J. Rizo

发表

Unsupervised Natural Experience Rapidly Alters Invariant Object Representation in Visual Cortex

S. Gerber, Xinran Liu, I. Dulubova, 2008 .

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release

T. Südhof, J. Rizo, A. Maximov, 2006, The EMBO journal.

Synaptotagmin I functions as a calcium regulator of release probability

T. Südhof, S. Gerber, J. Rizo, 2001, Nature.

Synaptic vesicle fusion

J. Rizo, Christian Rosenmund, 2008, Nature Structural &Molecular Biology.

Jasmonate perception by inositol phosphate-potentiated COI1-JAZ co-receptor

J. Rizo, G. Howe, S. He, 2010, Nature.

C2-domains, Structure and Function of a Universal Ca2+-binding Domain*

T. Südhof, J. Rizo, T C Südhof, 1998, The Journal of Biological Chemistry.

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.

Hongtao Yu, Josep Rizo, J. Rizo, 2002, Molecular cell.

Intramolecular occlusion of the diacylglycerol-binding site in the C1 domain of munc13-1.

Josep Rizo, J. Rizo, N. Shen, 2005, Biochemistry.

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

Thomas C. Südhof, Josep Rizo, T. Südhof, 2011, Cell.

Conformation of a heptapeptide substrate bound to protein farnesyltransferase.

J. Rizo, L. Gierasch, S. J. Stradley, 1993, Biochemistry.

Dose relationship between GnRH antagonists and pituitary suppression.

J. Rizo, L. Gierasch, A. Hagler, 1996, Human reproduction.

Solution structure of the Vam7p PX domain.

Josep Rizo, T. Südhof, I. Dulubova, 2002, Biochemistry.

Structural Analysis of Conserved Oligomeric Golgi Complex Subunit 2*

J. Rizo, F. Hughson, I. Pelczer, 2007, Journal of Biological Chemistry.

A partially disordered region connects gene repression and activation functions of EZH2

J. Rizo, Qi Zhang, Xin Liu, 2020, Proceedings of the National Academy of Sciences.

Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis

J. Rizo, Jian-Qiu Wu, J. Hopper, 2018, Molecular biology of the cell.

A conformational switch in syntaxin during exocytosis: role of munc18

T. Südhof, I. Dulubova, J. Rizo, 1999, The EMBO journal.

Membrane Bridging and Hemifusion by Denaturated Munc18

J. Rizo, Q. Jiang, A. B. Seven, 2011, PloS one.

SNARE-mediated lipid mixing depends on the physical state of the vesicles.

J. Rizo, J. Zimmerberg, D. Araç, 2006, Biophysical journal.

Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I.

T. Südhof, J. Rizo, X. Zhang, 1998, Biochemistry.

A dynamic t-SNARE complex.

J. Rizo, 2008, Structure.

NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin

T. Südhof, J. Rizo, J. Hazzard, 1999, Journal of biomolecular NMR.

Selective Interaction of Complexin with the Neuronal SNARE Complex

T. Südhof, J. Rizo, W. Antonin, 2000, The Journal of Biological Chemistry.

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity

J. Rizo, Christian Rosenmund, Hsiao-Tuan Chao, 2010, Nature Structural &Molecular Biology.

C 2-domains , Structure and Function of a Universal Ca 2 1-binding Domain *

T. Südhof, J. Rizo, 1998 .

A cascade of multiple proteins and lipids catalyzes membrane fusion

J. Rizo, W. Wickner, 2017, Molecular biology of the cell.

Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

J. Rizo, V. Ghetie, E. Vitetta, 2003, Nature Biotechnology.

Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation

J. Rizo, Guanghua Xiao, J. Hsieh, 2019, Nucleic acids research.

Faculty Opinions recommendation of The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

J. Rizo, 2003 .

Structural and mechanistic insights into secretagogin-mediated exocytosis

J. Rizo, E. Burstein, Yingfeng Tu, 2020, Proceedings of the National Academy of Sciences.

Accelerated Publications The C 2 B Domain of Synaptotagmin I Is a Ca 2 +-Binding Module †

J. Rizo, Y. Lao, D. Araç, 2022 .

Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells

T. Südhof, J. Rizo, O. Shin, 2002, Nature Neuroscience.

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

Milo M. Lin, J. Rizo, W. Im, 2022, eLife.

