J. Downing

J. Downing, S. Shurtleff, Anami R Patel, 2003, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Genomic Characterization and Experimental Modeling Of BCR-ABL1 -Like Acute Lymphoblastic Leukemia

Michael C. Rusch, M. Loh, J. Downing, 2013 .

An unexpected protein interaction promotes drug resistance in leukemia

J. Downing, Jing Ma, Taosheng Chen, 2017, Nature Communications.

Rare allelic forms of PRDM9 associated with childhood leukemogenesis

J. Downing, P. Awadalla, G. Gibson, 2013, Genome research.

St. Jude Cloud—a Pediatric Cancer Genomic Data Sharing Ecosystem

Aman N. Patel, Carmen L. Wilson, Samuel W. Brady, 2020, bioRxiv.

Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.

M. Loh, J. Downing, J. McPherson, 2016, Cancer cell.

Contribution of genetic variation and developmental stage to methylome dynamics in myeloid differentiation

J. Downing, Beisi Xu, J. Easton, 2017, bioRxiv.

Proceedings of the 15th Annual UT-KBRIN Bioinformatics Summit 2016

Bernie J. Daigle, Kelly L. Sovacool, Benjamin J. Harrison, 2016, BMC Bioinformatics.

Childhood acute lymphoblastic leukemia with equivocal chromosome markers of the t(I;I9) translocation

J. Downing, F. Behm, S. Raimondi, 1995 .

Human t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency.

J. Downing, M. Borowitz, A. Carroll, 1993, Blood.

The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia.

J. Downing, S. Raimondi, D. Head, 1994, Blood.

A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1.

J. Downing, H. Harada, A. Kimura, 2001, Biochemical and biophysical research communications.

Abstract 4869: Whole genome sequence analysis of MLL rearranged infant acute lymphoblastic leukemias reveals remarkably few somatic mutations: A Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Michael C. Rusch, R. Wilson, E. Mardis, 2012 .

CREBBP Mutations In Relapsed Acute Lymphoblastic Leukemia

J. Downing, C. Pui, K. Buetow, 2010 .

Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia

J. Downing, S. Shurtleff, Jen-Fen Fu, 2001, Genes, chromosomes & cancer.

Reference alignment of SNP microarray signals for copy number analysis of tumors

Cheng Cheng, Stan Pounds, James R. Downing, 2009, Bioinform..

Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line

J. Downing, C. Sherr, C. W. Rettenmier, 1988, Molecular and cellular biology.

Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors

Anang A. Shelat, Elaine R. Mardis, Elizabeth Stewart, 2017, Nature.

J. Downing, Ming Yan, D. Tenen, 2014, Blood.

hematopoiesis in mice Runx1 exon 6 related alternative splicing isoforms differentially regulate

J. Downing, Ming Yan, Dong-er Zhang, 2014 .

Golub , Monitoring and Class Prediction by Gene Expression Molecular Classification of Cancer : Class Discovery

J. Mesirov, E. Lander, D. Slonim, 2007 .

Rearrangement of CRLF 2 in B-progenitor – and Down syndrome – associated acute lymphoblastic leukemia

J. Downing, S. Raimondi, C. Pui, 2009 .

Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy

J. Downing, S. Shurtleff, S. Raimondi, 2015, British journal of haematology.

The genomic landscape of pediatric acute lymphoblastic leukemia

Diane A. Flasch, Samuel W. Brady, Michael C. Rusch, 2022, Nature Genetics.

Use of Genomic Technologies to Identify Novel Genetic Abnormalities and Therapeutic Targets In Acute Lymphoblastic Leukemia.

J. Downing, M. Relling, D. Gerhard, 2008 .

Extraction of cellular DNA from human cells and tissues fixed in ethanol.

J. Downing, E. Wakeland, L. Smith, 1987, Analytical biochemistry.

NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction for Detecting the t(2;5) of Non-Hodgkin's Lymphoma.

J. Downing, S. Shurtleff, S. Morris, 2001, Methods in molecular medicine.

primary erythroid cells The AML1-ETO fusion gene promotes extensive self-renewal of human

J. Downing, A. Burnett, R. Darley, 2013 .

Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue ofAML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy

J. Downing, S. Akira, K. Takeda, 2000, Molecular and Cellular Biology.

Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11

J. Downing, D. Steinemann, C. Mullighan, 2007, Oncogene.

Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.

J. Downing, M. L. Le Beau, Shann-Ching Chen, 2015, Blood.

The Role of the AML1 Transcription Factor in Leukemogenesis

J. Downing, R. Lorsbach, 2001, International journal of hematology.

age childhood acute lymphoblastic leukemia, regardless of presenting Rearrangement of the MLL gene confers a poor prognosis in

J. Downing, F. Behm, S. Raimondi, 2011 .

Childhood A cute L ymphoblastic L eukemia W ith t he MLL-ENL Fusion a nd t (11;19)(q23;p13 .3) T ranslocation

J. Downing, F. Behm, S. Raimondi, 1999 .

Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features.

