C. Mello

发表

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

A. Fire, Siqun Xu, M. Montgomery, 1998, Nature.

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

A. Pasquinelli, G. Ruvkun, A. Fire, 2001, Cell.

Chapter 19 DNA Transformation

Andrew Fire, A. Fire, C. Mello, 1995 .

The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis

C. Mello, D. Lambright, S. Corvera, 2006, Proceedings of the National Academy of Sciences.

Primal RNAs: The End of the Beginning?

C. Mello, D. Conte, 2010, Cell.

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Oliver J. Rando, Melissa J. Moore, Robert Sullivan, 2016, Science.

Derived DNA Structured RNA RNA-RNA Hybrid RNA-viral RNA Hybrid Integration into Cellular Genome ? Transcription of Virus-Derived DNA Slicing

C. Mello, D. Gammon, 2015 .

RNA interference-mediated antiviral defense in insects

C. Mello, D. Gammon, 2015, Current opinion in insect science.

CapSeq and CIP-TAP Identify Pol II Start Sites and Reveal Capped Small RNAs as C. elegans piRNA Precursors

C. Mello, E. Youngman, G. Pazour, 2012, Cell.

The RNase PARN-1 Trims piRNA 3′ Ends to Promote Transcriptome Surveillance in C. elegans

Zhiping Weng, Shikui Tu, Wen Tang, 2016, Cell.

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.

Pedro J. Batista, C. Mello, S. Luo, 2008, Molecular cell.

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

Andrew Fire, W. G. Kelly, Craig C Mello, 1999, Cell.

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants

Harrison W. Gabel, G. Ruvkun, C. Mello, 2005, Nature.

A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

D. Page, C. Mello, M. Carmell, 2016, eLife.

GCNA interacts with Spartan and Topoisomerase II to regulate genome stability

D. Page, C. Mello, G. Hannon, 2019, bioRxiv.

Revealing the world of RNA interference

C. Mello, D. Conte, 2004, Nature.

Sequence-Specific Inhibition of Small RNA Function

Phillip D Zamore, Craig C Mello, C. Mello, 2004, PLoS biology.

C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts

Weifeng Gu, C. Mello, E. Youngman, 2012, Cell.

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans.

Zhiping Weng, Shikui Tu, Wen Tang, 2018, Developmental cell.

MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans

C. Mello, T. Shin, Yingdee Unhavaithaya, 2002, Cell.

RNAi in C. elegans: Soaking in the Genome Sequence

C. Mello, A. Grishok, H. Tabara, 1998, Science.

A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans.

C. Mello, Y. Shi, Y Shi, 1998, Genes & development.

Microinjection for precision genome editing in Caenorhabditis elegans

C. Mello, Krishna S. Ghanta, T. Ishidate, 2021, STAR protocols.

The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing

C. Mello, M. Shirayama, T. Ishidate, 2022, bioRxiv.

The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans

C. Mello, S. Heuvel, M. Soto, 2006, Current Biology.

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

A. Fire, Siqun Xu, M. Montgomery, 1998, Nature.

GCNA interacts with Spartan and Topoisomerase II to regulate genome stability

D. Page, C. Mello, G. Hannon, 2019, bioRxiv.

Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi

Pedro J. Batista, C. Mello, N. Tolia, 2006, Cell.

The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos

Harold Weintraub, C. Mello, J. Priess, 1992, Cell.

Genetic requirements for inheritance of RNAi in C. elegans.

C. Mello, A. Grishok, H. Tabara, 2000, Science.

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

C. Mello, J. Yates, D. Conte, 2013, Cell.

Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi.

C. Mello, A. Pertsemlidis, E. Selker, 2010, Molecular cell.

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

C. Mello, H. Siomi, H. Tabara, 2002, Cell.

Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways

G. Ruvkun, C. Mello, J. Yates, 2006, Cell.

Cues from mRNA splicing prevent default Argonaute silencing in C. elegans.

C. Mello, M. Shirayama, Yekaterina V Makeyeva, 2021, Developmental cell.

The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans

C. Mello, J. Yates, D. Conte, 2020, bioRxiv.

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

C. Mello, D. Conte, M. Shirayama, 2012, Cell.

RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans

C. Mello, R. Plasterk, B. Tops, 2005, Nucleic acids research.

Inducible systemic RNA silencing in Caenorhabditis elegans.

C. Mello, A. Fire, L. Timmons, 2003, Molecular biology of the cell.

RNAi (Nematodes: Caenorhabditis elegans).

C. Mello, A. Grishok, 2002, Advances in genetics.

ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals.

