K. Arai

发表

Ca2+/Calmodulin-dependent Protein Kinase Cascade in Caenorhabditis elegans

K. Eto, N. Takahashi, Y. Kimura, 1999, The Journal of Biological Chemistry.

Expression of plasmid R388-encoded type II dihydrofolate reductase as a dominant selective marker in Saccharomyces cerevisiae

K. Arai, A. Miyajima, N. Arai, 1984, Molecular and cellular biology.

Stat5B Shuttles Between Cytoplasm and Nucleus in a Cytokine-Dependent and -Independent Manner1

K. Arai, Sumiko Watanabe, Minoru Yoshida, 2002, The Journal of Immunology.

A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester

K. Arai, M. Muramatsu, K. Kaibuchi, 1989, Molecular and cellular biology.

Role of SGP2, a suppressor of a gpa1 mutation, in the mating-factor signaling pathway of Saccharomyces cerevisiae

K. Arai, K. Matsumoto, N. Nakayama, 1988, Molecular and cellular biology.

GPA1Val-50 mutation in the mating-factor signaling pathway in Saccharomyces cerevisiae

K. Arai, K. Matsumoto, I. Miyajima, 1989, Molecular and cellular biology.

Regulation of the yeast pheromone response pathway by G protein subunits.

K. Arai, K. Matsumoto, Kunihiro Matsumoto, 1990, The EMBO journal.

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

K. Arai, T. Yokota, F. Lee, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Earliest event in the heat denaturation of myosin.

K. Arai, K. Takahashi, I. Kimura, 1980, Journal of biochemistry.

Biochemical Activities Associated with Mouse Mcm2 Protein*

K. Arai, K. Arai, H. Masai, 2001, The Journal of Biological Chemistry.

Colony-stimulating factors and cytokine receptor network.

K. Arai, T. Yokota, A. Miyajima, 1991, Current opinion in biotechnology.

Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5

K. Arai, N. Arai, J. Shlomai, 1991, Molecular and cellular biology.

cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4.

K. Arai, T. Yokota, H. Lee, 1993, Journal of immunology.

Reconstitution of the functional granulocyte macrophage colony stimulating factor promoter: evidence for distinct activation mechanisms that mediate the response to phorbol ester/calcium and human T cell leukemia virus type I Tax signals.

K. Arai, T. Yokota, N. Arai, 1993, International immunology.

Signals and nuclear factors that regulate the expression of interleukin-4 and interleukin-5 genes in helper T cells.

K. Arai, T. Yokota, H. Lee, 1994, The Journal of allergy and clinical immunology.

GATA-Binding Protein Expression of the IL-5 Gene : A Role for a Nuclear Factors Conferring Th 2-Specific-Regulatory Elements and cis Characterization of

K. Arai, A. O’Garra, N. Arai, 1998 .

Initiation of lagging-strand synthesis for pBR322 plasmid DNA replication in vitro is dependent on primosomal protein i encoded by dnaT.

K. Arai, H. Masai, 1988, The Journal of biological chemistry.

Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.

K. Arai, Y. Yamaguchi-Iwai, S. Bae, 1995, Blood.

B cell growth-promoting activity of recombinant human interleukin 4.

K. Arai, T. Yokota, Y. Takebe, 1987, Journal of immunology.

High affinity binding of human interleukin 4 to cell lines.

K. Arai, J. Banchereau, T. Yokota, 1987, Biochemical and biophysical research communications.

Ly49Q defines 2 pDC subsets in mice.

K. Arai, N. Arai, Yongjun Liu, 2005, Blood.

Studies on 30S ribosomal protein S1 from E. coli. I. Purification and physicochemical properties.

K. Arai, Y. Kaziro, T. Yokota, 1979, Journal of biochemistry.

ATL‐derived factor (ADF), an IL‐2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol‐reduction in the IL‐2 receptor induction.

K. Arai, H. Wakasugi, J. Hamuro, 1989, The EMBO journal.

Identification of a cell surface 105 kd protein (Aic-2 antigen) which binds interleukin-3.

K. Arai, A. Miyajima, S. Yonehara, 1990, International immunology.

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

K. Arai, T. Yokota, A. Miyajima, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor.

K. Arai, T. Yokota, A. Miyajima, 1991, Proceedings of the National Academy of Sciences of the United States of America.

NFATz: a novel rel similarity domain containing protein.

K. Arai, F. Bazan, K. Arai, 2000, Biochemical and biophysical research communications.

HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells.

K. Arai, M. Muramatsu, M. Yoshida, 1993, Oncogene.

Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.

K. Arai, T. Yokota, S. Mori, 1997, Biochemical and biophysical research communications.

Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets.

K. Arai, E. Masuda, N. Arai, 1998, Journal of immunology.

Signalling into the T-cell nucleus: NFAT regulation.

K. Arai, E. Masuda, N. Arai, 1998, Cellular signalling.

Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development

K. Arai, N. Takemoto, Naofumi Takemoto, 2002, The Journal of Immunology.

Signal transduction by the high‐affinity GM‐CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

K. Arai, N. Sato, A. Miyajima, 1993, The EMBO journal.

Two distinct signaling pathways downstream of Janus kinase 2 play redundant roles for antiapoptotic activity of granulocyte-macrophage colony-stimulating factor.

K. Arai, S. Watanabe, T. Itoh, 1999, Molecular biology of the cell.

c‐fps/fes protein‐tyrosine kinase is implicated in a signaling pathway triggered by granulocyte‐macrophage colony‐stimulating factor and interleukin‐3.

K. Arai, Y. Yazaki, H. Mano, 1993, The EMBO journal.

Erythropoiesis from acetyl LDL incorporating endothelial cells at the preliver stage.

K. Arai, M. Ogawa, D. Sugiyama, 2003, Blood.

Regulation of the IL-3 gene and structure and function of the IL-3 receptor

K. Arai, T. Yokota, J. Nishida, 1992 .

A 63-Base Pair DNA Segment Containing an Sp1 Site but Not a Canonical E2F Site Can Confer Growth-dependent and E2F-mediated Transcriptional Stimulation of the Human ASKGene Encoding the Regulatory Subunit for Human Cdc7-related Kinase*

K. Arai, N. Sato, K. Ohtani, 2002, The Journal of Biological Chemistry.

Growth Regulation of the Expression of Mouse cDNA and Gene Encoding a Serine/Threonine Kinase Related to Saccharomyces cerevisiae CDC7 Essential for G1/S Transition

K. Arai, N. Sato, K. Arai, 1998, The Journal of Biological Chemistry.

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

K. Arai, N. Sato, A. Miyajima, 1991, Cell.

Dbf4 motifs: conserved motifs in activation subunits for Cdc7 kinases essential for S-phase.

K. Arai, H. Masai, 2000, Biochemical and biophysical research communications.

Bipartite Binding of a Kinase Activator Activates Cdc7-related Kinase Essential for S Phase*

K. Arai, H. Masai, C. Taniyama, 2001, The Journal of Biological Chemistry.

Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7‐ASK kinase complex

K. Arai, N. Sato, H. Masai, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Studies on polypeptide elongation factors from Escherichia coli. II. Purification of factors Tu-guanosine diphosphate, Ts, and Tu-Ts, and crystallization of Tu-guanosine diphosphate and Tu-Ts.

