S. Kliewer

S. Kliewer, D. Mangelsdorf, A. Hofmann, 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Identification of a hormonal basis for gallbladder filling

S. Kliewer, A. Bookout, D. Mangelsdorf, 2006, Nature Medicine.

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

S. Kliewer, D. Mangelsdorf, M. Mohammadi, 2008, Cell metabolism.

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

K. Umesono, S. Kliewer, R. Evans, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Multiple Transcriptional Regulatory DomainsintheHuman Immunodeficiency VirusType1LongTerminal Repeat Are Involved inBasalandElA/ElB-Induced Promoter Activity

S. Kliewer, R. Gaynor, E. Soultanakis, 1989 .

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

S. Kliewer, G. Shulman, D. Mangelsdorf, 2011, Science.

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

S. Kliewer, A. Bookout, D. Mangelsdorf, 2010, Molecular endocrinology.

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

S. Kliewer, D. Mangelsdorf, B. Owen, 2015, Trends in Endocrinology & Metabolism.

Structural Basis of Human PXR Activation by the Hops Constituent Colupulone

Denise G. Teotico, S. Kliewer, M. Redinbo, 2008 .

Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells

S. Kliewer, W. Kraus, G. Dohm, 2002 .

Fibroblast growth factor 21: from pharmacology to physiology.

S. Kliewer, D. Mangelsdorf, 2010, The American journal of clinical nutrition.

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

K. Umesono, S. Kliewer, R. Evans, 1992, Nature.

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

S. Kliewer, D. Mangelsdorf, M. Mohammadi, 2014, Diabetes.

Cholesterol detoxification by the nuclear pregnane X receptor.

S. Kliewer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

I. Nuclear receptors and bile acid homeostasis

S. Kliewer, B. Goodwin, 2002 .

Identification of Ligands for Orphan Nuclear Receptors

T. Willson, S. Kliewer, 2003 .

PPARγ Mechanism of Action Studies

S. Kliewer, 2002 .

The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.

J. Lehmann, T. Willson, S. Kliewer, 1999, Recent progress in hormone research.

Metabolic Hormone FGF21 Is Induced in Ground Squirrels during Hibernation but Its Overexpression Is Not Sufficient to Cause Torpor

S. Kliewer, R. Gerard, Xunshan Ding, 2013, PloS one.

Fibroblast growth factor 21: from pharmacology to physiology.

S. Kliewer, D. Mangelsdorf, 2010, The American journal of clinical nutrition.

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

S. Kliewer, Y. Wan, Wei Wei, 2012, eLife.

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

S. Kliewer, Yuan Zhang, R. Evans, 2021, Cell reports.

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21.

S. Kliewer, D. Mangelsdorf, 2019, Cell metabolism.

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.

S. Kliewer, D. Mangelsdorf, D. Morgan, 2017, Cell metabolism.

FGF 19 , FGF 21 , and an FGF R 1 / b-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia Graphical

S. Kliewer, D. Mangelsdorf, D. Morgan, 2017 .

Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo*

S. Kliewer, D. Mangelsdorf, Y. Zhang, 2012, The Journal of Biological Chemistry.

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

S. Kliewer, R. Hammer, Yuan Zhang, 2008, Molecular endocrinology.

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

L. Moore, T. Willson, S. Kliewer, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

J. Lehmann, T. Willson, S. Kliewer, 1995, Cell.

The Role of the Vitamin D Receptor in Bile Acid Homeostasis

S. Kliewer, D. Mangelsdorf, D. R. Schmidt, 2011 .

The nuclear receptor PPARgamma - bigger than fat.

T. Willson, S. Kliewer, 1998, Current opinion in genetics & development.

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.

J. Lehmann, L. Moore, T. Willson, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport : A new syndrome of defective FGF 19 release

S. Kliewer, D. Mangelsdorf, A. Hofmann, 2010 .

AKR1B7 Is Induced by the Farnesoid X Receptor and Metabolizes Bile Acids*

S. Kliewer, M. Makishima, R. Yu, 2010, The Journal of Biological Chemistry.

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.

S. Kliewer, W. Kraus, G. Dohm, 2002, Diabetes.

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

S. Kliewer, R. Taussig, D. Mangelsdorf, 2013, American journal of physiology. Gastrointestinal and liver physiology.

FGF21 Regulates Sweet and Alcohol Preference.

