U. Hofmann

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Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Z. Nwosu, N. Battello, M. Rothley, 2018, Journal of Experimental & Clinical Cancer Research.

Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

Alexander Bauer, Klaus Maier, Ute Hofmann, 2009, Metabolic engineering.

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

U. Hofmann, J. Hampe, L. Kuepfer, 2017, npj Systems Biology and Applications.

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.

U. Hofmann, L. Kuepfer, R. Gebhardt, 2016, Journal of hepatology.

Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

Christian H. Holland, U. Hofmann, S. Dooley, 2021, Hepatology communications.

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

U. Hofmann, J. Brockmöller, M. Tzvetkov, 2016, Genome Medicine.

Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison.

Ute Hofmann, Mathias Haag, Falko Fend, 2017, Journal of proteome research.

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.

U. Hofmann, L. Kuepfer, R. Gebhardt, 2015, Journal of pharmaceutical sciences.

Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers

U. Hofmann, G. Mikus, T. Mürdter, 2002, BMC clinical pharmacology.

Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone

U. Hofmann, U. Klotz, K. Dilger, 2000, Clinical pharmacology and therapeutics.

Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency.

U. Hofmann, M. Haubitz, D. Busse, 2002, Kidney international.

Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

U. Hofmann, J. Brockmöller, M. Tzvetkov, 2020, Frontiers in Genetics.

Rapid, highly sensitive method for the determination of morphine and its metabolites in body fluids by liquid chromatography-mass spectrometry.

U. Hofmann, G. Mikus, G. Schänzle, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility

U. Hofmann, W. Schmidt-Heck, R. Guthke, 2017, Archives of Toxicology.

Gabapentin enhances the analgesic effect of morphine in healthy volunteers.

U. Hofmann, G. Mikus, S. Ammon, 2000 .

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).

U. Hofmann, M. Niemi, M. Fromm, 2005, British journal of clinical pharmacology.

A new [2H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates.

U. Hofmann, R. Kerb, T. Mürdter, 2014, Journal of labelled compounds & radiopharmaceuticals.

Cancer Therapy : Preclinical Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 ( OCT 1 )

U. Hofmann, H. Koepsell, C. Pott, 2014 .

Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry.

U. Hofmann, U. Klotz, M. Schwab, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D6*2 and Impaired Allele CYP2D6*41

U. Hofmann, M. Schwab, U. Zanger, 2020, Clinical pharmacology and therapeutics.

Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry.

U. Hofmann, M. Eichelbaum, O. von Richter, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells

U. Hofmann, A. Lampen, A. Braeuning, 2018, Drug Metabolism and Disposition.

Syddansk Universitet Low heritability in pharmacokinetics of talinolol a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol , a putative probe drug of MDR 1 and other membrane transporters

U. Hofmann, J. Brockmöller, M. Tzvetkov, 2016 .

Prediction of CYP2D6-mediated polymorphic drug metabolism (sparteine type) based on in vitro investigations.

U. Hofmann, H. Kroemer, G. Engel, 1996, Journal of chromatography. B, Biomedical applications.

Reconstitution of beta-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase.

U. Hofmann, V. Urlacher, R. Schmid, 2006, Biochemical and biophysical research communications.

Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways

U. Hofmann, C. Buechler, T. Weiss, 2017, PloS one.

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans.

U. Hofmann, M. Eichelbaum, G. Williamson, 2015, Molecular nutrition & food research.

Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling.

U. Hofmann, M. Haag, M. Schwab, 2018, Journal of proteome research.

Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na+-taurocholate cotransporting polypeptide inhibitor

U. Hofmann, W. Haefeli, M. Haag, 2015, Analytical and Bioanalytical Chemistry.

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

U. Hofmann, M. Haag, M. Schwab, 2022, Clinical and translational medicine.

Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

U. Hofmann, M. Haag, M. Schwab, 2020, Metabolites.

Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate.

U. Hofmann, W. Schlegel, U. Kuhlmann, 1993, European journal of biochemistry.

Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells

U. Hofmann, A. Seidel, A. Braeuning, 2020, International journal of molecular sciences.

RNAi in murine hepatocytes: the agony of choice—a study of the influence of lipid-based transfection reagents on hepatocyte metabolism

U. Hofmann, A. Shevchenko, J. Böttger, 2015, Archives of Toxicology.

Sex-dependent dynamics of metabolism in primary mouse hepatocytes

U. Hofmann, P. Juvan, C. Körner, 2021, Archives of Toxicology.

DISPOSITION OF ORAL AND INTRAVENOUS PRAVASTATIN IN MRP2-DEFICIENT TR– RATS

U. Hofmann, M. Eichelbaum, H. Kroemer, 2005, Drug Metabolism and Disposition.

Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load.

