J. Isaac

发表

A new intrathalamic pathway linking modality-related nuclei in the dorsal thalamus

J. Crabtree, G. Collingridge, J. Isaac, 1998, Nature Neuroscience.

New Intrathalamic Pathways Allowing Modality-Related and Cross-Modality Switching in the Dorsal Thalamus

J. Crabtree, J. Isaac, 2002, The Journal of Neuroscience.

Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro

J. Isaac, R. Muller, J. Mellor, 2009, The Journal of Neuroscience.

Evidence for silent synapses: Implications for the expression of LTP

J. Isaac, R. Nicoll, R. Malenka, 1995, Neuron.

The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity

Chris J. McBain, Michael C. Ashby, J. Isaac, 2007, Neuron.

A Critical Role of a Facilitatory Presynaptic Kainate Receptor in Mossy Fiber LTP

David Lodge, David Bleakman, G. Collingridge, 2001, Neuron.

Long-Term Depression at Thalamocortical Synapses in Developing Rat Somatosensory Cortex

Daniel E Feldman, D. Feldman, J. Isaac, 1998, Neuron.

Receptor trafficking and synaptic plasticity

G. Collingridge, J. Isaac, Y. T. Wang, 2004, Nature Reviews Neuroscience.

Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction

Andreas Lüthi, Tim A Benke, G. Collingridge, 1999, Neuron.

Lack of AMPA receptor desensitization during basal synaptic transmission in the hippocampal slice.

J. Isaac, R. Nicoll, R. Malenka, 1999, Journal of neurophysiology.

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

J. Isaac, P. Kind, D. Wyllie, 2019, Nature Communications.

Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in Fmr1-KO Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information Processing

J. Isaac, P. Kind, D. Wyllie, 2018 .

Developmental synaptic plasticity at the thalamocortical input to barrel cortex: Mechanisms and roles

J. Isaac, Michael I Daw, Helen L Scott, 2007, Molecular and Cellular Neuroscience.

Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs.

J. Isaac, A. Koretsky, Seungsoo Chung, 2017, Cell reports.

Thalamocortical Inputs Show Post-Critical-Period Plasticity

J. Isaac, J. Walters, A. Koretsky, 2012, Neuron.

Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales

John P. Lowry, Gary Gilmour, Keith G. Phillips, 2017, Cell reports.

Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover

J. Isaac, T. Usdin, A. Koretsky, 2020, The Journal of Neuroscience.

Silent Synapses during Development of Thalamocortical Inputs

Michael C. Crair, Robert C. Malenka, Roger A. Nicoll, 1997, Neuron.

Vesicular Release of Glutamate Utilizes the Proton Gradient Between the Vesicle and Synaptic Cleft

J. Isaac, N. Marrion, Jon T. Brown, 2009, Front. Syn. Neurosci..

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Caleb Webber, Guy B. Williams, Mara Cercignani, 2019, Brain : a journal of neurology.

Tackling gaps in developing life-changing treatments for dementia

Nick C Fox, J. Gallacher, J. Isaac, 2019, Alzheimer's & dementia.

PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses

G. Collingridge, J. Isaac, Z. Bortolotto, 2000, Neuron.

Protein Kinase C Phosphorylation of the Metabotropic Glutamate Receptor mGluR5 on Serine 839 Regulates Ca2+ Oscillations*

J. Isaac, K. Roche, C. Kim, 2005, Journal of Biological Chemistry.

Interhemispheric plasticity is mediated by maximal potentiation of callosal inputs

J. Isaac, A. Koretsky, S. Dodd, 2019, Proceedings of the National Academy of Sciences.

Identification of an Endoplasmic Reticulum-Retention Motif in an Intracellular Loop of the Kainate Receptor Subunit KA2

J. Isaac, K. Roche, Y. Nasu-Nishimura, 2006, The Journal of Neuroscience.

Rapid, Activity-Dependent Plasticity in Timing Precision in Neonatal Barrel Cortex

J. Isaac, Michael I Daw, Neil V Bannister, 2006, The Journal of Neuroscience.

Transfecting and Transducing Neurons with Synthetic Nucleic Acids and Biologically Active Macromolecules

J. Isaac, J. Kittler, J. G. Hanley, 2006 .

Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses

J. Isaac, F. L. Kidd, Fleur L. Kidd, 1999, Nature.

Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations

J. Isaac, S. Lauri, F. Maingret, 2005, The Journal of physiology.

Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex

J. Isaac, M. Ashby, Michael I Daw, 2007, Nature Neuroscience.

Endogenous Activation of Kainate Receptors Regulates Glutamate Release and Network Activity in the Developing Hippocampus

G. Collingridge, J. Isaac, C. Mulle, 2005, The Journal of Neuroscience.

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

J. Isaac, P. Kind, G. Hardingham, 2018, Nature Communications.

Maturation of a Recurrent Excitatory Neocortical Circuit by Experience-Dependent Unsilencing of Newly Formed Dendritic Spines

Michael C. Ashby, J. Isaac, M. Ashby, 2011, Neuron.

Postsynaptic silent synapses: evidence and mechanisms

J. Isaac, 2003, Neuropharmacology.

Silent glutamatergic synapses in the mammalian brain.