K. Arai, Y. Kaziro, M. Kawakita, 1972, The Journal of biological chemistry.

Role of NFATx (NFAT4/NFATc3) in Expression of Immunoregulatory Genes in Murine Peripheral CD4+ T Cells1

K. Arai, N. Arai, Y. Amasaki, 2003, The Journal of Immunology.

Cytokine receptors and signal transduction.

K. Arai, T. Yokota, A. Miyajima, 2005, Annual review of immunology.

Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells

K. Arai, H. Masai, O. Koiwai, 2005, Genes to cells : devoted to molecular & cellular mechanisms.

CDC7 kinase complex as a molecular switch for DNA replication.

K. Arai, N. Sato, H. Masai, 1999, Frontiers in bioscience : a journal and virtual library.

A chimeric serine/threonine kinase receptor system reveals the potential of multiple type II receptors to cooperate with transforming growth factor-beta type I receptor.

K. Arai, M. Muramatsu, K. Arai, 1997, Molecular biology of the cell.

Cytokines, Extracellular Transport and Processing

K. Arai, S. Miyatake, Y. Kamogawa, 2004 .

Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells.

K. Arai, T. Yokota, A. Miyajima, 1995, Oncogene.

Characterization of cis-acting sequences and trans-acting signals regulating early growth response 1 and c-fos promoters through the granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.

K. Arai, Sumiko Watanabe, K. Sakamoto, 1997, Blood.

Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin*♦

K. Arai, K. Tamai, K. Ohtani, 2006, Journal of Biological Chemistry.

Departments of 1 Molecular and Developmental Biology and 2 Dna Biology and Embryo Engineering

K. Arai, Kenji Nakamura, M. Katsuki, 2022 .

repeat.leukemia virus type 1 long terminal promoter and the R-U5 segment of human composed of the simian virus 40 early mammalian cDNA expression system SR alpha promoter: an efficient and versatile

K. Arai, Y. Takebe, J. Fujisawa, 2013 .

Recombinant adenovirus vectors for cytokine gene therapy in mice.

K. Arai, T. Yokota, T. Inoue, 1999, The Journal of allergy and clinical immunology.

Roles of the cytoplasmic domains of the α and β subunits of human granulocyte-macrophage colony-stimulating factor receptor

K. Arai, T. Yokota, Sumiko Watanabe, 1995 .

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

K. Arai, J. Banchereau, T. Yokota, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic AMP inhibits the activity of c-Jun N-terminal kinase (JNKp46) but not JNKp55 and ERK2 in human helper T lymphocytes.

K. Arai, Y. Harada, S. Watanabe, 1999, Biochemical and biophysical research communications.

Analysis of the 5′ promoters for human IL-3 and GM-CSF receptor α genes

K. Arai, Sumiko Watanabe, A. Muto, 2003 .

Regulation of nuclear factor of activated T-cell family transcription factors during T-cell development in the thymus.

K. Arai, N. Arai, Y. Amasaki, 2000, The Journal of allergy and clinical immunology.

Analysis of antiapoptosis activity of human GM-CSF receptor.

K. Arai, S. Watanabe, R. Liu, 2000, The Journal of allergy and clinical immunology.

Activation of c-Jun N-terminal kinase by human granulocyte macrophage-colony stimulating factor in BA/F3 cells.

K. Arai, S. Watanabe, T. Itoh, 1997, Biochemical and biophysical research communications.

Hematopoietic and lymphopoietic responses in human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor transgenic mice injected with human GM-CSF.

K. Arai, T. Inoue, Y. Hirabayashi, 1997, Blood.

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF)-dependent in vitro and in vivo proliferation and differentiation of all hematopoietic progenitor cells in hGM-CSF receptor transgenic mice.

K. Arai, T. Nakahata, S. Watanabe, 1997, The Journal of allergy and clinical immunology.

Regulation of expression of the IL-2 and IL-5 genes and the role of proteins related to nuclear factor of activated T cells.

K. Arai, T. Yokota, H. Lee, 1995, The Journal of allergy and clinical immunology.

Involvement of the interleukin‐2 receptor γ subunit in interleukin‐4‐dependent activation of mouse hematopoietic cells and splenic B cells

K. Arai, K. Sugamura, Sumiko Watanabe, 1995, European journal of immunology.

Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor.

K. Arai, K. Koike, S. Ishida, 1995, Molecular biology of the cell.

Function of the common beta subunit of the GM-CSF/IL-3/IL-5 receptors.

K. Arai, T. Yokota, N. Sato, 1994, Advances in experimental medicine and biology.

Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0.

K. Arai, H. Tokumitsu, E. Masuda, 1994, Molecular biology of the cell.

Activation of early response genes and cell proliferation by human interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 receptors: comparison with human interleukin-4 receptor signaling.

K. Arai, T. Yokota, A. Miyajima, 1994, The Journal of allergy and clinical immunology.

Differential regulation of early response genes and cell proliferation through the human granulocyte macrophage colony-stimulating factor receptor: selective activation of the c-fos promoter by genistein.

K. Arai, T. Yokota, A. Miyajima, 1993, Molecular biology of the cell.

Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH 3T3 cells: comparison with signalling in BA/F3 pro-B cells

K. Arai, A. Mui, S. Watanabe, 1993, Molecular and cellular biology.

Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells.

K. Arai, J. Banchereau, N. Sato, 1993, Blood.

Cytokine Network: Control of Allergic Response and Hemopoiesis by Hemopoietic Growth Factors

K. Arai, T. Yokota, A. Miyajima, 1992, The Journal of dermatology.

Use of mammalian cell expression cloning systems to identify genes for cytokines, receptors, and regulatory proteins.

K. Arai, T. Yokota, N. Nakayama, 1992 .

Essential Role of Sna41/Cdc45 in Loading of DNA Polymerase α onto Minichromosome Maintenance Proteins in Fission Yeast*

K. Arai, K. Arai, H. Masai, 2001, Journal of Biological Chemistry.

High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells.

K. Arai, M. Brownstein, T. Yokota, 1987, Methods in enzymology.

Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development.

K. Arai, Sumiko Watanabe, A. Muto, 2006, Developmental biology.

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

K. Arai, R. de Waal Malefyt, N. Arai, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for a low-affinity interleukin-3 receptor.

K. Arai, A. Miyajima, J. Schreurs, 1990, Growth factors.

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

K. Arai, G. Nabel, T. Mosmann, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Suppressors of a gpa1 mutation cause sterility in Saccharomyces cerevisiae.

K. Arai, K. Matsumoto, M. Nakafuku, 1988, Genetics.

Role of SGP 2 , a Suppressor of a gpal Mutation , in the Mating-Factor Signaling Pathway of Saccharomyces cerevisiae

K. Arai, Kunihiro Matsumoto, N. Nakayama, 2022 .

Limited hydrolysis of the polypeptide chain elongation factor Tu by trypsin. Isolation and characterization of the polypeptide fragments.

