H. Schwilden

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EEG During Anesthesia Is Not a Linear Random Process

C. Jeleazcov, J. Fechner, H. Schwilden, 2006 .

Closed-loop feedback control of propofol anaesthesia by quantitative EEG analysis in humans.

H. Schwilden, H. Stoeckel, J. Schüttler, 1989, British journal of anaesthesia.

Does the EEG During Isoflurane/Alfentanil Anesthesia Differ from Linear Random Data?

C. Jeleazcov, H. Schwilden, 2002, Journal of Clinical Monitoring and Computing.

Concepts of EEG processing: from power spectrum to bispectrum, fractals, entropies and all that.

Helmut Schwilden, H. Schwilden, 2006, Best practice & research. Clinical anaesthesiology.

Electroencephalogram Monitoring During Anesthesia with Propofol and Alfentanil: The Impact of Second Order Spectral Analysis

Christian Jeleazcov, Helmut Schwilden, C. Jeleazcov, 2005, Anesthesia and analgesia.

Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteers.

C. Jeleazcov, J. Fechner, H. Schwilden, 2005, Anesthesia and analgesia.

Target controlled anaesthetic drug dosing.

H Schwilden, J Schüttler, H. Schwilden, 2008, Handbook of experimental pharmacology.

Total intravenous anaesthesia with propofol and alfentanil by computer‐assisted infusion

H Schwilden, H Stoeckel, J Schüttler, 1988, Anaesthesia.

Closed‐loop Feedback Control of Methohexital Anesthesia by Quantitative EEG Analysis in Humans

H Schwilden, H Stoeckel, J Schüttler, 1987, Anesthesiology.

COMPARISON OF THE RESPIRATORY DEPRESSANT EFFECT OF ALFENTANIL AND PIRITRAMIDE WITH A PHARMACOKINETIC/PHARMACODYNAMIC MODEL

H. Schwilden, A. Hoeft, T. Bouillon, 1998 .

Pharmacokinetics as applied to total intravenous anaesthesia

H Schwilden, J Schüttler, H. Schwilden, 1983, Anaesthesia.

Electroencephalographic Feedback Control of Anesthetic Drug Administration

H. Schwilden, 1994 .

Modelling acute tolerance to the EEG effect of two benzodiazepines.

H. Schwilden, J. Schüttler, S. Albrecht, 2003, British journal of clinical pharmacology.

Threshold hypnotic concentration of methohexitone

H. Schwilden, H. Stoeckel, P. Lauven, 2004, European Journal of Clinical Pharmacology.

Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients.

H. Schwilden, M. Scheinin, J. Schüttler, 2012, British journal of anaesthesia.

Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study.

H. Schwilden, P. Neuvonen, K. Olkkola, 2012, British journal of anaesthesia.

Impact of the CYP3A5 genotype on midazolam pharmacokinetics and pharmacodynamics during intensive care sedation

H. Schwilden, M. Fromm, J. Schüttler, 2007, European Journal of Clinical Pharmacology.

Midazolam Therapeutic Drug Monitoring in Intensive Care Sedation: A 5-Year Survey

H. Schwilden, J. Schüttler, U. Reulbach, 2004, Therapeutic drug monitoring.

[Prevention of fentanyl rebound by administration of cimetidine (author's transl)].

H. Schwilden, H. Stoeckel, J. Schüttler, 1981, Der Anaesthesist.

Supra-additive effects of tramadol and acetaminophen in a human pain model

H. Schwilden, J. Schüttler, W. Koppert, 2008, PAIN.

Requested retraction of six studies on the PK/PD and tolerability of fospropofol.

J. Fechner, H. Schwilden, J. Schüttler, 2010, European journal of anaesthesiology.

Erroneously published fospropofol pharmacokinetic-pharmacodynamic data and retraction of the affected publications.

J. Fechner, H. Schwilden, J. Schüttler, 2010, Anesthesiology.

Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats

J. Fechner, H. Schwilden, M. Schywalsky, 2003, European journal of anaesthesiology.

Teletherapeutic drug administration by long distance closed-loop control of propofol.

