K. Klinger

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Rapid detection of chromosome aneuploidies in uncultured amniocytes by using fluorescence in situ hybridization (FISH).

K. Klinger, G. Landes, D. Shook, 1992, American journal of human genetics.

Genetic basis of cancer.

K. Klinger, K. Klinger, 1991, Current opinion in biotechnology.

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine

Laurie A. Smith, K. Klinger, O. Ibraghimov-Beskrovnaya, 2006, Nature.

Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease.

K. Klinger, R. Scheule, K. Ashe, 2010, Molecular genetics and metabolism.

The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization.

K. Klinger, J. Carpten, D. Stephan, 2000, Biochimica et biophysica acta.

Netrin-4 regulates angiogenic responses and tumor cell growth.

K. Klinger, B. Teicher, S. Madden, 2009, Experimental cell research.

Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function

K. Klinger, R. Burrier, B. Teicher, 2006, Molecular Cancer Therapeutics.

Vascular gene expression in nonneoplastic and malignant brain.

Viatcheslav R Akmaev, K. Klinger, B. Teicher, 2004, The American journal of pathology.

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

K. Klinger, P. Meltzer, J. Carpten, 2002, Nature Genetics.

Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data

K. Klinger, L. Sullivan, W. Holzgreve, 2002, Prenatal diagnosis.

PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies.

K. Klinger, L. Sullivan, J. Williams, 1997, American journal of human genetics.

Cellular and Subcellular Distribution of Polycystin-2, the Protein Product of thePKD2 Gene

K. Klinger, O. Ibraghimov-Beskrovnaya, R. Sandford, 2000 .

Identification of the M1101K mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and complete detection of cystic fibrosis mutations in the Hutterite population.

K. Klinger, L. Tsui, J. Zieleński, 1993, American journal of human genetics.

FISH: Sensitivity and Specificity on Sorted and Unsorted Cells

K. Klinger, 1994, Annals of the New York Academy of Sciences.

Correction of cilia structure and function alleviates multi-organ pathology in Bardet–Biedl syndrome mice

Laurie A. Smith, K. Klinger, O. Ibraghimov-Beskrovnaya, 2020, Human molecular genetics.

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

Laurie A. Smith, K. Klinger, O. Ibraghimov-Beskrovnaya, 2012, Human molecular genetics.

Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines.

K. Klinger, M. Iannuzzi, M. Welsh, 1990, The American journal of physiology.

Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease.

K. Klinger, P. Gabow, W. Kimberling, 1999, American journal of human genetics.

Loss of GM 3 synthase gene , but not sphingosine kinase 1 , is protective against murine nephronophthisis-related polycystic kidney disease

Laurie A. Smith, K. Klinger, O. Ibraghimov-Beskrovnaya, 2012 .

Issues in implementing prenatal screening for cystic fibrosis: Results of a working conference

K. Klinger, P. Rowley, W. Grody, 1999, Genetics in Medicine.

The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3.

K. Klinger, G. Landes, T. Burn, 1997, Genomics.

Canine PKD1 is a single-copy gene: genomic organization and comparative analysis.

K. Klinger, O. Ibraghimov-Beskrovnaya, P. Manavalan, 2002, Genomics.

Molecular analysis of human Chromosome 16 cosmid clones containing NotI sites

K. Klinger, G. Landes, D. Shook, 2004, Mammalian Genome.

Significant fetal-maternal hemorrhage after termination of pregnancy: implications for development of fetal cell microchimerism.

K. Klinger, J. Williams, D. Bianchi, 2001, American journal of obstetrics and gynecology.

Narrowing the position of the Treacher Collins syndrome locus to a small interval between three new microsatellite markers at 5q32-33.1.

K. Klinger, G. Landes, T. Houseal, 1993, American journal of human genetics.

The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3.

K. Klinger, G. Landes, T. Burn, 1997, Genomics.

Interlaboratory comparison of fetal male DNA detection from common maternal plasma samples by real-time PCR.

K. Klinger, J. Vidaver, W. Holzgreve, 2004, Clinical chemistry.

Abstracts for the committee on the genetic constitution of chromosome 1

Brien, J. Beckmann, K. Kidd, 1991 .