K. Arai, Y. Kaziro, S. Nakamura, 1976, Journal of biochemistry.

Analysis of novel disease-related genes in bronchial asthma.

K. Arai, S. Holgate, D. Davies, 2002, Cytokine.

Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family.

K. Arai, K. Arai, A. Miyajima, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Workshop 8Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein in multi-factor-dependent myeloid cell lines

K. Arai, M. Kasuga, A. Miyajima, 1988 .

AIC2A is a component of the purified high affinity mouse IL-3 receptor: temperature-dependent modulation of AIC2A structure.

K. Arai, A. Miyajima, W. May, 1991, International immunology.

Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal.

K. Arai, R. Nishinakamura, T. Inoue, 1995, Immunity.

Studies on the polypeptide elongation factors from E. coli. V. Properties of various complexes containing EF-Tu and EF-Ts.

K. Arai, Y. Kaziro, M. Kawakita, 1974, Journal of biochemistry.

Studies on the polypeptide elongation factors form E. coli. VI. Characterization of sulfhydryl groups in EF-Tu and EF-Ts.

K. Arai, Y. Kaziro, S. Nakamura, 1974, Journal of biochemistry.

Recombinant interleukin 4 promotes the growth of human T cells.

K. Arai, J. Banchereau, T. Yokota, 1987, Journal of immunology.

Structure, expression and divergence of T-cell receptor beta-chain variable regions.

K. Arai, Y. Chien, T. Yokota, 1984, Nature.

Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter

K. Arai, T. Yokota, N. Koyano-Nakagawa, 1994, Molecular and Cellular Biology.

Interleukin 3‐specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi‐factor‐dependent myeloid cell lines.

K. Arai, T. Akiyama, M. Kasuga, 1987, The EMBO journal.

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes

K. Arai, T. Yokota, Y. Takebe, 1987, The Journal of experimental medicine.

T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element

K. Arai, M. Yoshida, M. Seiki, 1988, Molecular and cellular biology.

Analyses of Saccharomyces cerevisiae Cdc7 kinase point mutants: dominant-negative inhibition of DNA replication on overexpression of kinase-negative Cdc7 proteins

K. Arai, H. Masai, T. Miyake, 1997, Molecular and General Genetics MGG.

Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae: autocrine cell‐cycle arrest results from forced expression of STE2

K. Arai, A. Miyajima, N. Nakayama, 1987, The EMBO journal.

A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B.

K. Arai, J. Yodoi, K. Sugimoto, 1991, International immunology.

Studies on polypeptide-chain-elongation factors from an extreme thermophile, Thermus thermophilus HB8. 3. Molecular properties.

K. Arai, S. Ohta, T. Oshima, 1978, European journal of biochemistry.

Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

K. Arai, T. Yokota, H. Lee, 1995, Journal of immunology.

Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells

K. Arai, J. Banchereau, N. Sato, 1993 .

Coordinate regulation of immune and inflammatory responses by T cell‐derived lymphokines

K. Arai, T. Yokota, A. Miyajima, 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Colony-stimulating factors, cytokines and hematopoiesis.

K. Arai, T. Yokota, A. Miyajima, 1989, Current opinion in immunology.

Characterization of the Mouse Interleukin 3 Receptor System

K. Arai, K. Maruyama, Jean Y. J. Wang, 1989 .

The AKR thymoma BW5147 is able to produce lymphokines when stimulated with calcium ionophore and phorbol ester.

K. Arai, T. Yokota, A. Zlotnik, 1988, Journal of immunology.

Recombinant murine granulocyte‐macrophage (GM) colony‐stimulating factor supports formation of GM and multipotential blast cell colonies in culture: Comparison with the effects of interleukin‐3

K. Arai, T. Yokota, J. Ihle, 1987, Journal of cellular physiology.

Use of the silkworm, Bombyx mori, and an insect baculovirus vector for high-level expression and secretion of biologically active mouse interleukin-3.

K. Arai, A. Miyajima, S. Maeda, 1987, Gene.

Molecular biology of T‐cell‐derived lymphokines: A model system for proliferation and differentiation of hemopoietic cells

K. Arai, T. Yokota, A. Miyajima, 1986, BioEssays : news and reviews in molecular, cellular and developmental biology.

A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3.

K. Arai, T. Yokota, G. Nabel, 1985, Journal of immunology.

Structure of the chromosomal gene for murine interleukin 3.

K. Arai, T. Yokota, F. Lee, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the Gene Encoding the α Subunit of the Human Interleukin 3 Receptor

K. Arai, T. Yokota, T. Hotta, 1995 .

Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor.

K. Arai, T. Yokota, A. Miyajima, 1995, Biochemical and biophysical research communications.

Cytokine receptors and signal transduction.

K. Arai, T. Yokota, A. Miyajima, 2005, Annual review of immunology.

Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis.

D. C. Woodruff, K. Arai, G. Haines, 2002, Human gene therapy.

Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene: coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation.

K. Arai, T. Yokota, M. Yoshida, 1991, International immunology.

A novel smoothelin-like, actin-binding protein required for choroidal fissure closure in zebrafish.

K. Arai, Sumiko Watanabe, R. Kurita, 2004, Biochemical and biophysical research communications.

The pulmonary alveolar proteinosis in granulocyte macrophage colony- stimulating factor/interleukins 3/5 beta c receptor-deficient mice is reversed by bone marrow transplantation

K. Arai, U. Dirksen, R. Nishinakamura, 1996, The Journal of experimental medicine.

CTBP1/RBP1, a Saccharomyces cerevisiae protein which binds to T-rich single-stranded DNA containing the 11-bp core sequence of autonomously replicating sequence, is a poly(deoxypyrimidine)-binding protein.

K. Arai, H. Masai, M. Ikeda, 1996, European journal of biochemistry.

Reduction of Inflammatory Cytokines and Prostaglandin E2 by IL-13 Gene Therapy in Rheumatoid Arthritis Synovium1

K. Arai, A. Koch, P. Campbell, 2000, The Journal of Immunology.

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors.

K. Arai, M. Katsuki, K. Nakao, 2001, Blood.

Differential response of NF‐κB1 p105 and NF‐κB2 p100 to HTLV‐I encoded tax

K. Arai, M. Muramatsu, Mitsuo Watanabe, 1994 .

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

M. Hunkapiller, K. Arai, N. Arai, 1988, The EMBO journal.

Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells.

K. Arai, T. Yokota, K. Arai, 1986, Nucleic acids research.

Interleukin‐7 inhibits pre‐T‐cell differentiation induced by the pre‐T‐cell receptor signal and the effect is mimicked by hGM‐CSF in hGM‐CSF receptor transgenic mice

K. Arai, Y. Yasuda, S. Miyatake, 2002, Immunology.

Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.

