S. Shurtleff

J. Downing, S. Shurtleff, Anami R Patel, 2003, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP.

S. Shurtleff, S. Taffet, K. Singhel, 1989, Cellular immunology.

Rapid expression of ornithine decarboxylase mRNA in a macrophage‐like cell line: cAMP repression of the requirement for prior protein synthesis

S. Shurtleff, S. Taffet, C. M. McElwain, 1988, Journal of cellular physiology.

IDH1 and IDH2 mutations in pediatric acute leukemia

S. Shurtleff, I. Radtke, C. Mullighan, 2011, Leukemia.

Abstract 4869: Whole genome sequence analysis of MLL rearranged infant acute lymphoblastic leukemias reveals remarkably few somatic mutations: A Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Michael C. Rusch, R. Wilson, E. Mardis, 2012 .

Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia

J. Downing, S. Shurtleff, Jen-Fen Fu, 2001, Genes, chromosomes & cancer.

Reference alignment of SNP microarray signals for copy number analysis of tumors

Cheng Cheng, Stan Pounds, James R. Downing, 2009, Bioinform..

Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy

J. Downing, S. Shurtleff, S. Raimondi, 2015, British journal of haematology.

Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients.

S. Shurtleff, F. Behm, G. Neale, 2005, Blood.

NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction for Detecting the t(2;5) of Non-Hodgkin's Lymphoma.

J. Downing, S. Shurtleff, S. Morris, 2001, Methods in molecular medicine.

Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies

Sara M. Federico, S. Shurtleff, C. Pui, 2019, Clinical Cancer Research.

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia

S. Shurtleff, D. Finkelstein, C. Drenberg, 2017, The Journal of clinical investigation.

Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

S. Shurtleff, R. Ribeiro, D. Pei, 2008, BMC Cancer.

11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.

J. Downing, S. Shurtleff, F. Behm, 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device.

S. Shurtleff, J. Cayuela, S. Schnittger, 2007, Cancer genetics and cytogenetics.

Early molecular detection of central nervous system relapse in a child with systemic anaplastic large cell lymphoma: Case report and review of the literature

S. Shurtleff, J. Biegel, G. Armstrong, 2005, Pediatric blood & cancer.

Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction.

J. Downing, D. Weisenburger, S. Shurtleff, 1995, Blood.

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

J. Downing, S. Shurtleff, M. Roussel, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Structural features of the colony‐stimulating factor 1 receptor that affect its association with phosphatidylinositol 3‐kinase.

J. Downing, S. Shurtleff, C. Rock, 1990, The EMBO journal.

transcription.an activator to a repressor of The t(12;21) translocation converts AML-1B

T. Golub, S. Shurtleff, N. Lenny, 2013 .

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

T. Golub, J. Downing, S. Shurtleff, 1996, Molecular and cellular biology.

Two independent retrotransposon insertions at the same site within the coding region of BTK

S. Shurtleff, Shannon M Norland, H. Kazazian, 2005, Human mutation.

Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX.

S. Shurtleff, D. Persons, J. Riberdy, 2011, Clinical immunology.

Bithalamic gliomas may be molecularly distinct from their unilateral high‐grade counterparts

Scott N. Hwang, S. Shurtleff, P. Northcott, 2018, Brain pathology.

Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase

J. Downing, S. Shurtleff, C. Sherr, 1991, Molecular and cellular biology.

Incidental diagnosis of diffuse intrinsic pontine glioma in children

S. Shurtleff, K. Wright, A. Gajjar, 2015, Pediatric blood & cancer.

The Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Sub-Classification of Leukemia: Final Report on 3252 Cases from the International MILE Study Group

J. Downing, S. Shurtleff, J. D. Vos, 2008 .

Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17.

S. Shurtleff, N. Copeland, D. Gilbert, 1995, Cytogenetics and cell genetics.

Pediatric Acute Myeloid Leukemia with Nucleophosmin Mutations Is Characterized by a Gene Expression Signature with Dysregulated HOX Gene Expression Distinct from MLL-Rearranged Leukemias.

J. Downing, S. Shurtleff, Xiaodong Zhou, 2005 .

High-Resolution SNP Array Profiling of Relapsed Acute Leukemia Identifies Genomic Abnormalities Distinct from Those Present at Diagnosis.

