P. Leprohon

发表

The initial state of the human gut microbiome determines its reshaping by antibiotics

F. Raymond, A. A. Ouameur, Maxime Déraspe, 2015, The ISME Journal.

Drug resistance analysis by next generation sequencing in Leishmania

P. Leprohon, M. Ouellette, E. Gazanion, 2014, International journal for parasitology. Drugs and drug resistance.

Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites

P. Leprohon, L. Maes, Yann G. J. Sterckx, 2020, Microorganisms.

Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae.

P. Leprohon, M. Ouellette, Marie‐Christine Brotherton, 2013, The Journal of antimicrobial chemotherapy.

Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum.

P. Leprohon, M. Ouellette, P. Bastien, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

P. Leprohon, M. Ouellette, B. Papadopoulou, 2016, F1000Research.

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

P. Leprohon, M. Ouellette, B. Papadopoulou, 2016, F1000Research.

Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

P. Leprohon, M. Ouellette, J. Corbeil, 2012, PLoS neglected tropical diseases.

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

P. Leprohon, M. Ouellette, S. Wyllie, 2021, Microorganisms.

Proteomic and Genomic Analyses of Antimony Resistant Leishmania infantum Mutant

P. Leprohon, M. Ouellette, G. Poirier, 2013, PloS one.

Role of the ABC Transporter MRPA (PGPA) in Antimony Resistance in Leishmania infantum Axenic and Intracellular Amastigotes

P. Leprohon, M. Ouellette, N. Saravia, 2005, Antimicrobial Agents and Chemotherapy.

Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis

P. Leprohon, M. Ouellette, F. Frézard, 2015, PLoS neglected tropical diseases.

Growth Phase Regulation of the Main Folate Transporter of Leishmania infantum and Its Role in Methotrexate Resistance*

P. Leprohon, M. Ouellette, D. Richard, 2004, Journal of Biological Chemistry.

Diverse Virulent Pneumophages Infect Streptococcus mitis

P. Leprohon, S. Moineau, Siham Ouennane, 2015, PloS one.

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms

P. Leprohon, M. Ouellette, Mansi Sharma, 2018, International journal for parasitology. Drugs and drug resistance.

Thiophene derivatives activity against the protozoan parasite Leishmania infantum

P. Leprohon, M. Ouellette, R. Skouta, 2022, International journal for parasitology. Drugs and drug resistance.

Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis.

H. Gingras, P. Leprohon, M. Ouellette, 2021, ACS infectious diseases.

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

P. Leprohon, M. Ouellette, W. Moreira, 2011, Cell Death and Disease.

Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations

P. Leprohon, M. Ouellette, Jie Feng, 2011, BMC Genomics.

Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.

H. Gingras, P. Leprohon, M. Ouellette, 2015, The Journal of antimicrobial chemotherapy.

ABC transporters involved in drug resistance in human parasites.

P. Leprohon, M. Ouellette, D. Légaré, 2011, Essays in biochemistry.

A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages

H. Gingras, P. Leprohon, M. Ouellette, 2015, BMC Genomics.

Gene Amplification and Point Mutations in Pyrimidine Metabolic Genes in 5-Fluorouracil Resistant Leishmania infantum

F. Raymond, P. Leprohon, M. Ouellette, 2013, PLoS neglected tropical diseases.

Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease

P. Leprohon, M. Ouellette, D. Légaré, 2011, Genome Biology.

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

H. Gingras, P. Leprohon, M. Ouellette, 2019, Nature Communications.

Gain- and Loss-of-Function Screens Coupled to Next-Generation Sequencing for Antibiotic Mode of Action and Resistance Studies in Streptococcus pneumoniae

H. Gingras, P. Leprohon, M. Ouellette, 2019, Antimicrobial Agents and Chemotherapy.

Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania

F. Raymond, H. Gingras, P. Leprohon, 2014, PLoS biology.

A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages

H. Gingras, P. Leprohon, M. Ouellette, 2015, BMC Genomics.

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism

P. Leprohon, M. Ouellette, J. Masson, 2016, PLoS genetics.

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

P. Leprohon, M. Ouellette, B. Rosen, 2019, mSystems.

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

P. Leprohon, B. Rosen, C. Packianathan, 2019 .

Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania

P. Leprohon, M. Ouellette, E. Gazanion, 2016, Proceedings of the National Academy of Sciences.

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum

F. Raymond, P. Leprohon, M. Ouellette, 2009, Nucleic acids research.

Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes.

