B. Shen

发表

Synthetic biology to access and expand nature's chemical diversity

Christopher A. Voigt, C. Voigt, M. Smanski, 2016, Nature Reviews Microbiology.

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

B. Shen, Soohyun Lee, Shu-Bing Qian, 2012, Proceedings of the National Academy of Sciences.

Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F)

P. G. Arnison, M. Bibb, B. Shen, 2013 .

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

P. G. Arnison, M. Bibb, B. Shen, 2013, Natural product reports.

A New Golden Age of Natural Products Drug Discovery

B. Shen, 2015, Cell.

Minimum Information about a Biosynthetic Gene cluster.

Carla S. Jones, M. Smanski, Jan Claesen, 2015, Nature chemical biology.

The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis.

B. Shen, P. Dorrestein, Z. Deng, 2006, Journal of the American Chemical Society.

A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites

B. Shen, K. Gevaert, W. Van Criekinge, 2014, Proteomics.

Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models.

B. Shen, Lin Qiu, M. Cameron, 2019, Molecular pharmaceutics.

Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus.

B. Shen, E. Powell, Sheng-Xiong Huang, 2010, Organic letters.

Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination

B. Shen, L. Duan, Yi-Zun Yu, 2010, Nature chemical biology.

NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide.

B. Shen, L. Duan, Ying Ding, 2010, Journal of the American Chemical Society.

Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.

B. Shen, L. Duan, Ying Ding, 2009, Chemistry & biology.

Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis

B. Shen, Ute Galm, 2006, Expert opinion on drug discovery.

Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase

B. Shen, W. Yan, Guohui Pan, 2021, Nature communications.

Crystal Structure of SgcJ, An NTF2-Like Superfamily Protein Involved in Biosynthesis of the 9-Membered Enediyne Antitumor Antibiotic C-1027

B. Shen, G. Phillips, A. Joachimiak, 2016, The Journal of Antibiotics.

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

B. Shen, G. Phillips, A. Joachimiak, 2016, Journal of the American Chemical Society.

In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin.

B. Shen, M. Cameron, Claudia H. Ruiz, 2017, Bioorganic & medicinal chemistry.

Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029.

B. Shen, J. Rudolf, Liao-Bin Dong, 2016, Bioorganic & Medicinal Chemistry.

The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery

B. Shen, S. Rajski, Claudia Unsin, 2013 .

Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

B. Shen, F. Hoffmann, H. Osada, 2009, Organic letters.

Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3β

B. Shen, Herb Chen, J. Adler, 2009, Molecular Cancer Therapeutics.

Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.

B. Shen, N. Colburn, J. Mcmahon, 2011, Journal of natural products.

Stereoselective functionalization of platensimycin and platencin by sulfa-Michael/aldol reactions.

B. Shen, Youchao Deng, Y. Duan, 2019, Organic & biomolecular chemistry.

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

B. Shen, Xiaohui Yan, J. Rudolf, 2016, Journal of Industrial Microbiology & Biotechnology.

A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases.

B. Shen, L. Zhao, Xiaohui Yan, 2019, Environmental microbiology.

A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases

B. Shen, L. Zhao, Xiaohui Yan, 2019, bioRxiv.

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.

B. Shen, J. Rudolf, Liao-Bin Dong, 2015, Molecular bioSystems.

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

B. Shen, Yi-Qiang Cheng, G. Tang, 2006, Journal of natural products.

BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation.

B. Shen, L. Du, Mei Chen, 2003, Biochemistry.

Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis*

B. Shen, H. Osada, J. Ju, 2008, Journal of Biological Chemistry.

Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

B. Shen, C. Hutchinson, C. Hutchinson, 1993, Biochemistry.

Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234

B. Shen, Xiaohui Yan, Xiangcheng Zhu, 2018, Journal of Industrial Microbiology & Biotechnology.

Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003.

B. Shen, L. Du, Mei Chen, 2002, Journal of natural products.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Jared T. Shaw, Derek S. Tan, D. E. Olson, 2018, ACS central science.

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2008, Proceedings of the National Academy of Sciences.

Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

E. L. Guenther, B. Shen, H. Cooke, 2009, Biochemistry.

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

B. Shen, G. Phillips, A. Joachimiak, 2018, Nature Chemical Biology.

The missing C-17 O-methyltransferase in geldanamycin biosynthesis.

B. Shen, Li-hua Xu, Min Yin, 2011, Organic letters.

Targeting Bacterial Genomes for Natural Product Discovery.

B. Shen, Guohui Pan, Edward Kalkreuter, 2019, Trends in pharmacological sciences.

Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation.