C. Mello, M. Shirayama, Rita Sharma, 2018, Molecular cell.

The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans

Z. Weng, C. Mello, M. Shirayama, 2018, Cell reports.

A Ribonuclease Coordinates siRNA Amplification and mRNA Cleavage during RNAi

C. Mello, J. Yates, S. Mitani, 2015, Cell.

The Vasa Homolog RDE-12 Engages Target mRNA and Multiple Argonaute Proteins to Promote RNAi in C. elegans

C. Mello, M. Shirayama, Weifeng Gu, 2014, Current Biology.

The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression.

C. Mello, D. Conte, M. Shirayama, 2013, Developmental cell.

Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi

C. Mello, D. Conte, J. Wohlschlegel, 2013, Nature Structural &Molecular Biology.

Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi

C. Mello, D. Conte, J. Wohlschlegel, 2011, Nature Structural &Molecular Biology.

Cloning Argonaute-associated small RNAs from Caenorhabditis elegans.

Pedro J. Batista, C. Mello, D. Conte, 2011, Methods in molecular biology.

Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway

Pedro J. Batista, C. Mello, E. Youngman, 2010, Proceedings of the National Academy of Sciences.

Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans

Pedro J. Batista, C. Mello, M. Shirayama, 2010, Proceedings of the National Academy of Sciences.

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.

Pedro J. Batista, C. Mello, J. Yates, 2009, Molecular cell.

The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

Pedro J. Batista, C. Mello, R. Ketting, 2009, Cell.

CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs

Pedro J. Batista, C. Mello, Eugene Berezikov, 2009, Cell.

Return to the RNAi world: rethinking gene expression and evolution.

C. Mello, 2007, Cell death and differentiation.

A Member of the Polymerase β Nucleotidyltransferase Superfamily Is Required for RNA Interference in C. elegans

C. Mello, M. J. Simard, H. Tabara, 2005, Current Biology.

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

C. Mello, R. Lin, J. Priess, 1997, Cell.

Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline

Shikui Tu, Ahmet R. Ozturk, C. Mello, 2018, Cell.

An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.

A. Fire, M. Montgomery, C. Mello, 1996, Development.

MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression

Stefan L Ameres, Z. Weng, C. Mello, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Specific miRNA stabilization by Gld2-catalyzed monoadenylation.

C. Mello, A. D’Ambrogio, J. Richter, 2012, Cell reports.

Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.

Ulla Hansen, Kavitha Venkatesan, Craig C Mello, 2003, Nucleic acids research.

Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi

C. Mello, D. Conte, J. Wohlschlegel, 2012, Nature Structural &Molecular Biology.

Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans

C. Mello, Gregoriy A Dokshin, Krishna S. Ghanta, 2018, Genetics.

Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility

C. Mello, Stephen Frenk, Shawn Ahmed, 2021, Nature Communications.

The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans

C. Mello, D. Gammon, Weifeng Gu, 2017, Current Biology.

Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF

Weifeng Gu, Craig C Mello, C. Mello, 2015, Genes & development.

The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.

C. Mello, E. Rogaev, M. Soto, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Divide and differentiate

C. Mello, M. Shirayama, Soyoung Kim, 2014, Cell cycle.

Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos

C. Mello, D. Conte, M. Soto, 2013, Proceedings of the National Academy of Sciences.

Micromanaging insulin secretion

C. Mello, M. Czech, 2004, Nature Medicine.

A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing

C. Mello, Hao Chen, E. Shen, 2022, bioRxiv.

RNA Interference in Caenorhabditis elegans

C. Mello, L. MacNeil, Albertha J. M. Walhout, 2003, Current protocols in molecular biology.

RNA Interference in Caenorhabditis Elegans

C. Mello, D. Conte, 2003, Current protocols in molecular biology.

pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans.

C. Mello, R. J. Hill, J. Priess, 1999, Development.

The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.

C. Mello, K. Kaibuchi, M. Soto, 2002, Genes & development.

morphogenesis and cell migrations in C . elegans The GEX-2 and GEX-3 proteins are required for tissue

C. Mello, K. Kaibuchi, M. Soto, 2002 .

SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.

C. Mello, M. Soto, J. Hogan, 2002, Developmental cell.

5′-Modifications improve potency and efficacy of DNA donors for precision genome editing

C. Mello, Xiao-ou Zhang, E. Sontheimer, 2021, eLife.

5′ Modifications Improve Potency and Efficacy of DNA Donors for Precision Genome Editing

C. Mello, E. Sontheimer, J. Watts, 2018, bioRxiv.

WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans

Hideyuki Okano, James R Priess, Hitoshi Sawa, 1999, Cell.

A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans

C. Mello, D. Conte, M. Shirayama, 2014, Genetics.

A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

Michael E. Sparks, C. Mello, J. Yates, 2014, eLife.