U. Hofmann, K. Mauch, R. Gebhardt, 2012, BMB reports.

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis.

U. Hofmann, F. Kamali, A. Rostami-Hodjegan, 2001, British journal of clinical pharmacology.

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

U. Hofmann, M. Schwab, U. Zanger, 2021, Frontiers in Pharmacology.

Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

U. Hofmann, P. Artursson, P. Hoffmann, 2022, International journal of molecular sciences.

In vitro interaction of codeine and diclofenac.

U. Hofmann, M. Eichelbaum, G. Mikus, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine.

U. Hofmann, M. Eichelbaum, C. Meese, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: Comparison of sparteine and dextromethorphan

U. Hofmann, M. Eichelbaum, H. Kroemer, 1996, Clinical pharmacology and therapeutics.

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

U. Hofmann, M. Schwarz, S. Vetter, 2015, Molecular Pharmacology.

Effects of ursodeoxycholic acid on P‐glycoprotein and cytochrome P450 3A4–dependent pharmacokinetics in humans

U. Hofmann, H. Glaeser, M. Fromm, 2006, Clinical pharmacology and therapeutics.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

U. Hofmann, S. Dooley, C. Trautwein, 2018, Hepatology.

Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein

U. Hofmann, M. Fromm, M. Eichelbaum, 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine.

U. Hofmann, J. Brockmöller, M. Schwab, 2002, British journal of clinical pharmacology.

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.

U. Hofmann, T. Morio, Motohiro Kato, 2018, Blood.

Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.

U. Hofmann, M. Schwab, W. Reinisch, 2012, Analytical chemistry.

Pentafluorophenyldiazoalkanes as novel derivatization reagents for the determination of sensitive carboxylic acids by gas chromatography—negative-ion mass spectrometry

U. Hofmann, C. Meese, Sabine Holzer, 1990 .

Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm

U. Hofmann, M. Schwab, U. Sechtem, 2021, JACC Case Reports.

Parameterization of large-scale autonomous network models from time-series metabolite data

U. Hofmann, K. Mauch, M. Reuss, 2010 .

Esomeprazole‐induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: Evidence from clinical and pharmacokinetic data

U. Hofmann, P. Malfertheiner, U. Klotz, 2005, Clinical pharmacology and therapeutics.

CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL

U. Hofmann, W. Klapper, M. Haag, 2022, Leukemia.

Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation

U. Hofmann, J. Steinbach, G. Maurer, 2018, International journal of molecular sciences.

Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line

U. Hofmann, M. Haag, M. Schwab, 2022, Frontiers in Molecular Biosciences.

External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease

U. Hofmann, T. Lehr, M. Schwab, 2021, Pharmaceutics.

Liver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration

U. Hofmann, M. Stumvoll, B. Vollmar, 2018, Scientific Reports.

Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice

U. Hofmann, J. Hengstler, A. Ghallab, 2022, International journal of molecular sciences.

CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth.

U. Hofmann, J. Fletcher, M. Schwab, 2019, Biochemical pharmacology.

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

U. Hofmann, M. Schwarz, S. Vetter, 2015, Drug Metabolism and Disposition.

DMD064667 1781..1787

U. Hofmann, M. Schwarz, S. Vetter, 2015 .

A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes

U. Hofmann, M. Schwab, M. Turpeinen, 2009, Drug Metabolism and Disposition.

Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data.

U. Hofmann, P. Malfertheiner, U. Klotz, 2005, Clinical pharmacology and therapeutics.

Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry.

U. Hofmann, M. Eichelbaum, M. Schwab, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S‐Methyltransferase

U. Hofmann, M. Relling, W. Evans, 2022, Clinical pharmacology and therapeutics.

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype

U. Hofmann, M. Eichelbaum, G. Mikus, 1997, Clinical pharmacology and therapeutics.

Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry.

U. Hofmann, T. Mettang, U. Kuhlmann, 1990, Analytical biochemistry.

Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis.

U. Hofmann, T. Mettang, C. Pauli–Magnus, 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Evidence for morphine‐independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites

U. Hofmann, J. Lötsch, M. Schwab, 2006, Clinical pharmacology and therapeutics.

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.