Dynamic Binding Mode of a Synaptotagmin-1-SNARE Complex in Solution

T. Südhof, J. Rizo, A. Cavalli, 2015, Nature Structural &Molecular Biology.

Molecular machinery turns full circle

J. Rizo, Karolina P. Stepien, Klaudia Jaczynska, 2021, eLife.

Synaptotagmin-1–, Munc18-1–, and Munc13-1–dependent liposome fusion with a few neuronal SNAREs

J. Rizo, Karolina P. Stepien, 2021, Proceedings of the National Academy of Sciences.

Analysis of asymmetry in lipid and content mixing assays with reconstituted proteoliposomes containing the neuronal SNAREs

J. Rizo, Xiaoxia Liu, Yun-Zu Pan, 2020, Scientific Reports.

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

J. Rizo, C. Brautigam, Eric A. Prinslow, 2017, eLife.

Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes.

J. Rizo, R. Guan, H. Dai, 2008, Biochemistry.

NMR measurement of the off rate from the first calcium‐binding site of the synaptotagmin I C2A domain

J. Rizo, P. Bernadó, M. Pons, 2002, FEBS letters.

Synaptotagmin-SNARE coupling enlightened

J. Rizo, 2010, Nature Structural &Molecular Biology.

A minimal domain responsible for Munc13 activity

N. Grishin, I. Dulubova, J. Rizo, 2005, Nature Structural &Molecular Biology.

Staging Membrane Fusion

J. Rizo, 2012, Science.

Synaptic vesicle fusion: today and beyond

J. Rizo, M. Lindau, M. Jackson, 2019, Nature Structural & Molecular Biology.

STRUCTURE OF ANTIMYCIN A1, A SPECIFIC ELECTRON TRANSFER INHIBITOR OF UBIQUINOL-CYTOCHROME C OXIDOREDUCTASE

J. Deisenhofer, J. Rizo, L. Esser, 1999 .

Unexpected Ca2+-binding properties of synaptotagmin 9.

T. Südhof, J. Rizo, A. Maximov, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy.

J. Rizo, D. Araç, T. Murphy, 2003, Biochemistry.

The structure of Escherichia coli heat‐stable enterotoxin b by nuclear magnetic resonance and circular dichroism

J. Rizo, L. Gierasch, Y. Kupersztoch, 1995, Protein science : a publication of the Protein Society.

Concise synthesis of L-α-phosphatidyl-D-myo-inositol 3,4-bisphosphate, an intracellular second messenger

J. Rizo, J. Falck, K. K. Reddy, 1997 .

Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids

T. Südhof, J. Rizo, W. Chiu, 2006, Nature Structural &Molecular Biology.

On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release

J. Rizo, Michael E Fealey, Klaudia Jaczynska, 2022, FEBS open bio.

Complexin/Synaptotagmin Interplay Controls

J. Rizo, L. Mayorga, H. Dai, 2007 .

Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.

T. Südhof, J. Rizo, Christian Rosenmund, 2005, Proceedings of the National Academy of Sciences of the United States of America.

How Tlg2p/syntaxin 16 'snares’ Vps45

T. Südhof, I. Dulubova, J. Rizo, 2002, The EMBO journal.

Assignment of the 1H, 15N and13 C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I

T. Südhof, J. Rizo, X. Shao, 1997, Journal of Biomolecular NMR.

Structure/Function Analysis of Ca2+ Binding to the C2A Domain of Synaptotagmin 1

T. Südhof, S. Gerber, A. C. Meyer, 2002, The Journal of Neuroscience.

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

T. Südhof, J. Rizo, Jun Xu, 2009, Proceedings of the National Academy of Sciences.

Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A

Josep Ubach, Josep Rizo, T. Südhof, 1998, Cell.

Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction.

J. Rizo, Xiaonan Dong, B. Levine, 2022, ACS medicinal chemistry letters.

Synaptic vesicle fusion without SNARE transmembrane regions.

J. Rizo, Junjie Xu, 2013, Developmental cell.

Erratum: Synaptotagmins: C2-domain proteins that regulate membrane traffic (Neuron (1996) 17 (379-388))

J. Rizo, T. Sudhof, 1996 .

A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.

