I. Huijbers

发表

Comparative expression analysis of the MAGED genes during embryogenesis and brain development

M. Bertrand, I. Huijbers, P. Chomez, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

Minimal Tolerance to a Tumor Antigen Encoded by a Cancer-Germline Gene

I. Huijbers, P. Chomez, C. Uyttenhove, 2012, The Journal of Immunology.

An inducible mouse model of melanoma expressing a defined tumor antigen.

I. Huijbers, P. Chomez, A. Berns, 2006, Cancer research.

In situ CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer

Emma M Schatoff, I. Huijbers, D. Adams, 2020, The EMBO journal.

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

I. Huijbers, M. Serresi, P. V. D. van den Berk, 2020, bioRxiv.

HideRNAs protect against CRISPR-Cas9 re-cutting after successful single base-pair gene editing

I. Huijbers, H. te Riele, C. Pritchard, 2022, Scientific reports.

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

I. Huijbers, H. Rosing, J. Beijnen, 2022, Acta pharmaceutica Sinica. B.

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development

I. Huijbers, P. Gros, B. Nagar, 2023, Scientific Reports.

CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis

I. Huijbers, C. Pritchard, J. Nieland, 2019, Scientific Reports.

Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle

I. Huijbers, M. Georges, C. Isacke, 2009, PLoS genetics.

Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients

Ji-Ying Song, Egbert F. Smit, Arno Velds, 2016, Cell reports.

A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

I. Huijbers, S. Al-Sarraj, C. Isacke, 2010, PloS one.

Generating Genetically Modified Mice: A Decision Guide.

I. Huijbers, 2017, Methods in molecular biology.

A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair

I. Huijbers, H. van Attikum, J. Jonkers, 2021, Cancer Research.

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division

I. Huijbers, R. Medema, J. Jonkers, 2018, British Journal of Cancer.

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

I. Huijbers, P. V. D. van den Berk, H. Jacobs, 2016, Nucleic acids research.

Using the GEMM-ESC strategy to study gene function in mouse models

I. Huijbers, A. Berns, C. Pritchard, 2015, Nature Protocols.

Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.

Amanda J. Wilson, I. Huijbers, E. Taskesen, 2011, Cell stem cell.

Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice.

I. Huijbers, B. J. Van den Eynde, L. Chasson, 2010, Cancer research.

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

I. Huijbers, A. Berns, A. Schlicker, 2015, Proceedings of the National Academy of Sciences.

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

I. Huijbers, A. Berns, M. Cozijnsen, 2014, EMBO molecular medicine.

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models

I. Huijbers, A. Berns, J. Jonkers, 2011, BioEssays : news and reviews in molecular, cellular and developmental biology.

Towards an understanding of C9orf82 protein/CAAP1 function

I. Huijbers, J. Neefjes, Ji-Ying Song, 2019, PloS one.

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

I. Huijbers, C. Pritchard, J. Nieland, 2021, Communications Biology.

Inhibition of carnitine palmitoyl-transferase 1 is a potential target in a mouse model of Parkinson’s disease

I. Huijbers, Angelique P. Corthals, H. Kjeldal, 2023, npj Parkinson's Disease.

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland

Jos Jonkers, Hatice Yücel, I. Huijbers, 2016, Genes & development.

Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models

I. Huijbers, Angelique P. Corthals, P. Gazerani, 2020, Scientific Reports.

Pericytes promote selective vessel regression to regulate vascular patterning.

I. Huijbers, C. Isacke, D. Huso, 2012, Blood.

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division

I. Huijbers, R. Medema, J. Jonkers, 2018, British Journal of Cancer.

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

I. Huijbers, M. Raaben, T. Brummelkamp, 2020, Nature Communications.

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development

I. Huijbers, W. Zwart, J. Jonkers, 2019, Genes & development.

Glioblastoma: Endosialin Marker for Pericytes

I. Huijbers, C. Isacke, Nicole Simonavicius, 2011 .

Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma

I. Huijbers, C. Isacke, D. Bax, 2008, Modern Pathology.

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

I. Huijbers, A. Ferrando, Laura Belver, 2022, Blood.

A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors.

I. Huijbers, J. van Rheenen, C. López-Iglesias, 2023, Developmental cell.

Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

I. Huijbers, P. Essers, S. Rottenberg, 2022, Cancer research communications.

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

I. Huijbers, J. Visvader, L. Wessels, 2019, Nature Communications.

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

I. Huijbers, J. Visvader, L. Wessels, 2019, Nature Communications.

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

I. Huijbers, M. Raaben, T. Brummelkamp, 2020, Nature Communications.

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair

I. Huijbers, R. Wolthuis, J. Dorsman, 2019, Scientific Reports.

A mouse model that is immunologically tolerant to reporter and modifier proteins

I. Huijbers, F. Scheeren, Ji-Ying Song, 2020, Communications Biology.

A mouse model that is immunologically tolerant to reporter and modifier proteins

I. Huijbers, T. Schumacher, F. Scheeren, 2020, Communications Biology.

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

I. Huijbers, C. Pritchard, J. Nieland, 2021, Communications biology.

Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer

I. Huijbers, A. Berns, C. Pritchard, 2014, Transgenic Research.

Direct Generation of Conditional Alleles Using CRISPR/Cas9 in Mouse Zygotes.

I. Huijbers, C. Pritchard, L. Kroese, 2017, Methods in molecular biology.

L11.05 RAPID VALIDATION OF CANCER GENES AND DRUG TARGETS IN GENETICALLY ENGINEERED MOUSE MODELS OF CANCER

I. Huijbers, A. Berns, M. Cozijnsen, 2013 .