K. Arai, M. Yoshida, R. Sen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Structure of mouse interleukin 3 (IL-3) binding protein (AIC2A). Amino acid residues critical for IL-3 binding.

K. Arai, A. Miyajima, T. Ogorochi, 1992, The Journal of biological chemistry.

Escherichia coli and Bacillus subtilis PriA proteins essential for recombination-dependent DNA replication: involvement of ATPase/helicase activity of PriA for inducible stable DNA replication.

K. Arai, T. Tanaka, H. Masai, 1999, Biochimie.

The structure of the IL4 gene and regulation of its expression.

K. Arai, N. Arai, Y. Naito, 1993, Research in immunology.

Protein kinase C mutants in the auto‐inhibitory region exhibit two distinct properties

K. Arai, M. Muramatsu, K. Kaibuchi, 1992, FEBS letters.

Transactivation Activity in T Cells Tissue-Specific Splicing and Is Essential for of NFATx1 Is Possibly Created by Carboxyl-Terminal 15-Amino Acid Sequence

K. Arai, E. Masuda, S. Imai, 1998 .

Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae.

K. Arai, K. Matsumoto, K. Kaibuchi, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Zebrafish Numb homologue: Phylogenetic evolution and involvement in regulation of left–right asymmetry

K. Arai, Sumiko Watanabe, I. Inoue, 2006, Mechanisms of Development.

A Constitutively Nuclear Form of NFATx Shows Efficient Transactivation Activity and Induces Differentiation of CD4+CD8+ T Cells*

K. Arai, N. Arai, S. Adachi, 2002, The Journal of Biological Chemistry.

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat

K. Arai, M. Yoshida, Y. Takebe, 1988, Molecular and cellular biology.

A Second Human Dbf4/ASK-related Protein, Drf1/ASKL1, Is Required for Efficient Progression of S and M Phases*

K. Arai, H. Masai, C. Taniyama, 2005, Journal of Biological Chemistry.

Mechanism of dnaB protein action. V. Association of dnaB protein, protein n', and other repriming proteins in the primosome of DNA replication.

K. Arai, A. Kornberg, J. Shlomai, 1981, The Journal of biological chemistry.

CELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40tax OF HTLV‐1

K. Arai, J. Fujisawa, M. Seiki, 1988, Japanese journal of cancer research : Gann.

Studies on polypeptide-chain-elongation factors from an extreme thermophile, Thermus thermophilus HB8. 1. Purification and some properties of the purified factors.

K. Arai, T. Oshima, Y. Kaziro, 1978, European journal of biochemistry.

Alignment of the tryptic fragments and location of sulfhydryl groups of the polypeptide chain elongation factor Tu.

K. Arai, K. Takahashi, Y. Kaziro, 1977, Biochemical and biophysical research communications.

Effects of interleukin-3 and interleukin-4 on the development of "connective tissue-type" mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3

K. Arai, A. Miyajima, M. Takagi, 1990 .

K. Arai, A. Miyajima, M. Takagi, 1990, Blood.

Stimulation of connective tissue-type mast cell proliferation by crosslinking of cell-bound IgE

K. Arai, A. Miyajima, M. Takagi, 1989, The Journal of experimental medicine.

Chromatin Remodeling and T Helper Subset Differentiation

K. Arai, N. Arai, Ken‐ichi Arai, 2000, IUBMB life.

The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit

K. Arai, T. Yokota, A. Miyajima, 1996, The Journal of experimental medicine.

Factors affecting the cytokine production of human T cells stimulated by different modes of activation.

K. Arai, Y. Harada, S. Watanabe, 1996, The Journal of allergy and clinical immunology.

Primary structure of elongation factor Tu from Escherichia coli.

K. Arai, B. Clark, K. Takahashi, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

K. Arai, K. Matsumoto, M. Nakafuku, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of dnaB protein action. I. Crystallization and properties of dnaB protein, an essential replication protein in Escherichia coli.

K. Arai, A. Kornberg, S. Yasuda, 1981, The Journal of biological chemistry.

Differential Requirement of Gα12, Gα13, Gαq, and Gβγ for Endothelin-1-Induced c-Jun NH2-Terminal Kinase and Extracellular Signal-Regulated Kinase Activation

K. Arai, M. Nishida, Y. Mori, 2003 .

Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation.

K. Arai, M. Nishida, Y. Mori, 2003, Molecular pharmacology.

The role of G proteins in yeast signal transduction.

K. Arai, K. Matsumoto, C. Brenner, 1988, Cold Spring Harbor symposia on quantitative biology.

Transcriptional control of cytokine genes.

K. Arai, N. Arai, L. Tsuruta, 1998, International reviews of immunology.

preliver stage Erythropoiesis from acetyl LDL incorporating endothelial cells at the

K. Arai, M. Ogawa, D. Sugiyama, 2013 .

Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast.

K. Arai, K. Ohta, H. Masai, 2006, Proceedings of the National Academy of Sciences of the United States of America.

B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency.

K. Arai, S. Nishikawa, K. Nakao, 2007, Developmental biology.

SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production.

K. Arai, M. Cho, N. Arai, 2008, International immunology.

NF-ATx 1 NF-ATx 1 Recruit Calcineurin to Murine Regions in the N-Terminal Domain of Murine Two Independent Calcineurin-Binding

K. Arai, E. Masuda, N. Arai, 1999 .

A fusion protein library: an improved method for rapid screening and characterization of DNA binding or interacting proteins.

K. Arai, H. Masai, M. Ikeda, 1996, Gene.

Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C.

K. Arai, M. Muramatsu, K. Kaibuchi, 1989, The Journal of biological chemistry.

Stimulation of mouse connective tissue-type mast cells by hemopoietic stem cell factor, a ligand for the c-kit receptor.

K. Arai, S. Nishikawa, K. Zsebo, 1992, Journal of immunology.

The Expression and Characterization of Recombinant Mouse IL-3

K. Arai, T. Yokota, T. Mosmann, 1988 .

Expression of murine and human granulocyte‐macrophage colony‐stimulating factors in S. cerevisiae: mutagenesis of the potential glycosylation sites.

K. Arai, J. Abrams, M. Bond, 1986, The EMBO journal.

Analysis of full-length cDNA clones carrying GAL1 of Saccharomyces cerevisiae: a model system for cDNA expression.

K. Arai, H. Okayama, A. Miyajima, 1984, Nucleic acids research.

Cytokine signal networks and a new era in biomedical research.

K. Arai, S. Watanabe, N. Arai, 1997, Molecules and cells.

K. Arai, K. Tamai, H. Masai, 2000 .

Granulocyte Macrophage-Colony Stimulating Factor-dependent Replication of Polyoma Virus Replicon in Hematopoietic Cells

K. Arai, Sumiko Watanabe, Y. Ito, 1995, The Journal of Biological Chemistry.

SRotPromoter: anEfficient andVersatile Mammalian cDNA Expression SystemComposedoftheSimian Virus 40Early Promoter andtheR-U5Segment ofHumanT-Cell Leukemia Virus Type1LongTerminal Repeat

K. Arai, Y. Takebe, M. Seiki, 1988 .

Signal transduction in Th clones: target of differential modulation by PGE2 may reside downstream of the PKC-dependent pathway.