H Schwilden, E Kochs, J Schüttler, 2007, British journal of anaesthesia.

Pharmacokinetics and pharmacodynamics of GPI 15715 or fospropofol (Aquavan injection) - a water-soluble propofol prodrug.

J. Fechner, H. Schwilden, J. Schüttler, 2008, Handbook of experimental pharmacology.

The effect of age on the pharmacokinetics and pharmacodynamics of midazolam

H. Schwilden, J. Schüttler, S. Albrecht, 1999, Clinical pharmacology and therapeutics.

The Pulsatile Pattern of Gonadotropin Secretion and Follicular Development during the Menstrual Cycle and in Women with Hypothalamic and Hyperandrogenemic Amenorrhea1

H. Schwilden, C. Roll, L. Wildt, 1983 .

Quantitative EEG analysis during anaesthesia with isoflurane in nitrous oxide at 1.3 and 1.5 MAC.

H Schwilden, H Stoeckel, H. Schwilden, 1987, British journal of anaesthesia.

Comparative Pharmacodynamics of Halogenated Anesthetics: Quantitative EEG Analysis to Objectify Central Nervous Effects

H. Schwilden, H. Stoeckel, 1987 .

Pharmacodynamic modelling of rocuronium in adolescents with Duchenne muscular dystrophy

H. Schwilden, H. Ihmsen, H. Schmitt, 2009, European journal of anaesthesiology.

Influence of Disease Progression on the Neuromuscular Blocking Effect of Mivacurium in Children and Adolescents with Duchenne Muscular Dystrophy

H. Schwilden, Joachim W. Schmidt, H. Ihmsen, 2009, Anesthesiology.

A843 Determination of the effective therapeutic infusions (ETI) of cis-atracurium during isoflurane or propofol/alfentanil anesthesia by closed-loop feedback control

H. Schwilden, T. Hemmerling, 1997 .

Quantitation of the interaction between atracurium and succinylcholine using closed-loop feedback control of infusion of atracurium.

H. Schwilden, K. Olkkola, 1990, Anesthesiology.

Desflurane reduces the effective therapeutic infusion rate (ETI) of cisatracurium more than isoflurane, sevoflurane, or propofol

H. Schwilden, T. Hemmerling, J. Schuettler, 2001, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

A general method for calculating the dosage scheme in linear pharmacokinetics

H. Schwilden, H. Schwilden, 2004, European Journal of Clinical Pharmacology.

[A microprocessor controlled infusion scheme for midazolam to achieve constant plasma levels (author's transl)].

H. Schwilden, H. Stoeckel, P. Lauven, 1982, Der Anaesthesist.

Awareness during laryngoscopy and intubation: quantitating incidence following induction of balanced anesthesia with etomidate and cisatracurium as detected with the isolated forearm technique.

H. Schwilden, M. St Pierre, J. Schuettler, 2000, Journal of clinical anesthesia.

Pharmacological models and their use in clinical anaesthesia.

H. Schwilden, H. Stoeckel, J. Schüttler, 1986, European journal of anaesthesiology.

APPLICATION OF A BENZODIAZEPINE ANTAGONIST (RD 15–1788) UNDER STEADY-STATE CONDITIONS OF MIDAZOLAM

H. Schwilden, D. Greenblatt, H. Stoeckel, 1982 .

[Optimal dosage strategies in total intravenous anesthesia using propofol and ketamine].

H. Schwilden, J. Schüttler, J. Nadstawek, 1991, Der Anaesthesist.

[Investigations on several EEG-parameters as indicators of the state of anaesthesia the median - a quantitative measure of the depth of anaesthesia (author's transl)].

H Schwilden, H Stoeckel, H. Schwilden, 1980, Anasthesie, Intensivtherapie, Notfallmedizin.

Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: etomidate as an example.