J. Downing, F. Behm, S. Raimondi, 1995, Blood.

Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.

J. Downing, A. Carroll, F. Uckun, 1994, Blood.

11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.

J. Downing, S. Shurtleff, F. Behm, 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia

J. Downing, S. Raimondi, D. Head, 1994 .

Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication

J. Downing, D. Ellison, A. Davidoff, 2017, Pediatric blood & cancer.

Genomic landscape of pediatric adrenocortical tumors article available. Please share how this access benefits you. Your story matters

Heather L. Mulder, Manne, E. Mardis, 2015 .

Mutations in the B-Cell Transcription Factor PAX5 Found in B-Progenitor Acute Lymphoblastic Leukemia Impair Normal PAX5 Activity.

Christopher B. Miller, J. Downing, C. Mullighan, 2006 .

Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.

J. Downing, C. Mullighan, C. Sherr, 2008, Genes & development.

Somatic mutations of the aml-1 gene are frequent in acute myeloid leukemia with fab mo morphology

J. Downing, F. Behm, L. Shih, 2000 .

Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin.

J. Downing, E. Jaffe, A. Feldman, 2004, The Lancet. Oncology.

Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction.

J. Downing, D. Weisenburger, S. Shurtleff, 1995, Blood.

Reverse transcriptase polymerase chain reaction for the Ki-1 anaplastic large cell lymphoma-associated t(2;5) translocation in Hodgkin's disease.

J. Downing, M. Ladanyi, S. Morris, 1994, The American journal of pathology.

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

J. Downing, E. Passegué, Jing Ma, 2015, eLife.

Mutations in the RAS Signaling, B-Cell Development, TP53/RB1, and JAK Signaling Pathways Are Common in High Risk B-Precursor Childhood Acute Lymphoblastic Leukemia (ALL): A Report From the Children's Oncology Group (COG) High-Risk (HR) ALL TARGET Project.

M. Loh, J. Downing, M. Relling, 2009 .

Next Generation Transcriptomic Resequencing Identifies Novel Genetic Alterations in High-Risk (HR) Childhood Acute Lymphoblastic Leukemia (ALL): A Report From the Children's Oncology Group (COG) HR ALL TARGET Project.

M. Loh, J. Downing, M. Relling, 2009 .

The core-binding factor leukemias: lessons learned from murine models.

J. Downing, 2003, Current opinion in genetics & development.

Diffuse large cell lymphoma in a patient with hairy cell leukemia: immunoglobulin gene analysis reveals separate clonal origins.

J. Downing, C. Grossi, P. Burrows, 1986, Blood.

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

Jacob D. Jaffe, J. Downing, S. Carr, 2013, Nature Genetics.

The non-Hodgkin's lymphoma-associated t(2;5) translocation: Molecular biology and clinical features

J. Downing, S. Morris, 1994 .

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

J. Downing, S. Shurtleff, M. Roussel, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Structural features of the colony‐stimulating factor 1 receptor that affect its association with phosphatidylinositol 3‐kinase.

J. Downing, S. Shurtleff, C. Rock, 1990, The EMBO journal.

Impact of genetic variation in FKBP5 on clinical response in pediatric acute myeloid leukemia patients: a pilot study

J. Downing, D. Campana, R. Ribeiro, 2011, Leukemia.

Emi1 Maintains Genomic Integrity during Zebraﬁsh Embryogenesis and Cooperates with p53 in Tumor Suppression (cid:1)

J. Downing, D. Neuberg, A. Look, 2009 .

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.

J. Downing, J. Korbel, I. Radtke, 2012, Blood.

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.

J. Downing, K. Dobbin, C. Mullighan, 2010, Blood.

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.

J. Downing, P. Pandolfi, R. M. Simpson, 2002, Blood.

CD16+ NK lymphoproliferative disorders: cellular and molecular characterization.

J. Downing, C. Grossi, V. Pistoia, 1987, Natural immunity and cell growth regulation.

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

T. Golub, J. Downing, S. Shurtleff, 1996, Molecular and cellular biology.

Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase

J. Downing, S. Shurtleff, C. Sherr, 1991, Molecular and cellular biology.

Rearrangement of CRLF 2 is associated with mutation of JAK kinases , alteration of IKZF 1 , Hispanic / Latino ethnicity , and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia *

J. Downing, K. Dobbin, C. Mullighan, 2010 .

Expression of a conditional AML 1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t ( 8 ; 21 ) acute myeloid leukemia

J. Downing, E. Yeoh, N. Lenny, 2002 .

Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia

J. Downing, S. Raimondi, C. Pui, 2009, Nature Genetics.

The Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Sub-Classification of Leukemia: Final Report on 3252 Cases from the International MILE Study Group

J. Downing, S. Shurtleff, J. D. Vos, 2008 .

Pediatric Acute Myeloid Leukemia with Nucleophosmin Mutations Is Characterized by a Gene Expression Signature with Dysregulated HOX Gene Expression Distinct from MLL-Rearranged Leukemias.