Bhavna S. Paratala, S. Kliewer, Yuan Zhang, 2016, Cell metabolism.

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members (cid:1)

S. Kliewer, K. White, M. Razzaque, 2007 .

Weaving βKlotho into bile acid metabolism

S. Kliewer, A. Moschetta, 2005 .

Nuclear Receptor LRH-1 Induces the Reproductive Neuropeptide Kisspeptin in the Hypothalamus

S. Kliewer, A. Bookout, D. Mangelsdorf, 2013, Molecular endocrinology.

Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.

Robert A. Harris, S. Kliewer, R. Bassel-Duby, 2008, American journal of physiology. Heart and circulatory physiology.

FGF 21 Regulates Sweet a nd Alcohol Preference Graphical

Bhavna S. Paratala, S. Kliewer, D. Mangelsdorf, 2016 .

Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

S. Kliewer, D. Mangelsdorf, James J. Lee, 2017, Proceedings of the National Academy of Sciences.

Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells

S. Kliewer, D. Mangelsdorf, R. Auchus, 2016, Molecular endocrinology.

Retinoid receptors.

K. Umesono, S. Kliewer, R. Evans, 1993, Recent progress in hormone research.

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

L. Moore, T. Willson, S. Kliewer, 2000, Molecular cell.

expressionII. Cold-adapted function and differential Pancreatic triacylglycerol lipase in a hibernating

S. Kliewer, D. Mangelsdorf, L. Drewes, 2015 .

CORRECTIONS

S. Kliewer, S. Prusiner, S. DeArmond, 1894, The Lancet.

Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes

S. Kliewer, D. Mangelsdorf, H. Xu, 2009, Proceedings of the National Academy of Sciences.

Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding.

S. Kliewer, P. Wright, R. Evans, 1993, Science.

Retinoic acid is a negative regulator of AP-1-responsive genes.

S. Kliewer, P. Rangarajan, R. Evans, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

L. Moore, S. Kliewer, D. D. Mckee, 2001, Molecular pharmacology.

The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones

J. Lehmann, L. Moore, T. Willson, 1996 .

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).

J. Lehmann, L. Moore, T. Smith-Oliver, 1995, The Journal of biological chemistry.

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

S. Kliewer, Jasmine Chen, R. Evans, 1994, Molecular endocrinology.

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

S. Kliewer, Y. Wan, Wei Wei, 2012, Proceedings of the National Academy of Sciences.

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

S. Kliewer, K. White, M. Razzaque, 2007, Molecular and Cellular Biology.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

J. Lehmann, T. Willson, S. Kliewer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

K. Umesono, S. Kliewer, R. Evans, 1991, Cell.

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

K. Umesono, S. Kliewer, R. Evans, 1992, Nature.

The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.

S. Kliewer, J. Cha, J. Repa, 2004, Molecular cell.

The nuclear pregnane X receptor regulates xenobiotic detoxification.

S. Kliewer, 2003, The Journal of nutrition.

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

S. Kliewer, John T. Moore, B. Goodwin, 2002, Molecular pharmacology.

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*

L. Moore, T. Willson, S. Kliewer, 2000, The Journal of Biological Chemistry.

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J. Lehmann, T. Willson, S. Kliewer, 1998, The Journal of clinical investigation.

Adenovirus early region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation of CREB/ATF and AP1

S. Kliewer, R. Gaynor, D. Harrich, 1990, Journal of virology.

Pxr, car and drug metabolism

T. Willson, S. Kliewer, 2002, Nature Reviews Drug Discovery.

Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes*

L. Moore, T. Willson, S. Kliewer, 2003, The Journal of Biological Chemistry.

Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity

S. Kliewer, R. Gaynor, E. Soultanakis, 1989, Journal of virology.

MicroRNA let-7 regulates 3T3-L1 adipogenesis.