J. Rizo, D. Araç, N. Shen, 2007, Journal of molecular biology.

Bipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C

T. Südhof, J. Rizo, B. Davletov, 1996, Science.

Role of Arg-277 in the binding of pyridoxal 5'-phosphate to Trypanosoma brucei ornithine decarboxylase.

J. Rizo, A. Osterman, M. Phillips, 1997, Biochemistry.

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution

J. Rizo, R. Pfuetzner, A. Brunger, 2022, FEBS open bio.

Sequence-specific assignment of methyl groups from the neuronal SNARE complex using lanthanide-induced pseudocontact shifts

J. Rizo, B. Quade, J. Swarbrick, 2016, Journal of biomolecular NMR.

Constrained peptides: models of bioactive peptides and protein substructures.

J. Rizo, L. Gierasch, L M Gierasch, 1992, Annual review of biochemistry.

How much can SNAREs flex their muscles?

J. Rizo, H. Dai, 2007, Nature Structural &Molecular Biology.

Application of gel-phase 13c-nmr to monitor solid phase peptide synthesis

J. Rizo, E. Giralt, E. Pedroso, 1984 .

Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.

J. Rizo, K. Green, G. Akkaraju, 2014, Metallomics : integrated biometal science.

Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids.

J. Rizo, A. Saghatelian, D. Siegel, 2019, Organic letters.

Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics.

J. Rizo, L. Gierasch, A. Hagler, 1993, Journal of medicinal chemistry.

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region

J. Rizo, Christian Rosenmund, B. Quade, 2021, eLife.

Control of neurotransmitter release and presynaptic plasticity by re-orientation of membrane-bound Munc13-1

J. Rizo, Christian Rosenmund, B. Quade, 2021, bioRxiv.

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

Xiaodong Wang, Lei Liu, Josep Rizo, 2014, Molecular cell.

The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?

T. Südhof, J. Rizo, 2012, Annual review of cell and developmental biology.

Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP

J. Rizo, Yun-Zu Pan, Junjie Xu, 2019, eLife.

Mechanism of neurotransmitter release coming into focus

J. Rizo, 2018, Protein science : a publication of the Protein Society.

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

J. Rizo, Rongguang Zhang, L. Kang, 2015, Nature Structural &Molecular Biology.

The Synaptic Vesicle Release Machinery.

Junjie Xu, Josep Rizo, J. Rizo, 2015, Annual review of biophysics.

The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors.

J. Rizo, R. Guan, D. Tomchick, 2011, Structure.

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

T. Südhof, Xinran Liu, I. Dulubova, 2009, The Journal of cell biology.

Supporting Online Material Materials and Methods Som Text Figs. S1 to 12 Tables S1 and S2 References and Notes Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

Christian Rosenmund, Jong-Cheol Rah, Josep Rizo, 2022 .

Computed structures of core eukaryotic protein complexes

S. Keeney, J. Rizo, S. Biggins, 2021, Science.

Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments.

J. Rizo, L. Gierasch, B. Kobe, 1993, Biochemistry.

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Michael Grabe, Carrie L. Partch, Qiu-Xing Jiang, 2013, Nature.

NMR Structures of the Selenoproteins Sep15 and SelM Reveal Redox Activity of a New Thioredoxin-like Family*

J. Deisenhofer, J. Rizo, V. Gladyshev, 2006, Journal of Biological Chemistry.

An unusual C2‐domain in the active‐zone protein piccolo: implications for Ca2+ regulation of neurotransmitter release

T. Südhof, S. Gerber, J. Rizo, 2001, The EMBO journal.

The Evolutionary Pressure to Inactivate

T. Südhof, J. Rizo, X. Shao, 1997, The Journal of Biological Chemistry.

Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

Josep Rizo, T. Südhof, J. Rizo, 1996, Neuron.

KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes.

J. Rizo, A. Jadhav, A. Simeonov, 2015, Chemistry & biology.

A plug release mechanism for membrane permeation by MLKL.

J. Rizo, B. Quade, Xiaodong Wang, 2014, Structure.

Endocytosis of Synaptotagmin 1 Is Mediated by a Novel, Tryptophan‐Containing Motif

J. Rizo, R. Kelly, D. Araç, 2003, Traffic.

Functional Analysis of Conserved Structural Elements in Yeast Syntaxin Vam3p*

T. Südhof, I. Dulubova, J. Rizo, 2001, The Journal of Biological Chemistry.

Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome.