J. Downing, S. Shurtleff, Xiaodong Zhou, 2005 .

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2014, The New England journal of medicine.

A New FOXO Pathway Required for Leukemogenesis

J. Downing, 2011, Cell.

High-Resolution SNP Array Profiling of Relapsed Acute Leukemia Identifies Genomic Abnormalities Distinct from Those Present at Diagnosis.

J. Downing, S. Shurtleff, I. Radtke, 2007 .

ERG Deletions Define a Novel Subtype of B-Progenitor Acute Lymphoblastic Leukemia.

Christopher B. Miller, J. Downing, S. Shurtleff, 2007 .

Genome-Wide Profiling of High-Risk Pediatric Acute Lymphoblastic Leukemia (ALL): The ALL Pilot Project for the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) Initiative.

J. Downing, M. Relling, Jing Ma, 2007 .

High-Resolution SNP-Array Profiling of Chronic Lymphocytic Leukemia

J. Downing, I. Radtke, L. Bullinger, 2010 .

Annual review of pathology : mechanisms of disease

James R. Downing, J. Downing, A. Abbas, 2006 .

Coding polymorphisms in CD 33 and response to gemtuzumab ozogamicin in pediatric patients with AML

Xueyuan Cao, Jeffrey E. Rubnitz, James R. Downing, 2009 .

Biomechanical Evaluation and Driver Experience with the Head and Neck Support

Robert P. Hubbard, Paul C. Begeman, James R. Downing, 1994 .

Expression of the AML-1 Oncogene Shortens the G1Phase of the Cell Cycle*

James R. Downing, J. Downing, N. Lenny, 2000, The Journal of Biological Chemistry.

Combination of Cladribine and Cytarabine is Effective for Childhood Acute Myeloid Leukemia: Results of the St. Jude AML97 Trial

Dario Campana, Jeffrey E. Rubnitz, James R. Downing, 2009, Leukemia.

Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain.

J. Downing, M. Roussel, C. Sherr, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Molecular analysis of the PML/RARα chimeric gene in pediatric acute promyelocytic leukemia

J. Downing, S. Shurtleff, F. Behm, 1996 .

Ikaros and acute leukemia

J. Downing, C. Mullighan, 2008, Leukemia & lymphoma.

ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain

James R. Downing, Hironori Harada, J. Downing, 2001, Molecular and Cellular Biology.

Diffuse large cell lymphoma in a patient with hairy cell leukemia: immunoglobulin gene analysis reveals separate clonal origins.

J. Downing, C. Grossi, P. Burrows, 1986, Blood.

Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses

Paul G. Thomas, Robert A. Carter, Jinghui Zhang, 2019, Science Translational Medicine.

Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts

J. Downing, M. L. Le Beau, Shann-Ching Chen, 2014, Haematologica.

Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia.

Elaine Coustan-Smith, Dario Campana, Xueyuan Cao, 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

R. Wilson, E. Mardis, J. Downing, 2017, Neuron.

TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.

J. Downing, S. Shurtleff, F. Behm, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Case-control study suggests a favorable impact of TEL rearrangement in patients with B-lineage acute lymphoblastic leukemia treated with antimetabolite-based therapy: a Pediatric Oncology Group study.

J. Downing, F. Behm, C. Pui, 1997, Blood.

Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital.

J. Downing, S. Shurtleff, F. Behm, 2009, Blood.

Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells.

J. Downing, A. Payne, K. Wong, 1980, Endocrinology.

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

J. Downing, M. Yi, N. Copeland, 2009, PLoS genetics.

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

J. Downing, S. Hiebert, S. Meyers, 1993, Molecular and cellular biology.

Studies on mitochondrial protein kinase activity of porcine corpora lutea.

J. Downing, M. J. Dimino, 1979, Endocrinology.

Acute myeloid leukemia.

J. Downing, B. Löwenberg, A. Burnett, 1999, The New England journal of medicine.

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

Amar Gajjar, Robert Huether, Xiaotu Ma, 2014, Nature Genetics.

Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas

Li Ding, Elaine R. Mardis, Amar Gajjar, 2012, Nature Genetics.

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia

J. Downing, J. Aster, W. Pear, 2014, Nature.

Use of Reverse Transcriptase Polymerase Chain Reaction for Diagnosis and Staging of Alveolar Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, and Desmoplastic Small Round Cell Tumor

J. Downing, S. Shurtleff, A. Pappo, 2001, Journal of pediatric hematology/oncology.

Germline Mutations in Predisposition Genes in Pediatric Cancer.

Li Ding, Amar Gajjar, Xiaotu Ma, 2015, The New England journal of medicine.

Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes.

M. Loh, J. Downing, J. Klco, 2018, JCI insight.

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

J. Downing, S. Shurtleff, S. Raimondi, 2009, Proceedings of the National Academy of Sciences.

Supplementary Notes MicroRNA Expression Profiles Classify Human Cancers

T. Golub, J. Downing, G. Getz, 2005 .

Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols.

