P. Puigserver

P. Puigserver, B. Spiegelman, Z. Wu, 2000, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes

P. Puigserver, F. Vazquez, C. Picó, 1997 .

Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.

P. Puigserver, C. Trautwein, Amy K. Rines, 2017, Cell metabolism.

Mechanisms of mitochondrial respiratory adaptation

P. Puigserver, C. F. Bennett, P. Latorre-Muro, 2022, Nature Reviews Molecular Cell Biology.

TITLE: Maintenance of Glucose Homeostasis through Acetylation of the Metabolic Transcriptional Coactivator PGC-1alpha PRINCIPAL INVESTIGATOR:

P. Puigserver, Principal Investigator, 2007 .

Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1α) expression in the murine brain

P. Puigserver, B. Spiegelman, N. Tritos, 2003, Brain Research.

Modulation of Estrogen Receptor-α Transcriptional Activity by the Coactivator PGC-1*

P. Puigserver, B. Spiegelman, D. McDonnell, 2000, The Journal of Biological Chemistry.

Adenosine activates thermogenic adipocytes

P. Puigserver, Amy K. Rines, Francisco Verdeguer, 2014, Cell Research.

Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives

P. Puigserver, K. Sharabi, Clint D. J. Tavares, 2019, Current Diabetes Reports.

Transcriptional regulation of adipogenesis.

P. Puigserver, B. Spiegelman, E. Rosen, 2000, Genes & development.

Insulin resistance: β-arrestin development

P. Puigserver, J. T. Rodgers, 2009, Cell Research.

ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas

P. Puigserver, S. Gygi, Mark P. Jedrychowski, 2017, Molecular Cancer Research.

Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production.

P. Puigserver, P. Griffin, K. Sharabi, 2021, Journal of medicinal chemistry.

The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator*

P. Puigserver, S. Gygi, P. Griffin, 2016, The Journal of Biological Chemistry.

correction: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

P. Puigserver, B. Spiegelman, M. Montminy, 2001, Nature.

In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity.

P. Puigserver, J. Dominy, C. Cantó, 2013, Methods in molecular biology.

Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats.

P. Puigserver, A. Palou, M. Gianotti, 1992, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha.

P. Puigserver, 2005, International journal of obesity.

Receptor feasts on sugar and cholesterol

P. Puigserver, J. T. Rodgers, 2007, Nature Medicine.

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11

P. Puigserver, E. Henske, G. Georgiou, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease.

P. Puigserver, Beste Mutlu, B. Mutlu, 2021, The Journal of clinical investigation.

Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.

P. Puigserver, J. Norris, D. McDonnell, 2000, The Journal of biological chemistry.

Effect of selective β-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes

P. Puigserver, M. Stock, C. Picó, 1996, Molecular and Cellular Endocrinology.

Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor*

Jiandie D. Lin, Paul T. Tarr, P. Puigserver, 2002, The Journal of Biological Chemistry.

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.

Jiandie D. Lin, Paul T. Tarr, P. Puigserver, 2002, Nature.

Mitochondrial biogenesis through activation of nuclear signaling proteins.

P. Puigserver, J. Dominy, 2013, Cold Spring Harbor perspectives in biology.

A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure

P. Puigserver, S. Kajimura, Zachary Taxin, 2022, bioRxiv.

Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity

P. Puigserver, M. Soustek, 2015, The EMBO journal.

Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: functional and physical association with the adipogenic transcription factor C/EBPalpha.

P. Puigserver, A. Palou, J. Ribot, 1998, European journal of cell biology.

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.

Jiandie D. Lin, P. Puigserver, B. Spiegelman, 2004, Genes & development.

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

P. Puigserver, B. Spiegelman, F. Vazquez, 2013, Cancer cell.

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Hanna Y. Irie, P. Puigserver, J. Brugge, 2009, Nature.

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

P. Puigserver, F. Vazquez, H. Widlund, 2016, Nature.

A metabolic prosurvival role for PML in breast cancer.

P. Puigserver, P. Pandolfi, M. Bhasin, 2012, The Journal of clinical investigation.

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

P. Puigserver, B. Spiegelman, 2003, Endocrine reviews.

Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression

P. Puigserver, G. Shulman, F. Vazquez, 2014, Nature.

Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression

P. Puigserver, G. Shulman, F. Vazquez, 2014, Nature.

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

Jerry Donovan, Francesco Oriente, P. Puigserver, 2003, Nature.

Activation of PPARγ coactivator-1 through transcription factor docking

Guillaume Adelmant, Bruce M. Spiegelman, P. Puigserver, 1999 .

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

P. Puigserver, B. Spiegelman, C. Park, 1998, Cell.

Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.

P. Puigserver, S. Gygi, W. Haas, 2012, Cell metabolism.

Regulation of adipogenesis and energy balance by PPARγ and PGC-1

P. Puigserver, Z. Wu, B. Spiegelman, 2000, International Journal of Obesity.

Transcriptional activation of adipogenesis.