K. Arai, R. Coffman, N. Arai, 1996, Cytokine.

EGF induces differentiation of an IL‐3‐dependent cell line expressing the EGF receptor.

K. Arai, M. Collins, A. Miyajima, 1989, The EMBO journal.

Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.

K. Arai, K. Arai, H. Masai, 1994, The EMBO journal.

Cdc7 kinase complex: A key regulator in the initiation of DNA replication

K. Arai, H. Masai, 2002, Journal of cellular physiology.

Human and Xenopus cDNAs encoding budding yeast Cdc7‐related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7

K. Arai, N. Sato, K. Arai, 1997, The EMBO journal.

Secretion of mature mouse interleukin-2 by Saccharomyces cerevisiae: use of a general secretion vector containing promoter and leader sequences of the mating pheromone alpha-factor.

K. Arai, M. Bond, A. Miyajima, 1985, Gene.

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

K. Arai, T. Yokota, T. Mosmann, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release.

K. Arai, N. Arai, A. Kaplan, 1988, The Journal of clinical investigation.

Purification of tubulin from bovine brain and its interaction with guanine nucleotides.

K. Arai, Y. Ihara, Y. Kaziro, 1975, Journal of biochemistry.

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

K. Arai, J. Banchereau, T. Yokota, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Chimeric opioid peptides: tools for identifying opioid receptor types.

K. Arai, T. Yokota, A. Miyajima, 1990, Proceedings of the National Academy of Sciences of the United States of America.

SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway.

K. Arai, Sumiko Watanabe, Y. Aoki, 2006, Developmental biology.

A novel method for the determination of guanosine 3':5'-cyclic monophosphate (cyclic GMP).

K. Arai, M. Shibuya, Y. Kaziro, 1975, Biochemical and biophysical research communications.

Mechanism of dnaB protein action. III. Allosteric role of ATP in the alteration of DNA structure by dnaB protein in priming replication.

K. Arai, A. Kornberg, 1981, The Journal of biological chemistry.

Unique primed start of phage phi X174 DNA replication and mobility of the primosome in a direction opposite chain synthesis.

K. Arai, A. Kornberg, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A general priming system employing only dnaB protein and primase for DNA replication.

K. Arai, A. Kornberg, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Definition of oriR, the minimum DNA segment essential for initiation of R1 plasmid replication in vitro.

K. Arai, H. Masai, Y. Kaziro, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells.

K. Arai, E. Masuda, S. Imai, 1998, Journal of immunology.

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter

K. Arai, T. Yokota, E. Masuda, 1995, The Journal of Biological Chemistry.

Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system.

K. Arai, S. Watanabe, M. Mohi, 1998, Molecular biology of the cell.

The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing.

K. Arai, N. Sato, Mitsumasa Kondo, 2006, Biochemical and biophysical research communications.

A study of troponin, a myofibrillar protein from rabbit skeletal muscle.

K. Arai, S. Watanabe, 1968, The Journal of biological chemistry.

Sulfhydryl groups of the "relaxing protein" from rabbit skeletal muscle.

K. Arai, I. Staprans, S. Watanabe, 1968, Journal of biochemistry.

Control of DNA Replication: Regulation and Activation of Eukaryotic Replicative Helicase, MCM

K. Arai, H. Masai, Z. You, 2005, IUBMB life.

Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells.

K. Arai, M. Nakafuku, Y. Nakagawa, 1996, Development.

Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae

K. Arai, K. Matsumoto, Y. Kaziro, 1988, Molecular and cellular biology.

Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.

K. Arai, A. Miyajima, S. Yonehara, 1990, Science.

Variability and repertoire size of T-cell receptor Vα gene segments

Mark M. Davis, K. Arai, Y. Chien, 1985, Nature.

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

K. Arai, C. Brenner, M. Nakafuku, 1987, Cell.

Negative regulation of retinal-neurite extension by β-catenin signaling pathway

K. Arai, Sumiko Watanabe, Yasuo Ouchi, 2005, Journal of Cell Science.

Type I interferon regulates pDC maturation and Ly49Q expression

K. Arai, S. Miyatake, Y. Kamogawa-Schifter, 2007, European journal of immunology.

Hypomorphic mutation in an essential cell‐cycle kinase causes growth retardation and impaired spermatogenesis

K. Arai, H. Masai, Jung Min Kim, 2003, The EMBO journal.

Cell Cycle and Developmental Regulations of Replication Factors in Mouse Embryonic Stem Cells*

Hisao Masai, K. Arai, H. Masai, 2005, Journal of Biological Chemistry.

Evidence that the level of the p55 component of the interleukin (IL) 2 receptor can control IL 2 responsiveness in a murine IL 3‐dependent cell

K. Arai, Kendall A. Smith, R. Mulligan, 1990, European journal of immunology.

Identification of a novel splicing form of zebrafish p73 having a strong transcriptional activity.

K. Arai, Sumiko Watanabe, Shinya Satoh, 2004, Biochemical and biophysical research communications.

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.

K. Arai, K. Sugamura, Sumiko Watanabe, 1993, Science.

Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling (*)

K. Arai, T. Yokota, Sumiko Watanabe, 1996, The Journal of Biological Chemistry.

Complexes of Rep protein with ATP and DNA as a basis for helicase action.

K. Arai, A. Kornberg, N. Arai, 1981, The Journal of biological chemistry.

Fluctuation of chromatin unfolding associated with variation in the level of gene expression

K. Arai, N. Sato, Masahito Nakayama, 2004, Genes to cells : devoted to molecular & cellular mechanisms.

Inactivation of Cdc7 kinase in mouse ES cells results in S‐phase arrest and p53‐dependent cell death

K. Arai, Kenji Nakamura, M. Katsuki, 2002, The EMBO journal.

Differential expression of granulocyte-macrophage colony-stimulating factor and IL-3 receptor subunits on human CD34+ cells and leukemic cell lines.

K. Arai, T. Yokota, Ken‐ichi Arai, 1995, The Journal of allergy and clinical immunology.

Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily.

K. Arai, T. Yokota, A. Miyajima, 1994, The Journal of biological chemistry.

Suppression of apoptotic death in hematopoietic cells by signalling through the IL‐3/GM‐CSF receptors.

K. Arai, T. Yokota, A. Miyajima, 1995, The EMBO journal.

Structure of the chromosomal gene for granulocyte‐macrophage colony stimulating factor: comparison of the mouse and human genes.

K. Arai, T. Yokota, F. Lee, 1985, The EMBO journal.

Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation

K. Arai, H. Arase, S. Miyatake, 2009, European journal of immunology.

Structural and functional studies of the dnaB protein using limited proteolysis. Characterization of domains for DNA-dependent ATP hydrolysis and for protein association in the primosome.

K. Arai, Y. Kaziro, N. Arai, 1984, The Journal of biological chemistry.

Calcium regulation in squid mantle and scallop adductor muscles.