B. Shen, Wenli Li, Xiuling Li, 2016, Bioorganic & medicinal chemistry.

Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates

B. Shen, C. Rader, A. Adhikari, 2021, Antibody therapeutics.

Engineered production of iso-migrastatin in heterologous Streptomyces hosts.

B. Shen, Zhinan Xu, S. Rajski, 2009, Bioorganic & medicinal chemistry.

Staurosporine produced by marine-derived actinomycete Streptomyces roseoflavus MB-97 isolated from coastal sediment

B. Shen, J. Ju, Jiang-chun Hu, 2008 .

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

B. Shen, G. Phillips, A. Joachimiak, 2016, Biochemistry.

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

B. Shen, G. Phillips, A. Joachimiak, 2014, Proteins.

Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics.

B. Shen, B. Moore, Anna Lechner, 2013, Biochemistry.

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

B. Shen, G. Wilding, D. Church, 2015, Proceedings of the National Academy of Sciences.

Purification andCharacterization oftheAcylCarrier Protein ofthe Streptomyces glaucescens Tetracenomycin CPolyketide Synthase

B. Shen, H. Gramajo, 1992 .

Triple hydroxylation of tetracenomycin A2 to tetracenomycin C in Streptomyces glaucescens. Overexpression of the tcmG gene in Streptomyces lividans and characterization of the tetracenomycin A2 oxygenase.

B. Shen, C. Hutchinson, 1994, The Journal of biological chemistry.

Divergent synthesis of complex diterpenes through a hybrid oxidative approach

B. Shen, J. Rudolf, Liao-Bin Dong, 2020, Science.

Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids.

B. Shen, Lin Qiu, Xiangcheng Zhu, 2018, ChemistrySelect.

A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin.

B. Shen, Xiangcheng Zhu, Y. Duan, 2017, Tetrahedron.

Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577.

B. Shen, Xiaohui Yan, Xiangcheng Zhu, 2019, Journal of natural products.

Leveraging a large microbial strain collection for natural product discovery

B. Shen, Christiana N. Teijaro, Andrew D. Steele, 2019, The Journal of Biological Chemistry.

Strain Prioritization and Genome Mining for Enediyne Natural Products

B. Shen, F. van Nieuwerburgh, L. Zhao, 2016, mBio.

Cloning, Sequencing, and Heterologous Expression of the elmGHIJ Genes Involved in the Biosynthesis of the Polyketide Antibiotic Elloramycin from Streptomyces olivaceus Tü2353

B. Shen, H. Decker, E. R. Rafanan, 2001 .

The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway.

B. Shen, S. V. Van Lanen, S. Bruner, 2007, Biochemistry.

The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides

B. Shen, C. Hutchinson, E. Wendt-Pienkowski, 1995 .

A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.

B. Shen, Bo Zhang, M. Ma, 2017, Angewandte Chemie.

Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity.

B. Shen, M. Ma, J. Ju, 2013, Journal of the American Chemical Society.

Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.

B. Shen, Hui Jiang, J. Ju, 2005, Journal of the American Chemical Society.

Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

B. Shen, M. Ma, Li-hua Xu, 2014, Organic letters.

Iso-migrastatin titer improvement in the engineered Streptomyces lividans SB11002 strain by optimization of fermentation conditions

B. Shen, Z. Lv, Yao-Zhou Zhang, 2010, Biotechnology and bioprocess engineering : BBE.

iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase*

B. Shen, Hui Jiang, C. Farnet, 2009, The Journal of Biological Chemistry.

Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

B. Shen, F. Hoffmann, J. Ju, 2009, Journal of the American Chemical Society.

Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues.

B. Shen, Hui Jiang, J. Ju, 2006, Organic letters.

Multifaceted Modes of Action for the Glutarimide‐Containing Polyketides Revealed

B. Shen, S. Rajski, 2010, Chembiochem : a European journal of chemical biology.

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2007, Journal of the American Chemical Society.

Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944*

B. Shen, Shuangjun Lin, J. Ju, 2010, The Journal of Biological Chemistry.

Opposite facial specificity for two hydroquinone epoxidases: (3-si,4-re)-2,5-dihydroxyacetanilide epoxidase from Streptomyces LL-C10037 and (3-re,4-si)-2,5-dihydroxyacetanilide epoxidase from Streptomyces MPP 3051.

B. Shen, S. Gould, 1991, Biochemistry.

Macrotetrolide biosynthesis: a novel type II polyketide synthase.

B. Shen, H. Kwon, 2002, Chemical record.

Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453.

B. Shen, Z. Deng, J. Ju, 2008, Acta biochimica et biophysica Sinica.

New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase.

B. Shen, Zhiguo Yu, M. Kron, 2012, Organic letters.

Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis.