P. Puigserver, B. Spiegelman, Z. Wu, 1999, Current opinion in cell biology.

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Jiandie D. Lin, Paul T. Tarr, P. Puigserver, 2002, Nature.

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity

P. Puigserver, Joeva J. Barrow, M. Soustek, 2015, Molecular and Cellular Biology.

Insulin regulation of gluconeogenesis

P. Puigserver, Amy K. Rines, K. Sharabi, 2018, Annals of the New York Academy of Sciences.

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.

P. Puigserver, B. Spiegelman, G. Adelmant, 2000, Molecular cell.

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Xiaohui Xie, Nick Patterson, Christoph Handschin, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Activation of PPARgamma coactivator-1 through transcription factor docking.

P. Puigserver, G. Adelmant, B. O’Malley, 1999, Science.

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Wilhelm Haas, P. Puigserver, B. Spiegelman, 2005, Nature.

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

Guillaume Adelmant, Bruce M. Spiegelman, Jerry Donovan, 2001, Nature.

GCN5-mediated Transcriptional Control of the Metabolic Coactivator PGC-1β through Lysine Acetylation*

P. Puigserver, S. Gygi, W. Haas, 2009, The Journal of Biological Chemistry.

Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.

Rutger O. Vogel, P. Puigserver, J. T. Rodgers, 2011, Molecular cell.

Atossa: a royal link between OXPHOS metabolism and macrophage migration

P. Puigserver, P. Latorre-Muro, 2022, The EMBO journal.

Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action

Gene W. Yeo, P. Puigserver, K. Sharabi, 2020, Proceedings of the National Academy of Sciences.

GCN5 ACETYLTRANSFERASE IN CELLULAR ENERGETIC AND METABOLIC PROCESSES.

P. Puigserver, B. Mutlu, 2020, Biochimica et biophysica acta. Gene regulatory mechanisms.

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.

Rutger O. Vogel, P. Puigserver, S. Gygi, 2016, Molecular cell.

Molecular pathophysiology of hepatic glucose production.

P. Puigserver, Amy K. Rines, K. Sharabi, 2015, Molecular aspects of medicine.

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

Alexander S. Banks, V. Mootha, P. Puigserver, 2012, Cell.

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle

Rutger O. Vogel, P. Puigserver, F. Vazquez, 2012, Molecular and Cellular Biology.

Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics

P. Puigserver, L. Guarente, 2012 .

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

P. Puigserver, L. Boros, Hong-Bin Fang, 2011, Cancer research.

Tumor and Stem Cell Biology PGC 1 a Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

P. Puigserver, L. Boros, Hong-Bin Fang, 2011 .

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5.

P. Puigserver, J. Dominy, Yoonjin Lee, 2010, Biochimica et biophysica acta.

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α

P. Puigserver, H. Meziane, J. Auwerx, 2008, Proceedings of the National Academy of Sciences.

Metabolic adaptations through the PGC‐1α and SIRT1 pathways

P. Puigserver, C. Lerin, Z. Gerhart-Hines, 2008 .

Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-α

P. Puigserver, Pere Puigserver, 2005, International Journal of Obesity.

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

P. Puigserver, B. Spiegelman, A. Medvedev, 2004, Molecular and Cellular Biology.

Suppression of β Cell Energy Metabolism and Insulin Release by PGC-1α

P. Puigserver, B. Spiegelman, B. Lowell, 2003 .

Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis

P. Puigserver, B. Spiegelman, J. Rhee, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

Jiandie D. Lin, V. Mootha, P. Puigserver, 2001, Molecular cell.

In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid.

P. Puigserver, F. Vazquez, C. Picó, 1996, The Biochemical journal.

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

Steven P Gygi, Wilhelm Haas, P. Puigserver, 2005, Nature.

Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.

P. Puigserver, S. Gygi, W. Haas, 2010, Cell metabolism.

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.

P. Puigserver, A. Pandey, C. Lerin, 2006, Cell metabolism.

mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

V. Mootha, P. Puigserver, F. Vazquez, 2007, Nature.

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

P. Puigserver, F. Alt, Olivia Baré, 2007, The EMBO journal.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

P. Puigserver, T. Shioda, Xiaoling Li, 2010, Genes & development.

Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation.

P. Puigserver, F. Vazquez, J. Dominy, 2012, Cancer cell.

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.

P. Puigserver, S. Gygi, Mark P. Jedrychowski, 2019, Molecular cell.

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex*

P. Puigserver, M. Tabata, J. Dominy, 2013, The Journal of Biological Chemistry.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Alexander S. Banks, P. Puigserver, L. Alhonen, 2014, Nature.

Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly

P. Puigserver, S. Gygi, Mark P. Jedrychowski, 2021, Nature Chemical Biology.

Breaking BRAF(V600E)–drug resistance by stressing mitochondria

P. Puigserver, H. Widlund, C. Luo, 2016, Pigment cell & melanoma research.

Foxo1 integrates insulin signaling with mitochondrial function in the liver

P. Puigserver, R. DePinho, M. White, 2009, Nature Medicine.

Tetracyclines promote survival and fitness in mitochondrial disease models

P. Puigserver, S. Gygi, Mark P. Jedrychowski, 2020, Nature metabolism.

Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.

P. Puigserver, C. Lerin, Z. Gerhart-Hines, 2008, FEBS letters.

Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency

P. Puigserver, A. Zhu, P. Sicinski, 2020, Cancer Research.

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

P. Puigserver, J. T. Rodgers, 2007, Proceedings of the National Academy of Sciences.

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Andre Fischer, P. Puigserver, L. Tsai, 2007, The EMBO journal.

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylationa

P. Puigserver, D. James, N. Turner, 2014, Molecular metabolism.

Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization.

P. Puigserver, F. Vazquez, C. Luo, 2014, Cancer research.

Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.

Jiandie D. Lin, Paul T. Tarr, P. Puigserver, 2002, The Journal of biological chemistry.

H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP.

P. Puigserver, F. Vazquez, H. Widlund, 2020, The Journal of clinical investigation.

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

Joshua A. Bittker, P. Puigserver, S. Schreiber, 2017, Cell.

Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease

P. Puigserver, C. F. Bennett, Conor T. Ronayne, 2021, The FEBS journal.

Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Effects of reversion to standard diet.

P. Puigserver, A. Palou, I. Lladó, 1991, The Biochemical journal.

A Hypoxia-Induced Positive Feedback Loop Promotes Hypoxia-Inducible Factor 1α Stability through miR-210 Suppression of Glycerol-3-Phosphate Dehydrogenase 1-Like

P. Puigserver, C. Clish, Amanda L. Souza, 2011, Molecular and Cellular Biology.

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction*

Jun Wang, Wei Zhao, Haiteng Deng, 2006, Journal of Biological Chemistry.

The sirtuin family's role in aging and age-associated pathologies.

P. Puigserver, J. Hall, J. Dominy, 2013, The Journal of clinical investigation.

O-GlcNAc Regulates FoxO Activation in Response to Glucose*

P. Puigserver, J. Shabanowitz, D. Hunt, 2008, Journal of Biological Chemistry.

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α

P. Puigserver, M. Lane, S. Cha, 2006, Proceedings of the National Academy of Sciences.

Evolution and Disease Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in

P. Puigserver, T. Schwarz, D. Wallace, 2014 .

A PGC-1α-O-GlcNAc Transferase Complex Regulates FoxO Transcription Factor Activity in Response to Glucose*

P. Puigserver, J. Shabanowitz, D. Hunt, 2009, Journal of Biological Chemistry.

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

John G Doench, P. Puigserver, S. Gygi, 2020, Nature Communications.

Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival

P. Puigserver, E. Perry, C. F. Bennett, 2023, bioRxiv.

The SLC25A47 locus controls gluconeogenesis and energy expenditure

P. Puigserver, S. Kajimura, C. Auger, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells

Rutger O. Vogel, P. Puigserver, S. Gygi, 2018, Cell Death & Disease.

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

P. Puigserver, S. Gygi, Mark P. Jedrychowski, 2014, Diabetes.

Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms.

P. Puigserver, J. Hall, John T. Cunningham, 2014, Molecular endocrinology.

Foxa2, a novel transcriptional regulator of insulin sensitivity

P. Puigserver, J. T. Rodgers, 2006, Nature Medicine.

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells.

P. Puigserver, N. Ruderman, M. Gauthier, 2009, Biochemical and biophysical research communications.

Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming.

P. Puigserver, J. Dominy, Z. Gerhart-Hines, 2011, Cold Spring Harbor symposia on quantitative biology.

Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool.

P. Puigserver, A. Palou, B. Cannon, 1992, The Biochemical journal.

Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth.

P. Puigserver, Eduardo Balsa-Martinez, 2015, Molecular cell.

Maintenance of Glucose Homeostasis Through Acetylation of the Metabolic Transcriptional Coactivator PGC1-alpha

P. Puigserver, 2009 .

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

P. Puigserver, L. Schaeffer, Shuo Lin, 2011, Proceedings of the National Academy of Sciences.

Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas

P. Puigserver, S. Gygi, Mark P. Jedrychowski, 2023, Nature communications.

Stem cells: Dietary fat promotes intestinal dysregulation

P. Puigserver, C. Luo, 2016, Nature.

Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.

Alexander S. Banks, P. Puigserver, S. Gygi, 2023, Cell metabolism.

A sweet way to regulate cellular growth: OGT and mTOR join forces.

P. Puigserver, P. Latorre-Muro, 2023, Molecular cell.