Tingwan Sun, S. Kliewer, A. Bookout, 2009, Molecular endocrinology.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

S. Kliewer, F. J. Poelwijk, D. Mangelsdorf, 2011, Genes & development.

SnapShot: Hormones of the Gastrointestinal Tract

S. Kliewer, D. Mangelsdorf, K. Coate, 2014, Cell.

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

S. Kliewer, R. Evans, R. Schüle, 1990, Cell.

Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development

S. Kliewer, D. Wheeler, A. Cooney, 2005, Molecular and Cellular Biology.

Peroxisome proliferator-activated receptors and reverse endocrinology

S. Kliewer, 2002 .

Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues.

T. Willson, S. Kliewer, T. Mansfield, 2001, Endocrinology.

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ∞ AND METABOLIC DISEASE

Millard H. Lambert, Timothy M. Willson, T. Willson, 2001 .

Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways.

J. Lehmann, S. Kliewer, J. Weiel, 1997, Biochemical pharmacology.

Discovery of Ligands for the Nuclear Peroxisome Proliferator‐activated Receptors

J. Lehmann, T. Willson, S. Kliewer, 1996, Annals of the New York Academy of Sciences.

Activation of the Nuclear Receptor Peroxisome Proliferator-activated Receptor γ Promotes Brown Adipocyte Differentiation*

J. Lehmann, W. Wilkison, S. Kliewer, 1996, The Journal of Biological Chemistry.

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21*

S. Kliewer, K. Rosenblatt, M. Mohammadi, 2007, Journal of Biological Chemistry.

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF 19 Subfamily Members Running Title: Klotho-dependent, endocrine-acting FGFs

S. Kliewer, K. White, M. Razzaque, 2007 .

The nuclear receptor PPARγ - Bigger than fat

T. Willson, S. Kliewer, 1998 .

B‐Lyl Cells: Immortal Ly‐1 + B Lymphocyte Cell Lines Spontaneously Arising in Murine Splenic Cultures

S. Kliewer, D. Baltimore, J. Braun, 1986, Immunological reviews.

Cloning and Characterization of Human Estrogen Receptor β Isoforms

J. Lehmann, L. Moore, T. Willson, 1998 .

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.

S. Kliewer, H. Xu, Mihwa Choi, 2005, Molecular cell.

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

S. Kliewer, D. Mangelsdorf, T. Nolan, 2016, PLoS pathogens.

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

S. Kliewer, D. Mangelsdorf, Jonathan D. C. Stoltzfus, 2021, bioRxiv.

Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis

S. Kliewer, D. Mangelsdorf, J. Lok, 2021, Proceedings of the National Academy of Sciences.

The 'Nuclear Option' Revisited: Confirmation of Ss-daf-12 Function and Therapeutic Potential in Strongyloides stercoralis and Other Parasitic Nematode Infections.

S. Kliewer, D. Mangelsdorf, J. Lok, 2022, Molecular and biochemical parasitology.

Nuclear receptors: emerging drug targets for parasitic diseases.

S. Kliewer, D. Mangelsdorf, Zhu Wang, 2017, The Journal of clinical investigation.

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

S. Kliewer, D. Mangelsdorf, Jonathan D. C. Stoltzfus, 2020, Parasites & Vectors.

FGF21 regulates circadian behavior and metabolism by acting on the nervous system

S. Kliewer, J. Takahashi, A. Bookout, 2013, Nature medicine.

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

S. Kliewer, R. Hammer, D. Mangelsdorf, 2007, Cell metabolism.

Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.

K. Umesono, S. Kliewer, P. Ghazal, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

S. Kliewer, D. Mangelsdorf, Matthew J. Potthoff, 2008, Diabetes.

NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2

S. Kliewer, P. Wright, R. Evans, 1997, The Journal of Biological Chemistry.

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

Millard H. Lambert, Timothy M. Willson, T. Willson, 2002, Nature.

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

S. Kliewer, T. Horvath, D. Mangelsdorf, 2016, Proceedings of the National Academy of Sciences.

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor*

Paul T Tarr, Peter Tontonoz, Timothy M Willson, 2002, The Journal of Biological Chemistry.

Use of the nuclear receptor PXR to predict drug interactions.

S. Kliewer, J. Moore, John T. Moore, 2000, Toxicology.

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

L. Moore, T. Willson, S. Kliewer, 2000, Molecular endocrinology.

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

L. Moore, S. Kliewer, M. Lambert, 2005, Molecular endocrinology.

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

L. Moore, S. Kliewer, M. Lambert, 2003, Biochemistry.

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

L. Moore, T. Willson, S. Kliewer, 2000 .

Regulation of cyp3a gene transcription by the pregnane x receptor.