J. Isaac, R. Nicoll, R. Malenka, 1999, Canadian journal of physiology and pharmacology.

Multiple, Developmentally Regulated Expression Mechanisms of Long-Term Potentiation at CA1 Synapses

G. Collingridge, J. Isaac, M. Palmer, 2004, The Journal of Neuroscience.

mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch

J. Isaac, K. Roche, M. Ashby, 2011, Neuron.

LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β

G. Collingridge, J. Isaac, Z. Bortolotto, 2007, Neuron.

Synaptic strength at the thalamocortical input to layer IV neonatal barrel cortex is regulated by protein kinase C

J. Isaac, N. Bannister, Helen L. Scott, 2007, Neuropharmacology.

ATP hydrolysis is required for the rapid regulation of AMPA receptors during basal synaptic transmission and long-term synaptic plasticity

J. Isaac, John T. R. Isaac, Wonil Lim, 2005, Neuropharmacology.

Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity

Paul Matthews, Andreas Lüthi, Tim A Benke, 2004, BMC Neuroscience.

An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings

W. W. Anderson, G. Collingridge, J. Isaac, 1998, Neuropharmacology.

Modulation of AMPA receptor unitary conductance by synaptic activity

Andreas Lüthi, Graham L. Collingridge, G. Collingridge, 1998, Nature.

Expression mechanisms of long-term potentiation in the hippocampus

J. Isaac, R. Nicoll, G. Hjelmstad, 1996, Journal of Physiology-Paris.

A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the Hippocampus

G. Collingridge, J. Isaac, Z. Bortolotto, 2003, Neuron.

Incorporation of inwardly rectifying AMPA receptors at silent synapses during hippocampal long-term potentiation

J. Isaac, J. Rah, D. Morita, 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

Glutamate Receptor δ2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase Cγ, and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

J. Isaac, D. Bredt, E. Nisenbaum, 2012, The Journal of Neuroscience.

Functional roles of protein interactions with AMPA and kainate receptors

G. Collingridge, J. Isaac, 2003, Neuroscience Research.

Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in rat hippocampus in vitro.

D A Turner, J. Isaac, D. Turner, 1997, The Journal of physiology.

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

J. Isaac, D. Bredt, E. Nisenbaum, 2016, Nature Medicine.

Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

G. Collingridge, J. Isaac, Z. Bortolotto, 2006, Nature Neuroscience.

Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors

J. Isaac, K. Roche, A. Sanz-Clemente, 2010, Neuron.

Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons

J. Isaac, E. Sher, J. Dage, 2014, Psychopharmacology.

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation

J. Isaac, S. H. Lee, D. Pak, 2010, Nature Neuroscience.

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

J. Isaac, T. K. Best, T. Haydar, 2010, Nature Neuroscience.

A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors

J. Isaac, A. V. Maricq, P. J. Brockie, 2009, Current Biology.

Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression

Graham L. Collingridge, G. Collingridge, J. Isaac, 2002, Nature Neuroscience.

Functional Maturation of CA1 Synapses Involves Activity-Dependent Loss of Tonic Kainate Receptor-Mediated Inhibition of Glutamate Release

G. Collingridge, J. Isaac, S. Lauri, 2006, Neuron.

Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex

J. Isaac, F. L. Kidd, 2000, Neuropharmacology.

Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

J. Isaac, M. Hutton, M. O'Neill, 2020, bioRxiv.

Altered Synapse Stability in the Early Stages of Tauopathy

J. Isaac, M. Hutton, AndrewD . Randall, 2017, Cell reports.

Rapid and Differential Regulation of AMPA and Kainate Receptors at Hippocampal Mossy Fibre Synapses by PICK1 and GRIP

G. Collingridge, J. Isaac, J. Henley, 2003, Neuron.

NSF Binding to GluR2 Regulates Synaptic Transmission

G. Collingridge, J. Isaac, S. Nakanishi, 1998, Neuron.

mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons , and Canonical Transient Receptor Potential 3 and Regulates

Steven W. Johnson, J. Isaac, P. Strata, 2015 .

Mathematical modelling of non‐stationary fluctuation analysis for studying channel properties of synaptic AMPA receptors

W. W. Anderson, M. Wikström, G. Collingridge, 2001, The Journal of physiology.

Experience-Dependent, Layer-Specific Development of Divergent Thalamocortical Connectivity

J. Isaac, P. Kind, Michael I Daw, 2014, Cerebral cortex.

A Presynaptic Kainate Receptor Is Involved in Regulating the Dynamic Properties of Thalamocortical Synapses during Development

J. Crabtree, G. Collingridge, J. Isaac, 2002, Neuron.

Two differential frequency‐dependent mechanisms regulating tonic firing of thalamic reticular neurons

J. Crabtree, J. Isaac, Rajen B Mistry, 2008, The European journal of neuroscience.

Kainate receptors and the induction of mossy fibre long-term potentiation.

G. Collingridge, J. Isaac, Z. Bortolotto, 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Regulation of Synaptic Strength and AMPA Receptor Subunit Composition by PICK1

Akira Terashima, Graham L. Collingridge, Jeremy M. Henley, 2004, The Journal of Neuroscience.

GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity.

G. Collingridge, J. Isaac, F. Duprat, 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

Christian C. Felder, Jack R. Mellor, J. Isaac, 2015, Cerebral cortex.

An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity

Young Ho Suh, G. Collingridge, J. Isaac, 2008, Neuron.

Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses

J. Isaac, E. Molnár, 2002, TheScientificWorldJournal.

Emergence of cortical inhibition by coordinated sensory–driven plasticity at distinct synaptic loci

J. Isaac, R. Chittajallu, John T.R. Isaac, 2010, Nature Neuroscience.

Regulation of NR1/NR2C N-Methyl-D-aspartate (NMDA) Receptors by Phosphorylation*♦

J. Isaac, K. Roche, John D Badger, 2006, Journal of Biological Chemistry.

A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking

Young Ho Suh, J. Isaac, K. Roche, 2010, Nature Neuroscience.

Thalamocortical input onto layer 5 pyramidal neurons measured using quantitative large-scale array tomography

Eugene W. Myers, Dmitri B. Chklovskii, Erhan Bas, 2013, Front. Neural Circuits.

Hippocalcin Functions as a Calcium Sensor in Hippocampal LTD

G. Collingridge, J. Isaac, J. Henley, 2005, Neuron.

Genetic and Real-World Clinical Data , Combined with Empirical Validation , Nominate Jak-Stat Signaling as a Target for Alzheimer ’ s Disease Therapeutic Development

Guy B. Williams, Nicole, Tobias C. Wood, 2019 .

Differential Regulation of Kainate Receptor Trafficking by Phosphorylation of Distinct Sites on GluR6*

J. Isaac, K. Roche, H. Jaffe, 2009, The Journal of Biological Chemistry.

Long-Term Depression of Kainate Receptor-Mediated Synaptic Transmission

J. Isaac, Kwangwook Cho, J. Jo, 2006, Neuron.

Experience-dependent development of NMDA receptor transmission

J. Isaac, K. Fox, J. Henley, 1999, Nature Neuroscience.

Protein Kinase C Phosphorylation of the Metabotropic Glutamate Receptor mGluR5 on Serine 839 Regulates Ca Oscillations*

J. Isaac, K. Roche, C. Kim, 2005 .

The AMPA Receptor Subunit GluA1 is Required for CA1 Hippocampal Long-Term Potentiation but is not Essential for Synaptic Transmission

Young Ho Suh, J. Isaac, Y. H. Suh, 2019, Neurochemical Research.

Mechanisms of bi-directional modulation of thalamocortical transmission in barrel cortex by presynaptic kainate receptors

J. Isaac, E. Molnár, J. Jouhanneau, 2011, Neuropharmacology.

Kainate receptor trafficking: physiological roles and molecular mechanisms.

J. Isaac, J. Mellor, K. Roche, 2004, Pharmacology & therapeutics.

Synaptic Plasticity in the Hippocampal Slice Preparation

W. W. Anderson, G. Collingridge, J. Isaac, 2001, Current protocols in neuroscience.

The synapse: center stage for many brain diseases

Christian Lüscher, J. Isaac, C. Lüscher, 2009, The Journal of physiology.

Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex

J. Crabtree, J. Isaac, J. Mellor, 2005, The Journal of Neuroscience.

Preclinical target validation using patient-derived cells

Arthur S Slutsky, J. Isaac, B. Pollock, 2015, Nature Reviews Drug Discovery.

Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.

G. Collingridge, J. Isaac, Z. Bortolotto, 2001, Neuropharmacology.

GABAA, NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus

J. Crabtree, J. Isaac, Z. Bashir, 2013, The European journal of neuroscience.

Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells.

J. Isaac, R. Nicoll, R. Malenka, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A Distinct Class of Slow (∼0.2–2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex

William M. Connelly, Vincenzo Crunelli, William M Connelly, 2015, The Journal of Neuroscience.

Protein Phosphatase 1 and LTD Synapses Are the Architects of Depression

J. Isaac, John T.R. Isaac, 2001, Neuron.

Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.

J. Isaac, F. L. Kidd, 2001, Journal of neurophysiology.

Glutamate Clearance Receptors at Thalamocortical Synapses: Role of Kinetics and Activation of Postsynaptic Kainate

S. Sherman, J. Isaac, R. Dingledine, 2015 .

Trafficking and surface expression of the glutamate receptor subunit, KA2.

J. Isaac, K. Roche, Dayna M. Hayes, 2003, Biochemical and biophysical research communications.

Electrophysiological Recordings from Neonatal Neocortical Brain Slices

J. Isaac, Michael I Daw, 2007, Current Protocols in Neuroscience.

Synaptic Transmission in the Hippocampal Slice Lack of AMPA Receptor Desensitization During Basal

J. Isaac, R. Nicoll, R. Malenka, 2015 .

The local anaesthetic QX-314 enables enhanced whole-cell recordings of excitatory synaptic currents in rat hippocampal slices in vitro

Howard V. Wheal, J. Isaac, H. Wheal, 1993, Neuroscience Letters.