hyaluronan in horses: physiological production rate, plasma and synovial fluid concentrations in control conditions and following sodium hyaluronate administration.

P. Toutain, J. Guéchot, M. Popot, 2010, Equine veterinary journal.

Ascorbic acid disposition kinetics in the plasma and tissues of calves.

P. Toutain, M. Hidiroglou, P. Toutain, 1997, American journal of physiology. Regulatory, integrative and comparative physiology.

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula

P. Toutain, O. Dyar, L. Guardabassi, 2021, Antibiotics.

Pharmacokinetic variables and bioavailability from muscle of creatine kinase in cattle.

P. Toutain, H. Lefebvre, J. P. Serthelon, 1994, American journal of veterinary research.

The withdrawal time estimation of veterinary drugs revisited.

P. Toutain, D. Concordet, P. Toutain, 1997, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint.

P. Toutain, C. Cester, 2004, American journal of veterinary research.

Thiopentone pharmacokinetics and electrocorticogram pattern in sheep.

J. D. Baggot, M. Alvinerie, P. Toutain, 1983, Journal of veterinary pharmacology and therapeutics.

Author’s Reply to Trechot: “Comment on Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Authors’ Reply to Coste et al.: “Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs

P. Toutain, A. Bousquet-Mélou, M. Devreese, 2021, Frontiers in Veterinary Science.

Spurious urine excretion drug profile in the horse due to bedding contamination and drug recycling: the case of meclofenamic acid.

P. Toutain, M. Popot, Y. Bonnaire, 2007, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetics of tolfenamic acid in the horse.

P. Toutain, B. Barbier, D. Courtot, 2010, Equine veterinary journal. Supplement.

Effect of dietary nitrogen intake on gentamicin disposition in sheep.

P. Toutain, M. Oukessou, 1992, Journal of veterinary pharmacology and therapeutics.

Licking behaviour induces partial anthelmintic efficacy of ivermectin pour-on formulation in untreated cattle.

M. Alvinerie, P. Toutain, H. Hoste, 2011, International journal for parasitology.

Comparison of pharmacokinetic profiles of doramectin and ivermectin pour-on formulations in cattle.

M. Alvinerie, P. Toutain, V. Gayrard, 1999, Veterinary parasitology.

Establishing bioequivalence of veterinary premixes (Type A medicated articles).

P. Toutain, D. Concordet, P. Lees, 2012, Journal of Veterinary Pharmacology and Therapeutics.

Intestinal secretion is a major route for parent ivermectin elimination in the rat.

M. Alvinerie, P. Toutain, C. Laffont, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control.

P. Toutain, M. Thevis, E. Lallemand, 2021, Journal of veterinary pharmacology and therapeutics.

Comparison of veterinary drugs and veterinary homeopathy: part 2

P. Toutain, P. Lees, L. Pelligand, 2017, Veterinary Record.

Population pharmacokinetics of marbofloxacin in aqueous humor after intravenous administration in dogs.

P. Toutain, D. Concordet, B. Boisramé, 2003, American journal of veterinary research.

Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?

Pierre-Louis Toutain, Didier Concordet, Peggy Gandia, 2019, Clinical Pharmacokinetics.

Authors’ Reply to Yu et al.: “Levothyrox® New and Old Formulations: Are They Switchable for Millions of Patients?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Authors’ Reply to Lechat et al.: “Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Authors’ Reply to Nicolas: “Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Authors’ Reply to Nicolas: “Why Were More than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?”

P. Toutain, J. Montastruc, D. Concordet, 2019, Clinical Pharmacokinetics.

Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves

P. Toutain, A. Mead, L. Pelligand, 2022, Antimicrobial agents and chemotherapy.

of the

P. Toutain, L. Pelligand, A. Rycroft, 2018 .

Disposition of prednisolone in the course of subclinical fascioliasis in sheep.

J. Sutra, P. Galtier, M. Alvinerie, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Biased computation of probability of target attainment for antimicrobial drugs

P. Toutain, D. Concordet, P. Gandia, 2023, CPT: pharmacometrics & systems pharmacology.

Vitamin E kinetics after intraperitoneal administration of DL-alpha-tocopherol and DL-alpha-tocopherol acetate in sheep.

P. Toutain, N. Hidiroglou, M. Laurentie, 1992, Annales de recherches veterinaires. Annals of veterinary research.

Pharmacokinetic/pharmacodynamic integration in drug development and dosage-regimen optimization for veterinary medicine

P. Toutain, Pierre-Louis Toutain, 2008, AAPS PharmSci.

Variations of plasma creatine kinase in rabbits following repetitive blood sampling effects of pretreatment with acepromazine, carazolol and dantrolene.

P. Toutain, J. Jaeg, H. Lefebvre, 1992, European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.

Quantitative evaluation of an experimental inflammation induced with Freund's complete adjuvant in dogs.

