Mikkel A. Algire

发表

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

Thomas H Segall-Shapiro, Thomas H. Segall-Shapiro, D. G. Gibson, 2010, Science.

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

Timothy B. Stockwell, D. G. Gibson, T. Stockwell, 2008, Science.

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.

Mikkel A. Algire, V. Ramakrishnan, J. Lorsch, 2007, Molecular cell.

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.

Mikkel A. Algire, A. Hinnebusch, J. Lorsch, 2007, Genes & development.

Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.

Mikkel A. Algire, J. Lorsch, David Maag, 2005, Molecular cell.

Cloning whole bacterial genomes in yeast

D. G. Gibson, C. Hutchison, R. Chuang, 2010, Nucleic acids research.

1 Synthetic Biology : Implications and Uses *

Mikkel A. Algire, M. Montague, S. Vashee, 2015 .

Synthetic Biology: Implications and Uses

Mikkel A. Algire, M. Montague, S. Vashee, 2011 .

One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome

J Craig Venter, D. G. Gibson, Michael G Montague, 2008, Proceedings of the National Academy of Sciences.

Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast

J. Craig Venter, Clyde A. Hutchison, John I. Glass, 2009, Science.

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

S. C. Panchal, Mikkel A. Algire, P. Ellis, 2018, Molecular Cancer Research.

Where to begin? The mechanism of translation initiation codon selection in eukaryotes.

Mikkel A. Algire, J. Lorsch, 2006, Current opinion in chemical biology.

Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selection.

Mikkel A. Algire, J. Lorsch, David Maag, 2006, Journal of molecular biology.

Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.

Mikkel A. Algire, K. Bromberg, M. Michaelides, 2021, Bioorganic & medicinal chemistry letters.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

Mikkel A. Algire, N. Soni, C. Arrowsmith, 2015, ACS medicinal chemistry letters.

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

Ana L. Aguirre, Mikkel A. Algire, C. Tse, 2017, Bioorganic & medicinal chemistry letters.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Mikkel A. Algire, K. Comess, Chaohong Sun, 2017, Nature chemical biology.

New Selectable Marker for Manipulating the Simple Genomes of Mycoplasma Species

J. Glass, C. Merryman, C. Lartigue, 2009, Antimicrobial Agents and Chemotherapy.

running title: A new marker for manipulating mycoplasma 3

J. Glass, C. Merryman, C. Lartigue, 2009 .

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Chunaram Choudhary, Saul H. Rosenberg, Ronen Marmorstein, 2017, Nature.

N‐ and C‐terminal residues of eIF1A have opposing effects on the fidelity of start codon selection

Jon R Lorsch, Alan G Hinnebusch, Mikkel A. Algire, 2007, The EMBO journal.

Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics

Timothy B. Stockwell, Peter W Mason, Thomas Strecker, 2013, Science Translational Medicine.

Development and characterization of a reconstituted yeast translation initiation system.

Mikkel A. Algire, A. Hinnebusch, A. Sachs, 2002, RNA.

The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.

Sarah E. Walker, Mikkel A. Algire, A. Hinnebusch, 2010, Molecular cell.

Discovery of a Potent and Selective Covalent p300/CBP Inhibitor.

Mikkel A. Algire, Chaohong Sun, K. Bromberg, 2021, ACS medicinal chemistry letters.

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.

Mikkel A. Algire, Chaohong Sun, J. Randolph, 2023, Journal of medicinal chemistry.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Mikkel A. Algire, L. Lam, Chaohong Sun, 2017, Nature.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Hongyu Zhao, Ying Wang, Zhiqin Ji, 2017, Bioorganic & medicinal chemistry letters.

Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics

Timothy B. Stockwell, D. G. Gibson, J. Glass, 2013, Science Translational Medicine.

Megabases for kilodollars

C. Merryman, Mikkel A. Algire, R. Krishnakumar, 2010, Nature Biotechnology.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Mikkel A. Algire, Justin D Dietrich, A. Petros, 2017, Nature chemical biology.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Mikkel A. Algire, Justin D Dietrich, P. Richardson, 2017, Bioorganic & medicinal chemistry letters.

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.

Mikkel A. Algire, V. Ramakrishnan, J. Lorsch, 2007, Molecules and Cells.