J. Rizo, V. Ghetie, E. Vitetta, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Munc 13 C 2 B domain is an activity-dependent Ca 2 + regulator of synaptic exocytosis

T. Südhof, J. Rizo, Christian Rosenmund, 2010 .

Snares and munc18 in synaptic vesicle fusion

Thomas C. Südhof, Josep Rizo, T. Südhof, 2002, Nature Reviews Neuroscience.

Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch

T. Südhof, J. Rizo, X. Shao, 1997, Neuron.

A conformational switch in the Piccolo C2A domain regulated by alternative splicing

Josep Rizo, T. Südhof, S. Gerber, 2004, Nature Structural &Molecular Biology.

The Mad2 spindle checkpoint protein has two distinct natively folded states

J. Rizo, Tomohiro Matsumoto, Hongtao Yu, 2004, Nature Structural &Molecular Biology.

Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release.

Demet Araç, Josep Rizo, J. Rizo, 2006, Trends in cell biology.

Conformation‐specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint

J. Rizo, Tomohiro Matsumoto, Hongtao Yu, 2004, The EMBO journal.

The Mad 2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad 1 or

J. Rizo, Hongtao Yu, Xuelian Luo, 2002 .

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release

T. Südhof, J. Rizo, D. Tomchick, 2017, Proceedings of the National Academy of Sciences.

Synaptic vesicle exocytosis.

T. Südhof, J. Rizo, 2011, Cold Spring Harbor perspectives in biology.

Equilibrium folding studies of cellular retinoic acid binding protein, a predominantly beta-sheet protein.

J. Rizo, L. Gierasch, Z. P. Liu, 1994, Biochemistry.

At the junction of SNARE and SM protein function.

J. Rizo, C. Carr, 2010, Current opinion in cell biology.

NMR structure and calcium-binding properties of the tellurite resistance protein TerD from Klebsiella pneumoniae.

J. Rizo, Chinpan Chen, A. B. Seven, 2010, Journal of molecular biology.

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4

T. Südhof, J. Rizo, M. Machius, 2004, Nature Structural &Molecular Biology.

Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide.

T. Südhof, J. Rizo, Yun Wang, 2005, Journal of molecular biology.

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

T. Südhof, I. Dulubova, J. Rizo, 2006, PLoS biology.

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

Ralf Schneggenburger, Josep Rizo, T. Südhof, 2005, The EMBO journal.

A Broken α-Helix in Folded α-Synuclein*

Reinhard Jahn, Josep Rizo, T. Südhof, 2003, The Journal of Biological Chemistry.

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans

J. Rizo, M. Zhen, Shangbang Gao, 2017, The Journal of Neuroscience.

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

J. Rizo, B. Quade, C. Brautigam, 2017, eLife.

p31comet Blocks Mad2 Activation through Structural Mimicry

J. Rizo, M. Machius, Hongtao Yu, 2007, Cell.

Rabphilin regulates SNARE‐dependent re‐priming of synaptic vesicles for fusion

T. Südhof, J. Rizo, P. Hanson, 2006, The EMBO journal.

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

J. Rizo, A. B. Seven, L. Su, 2013, Science.

Remote homology between Munc13 MUN domain and vesicle tethering complexes.

N. Grishin, J. Rizo, J. Pei, 2009, Journal of molecular biology.

Structure of the Janus-faced C2B domain of rabphilin

T. Südhof, J. Rizo, Jesus M. Garcia, 1999, Nature Cell Biology.

Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2.

T. Südhof, J. Rizo, D. Tomchick, 2014, Structure.

1H and 15N resonance assignments and secondary structure of cellular retinoic acid-binding protein with and without bound ligand

J. Rizo, L. Gierasch, Zhiping Liu, 1994, Journal of biomolecular NMR.

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

T. Südhof, J. Rizo, X. Shao, 1998, Biochemistry.

The LDL Receptor Clustering Motif Interacts with the Clathrin Terminal Domain in a Reverse Turn Conformation

J. Rizo, L. Gierasch, R. Kibbey, 1998, The Journal of cell biology.

Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity

J. Rizo, G. Raj, Shihong Ma, 2021, bioRxiv.

Synaptotagmin-1 and Doc2b exhibit distinct membrane remodeling mechanisms

J. Rizo, W. Roos, A. Groffen, 2019, bioRxiv.

Three-Dimensional Structure of the Complexin/SNARE Complex

T. Südhof, J. Rizo, M. Machius, 2002, Neuron.

A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis

Thomas C. Südhof, Anton Maximov, Josep Rizo, 2006, Cell.