H. Schwilden, H. Stoeckel, J. Schüttler, 1985, European journal of anaesthesiology.

Binding of Propofol to Human Serum Albumin

H. Schwilden, M. Schywalsky, H. Ihmsen, 2005, Arzneimittelforschung.

Model‐based adaptive closed‐loop feedback control of atracurium‐induced neuromuscular blockade

H Schwilden, H. Schwilden, K T Olkkola, 1991, Acta anaesthesiologica Scandinavica.

Adaptive closed-loop feedback control of vecuronium-induced neuromuscular relaxation.

H Schwilden, H. Schwilden, K. Olkkola, 1991, European journal of anaesthesiology.

[Optimization of the dosage of volatile anesthetics based on pharmacokinetic and dynamic models].

H Schwilden, H. Schwilden, 1985, Anasthesie, Intensivtherapie, Notfallmedizin.

Interaction of Isoflurane and Nitrous Oxide Combinations Similar for Median Electroencephalographic Frequency and Clinical Anesthesia

H. Schwilden, H. Ropcke, 1996, Anesthesiology.

Effective therapeutic infusions produced by closed-loop feedback control of methohexital administration during total intravenous anesthesia with fentanyl.

H Schwilden, H Stoeckel, H. Schwilden, 1990, Anesthesiology.

The Effects of a Benzodiazepine Antagonist Ro 15–1788 in the Presence of Stable Concentrations of Midazolam

H. Schwilden, D. Greenblatt, H. Stoeckel, 1985, Anesthesiology.

Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: etomidate as an example.

H. Schwilden, H. Stoeckel, J. Schüttler, 1985, European journal of anaesthesiology.

Pharmacokinetic and pharmacodynamic modelling of propofol ('Diprivan') in volunteers and surgical patients.

H. Schwilden, H. Stoeckel, J. Schüttler, 1985, Postgraduate medical journal.

EEG-controlled closed-loop dosing of propofol in rats.

H. Schwilden, M. Schywalsky, A. Tzabazis, 2004, British journal of anaesthesia.

EEG Parameters for Evaluation of Depth of Anaesthesia

H. Schwilden, H. Stoeckel, P. Lauven, 1981 .

[Principles of clinical pharmacokinetics in anaesthesiology (author's transl)].

H. Schwilden, H. Stoeckel, J. Schüttler, 1982, Anasthesie, Intensivtherapie, Notfallmedizin.

Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children.

H Schwilden, J Schüttler, C. Jeleazcov, 2008, British journal of anaesthesia.

Age dependent EEG effect in response to weight normalised propofol dosage in children: A-554

C. Jeleazcov, H. Schwilden, S. Albrecht, 2005 .

Isoflurane, nitrous oxide, and fentanyl pharmacodynamic interactions in surgical patients as measured by effects on median power frequency.

H. Schwilden, H. Röpcke, A. Hoeft, 1999, Journal of clinical anesthesia.

Model-Based Adaptive Control of Volatile Anesthetics by Quantitative EEG

J. Schüttler, H. Schwilden, H. Schwilden, 1995 .

Pharmacokinetic-pharmacodynamic modelling of the EEG effects of Ro 48-6791, a new short-acting benzodiazepine, in young and elderly subjects.

H. Schwilden, J. Schüttler, S. Albrecht, 1997, British journal of anaesthesia.

The Discriminant Power of Simultaneous Monitoring of Spontaneous Electroencephalogram and Evoked Potentials as a Predictor of Different Clinical States of General Anesthesia

Jürgen Schüttler, Gerhard Schneider, Bertram Scheller, 2006, Anesthesia and analgesia.

Pharmacokinetic/pharmacodynamic modelling of rocuronium in children with Duchenne muscular dystrophy: A-529

H. Schwilden, T. Münster, H. Ihmsen, 2006 .

Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy

C. Jeleazcov, J. Fechner, H. Schwilden, 2016, Anesthesiology.

Pharmacokinetic model identification and parameter estimation as an ill-posed problem

H. Schwilden, C. Elster, J. Honerkamp, 2004, European Journal of Clinical Pharmacology.

Piritramide and Alfentanil display similar respiratory depressant potency

H. Schwilden, A. Hoeft, T. Bouillon, 2003, Acta anaesthesiologica Scandinavica.

Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil.