B. Shen, Changsoo Chang, Christiana N. Teijaro, 2022, Journal of the American Chemical Society.

Cryptic sulfur incorporation in thioangucycline biosynthesis.

B. Shen, M. Rateb, Yu‐Chen Liu, 2021, Angewandte Chemie.

Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2010, Journal of the American Chemical Society.

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

B. Shen, J. Thorson, Geoff P. Horsman, 2010, Proceedings of the National Academy of Sciences.

Conversion of (2S)‐Arginine to (2S,3R)‐Capreomycidine by VioC and VioD from the Viomycin Biosynthetic Pathway of Streptomyces sp. Strain ATCC11861

B. Shen, J. Ju, Michael G. Thomas, 2004, Chembiochem : a European journal of chemical biology.

4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis.

B. Shen, J. Lohman, 2012, Methods in enzymology.

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM.

B. Shen, S. Bruner, T. Montavon, 2008, Bioorganic & medicinal chemistry letters.

A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.

B. Shen, Wen Liu, M. Toney, 2003, Journal of the American Chemical Society.

Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.

B. Shen, Dong Yang, K. Gates, 2018, Chemical communications.

Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement

B. Shen, Guohui Pan, Yong Huang, 2016, Applied Microbiology and Biotechnology.

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.

B. Shen, G. Phillips, A. Joachimiak, 2015, Biochemistry.

Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues.

B. Shen, B. Neilan, V. Murray, 2016, Bioorganic & medicinal chemistry.

Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.

B. Shen, Herb Chen, J. Adler, 2009, American journal of surgery.

Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Hosts

B. Shen, E. Wendt-Pienkowski, Yihua Chen, 2008, Journal of bacteriology.

Crystallization and preliminary X-ray analysis of tetracenomycin A2 oxygenase: a flavoprotein hydroxylase involved in polyketide biosynthesis.

B. Shen, A. Fisher, J. Beynon, 2000, Acta crystallographica. Section D, Biological crystallography.

Type I polyketide synthases that require discrete acyltransferases.

B. Shen, Yi-Qiang Cheng, Si-Kyu Lim, 2009, Methods in enzymology.

Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog.

B. Shen, Zhinan Xu, M. Tao, 2010, Molecular bioSystems.

Platensimycin-Encapsulated Poly(lactic-co-glycolic acid) and Poly(amidoamine) Dendrimers Nanoparticles with Enhanced Anti-Staphylococcal Activity in Vivo.

B. Shen, Xiangcheng Zhu, Xueqiong Feng, 2020, Bioconjugate chemistry.

Biosynthesis of enediyne antitumor antibiotics.

B. Shen, S. V. Van Lanen, 2008, Current topics in medicinal chemistry.

MIO-containing aminomutases for α- to β-amino acids.

B. Shen, Edward Kalkreuter, 2021, Trends in chemistry.

A new member of the 4-methylideneimidazole-5-one–containing aminomutase family from the enediyne kedarcidin biosynthetic pathway

B. Shen, Tingting Huang, J. Lohman, 2013, Proceedings of the National Academy of Sciences.

Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2012, Organic letters.

Decoding Human Cytomegalovirus

Marco Y. Hein, Nicholas T. Ingolia, B. Shen, 2012, Science.

Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141

B. Shen, J. Pelletier, Zhiguo Yu, 2011, The Journal of Antibiotics.

Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

B. Shen, C. Hutchinson, H. Nakayama, 1993, Journal of natural products.

Identification and characterization of a novel estrogenic ligand actinopolymorphol A.

B. Shen, F. Hoffmann, H. Xu, 2010, Biochemical pharmacology.

Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209

B. Shen, Zhiguo Yu, Kristopher C. Carver, 2011, The Journal of Antibiotics.

Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin

Tilman Schneider-Poetsch, Ben Shen, Rachel Green, 2010, Nature chemical biology.

Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin.

B. Shen, Hui Jiang, J. Ju, 2005, Journal of the American Chemical Society.

Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.

B. Shen, M. Spies, Weiming Wu, 2003, Biochemistry.

Biosynthesis of thiocarboxylic acid-containing natural products

B. Shen, K. Houk, Youchao Deng, 2018, Nature Communications.

Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action.

B. Shen, Zhiguo Yu, D. Andes, 2013, Medical mycology.

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.

B. Shen, L. Gawron, T. Beerman, 2007, Cancer research.

Platensimycin-Encapsulated Liposomes or Micelles as Biosafe Nanoantibiotics Exhibited Strong Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus Infection in Mice.

B. Shen, Meng Su, Y. Duan, 2020, Molecular pharmaceutics.

Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis.

B. Shen, Xiaohui Yan, Christiana N. Teijaro, 2021, ACS chemical biology.

Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo.