Convenient Syntheses of Fluorenylmethyl-Based Side Chain Derivatives of Glutamic and Aspartic acids, Lysine, and Cysteine

J. Rizo, E. Giralt, E. Pedroso, 1990 .

Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain Synaptotagmin 1 as a Phospholipid Binding Machine

T. Südhof, S. Gerber, J. Rizo, 2001, Neuron.

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain?

T. Südhof, J. Rizo, X. Shao, 1998, The EMBO journal.

Calcium Binding to PICK1 Is Essential for the Intracellular Retention of AMPA Receptors Underlying Long-Term Depression

J. Rizo, R. Malenka, A. Citri, 2010, The Journal of Neuroscience.

Prevalent mechanism of membrane bridging by synaptotagmin-1

J. Rizo, Q. Jiang, A. B. Seven, 2013, Proceedings of the National Academy of Sciences.

A cyclic hexapeptide model for asparagine side-chain/backbone interactions in a protein ß-turn

J. Rizo, L. Gierasch, M. Dhingra, 1991 .

Cyclic pentapeptides as models for reverse turns: Determination of the equilibrium distribution between type I and type II conformations of Pro‐Asn and Pro‐Ala β‐turns

J. Rizo, L. Gierasch, A. N. Stroup, 1990, Biopolymers.

All-atom molecular dynamics simulations of synaptic vesicle fusion I: a glimpse at the primed state

J. Rizo, W. Im, M. Lin, 2021, bioRxiv.

Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

J. Rizo, Rashmi Voleti, Klaudia Jaczynska, 2020, eLife.

Munc13 Mediates the Transition from the Closed Syntaxin–Munc18 complex to the SNARE complex

Wei Li, Cong Ma, Yibin Xu, 2011, Nature Structural &Molecular Biology.

Molecular Mechanisms Underlying Neurotransmitter Release.

J. Rizo, 2022, Annual review of biophysics.

Complexin/Synaptotagmin Interplay Controls Acrosomal Exocytosis*

J. Rizo, L. Mayorga, G. D. De Blas, 2007, Journal of Biological Chemistry.

Mechanics of membrane fusion

T. Südhof, J. Rizo, 1998, Nature Structural Biology.

Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy.

J. Rizo, Kyle D. Brewer, A. Zhou, 2013, Biochemistry.

The C2B domain of synaptotagmin I is a Ca2+-binding module.

T. Südhof, J. Rizo, Y. Lao, 2001, Biochemistry.

Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling.

J. Rizo, J. Rivier, S. Koerber, 2000, Journal of medicinal chemistry.

SNARE function revisited

J. Rizo, 2003, Nature Structural Biology.

Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif.

T. Südhof, I. Dulubova, J. Rizo, 2002, Developmental cell.

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

J. Rizo, M. Zhen, Shangbang Gao, 2020, Nature Communications.

Distinct domains of Complexin I differentially regulate neurotransmitter release

Nils Brose, Christian Rosenmund, Mingshan Xue, 2007, Nature Structural &Molecular Biology.

Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein.

T. Südhof, I. Dulubova, J. Rizo, 2004, Biochemistry.

Munc13 C2B-Domain – an Activity-Dependent Ca2+-Regulator of Synaptic Exocytosis

T. Südhof, J. Rizo, Christian Rosenmund, 2010, Nature Structural &Molecular Biology.

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

J. Rizo, Christian Rosenmund, Jayeeta Basu, 2017, Nature Communications.

Membrane bridging by Munc13-1 is crucial for neurotransmitter release

J. Rizo, Christian Rosenmund, B. Quade, 2019, eLife.

Functional synergy between the Munc13 C-terminal C1 and C2 domains

J. Rizo, Christian Rosenmund, B. Quade, 2016, eLife.

Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells

T. Südhof, J. Rizo, K. Mukherjee, 2003, Neuropharmacology.

Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants

J. Rizo, M. Zhen, Shangbang Gao, 2020, bioRxiv.

RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes

J. Rizo, C. Brautigam, M. Ho, 2018, Neuron.

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex

J. Rizo, X. Bai, Xuewu Zhang, 2022, bioRxiv.

Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis

T. Südhof, J. Rizo, Y. Lao, 2008, Proceedings of the National Academy of Sciences.

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

J. Rizo, M. Machius, Hongtao Yu, 2008, PLoS biology.

Peptide and Protein Secondary Structural Elements

Lila M. Gierasch, Josep Rizo, J. Rizo, 2007 .

Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles*

J. Rizo, J. Kowal, R. Riek, 2016, The Journal of Biological Chemistry.

Enlightening molecular mechanisms through study of protein interactions.

J. Rizo, K. Gardner, M. Rosen, 2012, Journal of molecular cell biology.

Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7

T. Südhof, J. Rizo, Christian Rosenmund, 2010, PloS one.

The Janus-Faced Nature of the C2B Domain Is Fundamental for Synaptotagmin-1 Function

J. Rizo, Christian Rosenmund, T. Craig, 2008, Nature Structural &Molecular Biology.

Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1*

T. Südhof, J. Rizo, Christian Rosenmund, 2006, Journal of Biological Chemistry.

C2-Domain Proteins Involved in Membrane Traffic

J. Rizo, 2006 .

Are neuronal SNARE proteins Ca2+ sensors?

J. Rizo, T. Sudhof, Jiong Tang, 2005, Journal of molecular biology.

Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I.

T. Südhof, S. Gerber, J. Rizo, 2002, Diabetes.

The relation of protein binding to function: what is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites?

T. Südhof, J. Rizo, M. Matos, 2000, European journal of cell biology.

Ca 2 binding to synaptotagmin : how many Ca 2 ions bind to the tip of a C 2-domain ?

T. Südhof, J. Rizo, X. Shao, 2013 .

Ca(2+)-binding mode of the C2A-domain of synaptotagmin.

J. Rizo, Jesus M. Garcia, J. Ubach, 2002, Methods in molecular biology.

Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion

J. Rizo, A. B. Seven, L. Su, 2017, Nature Protocols.

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

J. Rizo, Christian Rosenmund, D. Tomchick, 2017, eLife.

Evaluation of the tert-butyl group as a probe for NMR studies of macromolecular complexes

J. Rizo, F. Albericio, G. Acosta, 2021, Journal of Biomolecular NMR.

Re‐examining how Munc13‐1 facilitates opening of syntaxin‐1

J. Rizo, B. Quade, Karolina P. Stepien, 2020, Protein science : a publication of the Protein Society.

Analysis of asymmetry in lipid and content mixing assays with reconstituted proteoliposomes containing the neuronal SNAREs

J. Rizo, Xiaoxia Liu, Yun-Zu Pan, 2020, Scientific Reports.

Re-examining how complexin inhibits neurotransmitter release

J. Rizo, Christian Rosenmund, D. Tomchick, 2014, eLife.

Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex.

J. Rizo, R. Perez-Castillejos, Junjie Xu, 2013, Journal of molecular biology.

Crystal Structure of the RIM1α C2B Domain at 1.7 Å Resolution

T. Südhof, I. Dulubova, J. Rizo, 2007 .

The Top Loops of the C2 Domains from Synaptotagmin and Phospholipase A2 Control Functional Specificity*

T. Südhof, S. Gerber, J. Rizo, 2001, The Journal of Biological Chemistry.

1 Dynamic Synaptotagmin-1-SNARE Complex Binding Mode in Solution

T. Südhof, J. Rizo, A. Cavalli, 2015 .

Crystal Structure of the RIM 1 R C 2 B Domain at 1 . 7 Å Resolution

T. Südhof, I. Dulubova, J. Rizo, 2022 .

Membrane bridging by Munc13-1 is crucial for neurotransmitter release

J. Rizo, Christian Rosenmund, B. Quade, 2019, eLife.

Conformations of wild type and mutant OmpA signal sequences in membrane mimetic environments

J. Rizo, D. Hoyt, L. Gierasch, 1992 .

Conformational Analysis of a Highly Potent, Constrained Gonadotropin‐ Releasing Hormone Antagonist. Part 2. Molecular Dynamics Simulations.