K. Arai, K. Konno, S. Watanabe, 1981, Journal of biochemistry.

Structure, expression and divergence of T-cell receptor β-chain variable regions

Mark M. Davis, K. Arai, Y. Chien, 1984, Nature.

Nucleotide sequences of STE2 and STE3, cell type‐specific sterile genes from Saccharomyces cerevisiae

K. Arai, A. Miyajima, N. Nakayama, 1985, The EMBO journal.

Mutations on 170Glu, a substrate recognition residue in mouse cAMP-dependent protein kinase, generate enzymes with altered substrate affinity and biological functions.

K. Arai, M. Muramatsu, T. Tomoda, 1993, Biochimica et biophysica acta.

Gene structures of the alpha subunits of human IL-3 and granulocyte-macrophage colony-stimulating factor receptors: comparison with the cytokine receptor superfamily.

K. Arai, T. Yokota, H. Kosugi, 1995, The Journal of allergy and clinical immunology.

Studies on 30S ribosomal protein S1 from E. coli. II. Functional properties.

K. Arai, Y. Kaziro, T. Yokota, 1979, Journal of biochemistry.

Involvement of 30S ribosomal protein S1 in poly(U)-directed polyphenylalanine synthesis.

K. Arai, Y. Kaziro, T. Yokota, 1977, Journal of biochemistry.

The role of guanosine triphosphate hydrolysis in elongation factor Tu-promoted binding of aminoacyl transfer ribonucleic acid to ribosomes.

K. Arai, H. Yokosawa, Y. Kaziro, 1973, The Journal of biological chemistry.

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT

K. Arai, H. Tokumitsu, E. Masuda, 1993, Molecular and cellular biology.

Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines

K. Arai, T. Yokota, A. Miyajima, 1988 .

expressing hGM-CSF receptors but not erythropoietin receptors stimulates primitive and definitive erythropoiesis in mouse embryos Human granulocyte-macrophage colony-stimulating factor (hGM-CSF)

K. Arai, K. Nakao, S. Asano, 2013 .

F rpo : A Novel Single-Stranded DNA Promoter for Transcription and for Primer RNA Synthesis of DNA Replication

K. Arai, H. Masai, 1997, Cell.

Identification of eleven single-strand initiation sequences (ssi) for priming of DNA replication in the F, R6K, R100 and ColE2 plasmids.

K. Arai, H. Masai, S. Sasamoto, 1991, Gene.

Differential influence of tyrosine residues of the common receptor beta subunit on multiple signals induced by human GM-CSF.

K. Arai, S. Watanabe, T. Itoh, 1999, The Journal of allergy and clinical immunology.

hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.

K. Arai, H. Masai, T. Miyake, 1995, The EMBO journal.

Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein.

K. Arai, H. Lee, A. O’Garra, 1998, Journal of immunology.

JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells (*)

K. Arai, Sumiko Watanabe, T. Itoh, 1996, The Journal of Biological Chemistry.

Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities

Takashi Yokota, Frank Lee, Naoko Arai, 1987, Nucleic Acids Res..

Roles of phi X174 type primosome- and G4 type primase-dependent primings in initiation of lagging and leading strand syntheses of DNA replication.

K. Arai, H. Masai, Y. Kubota, 1990, The Journal of biological chemistry.

Leading strand synthesis of R1 plasmid replication in vitro is primed by primase alone at a specific site downstream of oriR.

K. Arai, H. Masai, 1989, The Journal of biological chemistry.

Site selection and structure of DNA-linked RNA primers synthesized by the primosome in phage phi X174 DNA replication in vitro.

K. Arai, T. Okazaki, T. Ogawa, 1983, The Journal of biological chemistry.

Mechanism of dnaB protein action. IV. General priming of DNA replication by dnaB protein and primase compared with RNA polymerase.

K. Arai, A. Kornberg, 1981, The Journal of biological chemistry.

Movement and site selection for priming by the primosome in phage phi X174 DNA replication.

K. Arai, A. Kornberg, R. Low, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Enzyme studies of phi X174 DNA replication.

K. Arai, A. Kornberg, U. Hübscher, 1981, Progress in nucleic acid research and molecular biology.

ENZYME STUDIES OF ΦX174 DNA REPLICATION1

K. Arai, A. Kornberg, N. Arai, 1980 .

Nucleotide sequence of dnaB and the primary structure of the dnaB protein from Escherichia coli.

K. Arai, M. Bond, Y. Kaziro, 1984, The Journal of biological chemistry.

The ABC-primosome. A novel priming system employing dnaA, dnaB, dnaC, and primase on a hairpin containing a dnaA box sequence.

K. Arai, H. Masai, N. Nomura, 1990, The Journal of biological chemistry.

Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain

K. Arai, E. Masuda, S. Imai, 1997, Molecular and cellular biology.

Molecular Cloning of a Mouse Counterpart for Human TGF-β Type I Receptor

K. Arai, M. Muramatsu, T. Kudoh, 1994 .

Induction of interleukin-4-dependent IgE synthesis and interleukin-5-dependent eosinophil differentiation by supernatants of a human helper T-cell clone

K. Arai, J. Banchereau, R. Geha, 1988, Journal of Clinical Immunology.

Isolation and Characterization of the Mouse Interleukin 3 Gene and Its Expression in Activated T Cells

K. Arai, R. Conaway, J. Conaway, 1988 .

Identification and characterization of a Xenopus homolog of Dbf4, a regulatory subunit of the Cdc7 protein kinase required for the initiation of DNA replication.

K. Arai, N. Sato, H. Masai, 2003, Journal of biochemistry.

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

K. Arai, T. Yokota, N. Arai, 1998, International immunology.

NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

K. Arai, H. Tokumitsu, C. Hannum, 1995, Molecular and cellular biology.

Mechanism of dnaB protein action. II. ATP hydrolysis by dnaB protein dependent on single- or double-stranded DNA.

K. Arai, A. Kornberg, 1981, The Journal of biological chemistry.

RepA and DnaA proteins are required for initiation of R1 plasmid replication in vitro and interact with the oriR sequence.

K. Arai, H. Masai, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms of primer RNA synthesis and D-loop/R-loop-dependent DNA replication in Escherichia coli.

K. Arai, H. Masai, 1996, Biochimie.

DnaA- and PriA-dependent primosomes: two distinct replication complexes for replication of Escherichia coli chromosome.

K. Arai, H. Masai, 1996, Frontiers in bioscience : a journal and virtual library.

Growth regulation of multi-factor-dependent myeloid cell lines: IL-4, TGF-beta and pertussis toxin modulate IL-3- or GM-CSF-induced growth by controlling cell cycle length.

K. Arai, A. Miyajima, S. Koyasu, 1989, Cell structure and function.

The carboxyl terminus of RAP30 is similar in sequence to region 4 of bacterial sigma factors and is required for function.