S. Kliewer, M. Redinbo, B. Goodwin, 2002, Annual review of pharmacology and toxicology.

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3

J. Collins, S. Kliewer, D. Mangelsdorf, 2021, PLoS pathogens.

Enhanced acetaminophen toxicity by activation of the pregnane X receptor.

S. Kliewer, J. Ward, C. Nicol, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

T. Willson, S. Kliewer, T. Ono, 1999, The Journal of Biological Chemistry.

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.

T. Willson, S. Kliewer, T. Mansfield, 2001, Endocrinology.

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.

Bryan Goodwin, S. Kliewer, T. Mansfield, 2003, The Journal of clinical investigation.

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.

J. Lehmann, T. Willson, S. Kliewer, 2000, Molecular cell.

An RNA polymerase II transcription factor inactivated in poliovirus-infected cells copurifies with transcription factor TFIID

S. Kliewer, A. Dasgupta, A Dasgupta, 1988, Molecular and cellular biology.

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

P. O’Reilly, P. Elliott, M. Jarvelin, 2016, Proceedings of the National Academy of Sciences.

Peroxisome proliferator-activated receptor gamma and metabolic disease.

T. Willson, S. Kliewer, M. Lambert, 2001, Annual review of biochemistry.

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D*

S. Kliewer, A. Bookout, D. Mangelsdorf, 2010, The Journal of Biological Chemistry.

Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.

Yong Li, Mihwa Choi, S. Kliewer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.

S. Kliewer, D. Mangelsdorf, Yang Xie, 2018, Cell metabolism.

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

S. Kliewer, J. L. Shenk, H. Xu, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

Yuan Zhang, Rucha Patel, S. Kliewer, 2015, Molecular endocrinology.

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

S. Kliewer, A. Bookout, D. Mangelsdorf, 2014, Cell metabolism.

FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons

S. Kliewer, Yuan Zhang, J. Friedman, 2022, bioRxiv.

Effects of fenofibrate on lipid parameters in obese rhesus monkeys.

J. Lehmann, W. Wilkison, S. Kliewer, 2001, Journal of lipid research.

Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors

Millard H. Lambert, Timothy M. Willson, T. Willson, 2000 .

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

Wen Xie, David D Moore, S. Kliewer, 2006, Pharmacological reviews.

Nuclear receptors. I. Nuclear receptors and bile acid homeostasis.

S. Kliewer, B. Goodwin, 2002, American journal of physiology. Gastrointestinal and liver physiology.

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

S. Kliewer, D. Mangelsdorf, Genaro Hernandez, 2020, Science Translational Medicine.

Peroxisome proliferator-activated receptors: from genes to physiology.

T. Willson, S. Kliewer, M. Lambert, 2001, Recent progress in hormone research.

Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists*

T. Willson, S. Kliewer, K. Brown, 2001, The Journal of Biological Chemistry.

FGF21 Counteracts Alcohol Intoxication by Activating the Noradrenergic Nervous System

S. Kliewer, R. Hammer, Yuan Zhang, 2023, Cell metabolism.

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.

J. Lehmann, L. Moore, S. Kliewer, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Unusual signaling pathway of steroid hormones: Dual action of progesterone

J. Lehmann, S. Kliewer, T. Perlmann, 1999 .

Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers

S. Kliewer, S. Lam, R. Deberardinis, 2023, Frontiers in Oncology.

Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development

S. Kliewer, D. Wheeler, A. Cooney, 2005, Molecular and Cellular Biology.

FGF21 Is an Exocrine Pancreas Secretagogue.

S. Kliewer, D. Mangelsdorf, Genaro Hernandez, 2017, Cell metabolism.

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

S. Kliewer, D. Mangelsdorf, Shengyi Sun, 2019, Genes & development.

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

S. Kliewer, D. Mangelsdorf, Hao Tang, 2015, PLoS genetics.

Loss of a phosphorylated form of transcription factor CREB/ATF in poliovirus-infected cells

S. Kliewer, R. Gaynor, A. Dasgupta, 1990, Journal of virology.

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.