B. Shen, Meng Su, Youchao Deng, 2019, Journal of medicinal chemistry.

Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

B. Shen, Xiaohui Yan, Xiangcheng Zhu, 2018, Front. Chem..

The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.

B. Shen, N. George, M. Tao, 2007, Molecular bioSystems.

Neaumycin: a new macrolide from Streptomyces sp. NEAU-x211.

B. Shen, Xiangjing Wang, Ji Zhang, 2012, Organic letters.

Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis.

B. Shen, Shuangjun Lin, Tingting Huang, 2012, Methods in enzymology.

Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases

B. Shen, G. Phillips, A. Joachimiak, 2015, Proceedings of the National Academy of Sciences.

Germicidins H–J from Streptomyces sp. CB00361

B. Shen, M. Rateb, M. Ma, 2016, The Journal of Antibiotics.

PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases.

B. Shen, Liao-Bin Dong, Yu‐Chen Liu, 2020, ACS chemical biology.

Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686.

B. Shen, Malina A. Bakowski, M. Rateb, 2019, ACS chemical biology.

Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.

B. Shen, Xiaohui Yan, C. Rader, 2018, Organic letters.

Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity.

B. Shen, M. Rateb, Xiangcheng Zhu, 2018, Journal of natural products.

Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.

B. Shen, Xiaohui Yan, Xiangcheng Zhu, 2018, Journal of natural products.

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.

B. Shen, Xiaohui Yan, C. Rader, 2017, Organic letters.

Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026

B. Shen, Xiangcheng Zhu, Y. Duan, 2016, Journal of Industrial Microbiology & Biotechnology.

Adipostatins A–D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

B. Shen, M. Rateb, Zhiguo Yu, 2015, The Journal of Antibiotics.

Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.

B. Shen, Zhiguo Yu, N. Ledeboer, 2011, Organic letters.

Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus.

B. Shen, Geoff P. Horsman, Min Yin, 2011, Journal of natural products.

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

B. Shen, Shengxiong Huang, Geoff P. Horsman, 2010, The Journal of Antibiotics.

Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.

M. Smanski, B. Shen, Zhiguo Yu, 2010, Organic letters.

Genetic Localization and Molecular Characterization of the nonS Gene Required for Macrotetrolide Biosynthesis inStreptomyces griseus DSM40695

B. Shen, Longkuan Xiang, W. Smith, 2000, Antimicrobial Agents and Chemotherapy.

Enediyne Biosynthesis and Self-Resistance: A Progress Report

B. Shen, J. Thorson, Yuan Li, 1999 .

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

Jean-Marc Nuzillard, Jean-Hugues Renault, Christoph Steinbeck, 2019, Natural product reports.

Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.

Wen Liu, Ben Shen, B. Shen, 2009, ACS chemical biology.

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

B. Shen, G. Phillips, A. Joachimiak, 2017, ACS omega.

Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase–Polyketide Synthase Interface for Leinamycin Biosynthesis

B. Shen, Guohui Pan, Yong Huang, 2016, Organic letters.

Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis

B. Shen, J. Rudolf, Tingting Huang, 2014, Organic letters.

Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases.

B. Shen, Hui Jiang, S. Rajski, 2009, Methods in enzymology.

Biosynthetic Origin of the Ether Ring in Platensimycin.

B. Shen, J. Rudolf, Liao-Bin Dong, 2016, Journal of the American Chemical Society.

Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine

B. Shen, J. Rudolf, Liao-Bin Dong, 2017, Biochemical pharmacology.

Functional Characterization of tlmK Unveiling Unstable Carbinolamide Intermediates in the Tallysomycin Biosynthetic Pathway*

B. Shen, M. Tao, Ute Galm, 2009, Journal of Biological Chemistry.

Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA.

B. Shen, Youchao Deng, Y. Duan, 2021, ACS medicinal chemistry letters.

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid

B. Shen, A. Demain, S. Siddiqui, 2017, The Journal of Antibiotics.

Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.

M. Smanski, B. Shen, J. Rudolf, 2014, Chemistry & biology.

Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600

M. Smanski, B. Shen, M. Rateb, 2013, The Journal of Antibiotics.

Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis.

B. Shen, J. Rudolf, Liao-Bin Dong, 2018, Journal of the American Chemical Society.

Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanus SB8005 strain by fermentation optimization

B. Shen, Zhinan Xu, M. Tao, 2010, Applied Microbiology and Biotechnology.

Bleomycin Biosynthesis inStreptomyces verticillusATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis☆☆☆★

B. Shen, L. Du, Mei Chen, 1999 .

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.

