J. Darnell

发表

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Tyson A. Clark, D. Licatalosi, A. Mele, 2008, Nature.

Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function

J. Darnell, R. Darnell, P. Jin, 2001, Cell.

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

D. Licatalosi, A. Mele, J. Fak, 2011, Cell.

De Novo Gene Disruptions in Children on the Autistic Spectrum

Kenny Q. Ye, M. Schatz, J. Troge, 2012, Neuron.

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

A. Mele, J. Darnell, R. Darnell, 2014, Nature Protocols.

Mapping of In Vivo RNA-Binding Sites by Ultraviolet (UV)-Cross-Linking Immunoprecipitation (CLIP).

A. Mele, J. Darnell, R. Darnell, 2018, Cold Spring Harbor protocols.

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome

J. Darnell, P. Kind, K. Li, 2022, Nature Communications.

Excess ribosomal protein production unbalances translation in Fragile X Syndrome

J. Darnell, P. Kind, K. Li, 2022, bioRxiv.

Fatty acid remodelling of phosphatidylinositol under conditions of de novo synthesis in rat liver microsomes.

J. Darnell, A. Saltiel, D. Osterman, 1991, Biochimica et biophysica acta.

Synthesis of phosphatidylinositol in rat liver microsomes is accompanied by the rapid formation of lysophosphatidylinositol.

J. Darnell, A. Saltiel, D. Osterman, 1991, Biochimica et biophysica acta.

Ribosome rescue and neurodegeneration

J. Darnell, 2014, Science.

Ultraviolet (UV) Cross-Linking of Live Cells, Lysate Preparation, and RNase Titration for Cross-Linking Immunoprecipitation (CLIP).

A. Mele, J. Darnell, R. Darnell, 2018, Cold Spring Harbor protocols.

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs

J. Darnell, R. Darnell, C. Fraser, 2009, Human molecular genetics.

FMRP RNA targets: identification and validation

J. Darnell, R. Darnell, O. Mostovetsky, 2005, Genes, brain, and behavior.

Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers.

J. Darnell, M. Grompe, B. Tarlow, 2015, Gastroenterology.

Fragile X Mental Retardation Protein Is Associated with Translating Polyribosomes in Neuronal Cells

J. Darnell, R. Darnell, G. Stefani, 2004, The Journal of Neuroscience.

Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.

S. Eddy, J. Darnell, R. Darnell, 2005, Genes & development.

Localization and local translation of mRNA at synapses: some observations and paradoxes.

O. Steward, J. Darnell, S. Farris, 2015 .

Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes

O. Steward, J. Darnell, S. Farris, 2015, Front. Mol. Neurosci..

Tumor-specific killer cells in paraneoplastic cerebellar degeneration

Loise M. Francisco, J. Darnell, R. Darnell, 1998, Nature Medicine.

The function of glycosyl phosphoinositides in hormone action.

J. Darnell, P. Cuatrecasas, A. Saltiel, 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

The distribution of glycosyl-phosphatidylinositol anchored proteins is differentially regulated by serum and insulin.

J. Darnell, M. Lisanti, A. Saltiel, 1989, Biochemical and biophysical research communications.

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

J. Darnell, R. Darnell, T. Maniatis, 2018, Genome Biology.

The role of glycosylphosphoinositides in signal transduction.

J. Darnell, A. Saltiel, D. Osterman, 1989, Recent progress in hormone research.

Cytoplasmic RNA-binding proteins and the control of complex brain function.

J. Darnell, J. Richter, 2012, Cold Spring Harbor perspectives in biology.

FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types

Christopher Y. Park, J. Fak, J. Darnell, 2019, bioRxiv.

Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

J. Darnell, R. Darnell, P. Jin, 2001, Cell.

Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism

Christopher Y. Park, O. Troyanskaya, J. Fak, 2018, bioRxiv.

Cholesterol levels in Fragile X syndrome

J. Darnell, B. Ouyang, E. Berry-Kravis, 2015, American journal of medical genetics. Part A.

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

Christopher Y. Park, J. Fak, J. Darnell, 2019, eLife.

The translation of translational control by FMRP: therapeutic targets for FXS

J. Darnell, E. Klann, 2013, Nature Neuroscience.

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

J. Darnell, R. Darnell, R. Paylor, 2009, PLoS genetics.

Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.

R. Abagyan, J. Darnell, R. Darnell, 2011, Structure.

Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors.

J. Darnell, R. Darnell, M. Albert, 2000, Cancer research.

A Post-Transcriptional Regulatory Mechanism Restricts Expression of the Paraneoplastic Cerebellar Degeneration Antigen cdr2 to Immune Privileged Tissues

J. Darnell, R. Darnell, J. Corradi, 1997, The Journal of Neuroscience.

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

Dinshaw J. Patel, J. Darnell, R. Darnell, 2015, Proceedings of the National Academy of Sciences.

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

J. Darnell, R. Darnell, A. Serganov, 2011, Nature Structural &Molecular Biology.

Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes

O. Steward, J. Darnell, S. Farris, 2015, Front. Mol. Neurosci..

Defects in translational regulation contributing to human cognitive and behavioral disease.

J. Darnell, J. Darnell, JC Darnell, 2011, Current opinion in genetics & development.

The fragile X mental retardation protein, FMRP, recognizes G-quartets.

J. Darnell, R. Darnell, S. Warren, 2004, Mental retardation and developmental disabilities research reviews.

FMRP association with and regulation of Fragile X granules exhibit circuit-dependent requirements for the KH2 RNA binding domain

J. Darnell, K. Sawicka, Katherine A. Shepard, 2018 .

Advances in Brief cdr 2 , a Target Antigen of Naturally Occurring Human Tumor Immunity , Is Widely Expressed in Gynecological Tumors 1

J. Darnell, R. Darnell, M. Albert, 2000 .

Supplemental Information Protein-RNA and Protein-Protein Recognition by Dual KH 1 / 2 Domains of the Neuronal Splicing Factor Nova-1

R. Abagyan, J. Darnell, R. Darnell, 2011 .

Coenzyme A-dependent, ATP-independent acylation of 2-acyl lysophosphatidylinositol in rat liver microsomes.

J. Darnell, A. Saltiel, 1991, Biochimica et biophysica acta.

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

J. Fak, S. Chi, J. Darnell, 2011, Cell.

Immunoprecipitation and SDS-PAGE for Cross-Linking Immunoprecipitation (CLIP).

J. Darnell, R. Darnell, K. Hung, 2018, Cold Spring Harbor protocols.

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

J. Darnell, R. Darnell, A. Serganov, 2015, Proceedings of the National Academy of Sciences of the United States of America.

Ribosome rescue and neurodegeneration

J. Darnell, 2014, Science.

Cytoplasmic RNA-binding proteins and the control of complex brain function.

J. Darnell, J. Richter, 2012, Cold Spring Harbor perspectives in biology.