A macromolecular structure produced by Pseudomonas aeruginosa is recognized by antibody to exotoxin A

K. Klinger, C. W. Shuster, 1984, Infection and immunity.

A linkage study of cystic fibrosis in extended multigenerational pedigrees.

K. Klinger, R. Schwartz, R. Doherty, 1986, American journal of human genetics.

Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction.

K. Klinger, B. Richards, G. Horn, 1989, Nucleic acids research.

Prenatal Diagnosis with Fetal Cells Isolated From Maternal Blood by Multiparameter Flow Cytometry

K. Klinger, D. Shook, S. Wachtel, 1991, American journal of obstetrics and gynecology.

Increased exon-trapping efficiency through modifications to the pSPL3 splicing vector.

K. Klinger, G. Landes, T. Burn, 1995, Gene.

Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.

K. Klinger, G. Landes, J. Millholland, 1996, Genome research.

Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms (Part 24 of 27)

J. Beckmann, K. Kidd, K. Klinger, 1991 .

Cystic fibrosis in the Ohio Amish: Gene frequency and founder effect

K. Klinger, 2004, Human Genetics.

Prenatal diagnosis by use of fetal cells isolated from maternal blood.

K. Klinger, S. Kaplan, W. Holzgreve, 1995, American journal of obstetrics and gynecology.

Three RFLPs are detected by an alpha spectrin genomic clone.

K. Klinger, A. Linnenbach, B. Forget, 1987, Nucleic acids research.

Micromethods for the spectrophotometric determination of bacterial protease activities

K. Klinger, 1983 .

High throughput parallel analysis of hundreds of patient samples for more than 100 mutations in multiple disease genes.

K. Klinger, S. Kotsopoulos, J. Skoletsky, 1997, Human molecular genetics.

Reaction of antibody in sera from cystic fibrosis patients with nontoxic forms ofPseudomonas aeruginosa exotoxin A

K. Klinger, J. Klinger, C. W. Shuster, 1985, European Journal of Clinical Microbiology.

Abstracts for the committee on the genetic constitution of the X chromosome (Part 3 of 3)

Brien, J. Beckmann, K. Kidd, 1991 .

Expression and characterization of the cystic fibrosis transmembrane conductance regulator

K. Klinger, M. Welsh, J. Marshall, 1990, Nature.

First trimester prenatal diagnosis of trisomy 21 in fetal cells from maternal blood

K. Klinger, S. Wachtel, J. Simpson, 1992, The Lancet.

Transcriptional response to GAA deficiency (Pompe disease) in infantile-onset patients.

K. Klinger, S. Marie, S. Madden, 2012, Molecular genetics and metabolism.

Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

M. King, K. Klinger, L. Cavalli-Sforza, 1986, American journal of human genetics.

Maternal origin of nucleated erythrocytes in peripheral venous blood of pregnant women

K. Klinger, S. Knuutila, W. El‐Rifai, 1995, Human Genetics.

Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: clinical experience with 4,500 specimens.

K. Klinger, B. Ward, K W Klinger, 1993, American journal of human genetics.

Rapid prenatal diagnosis by fluorescent in situ hybridization of chorionic villi: an adjunct to long-term culture and karyotype.

K. Klinger, D. Shook, W. Holzgreve, 1992, American journal of obstetrics and gynecology.

Multiplex PCR amplification from the CFTR gene using DNA prepared from buccal brushes/swabs.

K. Klinger, R. Stern, R. Parad, 1993, Human molecular genetics.

A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region.

K. Klinger, G. Landes, T. Burn, 1996, Genomics.

Prenatal detection of chromosome aneuploidies in uncultured chorionic villus samples by FISH.

K. Klinger, J. Philip, B. Ward, 1996, American journal of human genetics.

Alternative splicing of exon 3 of the human growth hormone receptor is the result of an unusual genetic polymorphism.

K. Klinger, M. Stallings-Mann, F. Rottman, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms

Jörg Schmidtke, Kenneth K. Kidd, Jacques S. Beckmann, 1991 .