B. Shen, Yi-Qiang Cheng, G. Tang, 2004, Chemistry & biology.

The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide–polyketide natural product biosynthesis

B. Shen, L. Du, D. J. Edwards, 2001, Journal of Industrial Microbiology and Biotechnology.

Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units*

B. Shen, Z. Deng, J. Ju, 2010, The Journal of Biological Chemistry.

Discovery of the leinamycin family of natural products by mining actinobacterial genomes

B. Shen, J. Suh, F. van Nieuwerburgh, 2017, Proceedings of the National Academy of Sciences.

Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2009, FEMS microbiology letters.

Natural product drug discovery: the times have never been better.

Ben Shen, B. Shen, Ute Galm, 2007, Chemistry & biology.

C-S bond cleavage by a polyketide synthase domain

B. Shen, M. Ma, J. Lohman, 2015, Proceedings of the National Academy of Sciences.

Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms.

Ben Shen, B. Shen, 2003, Current opinion in chemical biology.

Identifi cation of antifungal natural products via Saccharomyces cerevisiae bioassay : insights into macrotetrolide drug spectrum , potency and mode of action

B. Shen, D. Andes, B. Klein, 2013 .

A designer bleomycin with significantly improved DNA cleavage activity.

B. Shen, M. Tao, Y. Duan, 2012, Journal of the American Chemical Society.

Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600.

B. Shen, Y. Duan, Cheng-lin Jiang, 2009, Organic letters.

Combinatorial Biosynthesis of Anticancer Natural Products

B. Shen, M. Thomas, K. Bixby, 2005 .

Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus.

B. Shen, Xiangcheng Zhu, Youchao Deng, 2018, Journal of natural products.

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates.

B. Shen, Geoff P. Horsman, A. Bechthold, 2018, Biochemistry.

Hybrid Peptide–Polyketide Natural Product Biosynthesis

B. Shen, Guohui Pan, Song Meng, 2020 .

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.

B. Shen, J. Cleveland, M. Ma, 2018, Biochemistry.

Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.

B. Shen, J. Cleveland, M. Ma, 2015, Bioorganic & medicinal chemistry letters.

Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules.

B. Shen, L. Du, Yi-Qiang Cheng, 2003, Genetic engineering.

Identification and Localization of the Gene Cluster Encoding Biosynthesis of the Antitumor Macrolactam Leinamycin in Streptomyces atroolivaceus S-140

B. Shen, Yi-Qiang Cheng, G. Tang, 2002, Journal of bacteriology.

Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules.

B. Shen, L. Du, C. Sánchez, 2001, Metabolic engineering.

Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues.

B. Shen, Liao-Bin Dong, Qihui Teng, 2017, Organic letters.

In Vivo Manipulation of the Bleomycin Biosynthetic Gene Cluster in Streptomyces verticillus ATCC15003 Revealing New Insights into Its Biosynthetic Pathway*

B. Shen, Wen Liu, M. Tao, 2008, Journal of Biological Chemistry.

A Dedicated Phosphopantetheinyl Transferase for the Fredericamycin Polyketide Synthase from Streptomyces griseus*

B. Shen, Yong Huang, E. Wendt-Pienkowski, 2006, Journal of Biological Chemistry.

Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues

B. Shen, Hui Jiang, J. Cleveland, 2014, Biochemistry.

New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus.

B. Shen, J. Ju, Jeong-Woo Seo, 2007, Organic letters.

Chain Initiation in the Leinamycin-producing Hybrid Nonribosomal Peptide/Polyketide Synthetase from Streptomyces atroolivaceus S-140

B. Shen, Yi-Qiang Cheng, G. Tang, 2007, Journal of Biological Chemistry.

Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold.

B. Shen, G. Phillips, C. Bingman, 2013, Biochemistry.

Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis.

B. Shen, T. Liu, J. Ju, 2011, Organic letters.

Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis.

B. Shen, Yong Huang, Tao Liu, 2009, Journal of the American Chemical Society.

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

B. Shen, Yi-Qiang Cheng, G. Tang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

B. Shen, M. Ma, J. Rudolf, 2017, Natural product reports.

Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2008, Journal of the American Chemical Society.

The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster.

B. Shen, J. Ju, Xiangcheng Zhu, 2020, Journal of natural products.

Biosynthesis of Enediyne Natural Products

B. Shen, C. Townsend, Christiana N. Teijaro, 2019 .

Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase.

B. Shen, C. Hutchinson, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin.

B. Shen, Guohui Pan, Zhengren Xu, 2018, Journal of the American Chemical Society.

Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation.

B. Shen, C. Walsh, T. L. Schneider, 2003, Biochemistry.

An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.

B. Shen, L. Du, Mei Chen, 2000, FEMS microbiology letters.

Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production

B. Shen, Xiaohui Yan, Christiana N. Teijaro, 2021, Journal of industrial microbiology & biotechnology.

Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity.