U. Hofmann, C. Bokemeyer, M. Eichelbaum, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Dihydrocodeine: A new opioid substrate for the polymorphic CYP2D6 in humans

U. Hofmann, M. Fromm, G. Mikus, 1995, Clinical pharmacology and therapeutics.

Determination of 6-Thioguanosine Diphosphate and Triphosphate and Nucleoside Diphosphate Kinase Activity in Erythrocytes: Novel Targets for Thiopurine Therapy?

U. Hofmann, M. Neurath, S. Shi, 2010, Therapeutic drug monitoring.

Inflammation-Associated MicroRNA-130b Down-Regulates Cytochrome P450 Activities and Directly Targets CYP2C9

U. Hofmann, M. Schwab, U. Zanger, 2015, Drug Metabolism and Disposition.

Sensitive and rapid quantification of busulfan in small plasma volumes by liquid chromatography-electrospray mass spectrometry.

U. Hofmann, P. Dreger, M. Schwab, 2001, Clinical chemistry.

Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers

U. Hofmann, G. Mikus, S. Ammon, 2000, Anesthesia and analgesia.

Determination of tetrahydrothiophene formation as a probe of in vitro busulfan metabolism by human glutathione S-transferase A1-1: use of a highly sensitive gas chromatographic-mass spectrometric method.

U. Hofmann, H. Kroemer, B. Sperker, 1999, Journal of chromatography. B, Biomedical sciences and applications.

LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

U. Hofmann, P. Kremsner, Asma Ahmed, 2014, Analytical and Bioanalytical Chemistry.

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

U. Hofmann, S. Sindrup, F. Nielsen, 2004, European Journal of Clinical Pharmacology.

Highly sensitive and specific gas chromatographic-tandem mass spectrometric method for the determination of trace amounts of antipyrine metabolites in biological material.

U. Hofmann, M. Eichelbaum, G. Engel, 1995, Journal of chromatography. B, Biomedical applications.

Synthesis of novel prostaglandin F2α isomers and structure of an enzymatically formed 13-hydroxyprostaglandin endoperoxide

U. Hofmann, M. Hecker, V. Ullrich, 1987 .

Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

Klaus Maier, Ute Hofmann, Matthias Reuss, 2010, BMC Systems Biology.

Increased Absorption of Digoxin from the Human Jejunum Due to Inhibition of Intestinal Transporter-Mediated Efflux

U. Hofmann, H. Glaeser, M. Fromm, 2007, Clinical pharmacokinetics.

Influence of Age and Cytochrome P450 2C9 Genotype on the Steady-State Disposition of Diclofenac and Celecoxib

U. Hofmann, U. Klotz, K. Dilger, 2003, Clinical pharmacokinetics.

Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS.

U. Hofmann, G. Ott, A. Walch, 2020, Analytica chimica acta.

Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range.

U. Hofmann, M. Eichelbaum, G. Mikus, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

U. Hofmann, M. Eichelbaum, P. Neuhaus, 2001, Pharmacogenetics.

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

U. Hofmann, M. Relling, C. Pui, 2016, Nature Genetics.

High variation of tioguanine absorption in patients with chronic active Crohn's disease

U. Hofmann, K. Dilger, W. Kreisel, 2003, Alimentary pharmacology & therapeutics.

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid‐lowering efficacy of multiple‐dose pravastatin

U. Hofmann, M. Niemi, M. Eichelbaum, 2006, Clinical pharmacology and therapeutics.

6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease.

U. Hofmann, R. Kiesslich, M. Neurath, 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine, and norantipyrine formation

U. Hofmann, M. Eichelbaum, G. Engel, 1996, Clinical pharmacology and therapeutics.

Chronopharmacology of intravenous and oral modified release verapamil.

U. Hofmann, M. Eichelbaum, K. Dilger, 1999, British journal of clinical pharmacology.

UDP‐Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

M Schwab, U. Hofmann, P. Neuvonen, 2010, Clinical pharmacology and therapeutics.

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

Ute Hofmann, Claus Hellerbrand, Heiko van der Kuip, 2011, Genome Medicine.

Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells

U. Hofmann, J. Steinbach, P. Harter, 2018, The Journal of Biological Chemistry.

A pilot ‘window of opportunity’ neoadjuvant study of metformin in localised prostate cancer

U. Hofmann, J. Trachtenberg, K. Hersey, 2014, Prostate Cancer and Prostatic Disease.

Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance

Z. Nwosu, N. Battello, W. Piorońska, 2020, EBioMedicine.

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

U. Hofmann, G. Ott, A. Hartmann, 2016, Scientific Reports.

Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins

U. Hofmann, K. Giacomini, M. Eichelbaum, 2021, British journal of pharmacology.

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.

U. Hofmann, U. Brinkmann, M. Fromm, 2002, British journal of clinical pharmacology.

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17

U. Hofmann, P. Neuvonen, M. Niemi, 2005, Pharmacogenetics and genomics.

A Predominate Role of CYP 1 A 2 for the Metabolism of Nabumetone to the Active Metabolite , 6-Methoxy-2-naphthylacetic Acid , in Human Liver Microsomes

U. Hofmann, M. Schwab, M. Turpeinen, 2009 .

Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

U. Hofmann, C. Menéndez, T. Lehr, 2018, Antimicrobial Agents and Chemotherapy.

Disposition of propafenone in a poor metabolizer of CYP2D6 with Gilbert's syndrome.

U. Hofmann, M. Eichelbaum, K. Dilger, 2000, Therapeutic drug monitoring.

Heritability of metoprolol and torsemide pharmacokinetics

U. Hofmann, J. Brockmöller, M. Tzvetkov, 2015, Clinical pharmacology and therapeutics.

Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression

U. Hofmann, T. Fehm, H. Neubauer, 2020, Breast Cancer Research.

Syntheses of Metabolites of S‐Carboxymethyl‐L‐cysteine and S‐Methyl‐L‐cysteine and of Some Isotopically Labelled (2H, 13C) Analogues

U. Hofmann, Claus O. Meese, Dagmar Specht, 1990, Archiv der Pharmazie.

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

U. Hofmann, M. Eichelbaum, H. Kroemer, 1996, European Journal of Clinical Pharmacology.

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression

Christian H. Holland, T. Luedde, U. Hofmann, 2021, Cells.

Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney

U. Hofmann, P. Boor, L. Kuepfer, 2021, Archives of Toxicology.

Polymorphic sulphoxidation of carbocisteine

U. Hofmann, M. Eichelbaum, C. Meese, 1990, The Lancet.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Nils Blüthgen, Reinhard Guthke, Jan G. Hengstler, 2016, Archives of Toxicology.

Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study

U. Hofmann, M. Eichelbaum, D. Busse, 2006, European Journal of Clinical Pharmacology.

The Impact of Thyroid Disease on the Regulation, Expression, and Function of ABCB1 (MDR1/P Glycoprotein) and Consequences for the Disposition of Digoxin

U. Hofmann, M. Eichelbaum, S. Igel, 2010, Clinical pharmacology and therapeutics.

Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases.

U. Hofmann, M. Neurath, R. Atreya, 2016, Journal of Crohn's & colitis.

Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay.

U. Hofmann, M. Schwab, A. Ventura, 2017, Chemico-Biological Interactions.

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death

U. Hofmann, J. Steinbach, M. Mittelbronn, 2017, Brain : a journal of neurology.

Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial

U. Hofmann, A. Luini, M. Cazzaniga, 2014, Breast Cancer Research and Treatment.

Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)

U. Hofmann, H. Koepsell, C. Pott, 2013, Clinical Cancer Research.

Identification of metabolic fluxes in hepatic cells from transient 13C‐labeling experiments: Part II. Flux estimation

Klaus Maier, Ute Hofmann, Matthias Reuss, 2008, Biotechnology and bioengineering.

Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis

U. Hofmann, P. Scheurich, M. Schwab, 2011, PloS one.

Patient Education in a 14-month Randomised Trial Fails to Improve Adherence in Ulcerative Colitis: Influence of Demographic and Clinical Parameters on Non-adherence

U. Hofmann, S. Nikolaus, M. Schwab, 2017, Journal of Crohn's & colitis.

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

U. Hofmann, A. Schuppert, L. Kuepfer, 2017, Scientific Reports.

Enzymatically Modified Low‐Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease

U. Hofmann, G. Ott, M. Schwab, 2015, Journal of the American Heart Association.

Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner

U. Hofmann, D. Schuppan, F. Lang, 2016, Epigenetics.

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

Ute Hofmann, U. Hofmann, M. Schwab, 2011, PloS one.

Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high–pressure liquid chromatography–electrospray ionization tandem mass spectrometry

U. Hofmann, M. Schwab, T. Mürdter, 2005, Journal of Inherited Metabolic Disease.

Propafenone for the Prevention of Atrial Tachyarrhythmias After Cardiac Surgery: A Randomized, Double‐blind Placebo‐controlled Trial

U. Hofmann, C. Meisner, M. Eichelbaum, 2008, Clinical pharmacology and therapeutics.

Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes

Ute Hofmann, Thomas S Weiss, Stephan Riedmaier, 2010, Drug Metabolism and Disposition.

High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs.

U. Hofmann, Maren C. Podszun, Nadine Grebenstein, 2013, Toxicology and applied pharmacology.

Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry.

U. Hofmann, M. Fromm, S. Drescher, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2

U. Hofmann, J. Brockmöller, S. Möller, 2016, Clinical pharmacology and therapeutics.

Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6.

U. Hofmann, M. Fromm, M. Eichelbaum, 1999, Pharmacogenetics.

Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers

U. Hofmann, W. Haefeli, M. Haag, 2023, Frontiers in Pharmacology.

Performance comparison of narrow-bore and capillary liquid-chromatography for non-targeted metabolomics profiling by HILIC-QTOF-MS.

U. Hofmann, M. Haag, M. Schwab, 2023, Talanta.

Loss of analgesic effect of morphine due to coadministration of rifampin

U. Hofmann, M. Fromm, M. Eichelbaum, 1997, PAIN.

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

U. Hofmann, M. Schwab, S. Winter, 2011, Front. Pharmacol..

Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry.

U. Hofmann, M. Schwab, M. Ramharter, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry.

U. Hofmann, M. Eichelbaum, H. Kroemer, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide.

U. Hofmann, M. Eichelbaum, H. Kroemer, 1995, Journal of chromatography. B, Biomedical applications.

Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death

P. Oefner, U. Hofmann, J. Steinbach, 2020, Cancers.

Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique.

U. Hofmann, M. Eichelbaum, G. Williamson, 2013, The American journal of clinical nutrition.

Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

U. Hofmann, U. Zanger, K. Klein, 2021, Scientific reports.

A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells

Ute Hofmann, Georg Damm, U. Hofmann, 2015, Drug Metabolism and Disposition.

Comparison of the Impact of Inflammatory Signaling on Absorption , Distribution , Metabolism , and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells s

Ulrich M. Zanger, Ute Hofmann, Georg Damm, 2014 .

Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice

U. Hofmann, M. Niemi, M. Fromm, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans

U. Hofmann, H. Glaeser, M. Fromm, 2004, Clinical pharmacology and therapeutics.

Disposition and first‐pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender?

U Klotz, U. Hofmann, U. Klotz, 1996, Clinical pharmacology and therapeutics.

Identification of metabolic fluxes in hepatic cells from transient 13C‐labeling experiments: Part I. Experimental observations

U. Hofmann, K. Mauch, M. Reuss, 2008, Biotechnology and bioengineering.

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

U. Hofmann, J. Hampe, L. Kuepfer, 2017, npj Systems Biology and Applications.

Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

U. Hofmann, L. Blank, L. Kuepfer, 2021, CPT: pharmacometrics & systems pharmacology.

CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL

U. Hofmann, W. Klapper, M. Haag, 2022, Leukemia.

Liver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration

U. Hofmann, M. Stumvoll, B. Vollmar, 2018, Scientific Reports.

Chemically induced mouse liver tumors are resistant to treatment with atorvastatin

U. Hofmann, A. Buchmann, M. Schwarz, 2014, BMC Cancer.

Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins

U. Hofmann, M. Eichelbaum, A. Busjahn, 2009, Clinical pharmacology and therapeutics.

Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters

U. Hofmann, M. Fromm, M. Schwab, 2021, Pharmaceutics.

Simple and sensitive method for the determination of celecoxib in human serum by high-performance liquid chromatography with fluorescence detection.

U. Hofmann, U. Klotz, T. Mürdter, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing.

U. Hofmann, G. Mikus, S. Ammon, 1999, British journal of clinical pharmacology.

Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry.

U. Hofmann, G. Mikus, M. Fromm, 1995, Journal of chromatography. B, Biomedical applications.

Comparative analysis of 3D culture methods on human HepG2 cells

Jan G. Hengstler, Albert Braeuning, Alfonso Lampen, 2016, Archives of Toxicology.