P. Toutain, D. Concordet, C. Legrand, 1994, Journal of pharmacological and toxicological methods.

Pharmacokinetic study of 45Ca administered intravenously following intramuscular injection of vitamin D3 or 25-hydroxyvitamin D3 in early weaned lambs.

P. Toutain, S. Raffy, M. Hidiroglou, 1999, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

How to extrapolate a withdrawal time from an EHSLC published detection time: a Monte Carlo simulation appraisal.

P. Toutain, 2010, Equine veterinary journal.

Control of medication in horses: detection time, withdrawal time and beyond.

P. Toutain, 2013, The Veterinary Journal.

Effect of an endurance-like exercise on the disposition and detection time of phenylbutazone and dexamethasone in the horse: application to medication control.

P. Toutain, M. Doucet, M. Popot, 2010, Equine Veterinary Journal.

Demonstration of applicability of PK/PD concepts to determine a dosage regimen for tulathromycin in the calf

P. Toutain, P. Lees, L. Pelligand, 2015 .

Control of methylxanthines in the competition horse: pharmacokinetic/pharmacodynamic studies on caffeine, theobromine and theophylline for the assessment of irrelevant concentrations.

P. Toutain, M. Thevis, W. Schänzer, 2017, Drug testing and analysis.

Determination of xylazine in plasma using high-performance liquid chromatography.

M. Alvinerie, P. Toutain, 1981, Journal of chromatography.

Electromyographic evaluation of the spontaneous and drug-induced motility of the cervix in sheep.

P. Toutain, R. Garcia-Villar, Y. Ruckebusch, 1982, Journal of pharmacological methods.

Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens

P. Toutain, A. Mead, L. Pelligand, 2023, Scientific reports.

Modelling the loss of metabolic capacities of cultured hepatocytes: application to measurement of Michaelis-Menten kinetic parameters in in vitro systems

P. Toutain, V. Laroute, C. Laffont, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study

P. Toutain, J. Montastruc, 2020, Drug Safety.

Influence of feeding and analytical method on the bioequivalence of a racemic drug undergoing enantioselective enterohepatic recycling.

P. Toutain, V. Laroute, N. Priymenko, 2004, Journal of pharmaceutical sciences.

Sleep and activity, age and fatness, and the energy expenditure of confined sheep

J. D. McDonald, P. Toutain, A. Webster, 1977, British Journal of Nutrition.

Comparison of veterinary drugs and veterinary homeopathy: part 1

P. Toutain, L. Pelligand, P. Lees, 2017, Veterinary Record.

Re: "Evaluation of Enrofloxacin for Use in Cryopreservation of Zebu Bull (Bos indicus) Semen" by Ishaq et al. (Biopreserv Biobank 2019;[Epub ahead of print]; DOI: 10.1089/bio.2018.0133).

P. Toutain, J. Mochel, P. Dowling, 2020, Biopreservation and biobanking.

Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses

P. Toutain, E. Lallemand, A. Ferran, 2023, Frontiers in Microbiology.

Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

P. Toutain, E. Jeunesse, F. Woehrlé, 2013, BMC Veterinary Research.

Use of Monte Carlo simulation to determine pharmacodynamic cutoffs of amoxicillin to establish a breakpoint for antimicrobial susceptibility testing in pigs.

P. Toutain, P. de Backer, S. Croubels, 2014, American journal of veterinary research.

Pharmacokinetic/pharmacodynamic approach to assess irrelevant plasma or urine drug concentrations in postcompetition samples for drug control in the horse.

P. Toutain, V. Lassourd, 2010, Equine veterinary journal.

[3H]idazoxan binding to the ovine myometrium. Binding characteristics and changes due to steroid hormones.

P. Toutain, M. Lafontan, R. Garcia-Villar, 1990, The Journal of pharmacology and experimental therapeutics.

Preclinical pharmacology of robenacoxib: a novel selective inhibitor of cyclooxygenase-2.

P. Toutain, P. Lees, R. Fujimoto, 2009, Journal of veterinary pharmacology and therapeutics.

Impact of Low and High Doses of Marbofloxacin on the Selection of Resistant Enterobacteriaceae in the Commensal Gut Flora of Young Cattle: Discussion of Data from 2 Study Populations.

P. Toutain, H. Seegers, S. Assié, 2017, Foodborne pathogens and disease.

Quantification of fipronil and its metabolite fipronil sulfone in rat plasma over a wide range of concentrations by LC/UV/MS.

P. Toutain, C. Viguié, M. Lacroix, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Exposure variability of fosfomycin administered to pigs in food or water: impact of social rank.

P. Toutain, M. O. Tapia, A. Soraci, 2014, Research in veterinary science.

Kinetic and insecticidal properties of ivermectin residues in the milk of dairy cows.

P. Galtier, M. Alvinerie, P. Toutain, 1988, Journal of veterinary pharmacology and therapeutics.

CHAPTER 6 Pharmacokinetic Modeling of the Disposition of Topical Ivermectin in Cattle as determined by Animal Behaviour

M. Alvinerie, P. Toutain, J. Fink-Gremmels, 2002 .