K. Arai, R. Conaway, J. Conaway, 1992, The Journal of biological chemistry.

Escherichia coli dnaT gene function is required for pBR322 plasmid replication but not for R1 plasmid replication

K. Arai, H. Masai, 1989, Journal of bacteriology.

Roles of JAK kinases in human GM-CSF receptor signal transduction.

K. Arai, Sumiko Watanabe, S. Watanabe, 1996, The Journal of allergy and clinical immunology.

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

K. Arai, J. Banchereau, T. Yokota, 1988, Immunological reviews.

A monoclonal antibody with IL-3-like activity blocks IL-3 binding and stimulates tyrosine phosphorylation.

K. Arai, A. Miyajima, M. Sugawara, 1989, Journal of immunology.

Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.

K. Arai, Sumiko Watanabe, Y. Aoki, 2004, Biochimie.

Synergistic action of interleukin-10 (IL-10) with IL-3, IL-4 and stem cell factor on colony formation from murine mast cells in culture.

K. Arai, A. Miyajima, A. Komiyama, 1995, International journal of hematology.

Molecular cloning of rabbit CAP-50, a calcyclin-associated annexin protein.

K. Arai, M. Muramatsu, H. Tokumitsu, 1992, Biochemical and biophysical research communications.

Melk-Like Kinase Plays a Role in Hematopoiesis in the Zebra Fish

K. Arai, Sumiko Watanabe, Rika Saito, 2005, Molecular and Cellular Biology.

Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1.

K. Arai, E. Masuda, N. Arai, 1999, Journal of immunology.

A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF.

K. Arai, T. Yokota, T. Inoue, 1995, Molecular biology of the cell.

A Critical Role of the 3′ Terminus of Nascent DNA Chains in Recognition of Stalled Replication Forks*

Hisao Masai, Taku Tanaka, Daisuke Kohda, 2003, Journal of Biological Chemistry.

ATPase/helicase motif mutants of Escherichia coli PriA protein essential for recombination‐dependent DNA replication

K. Arai, H. Masai, C. Taniyama, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33-1A5.

K. Arai, H. Huang, L. Herzenberg, 1987, Journal of immunology.

Replication of phi X174 dna with purified enzymes. I. Conversion of viral DNA to a supercoiled, biologically active duplex.

K. Arai, A. Kornberg, J. Shlomai, 1981, The Journal of biological chemistry.

Purification and properties of Escherichia coli protein i, a prepriming protein in phi X174 DNA replication.

K. Arai, A. Kornberg, R. McMacken, 1981, The Journal of biological chemistry.

Nucleus in a Cytokine-Dependent and Stat 5 B Shuttles Between Cytoplasm and and Sumiko

K. Arai, Sumiko Watanabe, Minoru Yoshida, 2002 .

Initiation of polyoma virus origin-dependent DNA replication through STAT5 activation by human granulocyte-macrophage colony-stimulating factor.

K. Arai, S. Watanabe, R. Zeng, 2001, Blood.

Roles of the JAK-STAT system in signal transduction via cytokine receptors.

K. Arai, S. Watanabe, 1996, Current opinion in genetics & development.

Isolation and Characterization of Mouse and Human cDNA Clones Encoding IL-4 and IgA-Enhancing Factor/Eosinophil CSF (IL-5)

K. Arai, J. Banchereau, R. Coffman, 1987 .

Roles of JAK2 in Human GM-CSF Receptor Signals

K. Arai, Sumiko Watanabe, T. Itoh, 1996 .

Roles of Jak Kinases in Human GM-CSF Receptor

K. Arai, Sumiko Watanabe, T. Nakahata, 1996 .

Cell Cycle-dependent Interaction of Mad2 with Conserved Box1/2 Region of Human Granulocyte-Macrophage Colony-stimulating Factor Receptor Common βc*

K. Arai, Sumiko Watanabe, N. Dohmae, 2001, The Journal of Biological Chemistry.

The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cells.

K. Arai, Y. Yamaguchi-Iwai, E. Masuda, 1994, Biochemical and biophysical research communications.

Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells.

K. Arai, M. Muramatsu, N. Arai, 1994, Biochemical and biophysical research communications.

Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.

K. Arai, E. Masuda, N. Arai, 1994, Biochemical and biophysical research communications.

Adjuvant-Induced Arthritis Vascularization, and Bony Destruction in Rat Inflammation, Proinflammatory Cytokines, IL-4 Adenoviral Gene Therapy Reduces

K. Arai, Pawan Kumar, A. Koch, 2000 .

Amino acid sequences of two sulfhydryl-containing tryptic peptides of the polypeptide chain elongation factor Tu.

K. Arai, K. Takahashi, Y. Kaziro, 1975, Biochemical and biophysical research communications.

Studies on the polypeptide elongation factors from E. coli. 3. Molecular characteristics of EF-Tu-guanosine diphosphate, EP-Ts, and EF-Tu-Ts complex.

K. Arai, Y. Kaziro, M. Kawakita, 1974, Journal of biochemistry.

Bovine papilloma virus encoded E2 protein activates lymphokine genes through DNA elements, distinct from the consensus motif, in the long control region of its own genome.

K. Arai, M. Yoshida, T. Heike, 1989, The EMBO journal.

sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polα

K. Arai, H. Masai, M. Uchiyama, 2001, Zeitschrift für Induktive Abstammungs- und Vererbungslehre.

DnaA-dependent Assembly of the ABC Primosome at the A Site, A Single-stranded DNA Hairpin Containing a DnaA Box

K. Arai, H. Masai, 1995 .

Suppression of lens growth by alphaA-crystallin promoter-driven expression of diphtheria toxin results in disruption of retinal cell organization in zebrafish.

K. Arai, Sumiko Watanabe, B. Link, 2003, Developmental biology.

Structure of Escherichia coli dnaC. Identification of a cysteine residue possibly involved in association with dnaB protein.

K. Arai, M. Bond, A. Miyajima, 1987, The Journal of biological chemistry.

DNA Binding of PriA Protein Requires Cooperation of the N-terminal D-loop/Arrested-fork Binding and C-terminal Helicase Domains*

K. Arai, D. Kohda, H. Masai, 2002, The Journal of Biological Chemistry.

Cloning of the Escherichia coli gene for primosomal protein i: the relationship to dnaT, essential for chromosomal DNA replication.

K. Arai, M. Bond, H. Masai, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Replication of øX174 DNA Reconstituted with Purified Enzymes

K. Arai, A. Kornberg, N. Arai, 1983 .

POLYPEPTIDE CHAIN ELONGATION FACTORS FROM AN EXTREME THERMOPHILE, THERMUS THERMOPHILUS HB8

K. Arai, Y. Kaziro, N. Arai, 1978 .

Further studies on the interaction of the polypeptide chain elongation factor G with guanine nucleotides.

K. Arai, Y. Kaziro, N. Arai, 1977, Journal of biochemistry.

Structural fluctuation of the polypeptide-chain elongation factor Tu. A comparison of factors from Escherichia coli and Thermus thermophilus HB8.