J. Downing, C. Pui, W. Evans, 2006, Blood.

HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells

J. Downing, C. Naeve, D. Rice, 1999, Molecular and Cellular Biology.

Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

Jinghui Zhang, Matthew Parker, Elaine R Mardis, 2012, JAMA.

Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate

J. Downing, J. Garcia, T. Luo, 1997, Journal of virology.

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

J. Downing, D. Largaespada, B. Moriarity, 2016, Oncogene.

C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma

Li Ding, Elaine R. Mardis, Timothy N. Phoenix, 2014, Nature.

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2014, Nature Communications.

Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology

Heather L. Mulder, Michael C. Rusch, R. Wilson, 2016, Acta Neuropathologica.

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.

J. Downing, A. Rust, C. Mullighan, 2015, Blood.

The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias

Cheng Cheng, Li Ding, Robert Huether, 2015, Nature Genetics.

Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.

M. Loh, J. Downing, D. Gerhard, 2013, Blood.

lymphoblastic leukemia: a report from the Children's Oncology Group Key pathways are frequently mutated in high-risk childhood acute

Michael N. Edmonson, J. Downing, M. Relling, 2013 .

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Heather L. Mulder, S. Ranade, R. Wilson, 2012, Cancer cell.

report from The Children's Oncology Group TARGET Project Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a

Michael N. Edmonson, M. Loh, J. Downing, 2012 .

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Michael N. Edmonson, M. Loh, J. Downing, 2011, Blood.

Genomic Assessment of Pediatric Acute Leukemia

J. Downing, C. Mullighan, C. Flotho, 2005, Cancer journal.

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

J. Downing, C. Naeve, D. Shapiro, 1993, Cancer research.

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

J. Downing, J. Dick, A. Poeppl, 2011, Nature.

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.

Li Ding, Xiaotu Ma, Jinghui Zhang, 2014, Cancer discovery.

The genomic landscape of core-binding factor acute myeloid leukemias

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2016, Nature Genetics.

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions

J. Downing, C. Mullighan, J R Downing, 2009, Leukemia.

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

Howard Y. Chang, J. Rinn, D. Witten, 2009, Cell stem cell.

Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.

J. Downing, S. Morrison, H. Ames, 2009, Cancer cell.

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.

Elizabeth Stewart, Jinghui Zhang, Heather L. Mulder, 2018, Cancer cell.

Non-Hodgkin's lymphoma in childhood.

J. Downing, C. Pui, J. Sandlund, 1996, The New England journal of medicine.

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.

Cheng Cheng, Elaine Coustan-Smith, Dario Campana, 2009, The Lancet. Oncology.

Satelite Symposium V, Meet-the-Professor Sessions I and II, Main Sessions I-IX

J. Downing, M. Relling, D. Campana, 2004, Annals of Hematology.

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.

Dario Campana, James Downing, Sheila Shurtleff, 2005, Blood.

The neoepitope landscape in pediatric cancers

Michael N. Edmonson, J. Downing, D. Green, 2017, Genome Medicine.

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors.

J. Downing, Weili Sun, 2004, Blood.

THE AML1‐ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE

J. Downing, 1999, British journal of haematology.

St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem.

Aman N. Patel, Carmen L. Wilson, Samuel W. Brady, 2021, Cancer discovery.

The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment

Benjamin J. Raphael, Heather L. Mulder, Samuel W. Brady, 2019, Molecular Cancer Research.

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells.

J. Downing, A. Burnett, R. Darley, 2003, Blood.

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

J. Downing, Jing Ma, Guangchun Song, 2018, Nature Communications.

Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia

J. Downing, Jing Ma, C. Mullighan, 2008 .

Tumor-specific genetic lesions and their influence on therapy in pediatric acute lymphoblastic leukemia.

J. Downing, C. Mullighan, 2006, Hematology. American Society of Hematology. Education Program.

Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)

Shondra M. Pruett-Miller, J. Downing, Cheng Cheng, 2021, Scientific Reports.

Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age.

J. Downing, F. Behm, S. Raimondi, 1996, Blood.

Favorable impact of the t(9;11) in childhood acute myeloid leukemia.

J. Downing, S. Shurtleff, F. Behm, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation.

J. Downing, F. Behm, S. Raimondi, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

Aman N. Patel, Samuel W. Brady, Michael C. Rusch, 2021, Cancer discovery.

subtypes of T-cell acute lymphoblastic leukemia tumor suppressor is mutated across the major molecular BCL11B The

J. Downing, L. Chin, F. Alt, 2013 .

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.

J. Downing, L. Chin, F. Alt, 2011, Blood.

Molecular analysis of t(11;19) breakpoints in childhood acute leukemias.

J. Downing, F. Behm, S. Raimondi, 1996, Blood.

Lmo2 Induces Hematopoietic Stem Cell‐Like Features in T‐Cell Progenitor Cells Prior to Leukemia

X. Chen, J. Downing, C. Mullighan, 2013, Stem cells.

Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia

Michael N. Edmonson, J. Downing, C. Pui, 2015, PLoS genetics.