J. Rizo, L. Gierasch, A. Hagler, 1992 .

Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 1. Nuclear magnetic resonance

J. Rizo, L. Gierasch, A. Hagler, 1992 .

Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 2. Molecular dynamics simulations

J. Rizo, L. Gierasch, A. Hagler, 1992 .

Defining the active conformation of gonadotropin releasing hormone (GnRH) through design and conformational analysis of constrained GnRH analogs

J. Rizo, L. Gierasch, A. Hagler, 1994 .

Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules

T. Südhof, I. Dulubova, J. Rizo, 2006 .

Insights into Mad 2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad 2 Dimer

J. Rizo, M. Machius, Hongtao Yu, 2008 .

Reversible protection of lysine to facilitate the purification of protected peptide segments

J. Rizo, E. Giralt, E. Pedroso, 1992 .

Use of polar picolyl protecting groups in peptide synthesis

J. Rizo, E. Giralt, E. Pedroso, 1988 .

Use of Polar Picolyl Protecting Groups in Peptide Synthesis.

J. Rizo, E. Giralt, E. Pedroso, 1989 .

The N-terminal Domains of Syntaxin 7 and vti1b Form Three-helix Bundles That Differ in Their Ability to Regulate SNARE Complex Assembly* 210

I. Dulubova, J. Rizo, W. Antonin, 2002, The Journal of Biological Chemistry.

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

J. Rizo, Karolina P. Stepien, Eric A. Prinslow, 2019, Nature Communications.

Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus

Josep Rizo, T. Südhof, I. Dulubova, 2007, The Journal of Neuroscience.

Munc18-1 binds directly to the neuronal SNARE complex

T. Südhof, I. Dulubova, J. Rizo, 2007, Proceedings of the National Academy of Sciences.

Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins

T. Südhof, I. Dulubova, J. Rizo, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Ultrastructure of Synapses in the Mammalian

K. Harris, T. Südhof, J. Rizo, 2012 .

Vam3p structure reveals conserved and divergent properties of syntaxins

T. Südhof, I. Dulubova, J. Rizo, 2001, Nature Structural Biology.

NMR EVIDENCE FOR THE REASSEMBLY OF AN ALPHA /BETA DOMAIN AFTER CLEAVAGE OF AN ALPHA -HELIX : IMPLICATIONS FOR PROTEIN DESIGN

W.-F. Yu, M. L. Tasayco, J. Rizo, 1998 .

A protein sequence that can encode native structure by disfavoring alternate conformations

Min Goo Lee, J. Rizo, J. Hunt, 2002, Nature Structural Biology.

Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle.

Josep Rizo, J. Rizo, Yi Xu, 2010, Biochemistry.

NMR analysis of the closed conformation of syntaxin-1

I. Dulubova, J. Rizo, Jun Lu, 2008, Journal of biomolecular NMR.

Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.

T. Südhof, J. Rizo, M. Machius, 2005, Biochemistry.

Primary Role of Functional Ischemia, Quantitative Evidence for the Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy

T. Südhof, I. Dulubova, J. Rizo, 2007, PloS one.

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior

J. Rizo, Shangbang Gao, Mengjia Huang, 2023, bioRxiv.

Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis

J. Rizo, Jian-Qiu Wu, J. Hopper, 2018, Molecular biology of the cell.

Cavity formation before stable hydrogen bonding in the folding of a β-clam protein

J. Rizo, L. Gierasch, Zhiping Liu, 1997, Nature Structural Biology.

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

I. Dulubova, J. Rizo, Z. Otwinowski, 2012, Proceedings of the National Academy of Sciences.

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans

J. Rizo, M. Zhen, Shangbang Gao, 2017, The Journal of Neuroscience.

The Synaptic Vesicle Release Machinery.

J. Rizo, Junjie Xu, 2015, Annual review of biophysics.

Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation

J. Rizo, Wei Li, B. E. Horne, 2011, Proceedings of the National Academy of Sciences.

At the junction of SNARE and SM protein function.

J. Rizo, C. Carr, 2010, Current opinion in cell biology.

Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5.

N. Grishin, I. Dulubova, J. Rizo, 2005, Journal of molecular biology.

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

T. Südhof, Xinran Liu, I. Dulubova, 2009, The Journal of cell biology.

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

J. Rizo, Seungmee Park, Junjie Xu, 2017, eLife.