B. Shen, P. Schultz, Fei Gan, 2018, Bioorganic & medicinal chemistry letters.

Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases

B. Shen, Xiaohui Yan, J. Rudolf, 2018, Chembiochem : a European journal of chemical biology.

The discovery and development of microbial bleomycin analogues

B. Shen, Xiaohui Yan, Xiangcheng Zhu, 2018, Applied Microbiology and Biotechnology.

Engineered production and evaluation of 6′-deoxy-tallysomycin H-1 revealing new insights into the structure–activity relationship of the anticancer drug bleomycin

B. Shen, Liao-Bin Dong, Dong Yang, 2017, The Journal of Antibiotics.

Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6′-deoxy-bleomycin Z production

B. Shen, Xiangcheng Zhu, Y. Duan, 2017, Applied Microbiology and Biotechnology.

Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.

B. Shen, M. Tao, E. Wendt-Pienkowski, 2011, Journal of natural products.

The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.

B. Shen, N. George, M. Tao, 2009, Molecular bioSystems.

Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation.

B. Shen, N. George, M. Tao, 2007, Journal of natural products.

Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

B. Shen, M. Hager, J. Thorson, 2005, Chemical reviews.

The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.

B. Shen, L. Du, D. J. Edwards, 2000, Chemistry & biology.

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

M. Smanski, B. Shen, Yihua Chen, 2010, Applied Microbiology and Biotechnology.

Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.

B. Shen, Wen Liu, S. V. Van Lanen, 2007, Journal of the American Chemical Society.

Biosynthesis of the β-Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring β-Amino Acyl-S-carrier Protein Intermediates

B. Shen, P. Dorrestein, N. Kelleher, 2005 .

Biosynthesis of Aromatic Polyketides

B. Shen, 2000 .

Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus

B. Shen, H. Osada, J. Ju, 2006, Journal of bacteriology.

Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein

B. Shen, Wen Liu, 2000, Antimicrobial Agents and Chemotherapy.

Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis.

M. Smanski, B. Shen, Ryan M. Peterson, 2012, Current opinion in chemical biology.

Iterative type I polyketide synthases for enediyne core biosynthesis.

B. Shen, Geoff P. Horsman, S. V. Van Lanen, 2009, Methods in enzymology.

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

B. Shen, P. Dorrestein, N. Kelleher, 2008, Proceedings of the National Academy of Sciences.

Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

M. Smanski, B. Shen, Zhiguo Yu, 2011, Proceedings of the National Academy of Sciences.

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.

B. Shen, J. Rudolf, Liao-Bin Dong, 2019, Journal of the American Chemical Society.

Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2009, Journal of the American Chemical Society.

Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors

B. Shen, Jun Liu, A. Kaji, 2012, Nucleic acids research.

Strain Prioritization for Natural Product Discovery by a High-Throughput Real-Time PCR Method

B. Shen, Xiangcheng Zhu, J. Rudolf, 2014, Journal of natural products.

Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.

M. Smanski, B. Shen, Zhiguo Yu, 2012, Journal of natural products.

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads

B. Shen, Xiaohui Yan, J. Rudolf, 2014, Bioorganic & medicinal chemistry letters.

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

B. Shen, C. Farnet, Wen Liu, 2005, Chemistry & biology.

Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model

B. Shen, J. Thorson, Qunjie Gao, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A genomics-guided approach for discovering and expressing cryptic metabolic pathways

Brian O. Bachmann, Alfredo Staffa, Wen Liu, 2003, Nature Biotechnology.

Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

Wen Liu, Ben Shen, B. Shen, 2002, Science.

The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis.

B. Shen, Hui Jiang, S. V. Van Lanen, 2008, Journal of the American Chemical Society.

Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases.

M. Smanski, B. Shen, Ryan M. Peterson, 2012, Methods in enzymology.

Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion.

B. Shen, M. Rateb, M. Ma, 2015, Journal of natural products.

SHP2 is a target of the immunosuppressant tautomycetin.

B. Shen, R. Chan, Zhon-Yin Zhang, 2011, Chemistry & biology.

Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D

B. Shen, M. Rateb, Dong Yang, 2017, The Journal of Antibiotics.

New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883

B. Shen, Guohui Pan, Xiangcheng Zhu, 2016, The Journal of Antibiotics.

Biosynthetic Potential-Based Strain Prioritization for Natural Product Discovery: A Showcase for Diterpenoid-Producing Actinomycetes

Yijun Yan, Ming Ma, Ben Shen, 2014, Journal of natural products.

(#Issue1)Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I, and J

Tingting Huang, Yijun Yan, Michael A. Kron, 2013, Journal of antibiotics (Tokyo. 1968).