A. A. Ouameur, P. Leprohon, M. Ouellette, 2012, Journal of proteome research.

MRPA-independent mechanisms of antimony resistance in Leishmania infantum

P. Leprohon, M. Ouellette, C. Fernández-Prada, 2020, International journal for parasitology. Drugs and drug resistance.

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

P. Leprohon, C. Fernández-Prada, R. D. do Monte-Neto, 2021, Parasites & Vectors.

Differences in Antibiotic-Induced Oxidative Stress Responses between Laboratory and Clinical Isolates of Streptococcus pneumoniae

Michel G. Bergeron, Marc Ouellette, Philippe Leprohon, 2015, Antimicrobial Agents and Chemotherapy.

Antileishmanial Aminopyrazoles: Studies into Mechanisms and Stability of Experimental Drug Resistance

P. Leprohon, M. Ouellette, L. Maes, 2020, Antimicrobial Agents and Chemotherapy.

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms

Terry K. Smith, Isabel M. Vincent, P. Leprohon, 2016, PLoS neglected tropical diseases.

Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance

P. Leprohon, M. Ouellette, D. Légaré, 2016, Parasitology Research.

Modulation of Leishmania ABC Protein Gene Expression through Life Stages and among Drug-Resistant Parasites

P. Leprohon, M. Ouellette, B. Papadopoulou, 2006, Eukaryotic Cell.

Intracellular Localization of the ABCC Proteins of Leishmania and Their Role in Resistance to Antimonials

P. Leprohon, M. Ouellette, D. Légaré, 2009, Antimicrobial Agents and Chemotherapy.

Mutations in an aquaglyceroporin as a proven marker of antimony clinical resistance in the parasite Leishmania donovani.

P. Leprohon, M. Ouellette, S. Sundar, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Decreased glutamate transport in acivicin resistant Leishmania tarentolae

P. Leprohon, M. Ouellette, Arijit Bhattacharya, 2021, PLoS neglected tropical diseases.

Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae

P. Leprohon, M. Ouellette, M. Bergeron, 2017, Scientific Reports.

Genomic Characterization of Ciprofloxacin Resistance in a Laboratory-Derived Mutant and a Clinical Isolate of Streptococcus pneumoniae

P. Leprohon, M. Ouellette, G. Zhanel, 2013, Antimicrobial Agents and Chemotherapy.

pneumoniae and a Clinical Isolate of Streptococcus Resistance in a Laboratory-Derived Mutant Genomic Characterization of Ciprofloxacin

P. Leprohon, G. Zhanel, Andréanne Lupien, 2013 .

Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen

H. Gingras, P. Leprohon, M. Ouellette, 2020, Microbial genomics.

Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli

H. Gingras, B. Dridi, P. Leprohon, 2018, Microbial genomics.

Genomic Analyses of DNA Transformation and Penicillin Resistance in Streptococcus pneumoniae Clinical Isolates

P. Leprohon, M. Ouellette, M. Bergeron, 2013, Antimicrobial Agents and Chemotherapy.

Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing.

H. Gingras, P. Leprohon, M. Ouellette, 2015, The Journal of antimicrobial chemotherapy.

Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae.

P. Leprohon, M. Ouellette, Jie Feng, 2011, Journal of proteome research.

New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing

P. Leprohon, M. Ouellette, B. Papadopoulou, 2020, Microbial cell.

Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania.

Christopher Fernandez-Prada, Jade-Eva Potvin, Philippe Leprohon, 2019, Methods in molecular biology.

and Marc Ouellette Resistance to Antimonials and Their Role in Leishmania Proteins of Intracellular Localization of the ABCC

P. Leprohon, M. Ouellette, D. Légaré, 2009 .

Generation of Leishmania Hybrids by Whole Genomic DNA Transformation

P. Leprohon, M. Ouellette, A. Coelho, 2012, PLoS neglected tropical diseases.

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection

P. Leprohon, M. Ouellette, Sophia Bigot, 2023, PLoS neglected tropical diseases.

New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens

H. Gingras, P. Leprohon, M. Ouellette, 2023, Antimicrobial agents and chemotherapy.

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum

P. Leprohon, M. Ouellette, Arijit Bhattacharya, 2021, PLoS neglected tropical diseases.

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria

H. Gingras, P. Leprohon, M. Ouellette, 2019, mSystems.

Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum

P. Leprohon, F. Fani, M. Queffeulou, 2023, International journal for parasitology. Drugs and drug resistance.

Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis

H. Gingras, P. Leprohon, J. Bourbeau, 2023, Scientific reports.

ABC transporters involved in drug resistance in human parasites.

P. Leprohon, M. Ouellette, D. Légaré, 2011, Essays in biochemistry.

Intracellular Localization of the ABCC Proteins of Leishmania and Their Role in Resistance to Antimonials

P. Leprohon, M. Ouellette, D. Légaré, 2009, Antimicrobial Agents and Chemotherapy.

Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.

H. Gingras, P. Leprohon, M. Ouellette, 2015, The Journal of antimicrobial chemotherapy.

Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning

H. Gingras, P. Leprohon, Chantal Godin, 2024, mBio.