K. Arai, S. Ohta, Y. Kaziro, 1977, European journal of biochemistry.

Properties and function of the sulfhydryl group in the polypeptide chain elongation factor G from E. coli.

K. Arai, Y. Kaziro, S. Nakamura, 1977, Journal of biochemistry.

Conformational transition of polypeptide chain elongation factor G as determined by electron spin resonance.

K. Arai, Y. Kaziro, S. Ohnishi, 1976, Journal of biochemistry.

Formation of a binary complex between elongation factor G and guanine nucleotides.

K. Arai, Y. Kaziro, N. Arai, 1975, Journal of biochemistry.

Conformational transitions of polypeptide chain elongation factor Tu. I. Studies with hydrophobic probes.

K. Arai, Y. Kaziro, M. Kawakita, 1975, Journal of biochemistry.

Conformational transition in polypeptide elongation factor Tu as revealed by electron spin resonance.

K. Arai, Y. Kaziro, T. Maeda, 1974, The Journal of biological chemistry.

Human GM-CSF induces HIV-1 LTR by multiple signalling pathways.

K. Arai, Sumiko Watanabe, C. Morimoto, 2002, Biochimie.

Inducible and non-inducible factors co-operatively activate the GM-CSF promoter by interacting with two adjacent DNA motifs.

K. Arai, K. Sugimoto, N. Arai, 1990, International immunology.

Analysis of mechanisms involved in the prevention of γ irradiation-induced apoptosis by hGM-CSF

K. Arai, Sumiko Watanabe, M. Mohi, 2000, Oncogene.

Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF.

K. Arai, S. Watanabe, M. Mohi, 2000, Oncogene.

Letter: Crystallization of phenylalanyl-tRNAPhe-EF-Tu-GTP complex.

K. Arai, Y. Kaziro, S. Nishimura, 1973, Biochimica et biophysica acta.

Analysis of the 5' promoters for human IL-3 and GM-CSF receptor alpha genes.

K. Arai, Sumiko Watanabe, A. Muto, 2003, Biochemical and biophysical research communications.

Thymocyte proliferation and differentiation in human granulocyte-macrophage colony-stimulating factor receptor transgenic mice.

K. Arai, S. Watanabe, Y. Yasuda, 1997, The Journal of allergy and clinical immunology.

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) induces inhibition of intrathymic T-cell development in hGM-CSF receptor transgenic mice.

K. Arai, T. Moore, S. Watanabe, 1997, Blood.

Specification of the Retinal Fate of Mouse Embryonic Stem Cells by Ectopic Expression of Rx/rax, a Homeobox Gene

K. Arai, T. Manabe, Sumiko Watanabe, 2004, Molecular and Cellular Biology.

Conservation of the primosome in successive stages of phi X174 DNA replication.

K. Arai, A. Kornberg, R. Low, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Replication of duplex DNA of phage phi X174 reconstituted with purified enzymes.

K. Arai, A. Kornberg, N. Arai, 1980, Proceedings of the National Academy of Sciences of the United States of America.

T Cell Activation Signals and Regulation of Lymphokine Gene by Viral and Cellular Transactivators

K. Arai, M. Muramatsu, T. Yokota, 1989 .

Conformational Transitions of Polypeptide Chain Elongation Factor Tu. II. Further Studies by Electron Spin Resonance

K. Arai, Y. Kaziro, S. Ohnishi, 1976 .

Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins.

K. Arai, T. Yokota, N. Arai, 1997, International immunology.

Interactions between elongation factor tu-guanosine triphosphate and ribosomes and the role of ribosome-bound transfer RNA in guanosine triphosphatase reaction.

K. Arai, Y. Kaziro, M. Kawakita, 1974, Journal of biochemistry.

Purification of the 120 kDa component of the human nuclear factor of activated T cells (NF-AT): reconstitution of binding activity to the cis-acting element of the GM-CSF and IL-2 promoter with AP-1.

K. Arai, H. Tokumitsu, E. Masuda, 1993, Biochemical and biophysical research communications.

The role of CD11b in phagocytosis and dendritic cell development.

K. Arai, N. Arai, S. Miyatake, 2008, Immunology letters.

Transcriptional Repressor foxl1 Regulates Central Nervous System Development by Suppressing shh Expression in Zebra Fish

K. Arai, Sumiko Watanabe, Shinya Satoh, 2006, Molecular and Cellular Biology.

Transforming growth factor-beta is a survival factor for neonate cortical neurons: coincident expression of type I receptors in developing cerebral cortices.

K. Arai, M. Muramatsu, T. Shirasawa, 1996, Developmental biology.

Operon structure of dnaT and dnaC genes essential for normal and stable DNA replication of Escherichia coli chromosome.

K. Arai, H. Masai, 1988, The Journal of biological chemistry.

Roles of the cytoplasmic domains of the alpha and beta subunits of human granulocyte-macrophage colony-stimulating factor receptor.

K. Arai, T. Yokota, A. Miyajima, 1995, The Journal of allergy and clinical immunology.

Studies on the polypeptide elongation factors from E. coli. IV. Crystalline Tu-GTP, Tu-Gpp(CH2)p, and phenylalanyl-tRNA-Tu-GTP complex.

K. Arai, Y. Kaziro, M. Kawakita, 1974, Journal of biochemistry.

Definitive hematopoiesis from acetyl LDL incorporating endothelial cells in the mouse embryo.

K. Arai, D. Sugiyama, K. Tsuji, 2005, Stem cells and development.

12 – High-Efficiency Cloning of Full-Length cDNA; Construction and Screening of cDNA Expression Libraries for Mammalian Cells

K. Arai, M. Brownstein, T. Yokota, 1989 .

A suppressive lymphokine derived from Ts clone 13G2 is IL-10.

K. Arai, T. Yokota, T. Hisatsune, 1992, Lymphokine and cytokine research.

Isolation and characterization of expressible cDNA clones for mouse Thy-1: a model system for cDNA expression of cell surface proteins.

K. Arai, R. Coffman, T. Yokota, 1986, Journal of immunology.

Constitutive Activation of JAK2 Confers Murine Interleukin-3-independent Survival and Proliferation of BA/F3 Cells*

K. Arai, Sumiko Watanabe, T. Itoh, 1999, The Journal of Biological Chemistry.

Primary structure of elongation fac

K. Arai, S. Nakamura, K. Takahashi, 2016 .

Interaction of guanosine 5'-diphosphate, 2'-(or 3'-) diphosphate(ppGpp) with elongation factors from E. coli.

K. Arai, Y. Kaziro, N. Arai, 1972, Biochemical and biophysical research communications.

Interleukin-4 adenoviral gene therapy reduces production of inflammatory cytokines and prostaglandin E2 by rheumatoid arthritis synovium ex vivo.

K. Arai, A. Koch, K. Katschke, 1999, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Roles of JAK kinase in human GM-CSF receptor signals.

K. Arai, S. Watanabe, T. Itoh, 1997, Leukemia.

Cytokine Receptors

K. Arai, Sumiko Watanabe, Y. Kato, 2014, Inflammation Research.