Biosynthesis of Antibiotic LLC 10037 a : The Steps beyond 3-Hydroxy anthranilic Acid

B. Shen, Y. G. Whittle, Steven J. Could, 2001 .

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis.

B. Shen, G. Phillips, A. Joachimiak, 2019, Journal of the American Chemical Society.

Biosynthesis of hybrid peptide-polyketide natural products.

B. Shen, L. Du, L Du, 2001, Current opinion in drug discovery & development.

The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells.

B. Shen, V. Murray, Dong Yang, 2018, Bioorganic & medicinal chemistry.

Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses

B. Shen, T. Beerman, J. Ju, 2007, Proceedings of the National Academy of Sciences.

Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson

B. Shen, H. Ikeda, 2011, The Journal of Antibiotics.

Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis.

B. Shen, H. Osada, J. Ju, 2009, Journal of natural products.

Biosynthesis of Pharmaceutical Natural Products and Their Pathway Engineering

M. Smanski, B. Shen, Z. Deng, 2012 .

Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A.

B. Shen, C. Hutchinson, 1993, Science.

Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

Wen Liu, Ben Shen, B. Shen, 2003 .

Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships.

B. Shen, Dong Yang, C. Rader, 2023, Journal of medicinal chemistry.

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

B. Shen, Geoff P. Horsman, E. Wendt-Pienkowski, 2013, Molecular bioSystems.

Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin*

B. Shen, H. Cooke, Shuangjun Lin, 2008, Journal of Biological Chemistry.

Functional Characterization of Cytochrome P450 Hydroxylase YpmL in Yangpumicin A Biosynthesis and Its Application for Anthraquinone-Fused Enediyne Structural Diversification.

B. Shen, Xiaohui Yan, Gengnan Li, 2022, Organic letters.

Characterization of TnmH as an O-Methyltransferase Revealing In-sights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy to Prepare Antibody-Tiancimycin Conjugates.

B. Shen, Xiaohui Yan, C. Rader, 2020, Journal of medicinal chemistry.

Signal Mimics Derived from a Metagenomic Analysis of the Gypsy Moth Gut Microbiota

B. Shen, J. Handelsman, C. Guan, 2007, Applied and Environmental Microbiology.

Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins

B. Shen, Guohui Pan, W. Xiang, 2016, Applied Microbiology and Biotechnology.

C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells.

B. Shen, M. McHugh, L. Gawron, 2009, Cancer research.

C-O Bond Formation by Polyketide Synthases

B. Shen, S. Hwang, H. Kwon, 2002, Science.

Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production.

B. Shen, Wen Liu, J. M. Murrell, 2004, Journal of natural products.

Progress in combinatorial biosynthesis for drug discovery.

Ben Shen, B. Shen, S. V. Van Lanen, 2006, Drug discovery today. Technologies.

Microbial genomics for the improvement of natural product discovery.

Ben Shen, B. Shen, S. V. Van Lanen, 2006, Current opinion in microbiology.

Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin

M. Smanski, B. Shen, S. Rajski, 2009, Antimicrobial Agents and Chemotherapy.

Introduction to the special issue: “Natural Product Discovery and Development in the Genomic Era: 2021”

B. Shen, R. H. Baltz, Yi Tang, 2021, Journal of industrial microbiology & biotechnology.

Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.

Yong Huang, Hao Jiang, Ben Shen, 2005, Journal of the American Chemical Society.

Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2010, Organic letters.

In Vivo Investigation of the Roles of FdmM and FdmM1 in Fredericamycin Biosynthesis Unveiling a New Family of Oxygenases*

B. Shen, S. Rajski, Yihua Chen, 2009, The Journal of Biological Chemistry.

Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis.

C R Hutchinson, B. Shen, Arif Ali, 1995, Biochemistry.

Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation.

B. Shen, J. Ju, S. Rajski, 2008, Journal of natural products.

Epoxyquinones from 2,5-dehydroxyacetanilide : opposite facial specificity in the epoxidation by enzymes from Streptomyces LL-C10037 and Streptomyces MPP 3051

B. Shen, S. Gould, 1991 .

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2009, Proceedings of the National Academy of Sciences.

Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning the Oxazolomycin Biosynthetic Gene Cluster from Streptomyces albus JA3453

B. Shen, Z. Deng, J. Ju, 2006, Journal of bacteriology.

The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis.

B. Shen, J. Lohman, 2020, Biochemistry.

Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions.

B. Shen, Lin Qiu, Meng Su, 2018, Journal of medicinal chemistry.

A Mutasynthetic Library of Platensimycin and Platencin Analogues.

B. Shen, J. Rudolf, Liao-Bin Dong, 2016, Organic letters.

Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase

B. Shen, Wei Yan, Guohui Pan, 2021, Nature Communications.

Advances in polyketide synthase structure and function.