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways

X. Chen, J. Downing, N. Copeland, 2014, PloS one.

Acute leukemia: a pediatric perspective.

J. Downing, K. Shannon, James R Downing, 2002, Cancer cell.

The E2A-HLF Oncoprotein ActivatesGroucho-Related Genes and SuppressesRunx1

J. Downing, A. Look, N. Lenny, 2001, Molecular and Cellular Biology.

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.

J. Downing, C. Murre, B. Monia, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations

Heather L. Mulder, Samuel W. Brady, Michael C. Rusch, 2020, Nature Communications.

12p Abnormalities and the TEL Gene (ETV6) in Childhood Acute Lymphoblastic Leukemia

J. Downing, F. Behm, S. Raimondi, 1997 .

12 p Abnormalities and the TEL Gene ( ETV 6 ) in Childhood Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, F. Behm, 1997 .

Hospital results of Total Therapy Study XIIIB at St Jude Children's Research Improved outcome for children with acute lymphoblastic leukemia:

J. Downing, F. Behm, S. Raimondi, 2013 .

Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.

Cheng Cheng, Ching-Hon Pui, Wenjian Yang, 2009, Blood.

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase.

J. Downing, D. Campana, C. Pui, 2007, The Journal of clinical investigation.

Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia.

J. Downing, M. Relling, Cheng Cheng, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital.

Cheng Cheng, Dario Campana, Ching-Hon Pui, 2004, Blood.

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Xiaotu Ma, Jinghui Zhang, Scott Newman, 2018, Nature Communications.

Frequent Deletion of p16*NK4a/MTSl and in Pediatric Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, F. Behm, 2011 .

Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.

Carmen L. Wilson, Michael C. Rusch, Michael N. Edmonson, 2019, Journal of the National Cancer Institute.

MYCN amplification and ATRX mutations are incompatible in neuroblastoma

Heather L. Mulder, Michael P. Meers, Shondra M. Pruett-Miller, 2018, Nature Communications.

Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

Heather L. Mulder, Carmen L. Wilson, J. Downing, 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Structure and evolution of double minutes in diagnosis and relapse brain tumors

Heather L. Mulder, Michael C. Rusch, J. Downing, 2018, Acta Neuropathologica.

CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data

J. Downing, M. Edmonson, Jing Ma, 2020, Genome Biology.

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.

J. Downing, E. Yeoh, N. Lenny, 2002, Cancer cell.

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms

J. Downing, M. Roussel, C. Sherr, 1989, Molecular and cellular biology.

polymerase chain reaction in acute myelogenous leukemia containing An AML1/ETO fusion transcript is consistently detected by RNA-based

J. Downing, C. Willman, K. Theil, 2011 .

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia

Michael C. Rusch, J. Downing, M. Babu, 2022, Blood cancer discovery.

Germline genomic variants associated with childhood acute lymphoblastic leukemia

Ching-Hon Pui, James Downing, Cheryl Willman, 2009, Nature Genetics.

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Richard A. Moore, M. Loh, J. Downing, 2018, Nature.

Polygenic Determinants for Subsequent Breast Cancer Risk in Survivors of Childhood Cancer: The St Jude Lifetime Cohort Study (SJLIFE)

Heather L. Mulder, Carmen L. Wilson, J. Downing, 2018, Clinical Cancer Research.

DNA Methylation Clusters and Their Relation to Cytogenetic Features in Pediatric AML

J. Downing, S. Raimondi, R. Ribeiro, 2020, Cancers.

Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16.

J. Downing, S. Raimondi, M. Relling, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The biology of pediatric acute megakaryoblastic leukemia.

J. Downing, T. Gruber, 2015, Blood.

PTEN action in leukemia dictated by the tissue microenvironment

J. Downing, S. Lowe, J. Teruya-Feldstein, 2014, Nature.

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

James Downing, Megan E McNerney, Megan E. McNerney, 2013, Cancer discovery.

MLL fusion genes in the 11q23 acute leukemias.

J. Downing, A. Look, 1996, Cancer treatment and research.

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations.

J. Downing, S. Shurtleff, I. Radtke, 2010, Blood.

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.

J. Downing, C. Mullighan, Jin Xu, 2013, Blood.

Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.

J. Downing, S. Shurtleff, V. Valentine, 1995, Genomics.

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Heather L. Mulder, Michael C. Rusch, Michael N. Edmonson, 2016, Nature Genetics.

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J. Downing, M. Relling, C. Pui, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Rohini Rau-Murthy, Jinghui Zhang, Kenneth Offit, 2013, Nature Genetics.

pediatric B-progenitor acute lymphoblastic leukemia , Hispanic / Latino ethnicity , and a poor outcome in IKZF 1 alteration of kinases , JAK is associated with mutation of CRLF 2 Rearrangement of

J. Downing, K. Dobbin, C. Mullighan, 2010 .

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.

J. Downing, E. Bedrick, C. Mullighan, 2010, Blood.

Cancer genomes--continuing progress.