J. Lehmann, T. Smith-Oliver, T. Willson, 1997, Chemistry & biology.

Cell-free ligand binding assays for nuclear receptors.

S. Kliewer, Stacey A. Jones, D. Parks, 2003, Methods in enzymology.

NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.

S. Kliewer, P. Wright, R. Evans, 1994, European journal of biochemistry.

Structural insights into gene repression by the orphan nuclear receptor SHP

S. Kliewer, D. Mangelsdorf, C. Zechner, 2013, Proceedings of the National Academy of Sciences.

Activation of the orphan receptor RIP14 by retinoids.

J. Lehmann, T. Willson, S. Kliewer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-α (PPARα) Generates a PPARδ Phenotype

K. Umesono, S. Kliewer, M. Lambert, 2000 .

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.

T. Willson, S. Kliewer, J. Collins, 2001, The Journal of biological chemistry.

Pregnane X receptor: predicting and preventing drug interactions.

S. Kliewer, 2005, Thrombosis research.

The retinoid X receptors. Modulators of multiple hormonal signaling pathways.

K. Umesono, S. Kliewer, R. Evans, 1994 .

Functional and structural comparison of PXR and CAR.

L. Moore, S. Kliewer, John T. Moore, 2003, Biochimica et biophysica acta.

Role of peroxisome proliferator-activated receptors in atherosclerosis

S. Kliewer, J. Su, D. Winegar, 2000 .

Abstract 5757: A new functional classification of lung and breast cancers based on siRNA mediated knockdown of 48 NRs and 72 CoRegulators

S. Kliewer, S. Fuqua, J. Minna, 2012 .

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

S. Kliewer, R. Kittler, D. Mangelsdorf, 2018, Proceedings of the National Academy of Sciences.

Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype.

K. Umesono, S. Kliewer, M. Lambert, 2000, Molecular endocrinology.

A peroxisome proliferator-activated receptor g ligand inhibits adipocyte differentiation

J. Lehmann, L. Moore, T. Willson, 1999 .

Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 7

S. Kliewer, D. Mangelsdorf, H. Xu, 2009 .

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.

L. Moore, S. Kliewer, Stacey A. Jones, 2002, Methods in enzymology.

Direct G Protein Modulation of Cav2 Calcium Channels

B. Spiegelman, S. Kliewer, G. Eichele, 2006, Pharmacological Reviews.

Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes*

S. Kliewer, D. Mangelsdorf, H. Xu, 2011, The Journal of Biological Chemistry.

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members

S. Kliewer, K. White, M. Razzaque, 2007 .

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.

J. Lehmann, L. Moore, T. Willson, 1996, Journal of medicinal chemistry.

Nuclear receptor regulation of genes involved in bile acid metabolism.

T. Willson, S. Kliewer, John T. Moore, 2002, Critical reviews in eukaryotic gene expression.

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

S. Kliewer, G. Shulman, D. Mangelsdorf, 2011, Science.

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

S. Kliewer, D. Mangelsdorf, J. Repa, 2005, Cell metabolism.

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.

S. Kliewer, D. Mangelsdorf, Matthew J. Potthoff, 2011, Cell metabolism.

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.

S. Kliewer, D. Mangelsdorf, Matthew J. Potthoff, 2012, Genes & development.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

S. Kliewer, F. J. Poelwijk, D. Mangelsdorf, 2011, Genes & development.

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.

S. Kliewer, A. Bookout, D. Mangelsdorf, 2012, Cell metabolism.

Structural insights into gene repression by the orphan nuclear receptor SHP

S. Kliewer, D. Mangelsdorf, C. Zechner, 2013, Proceedings of the National Academy of Sciences.

Cholesterol detoxification by the nuclear pregnane X receptor.

S. Kliewer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

FGF21 Regulates Sweet and Alcohol Preference.

Bhavna S. Paratala, S. Kliewer, Yuan Zhang, 2016, Cell metabolism.

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

S. Kliewer, A. Bookout, D. Mangelsdorf, 2015, Molecular endocrinology.

Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

S. Kliewer, D. Mangelsdorf, James J. Lee, 2017, Proceedings of the National Academy of Sciences.