Ben Shen, B. Shen, S. V. Van Lanen, 2008, Current opinion in drug discovery & development.

Substrate Specificity of the Adenylation Enzyme SgcC1 Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027*

B. Shen, P. Dorrestein, N. Kelleher, 2006, Journal of Biological Chemistry.

Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

B. Shen, F. Hoffmann, H. Osada, 2010, Journal of the American Chemical Society.

Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents.

B. Shen, Wen Liu, K. Nonaka, 2003, Current medicinal chemistry.

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin.

B. Shen, L. Du, M. Toney, 2001, Chemistry & biology.

The Mechanism of MIO-Based Aminomutases in β-Amino Acid Biosynthesis

B. Shen, H. Cooke, S. Bruner, 2007 .

Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts

B. Shen, Christiana N. Teijaro, A. Adhikari, 2019, Journal of Industrial Microbiology & Biotechnology.

Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

B. Shen, C. Hutchinson, 1993, Biochemistry.

Structure and absolute stereochemistry of the epoxyquinol LL-C10037.alpha. and related metabolites from Streptomyces LL-C10037

B. Shen, S. Gould, D. Keszler, 1990 .

REV Hybrid Peptide Polyketide Natu Prospects toward Engin

B. Shen, L. Du, 2001 .

Biosynthesis of thiocarboxylic acid-containing natural products

B. Shen, K. Houk, Youchao Deng, 2018, Nature Communications.

Resistance to Enediyne Antitumor Antibiotics by Sequestration.

B. Shen, G. Phillips, A. Joachimiak, 2018, Cell chemical biology.

Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.

B. Shen, C. Hutchinson, E. R. Rafanan, 2000, Organic letters.

Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003.

B. Shen, L. Du, 1999, Chemistry & biology.

Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells.

B. Shen, V. Murray, Dong Yang, 2017, The international journal of biochemistry & cell biology.

Analysis of the Gypsy Moth Gut Microbiota . Appl . 2007 . Signal Mimics Derived from a Metagenomic

B. Shen, J. Handelsman, C. Guan, 2007 .

Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes.

B. Shen, Wenli Li, Dong Yang, 2012, Organic Letters.

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.

Mitchell D. Miller, B. Shen, G. Phillips, 2018, ACS chemical biology.

Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis

B. Shen, Xiaohui Yan, Liao-Bin Dong, 2021, Journal of industrial microbiology & biotechnology.

Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis

B. Shen, A. Demain, V. Gullo, 2013, Applied Microbiology and Biotechnology.

BlmB and TlmB Provide Resistance to the Bleomycin Family of Antitumor Antibiotics by N-Acetylating Metal-Free Bleomycin, Tallysomycin, Phleomycin, and Zorbamycin

B. Shen, M. Tao, J. Rudolf, 2014, Biochemistry.

Accessing Natural Products by Combinatorial Biosynthesis

B. Shen, 2004, Science's STKE.

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

B. Shen, H. Cooke, S. V. Van Lanen, 2007, Journal of the American Chemical Society.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

Tyler A. Johnson, Roger G. Linington, M. K. Harper, 2018, Natural product reports.

Minimum Information about a Biosynthetic Gene cluster.

M. Smanski, Jan Claesen, B. Shen, 2015, Nature chemical biology.

Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

B. Shen, F. Hoffmann, J. Ju, 2008, Bioorganic & medicinal chemistry letters.

SHP2 is a target of the immunosuppressant tautomycetin.

B. Shen, R. Chan, Zhon-Yin Zhang, 2011, Chemistry & biology.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

M. Bibb, B. Shen, M. Fischbach, 2013, Natural product reports.

The discovery and development of microbial bleomycin analogues

B. Shen, Xiaohui Yan, Xiangcheng Zhu, 2018, Applied Microbiology and Biotechnology.

In Vivo Manipulation of the Bleomycin Biosynthetic Gene Cluster in Streptomyces verticillus ATCC15003 Revealing New Insights into Its Biosynthetic Pathway*

B. Shen, Wen Liu, M. Tao, 2008, Journal of Biological Chemistry.

Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase

M. Bibb, B. Shen, H. Gramajo, 1992, Journal of bacteriology.

Polyketide Synthases: Enzyme Complexes and Multifunctional Proteins Directing the Biosynthesis of Bacterial Metabolites from Fatty Acids

B. Shen, C. Hutchinson, E. Wendt-Pienkowski, 1992 .

Purification and Characterization of the Acyl Carrier Protein of the Streptomyces

M. Bibb, B. Shen, C. Hutchinson, 2022 .

Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2009, Journal of the American Chemical Society.

A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.

B. Shen, M. Ma, Guohui Pan, 2017, Angewandte Chemie.