J. Downing, 2009, The New England journal of medicine.

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

James R. Downing, Jing Ma, Sergei Doulatov, 2011, Nature.

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia.

J. Downing, Cheng Cheng, D. Campana, 2007, Blood.

Acute lymphoblastic leukemia.

Ching-Hon Pui, J. Downing, M. Relling, 2004, The New England journal of medicine.

12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia.

J. Downing, S. Shurtleff, F. Behm, 1997, Blood.

Clinical Impact of Minimal Residual Disease in Children with Different Subtypes of Acute Lymphoblastic Leukemia Treated with Response-Adapted Therapy

Pui, J. Downing, S. Raimondi, 2016, Leukemia.

Integrated Genomic and Mutational Profiling Of Adolescent and Young Adult ALL Identifies a High Frequency Of BCR-ABL1-Like ALL with Very Poor Outcome

M. Loh, J. Downing, C. Bloomfield, 2013 .

High incidence of TEL/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan.

J. Downing, S. Shurtleff, C. Pui, 1996, Leukemia.

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Aman N. Patel, Erin K. Hedlund, J. Downing, 2018, Nature Communications.

Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids.

J. Downing, M. Relling, Cheng Cheng, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Genomics and the continuum of cancer care.

Michael R Stratton, Ultan McDermott, J. Downing, 2011, The New England journal of medicine.

AMKL chimeric transcription factors are potent inducers of leukemia

Michael C. Rusch, J. Downing, A. Gedman, 2017, Leukemia.

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

J. Downing, Linheng Li, D. Scadden, 2018, Nature Communications.

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Kiran C. Bobba, Kimberly J. Johnson, R. Wilson, 2011 .

A relationship between adenosine 5'-triphosphate and pregnenolone syntheses by ovarian mitochondria as demonstrated with aminoglutethimide.

J. Downing, M. J. Dimino, T. R. Chavis, 1980, Endocrinology.

pediatric B-precursor acute lymphoblastic leukemia residual disease improve risk classification and outcome prediction in Gene expression classifiers for relapse-free survival and minimal

J. Downing, E. Bedrick, C. Mullighan, 2010 .

Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.

J. Downing, M. Relling, Cheng Cheng, 2015, The Lancet. Oncology.

A 6-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia

J. Downing, S. Raimondi, J. Klco, 2019, Leukemia.

Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.

Samuel W. Brady, J. Downing, S. Raimondi, 2021, Blood cancer discovery.

Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells

J. Downing, S. Shurtleff, Cheng Cheng, 2015, Scientific Reports.

Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression

Charles Lee, J. Downing, D. Neuberg, 2009, Molecular and Cellular Biology.

Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

Yadav Sapkota, Celeste Rosencrance, Xiaotu Ma, 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression.

J. Downing, N. Lenny, R. Lorsbach, 2004, Blood.

knock-in mice reveals differential lineage expression Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP

J. Downing, N. Lenny, R. Lorsbach, 2013 .

knock-in mice reveals differential lineage expression Role of RUNX 1 in adult hematopoiesis : analysis of RUNX 1

J. Downing, N. Lenny, R. Lorsbach, 2004 .

ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases.

J. Downing, S. Shurtleff, F. Behm, 2003, Blood.

Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators

Heather L. Mulder, J. Downing, J. Klco, 2021, Blood cancer discovery.

Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma

Aman N. Patel, Michael N. Edmonson, J. Downing, 2019, Cold Spring Harbor molecular case studies.

Global gene expression as a function of germline genetic variation.

E. Cook, J. Downing, M. Relling, 2005, Human molecular genetics.

The Genomic Landscape of Childhood and Adolescent Melanoma

Li Ding, Jinghui Zhang, Matthew Parker, 2014, The Journal of investigative dermatology.

Disseminated intrathoracic desmoplastic small round-cell tumor: a case report.

J. Downing, S. Shurtleff, A. Pappo, 1996, Journal of pediatric hematology/oncology.

Universal monitoring of minimal residual disease in acute myeloid leukemia.

J. Downing, S. Shurtleff, D. Campana, 2018, JCI insight.

Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes

Heather L. Mulder, Michael C. Rusch, Michael N. Edmonson, 2017, Nature Genetics.

An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase

Torsten Haferlach, Giuseppe Basso, Robin Foà, 2008, British journal of haematology.

RB1 gene inactivation by chromothripsis in human retinoblastoma

R. Wilson, L. Fulton, R. Fulton, 2014, Oncotarget.

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Steven J. M. Jones, Richard A. Moore, M. Loh, 2018, Nature.

Pathology and immunology of leukemia

J. Downing, D. Head, 1992, Current opinion in oncology.

Data Access and Interactive Visualization of Whole Genome Sequence of Sickle Cell Patients within the St. Jude Cloud

Jian Wang, John Easton, Michael Rusch, 2018, Blood.