Lysosomal-Immune Axis Is Associated with COVID 19 Disease Severity: Insights from Patient Single Cell Data

K. Klinger, D. Rajpal, E. Teeple, 2021, bioRxiv.

Network Analysis and Human Single Cell Brain Transcriptomics Reveal Novel Aspects of Alpha-Synuclein (SNCA) Biology

K. Klinger, S. Madden, Can Kayatekin, 2020, bioRxiv.

Genetic and physical mapping of the Treacher Collins syndrome locus: refinement of the localization to chromosome 5q32-33.2.

K. Klinger, G. Landes, M. L. Le Beau, 1992, Human molecular genetics.

Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene

X. Estivill, K. Klinger, B. Kerem, 1992, Human Genetics.

Characterization and rapid diagnostic analysis of DNA polymorphisms closely linked to the cystic fibrosis locus.

K. Klinger, B. Richards, G. Horn, 1990, Clinical chemistry.

Characterization and rapid analysis of the highly polymorphic VNTR locus D4S125 (YNZ32), closely linked to the Huntington disease gene.

K. Klinger, B. Richards, G. Horn, 1991, Genomics.

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

Matthew P. Anderson, K. Klinger, M. Welsh, 1990, Nature.

Polycystin 1 is required for the structural integrity of blood vessels.

K. Klinger, O. Ibraghimov-Beskrovnaya, M. Arnaout, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein.

K. Klinger, G. Landes, O. Ibraghimov-Beskrovnaya, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson’s Disease and Multiple System Atrophy

K. Klinger, D. Rajpal, S. Madden, 2021, bioRxiv.

Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence.

K. Klinger, M. Goldberg, B. Teicher, 2010, Experimental cell research.

Cystic fibrosis population carrier screening: 2004 revision of American College of Medical Genetics mutation panel

Victoria M. Pratt, Michael S. Watson, Wayne W. Grody, 2004, Genetics in Medicine.

Laboratory standards and guidelines for population-based cystic fibrosis carrier screening

K. Klinger, W. Grody, M. Watson, 2001, Genetics in Medicine.

Predictive testing for Huntington's disease with use of a linked DNA marker.

K. Klinger, L. Farrer, J. Gusella, 1988, The New England journal of medicine.

Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.

K. Klinger, R. Winqvist, P. Andreasen, 1987, Proceedings of the National Academy of Sciences of the United States of America.

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

K. Klinger, S. Sardi, L. Shihabuddin, 2010, The Journal of clinical investigation.

Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.

K. Klinger, G. Landes, J. Carpten, 2001, Genomics.

Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1.

K. Klinger, G. Landes, O. Ibraghimov-Beskrovnaya, 2000, Human molecular genetics.

Intra- and extragenic marker haplotypes of CFTR mutations in cystic fibrosis families

K. Klinger, L. Tsui, B. Kerem, 1992, Human Genetics.

A 2.5 kb polypyrimidine tract in the PKD1 gene contains at least 23 H-DNA-forming sequences.

K. Klinger, G. Landes, G. Germino, 1996, Microbial & comparative genomics.

Alterations in Vascular Gene Expression in Invasive Breast Carcinoma

K. Klinger, Liangfeng Han, P. Argani, 2004, Cancer Research.

High resolution mapping of overlapping cosmids by fluorescence in situ hybridization.

K. Klinger, G. Landes, T. Houseal, 1994, Cytometry.

Cystic fibrosis mutations in the Hutterite Brethren.

K. Klinger, R. Schwartz, K. Morgan, 1990, American journal of human genetics.

Genealogical analysis of cystic fibrosis families and chromosome 7q RFLP haplotypes in the Hutterite Brethren.

K. Klinger, R. Schwartz, K. Morgan, 1989, American journal of human genetics.

Fetal cells in maternal blood: determination of purity and yield by quantitative polymerase chain reaction.

K. Klinger, D. Bianchi, A. Shuber, 1994, American journal of obstetrics and gynecology.

Cystic fibrosis carrier detection using a linked gene probe.

K. Klinger, M. Farrall, R. Williamson, 1986, Journal of medical genetics.

The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function.