Repression of gene expression in the embryonic germ lineage of C. elegans

A. Fire, C. Mello, J. Priess, 1996, Nature.

The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos

Bruce Bowerman, C. Mello, J. Priess, 1993, Cell.

The PIE-1 protein and germline specification in C. elegans embryos

C. Mello, J. Priess, Wei Zhang, 1996, Nature.

The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.

C. Mello, J. Priess, M. Shirayama, 2004, Developmental biology.

MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos

C. Mello, J. Priess, B. Draper, 1996, Cell.

A Co-CRISPR Strategy for Efficient Genome Editing in C. elegans

C. Mello, D. Conte, M. Shirayama, 2014 .

HAT activity is essential for CBP‐1‐dependent transcription and differentiation in Caenorhabditis elegans

C. Mello, Yang Shi, D. Calvo, 2002, EMBO reports.

Chromatin regulation during C. elegans germline development.

C. Mello, T. Shin, 2003, Current opinion in genetics & development.

Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene

C. Mello, J. Kramer, M. H. Sibley, 1993, The Journal of cell biology.

PIE-1 promotes SUMOylation and activation of HDAC1 during the C. elegans oogenesis

C. Mello, M. Dong, Yue-He Ding, 2020 .

POS-1 and germ cell specification

C. Mello, R. J. Hill, J. Priess, 1998 .

NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division.

C. Mello, M. Shirayama, L. Maduzia, 2010, Developmental biology.

Influenza A virus preferentially snatches noncoding RNA caps

C. Mello, Weiwei Dai, R. Finberg, 2015, RNA.

POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.

C. Mello, Z. Bao, J. Srinivasan, 2015, Developmental cell.

The Translin-TRAX complex/C3PO is a ribonuclease in tRNA processing

C. Mello, Qinghua Liu, Yi Liu, 2012, Nature Structural &Molecular Biology.

Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans

C. Mello, Krishna S. Ghanta, 2020, Genetics.

HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

C. Mello, M. Dong, Yue-He Ding, 2021, eLife.

HDAC1 SUMOylation promotes Argonaute directed transcriptional silencing in C. elegans

C. Mello, M. Dong, Yue-He Ding, 2020, bioRxiv.

PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

C. Mello, M. Dong, Yue-He Ding, 2021, eLife.

A C. elegans model for the rare human channelopathy, Timothy syndrome type 1

C. Mello, D. Albrecht, R. Lagoy, 2018, microPublication. Biology.

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.

K. Kemphues, C. Mello, J. Priess, 1996, Development.

Inductive asymmetric cell division

C. Mello, M. Shirayama, Soyoung Kim, 2013, Worm.

Inductive asymmetric cell division: The WRM leads the way

C. Mello, M. Shirayama, Soyoung Kim, 2014 .

The CERV protein of Cer1, a C. elegans LTR retrotransposon, is required for nuclear export of viral genomic RNA and can form giant nuclear rods

C. Mello, J. Priess, Bing-hua Sun, 2023, PLoS genetics.

The Time to Demand Funding

C. Mello, J. Walsh, 2009, Science.

Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos.

C. Mello, M. Shirayama, Soyoung Kim, 2005, Genes & development.

Craig C. Mello (1960

V. Ambros, K. Kemphues, C. Mello, 2017 .

elegans embryos-catenin asymmetries in early C . β Wnt signaling drives WRM-1 / Material Supplemental

C. Mello, M. Shirayama, Soyoung Kim, 2013 .

Wnt signaling drives WRM-1/ (cid:1) -catenin asymmetries in early C. elegans embryos

C. Mello, M. Shirayama, Soyoung Kim, 2005 .

Return to the RNAi World: Rethinking Gene Expression and Evolution (Nobel Lecture)

C. Mello, Craig C. Mello, 2007 .

Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4

C. Mello, Yue-He Ding, Chunwei Zheng, 2023, bioRxiv.

Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF Authors

C. Mello, O. Rando, Benjamin R. Carone, 2015 .

Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.

C. Mello, T. Shin, G. Seydoux, 1999, Genes & development.

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

V. Ambros, C. Mello, C. Mello, 1991, The EMBO journal.

MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.

C. Mello, R. Lin, J. Yasuda, 1999, Molecular cell.

A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

Michael E. Sparks, C. Mello, J. Yates, 2014, eLife.

The Coding Regions of Germline mRNAs Confer Sensitivity to The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans Argonaute Regulation in C. elegans

C. Mello, M. Shirayama, Shikui Tu, 2022 .

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.

Pedro J. Batista, C. Mello, G. Schroth, 2008, Molecular cell.

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

C. Mello, J. Yates, D. Conte, 2013, Cell.

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans.

Z. Weng, C. Mello, M. Shirayama, 2018, Developmental cell.