Genome-wide association analysis identifies SNPs predictive of in vitro leukemic cell sensitivity to cytarabine in pediatric AML

J. Downing, R. Ribeiro, J. Rubnitz, 2018, Oncotarget.

childhood acute lymphoblastic leukemia A set of genes that regulate cell proliferation predict treatment outcome in

J. Downing, Cheng Cheng, D. Campana, 2013 .

Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells

J. Downing, M. Relling, C. Pui, 2003, Nature Genetics.

RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients.

J. Downing, S. Raimondi, D. Campana, 2013, Pharmacogenomics.

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

Ashley D. Hill, M. Loh, J. Downing, 2019, Nature Genetics.

TGF-β Signaling, Tumor Suppression, and Acute Lymphoblastic Leukemia

James R. Downing, J. Downing, 2004 .

TGF-beta signaling, tumor suppression, and acute lymphoblastic leukemia.

J. Downing, 2004, New England Journal of Medicine.

Factor 1 Receptor Detect Ligand-Induced Conformational Changesanda Binding Site forPhosphatidylinositol

J. Downing, S. Shurtleff, C. Sherr, 1991 .

PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate.

J. Downing, A. Reynolds, A. B. Reynolds, 1991, Oncogene.

Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2.

Cheng Cheng, Elaine Coustan-Smith, Dario Campana, 2006, Blood.

FLT3-Targeted Therapy Selectively Kills MLL-Rearranged Infant and Childhood ALL Blasts In Vitro and in Vivo.

J. Downing, S. Shurtleff, D. Campana, 2004 .

Shared acquired genomic changes in zebrafish and human T-ALL

J. Downing, A. Look, C. Mullighan, 2011, Oncogene.

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia

J. Downing, B. Taylor, J. Aster, 2020, Leukemia.

Corrigendum: C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

Heather L. Mulder, Erin K. Hedlund, R. Wilson, 2014, Nature.

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Heather L. Mulder, J. Downing, S. Shurtleff, 2019, Nature Medicine.

Expression of the adaptor protein BLNK/SLP-65 in childhood acute lymphoblastic leukemia

J. Downing, M. Ross, D. Campana, 2004, Leukemia.

An unexpected protein interaction promotes drug resistance in leukemia

J. Downing, Jing Ma, Taosheng Chen, 2017, Nature Communications.

Transforming activities of human CSF-1 receptors with different point mutations at codon 301 in their extracellular domains.

J. Downing, M. Roussel, C. Sherr, 1990, Oncogene.

Targeted Inhibition of the MLL Transcriptional Complex By Proteosome Inhibitors Elicits a High Response Rate in Relapsed/Refractory MLL Rearranged Leukemia

J. Downing, Cheng Cheng, Jing Ma, 2014 .

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

J. Downing, Jing Ma, Guangchun Song, 2018, Nature Communications.

Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes.

J. Downing, V. Valentine, D. Shapiro, 1994, Genomics.

Can treating the SYK cell cure leukemia?

J. Downing, James R Downing, 2009, Cancer cell.

Simple rules underlying gene expression profiles of more than six subtypes of acute lymphoblastic leukemia (ALL) patients

Huiqing Liu, Jinyan Li, Limsoon Wong, 2003, Bioinform..

Ligand-induced phosphorylation of the colony-stimulating factor 1 receptor can occur through an intermolecular reaction that triggers receptor down modulation

J. Downing, M. Roussel, C. Sherr, 1990, Molecular and cellular biology.

Gene Expression Profiling of Acute Myeloid Leukemia Shows Therapeutically Meaningful Patterns of Association with Ara-CTP Pharmacokinetics and Pharmacodynamics

J. Downing, R. Ribeiro, S. Baker, 2008 .

CC-PROMISE effectively integrates two forms of molecular data with multiple biologically related endpoints

Stan Pounds, Xueyuan Cao, James R. Downing, 2016, BMC Bioinformatics.

Nature GeNetics ADVANCE ONLINE PUBLICATION

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2013 .

Pediatric acute lymphoblastic leukemia.

J. Downing, M. Relling, John Calvin Reed, 2003, Hematology. American Society of Hematology. Education Program.

Long-term results of St. Jude Total Therapy studies 11, 12, 13A, 13B and 14 for childhood acute lymphoblastic leukemia

J. Downing, D. Campana, C. Pui, 2009, Leukemia.

A Revised Definition for Cure of Childhood Acute Lymphoblastic Leukemia

J. Downing, S. Raimondi, M. Relling, 2014, Leukemia.

Author response: Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

J. Downing, E. Passegué, Jing Ma, 2015 .

Characteristics and outcome of t(8;21)-positive childhood acute myeloid leukemia: a single institution's experience

J. Downing, F. Behm, S. Raimondi, 2002, Leukemia.

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

J. Downing, S. Shurtleff, Xiaodong Zhou, 2007, Leukemia.

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo.

J. Downing, B. Dortland, M. D. Bruijn, 2000, Immunity.

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

J. Downing, Cheng Cheng, A. Melnick, 2010 .

Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup

J. Downing, F. Behm, M. Relling, 1999, Leukemia.

Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project

Erin K. Hedlund, E. Mardis, J. Downing, 2014 .

Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia

J. Downing, S. Raimondi, P. Rao, 2001, Leukemia.

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Charles P. Lin, J. Downing, Linheng Li, 2018, Nature Communications.

Comparative Analysis of Different Approaches to Measure Treatment Response in Acute Myeloid Leukemia

J. Downing, S. Shurtleff, S. Raimondi, 2012 .

Redefining "rare" in paediatric cancers.

J. Downing, C. Pui, A. Pappo, 2016, The Lancet Oncology.

Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1

J. Downing, S. Raimondi, M. Relling, 2009, Leukemia.

Comparison Of Mutational Profiles Of Diagnosis and Relapsed Pediatric B-Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

M. Loh, J. Downing, M. Relling, 2013 .

The Genomic Landscape of Childhood T-Lineage Acute Lymphoblastic Leukemia

M. Loh, J. Downing, M. Relling, 2015 .

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

J. Downing, A. Melnick, C. Mullighan, 2013 .

Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1).

J. Downing, S. Raimondi, C. Naeve, 1999, Gene.

Lack of TEL-AML1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan.

J. Downing, C. Pui, D. Liang, 1996, Leukemia.

Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project

Michael C. Rusch, E. Mardis, J. Downing, 2011 .

Acute leukemia: subtype discovery and prediction of outcome by gene expression profiling.

J. Downing, 2003 .

Solid Alveolar Rhabdomyosarcomas with the t(2;13): Report of Two Cases with Diagnostic Implications

J. Downing, E. Douglass, D. Shapiro, 1994, The American journal of surgical pathology.

NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction Analysis for Detection of the t(2;5) Translocation of Non-Hodgkin's Lymphoma.

J. Downing, S. Shurtleff, S. Morris, 1996, Methods in molecular medicine.

Ikzf1 Haploinsufficiency Contributes to the Pathogenesis of BCR-ABL1 Positive Acute Lymphoblastic Leukemia.

J. Downing, C. Mullighan, Racquel Collins-Underwood, 2009 .

PROMISE: a tool to identify genomic features with a specific biologically interesting pattern of associations with multiple endpoint variables

Cheng Cheng, Stan Pounds, Xueyuan Cao, 2009, Bioinform..

Retroviral and Chemical Mutagenesis Identifies Pax5 as a Tumor Suppressor in B-Progenitor Acute Lymphoblastic Leukemia

J. Downing, C. Mullighan, Perdeep K. Mehta, 2008 .

Ultra-High Resolution Analysis of Genomic Alterations in High-Risk Acute Lymphoblastic Leukemia.

J. Downing, S. Shurtleff, Jing Ma, 2008 .

Genome-Wide Analysis of Genetic Alterations in Chronic Myelogenous Leukemia.

J. Downing, S. Shurtleff, I. Radtke, 2008 .

Mouse models of human AML accurately predict chemotherapy response.

J. Downing, S. Lowe, I. Radtke, 2009, Genes & development.

Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.

J. Downing, M. Relling, Cheng Cheng, 2015, The Lancet. Oncology.

Gene expression profiling of pediatric acute myelogenous leukemia.

J. Downing, W. Williams, R. Mahfouz, 2004, Blood.

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

Benjamin J. Raphael, Joshua F. McMichael, Mark D. M. Leiserson, 2013, The New England journal of medicine.

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, Jing Ma, 2008, Science.

Global genomic characterization of acute lymphoblastic leukemia.

J. Downing, C. Mullighan, 2009, Seminars in hematology.

POST: A framework for set-based association analysis in high-dimensional data.

Dale B. Armstrong, J. Downing, S. Raimondi, 2018, Methods.

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

J. Downing, W. Williams, S. Raimondi, 2022 .

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.

Erin K. Hedlund, Michael C. Rusch, E. Mardis, 2014, Cancer discovery.

Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.

Michael C. Rusch, J. Downing, J. McPherson, 2016, Cancer cell.

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML

J. Downing, A. Loguinov, C. Vulpe, 2022, Blood advances.

Profiling in acute leukemia.

J. Downing, 2003, Clinical advances in hematology & oncology : H&O.

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Erin K. Hedlund, Michael C. Rusch, L. Fulton, 2013 .

Germline Mutations in Predisposition Genes in Pediatric Cancer.

J. Downing, C. Aalfs, E. Overwater, 2016, The New England journal of medicine.

Cryptic Truncating Rearrangements of the Erythropoietin Receptor in Ph-like Acute Lymphoblastic Leukemia

Michael C. Rusch, J. Downing, C. Pui, 2014 .

Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels.

J. Downing, S. Raimondi, M. Relling, 2015, Blood.

Annual review of pathology : mechanisms of disease

J. Downing, A. Abbas, Vinay Kumar, 2006 .

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Michael C. Rusch, S. Ranade, E. Mardis, 2012, Cancer cell.

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Ashley D. Hill, Roberts R. Michael, Diane A. Flasch, 2019, Blood.