K. Klinger, M. Goldberg, B. Teicher, 2011, International journal of oncology.

Multicolor fluorescence in situ hybridization for the simultaneous detection of probe sets for chromosomes 13, 18, 21, X and Y in uncultured amniotic fluid cells.

K. Klinger, G. Landes, D. Ward, 1992, Human molecular genetics.

A modified two-step phage display selection for isolation of polycystin-1 ligands

K. Klinger, G. Landes, O. Ibraghimov-Beskrovnaya, 2000, Functional & Integrative Genomics.

New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies.

K. Klinger, G. Landes, O. Ibraghimov-Beskrovnaya, 2004, Genomics.

Functional polycystin-1 expression is developmentally regulated during epithelial morphogenesis in vitro: downregulation and loss of membrane localization during cystogenesis.

K. Klinger, O. Ibraghimov-Beskrovnaya, H. Husson, 2002, Human molecular genetics.

Erratum: Alterations in vascular gene expression in invasive breast carcinoma (Cancer Research (November 1, 2004) 64, 1 (7857-7866))

K. Klinger, P. Argani, S. Sukumar, 2004 .

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson’s Disease and Multiple System Atrophy

K. Klinger, D. Rajpal, S. Madden, 2021, bioRxiv.

Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.

K. Klinger, O. Ibraghimov-Beskrovnaya, R. Sandford, 2000, Journal of the American Society of Nephrology : JASN.

Detection of fetal cells with 47,XY,+21 karyotype in maternal peripheral blood

K. Klinger, T. Houseal, D. Bianchi, 1992, Human Genetics.

A simplified procedure for developing multiplex PCRs.

K. Klinger, A. Shuber, V. Grondin, 1995, Genome research.

Maternal origin of transferrin receptor positive cells in venous blood of pregnant women

K. Klinger, S. Knuutila, M. Larramendy, 1996, Clinical genetics.

Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease.

K. Klinger, G. Landes, G. Germino, 1998, Molecular cell.

The region surrounding the PKD1 gene: a 700-kb P1 contig from a YAC-deficient interval.

K. Klinger, G. Landes, D. Housman, 1996, Genome research.

Number of Number of Median (range) Number of cells male female cells recovered and identified as cases cases analysed by FISHmale by FISH Centre

K. Klinger, W. Holzgreve, F. Bischoff, 2003 .

Abstracts for the committee on the genetic constitution of chromosome 6

Brien, J. Beckmann, K. Kidd, 1991 .

Statement from the National Institutes of Health workshop on population screening for the cystic fibrosis gene.

K. Klinger, N. Holtzman, F. Collins, 1990, The New England journal of medicine.

Cystic fibrosis mutations in North American populations of French ancestry: analysis of Quebec French-Canadian and Louisiana Acadian families.

K. Klinger, L. Tsui, B. Kerem, 1990, American Journal of Human Genetics.

Abstracts for the committee on comparative gene mapping

Brien, J. Beckmann, K. Kidd, 1991 .

Genetics of Cystic Fibrosis

K. Klinger, Ph.D Katherine Wood Klinger, Dr. Klinger, 1985 .

Molecular and genetic analyses at the CF locus.

K. Klinger, P. Stanislovitis, G. Horn, 1991, Advances in experimental medicine and biology.

Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms (Part 23 of 27)

J. Beckmann, K. Kidd, K. Klinger, 1991 .

Abstracts for the committee on the genetic constitution of chromosome 15

Brien, J. Beckmann, K. Kidd, 1991 .

Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms (Part 27 of 27)

J. Beckmann, K. Kidd, K. Klinger, 1991 .

Inhibition of Glycogen Biosynthesis via mTORC1 Suppression as an Adjunct Therapy for Pompe Disease

K. Klinger, R. Scheule, K. Ashe, 2011 .

Low False-Positive Rate of Aneuploidy Detection Using Fetal Cells Isolated from Maternal Blood

K. Klinger, W. Holzgreve, L. Jackson, 1998, Fetal Diagnosis and Therapy.

FETAL CELL QUANTITATION IN MATERNAL BLOOD SAMPLES FROM NORMAL AND ANEUPLOID PREGNANCIES. • 838

K. Klinger, D. Bianchi, A. Shuber, 1996, Pediatric Research.