H. Schwilden, A. Hoeft, T. Bouillon, 1999, Anesthesiology.

Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers.

J. Fechner, H. Schwilden, J. Schüttler, 2003, Anesthesiology.

Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects.

H. Schwilden, M. Schywalsky, A. Tzabazis, 2002, European journal of anaesthesiology.

Concentration–Effect Relations, Prediction Probabilities (Pk), and Signal-to-noise Ratios of Different Electroencephalographic Parameters during Administration of Desflurane, Isoflurane, and Sevoflurane in Rats

H. Schwilden, M. Schywalsky, H. Ihmsen, 2008, Anesthesiology.

Pbarmacokinetic 4 barmacodynam ~ c Modeling of the-Respiratory Depressant Eflect of Alfentanil

H. Schwilden, A. Hoeft, T. Bouillon, 2006 .

Comparison of Bupivacaine and Bupivacaine with Fentanyl in Continuous Extradural Analgesia during Labour

H. Schwilden, I. Grant, J. Mcclure, 1990 .

Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion.

C. Jeleazcov, J. Fechner, H. Schwilden, 2004, Anesthesiology.

Development of acute tolerance to the EEG effect of propofol in rats.

H. Schwilden, M. Schywalsky, A. Tzabazis, 2005, British journal of anaesthesia.

Closed-loop feedback controlled administration of alfentanil during alfentanil-nitrous oxide anaesthesia.

H Schwilden, H Stoeckel, H. Schwilden, 1993, British journal of anaesthesia.

ACTION OF A BENZODIAZEPINE ANTAGONIST DURING MIDAZOLAM INFUSION IN STEADY-STATEQUANTITATIVE EEG STUDIES

H. Schwilden, H. Stoeckel, J. Schüttler, 1982 .

Pharmacokinetic/-dynamic modelling of the new propofol prodrug GPI-15715 in rats

H. Schwilden, M. Schywalsky, J. Vornov, 2002 .

Concurrent recording of AEP, SSEP and EEG parameters during anaesthesia: a factor analysis.

C. Jeleazcov, H. Schwilden, E. Pöppel, 2005, British journal of anaesthesia.

Neuropharmacology of anaesthetics

H. Schwilden, 1994 .

Pharmacokinetics as applied to total intravenous anaesthesia

H Schwilden, J Schüttler, H. Schwilden, 1983, Anaesthesia.

Distribution of EEG Frequency Bands as Revealed by Factor Analysis During Anaesthesia with Halothane and Enflurane

H. Schwilden, H. Stoeckel, 1982 .

Regulation of the Depth of Anaesthesia: The Ultimate Goal of Quantitative Anaesthesia

H. Schwilden, H. Stoeckel, J. Schüttler, 1989 .

[Comparison of various empirical dosage suggestions for etomidate infusions on the basis of pharmacokinetic data (author's transl)].

H. Schwilden, H. Stoeckel, J. Schüttler, 1981, Anasthesie, Intensivtherapie, Notfallmedizin.

[Infusion model for etomidate (author's transl)].

H. Schwilden, H. Stoeckel, J. Schüttler, 1980, Der Anaesthesist.

Pharmacokinetics and MAC: Practical Implications for Dosage of Volatile Anesthetics

H. Schwilden, H. Stoeckel, J. Schüttler, 1987 .

Automated EEG Preprocessing during Anaesthesia: New Aspects Using Artificial Neural Networks / Automatische EEG-Präprozessierung während der Anästhesie: neue Aspekte unter Verwendung von künstlichen neuronalen Netzen

F Bremer, H Schwilden, C. Jeleazcov, 2004, Biomedizinische Technik. Biomedical engineering.