J. Downing, S. Shurtleff, I. Radtke, 2007 .

ERG Deletions Define a Novel Subtype of B-Progenitor Acute Lymphoblastic Leukemia.

Christopher B. Miller, J. Downing, S. Shurtleff, 2007 .

Rapid immune reconstitution after a reduced‐intensity conditioning regimen and a CD3‐depleted haploidentical stem cell graft for paediatric refractory haematological malignancies

S. Shurtleff, F. Behm, D. Srivastava, 2006, British journal of haematology.

Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

S. Shurtleff, R. Ribeiro, D. Pei, 2011, BMC cancer.

D-type cyclin-dependent kinase activity in mammalian cells

S. Shurtleff, M. Shibuya, D. Quelle, 1994, Molecular and Cellular Biology.

Molecular analysis of the PML/RARα chimeric gene in pediatric acute promyelocytic leukemia

J. Downing, S. Shurtleff, F. Behm, 1996 .

Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia.

Elaine Coustan-Smith, Dario Campana, Xueyuan Cao, 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.

J. Downing, S. Shurtleff, F. Behm, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

S. Shurtleff, F. Behm, S. Raimondi, 1995, Leukemia.

Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital.

J. Downing, S. Shurtleff, F. Behm, 2009, Blood.

Use of Reverse Transcriptase Polymerase Chain Reaction for Diagnosis and Staging of Alveolar Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, and Desmoplastic Small Round Cell Tumor

J. Downing, S. Shurtleff, A. Pappo, 2001, Journal of pediatric hematology/oncology.

Germline Mutations in Predisposition Genes in Pediatric Cancer.

Li Ding, Amar Gajjar, Xiaotu Ma, 2015, The New England journal of medicine.

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

J. Downing, S. Shurtleff, S. Raimondi, 2009, Proceedings of the National Academy of Sciences.

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

S. Shurtleff, M. Roussel, D. Bar-Sagi, 1993, Genes & development.

C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma

Li Ding, Elaine R. Mardis, Timothy N. Phoenix, 2014, Nature.

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2014, Nature Communications.

Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology

Heather L. Mulder, Michael C. Rusch, R. Wilson, 2016, Acta Neuropathologica.

The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias

Cheng Cheng, Li Ding, Robert Huether, 2015, Nature Genetics.

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Heather L. Mulder, S. Ranade, R. Wilson, 2012, Cancer cell.

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.

Li Ding, Xiaotu Ma, Jinghui Zhang, 2014, Cancer discovery.

The genomic landscape of core-binding factor acute myeloid leukemias

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2016, Nature Genetics.

Analysis of error profiles in deep next-generation sequencing data

Heather L. Mulder, Diane A. Flasch, S. Shurtleff, 2019, Genome Biology.

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

Howard Y. Chang, J. Rinn, D. Witten, 2009, Cell stem cell.

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas

S. Shurtleff, Jing Ma, T. Forshew, 2010, Acta Neuropathologica.

Diagnostic Utility of a Custom 34-Gene Anchored Multiplex PCR-Based Next-Generation Sequencing Fusion Panel for the Diagnosis of Bone and Soft Tissue Neoplasms With Identification of Novel USP6 Fusion Partners in Aneurysmal Bone Cysts.

S. Shurtleff, J. Goldblum, D. H. Farkas, 2020, Archives of pathology & laboratory medicine.

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.

Elizabeth Stewart, Jinghui Zhang, Heather L. Mulder, 2018, Cancer cell.

Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia.

S. Shurtleff, D. Campana, C. Pui, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT 3‐ITD AML

Karl W. Kroll, J. Byrd, S. Shurtleff, 2019, Clinical and translational science.

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.

Dario Campana, James Downing, Sheila Shurtleff, 2005, Blood.

Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

S. Shurtleff, F. Behm, S. Raimondi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.

S. Shurtleff, F. Behm, S. Raimondi, 1995, Blood.

Favorable impact of the t(9;11) in childhood acute myeloid leukemia.

J. Downing, S. Shurtleff, F. Behm, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas

Scott N. Hwang, S. Shurtleff, P. Northcott, 2016, Acta Neuropathologica.

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

Aman N. Patel, Samuel W. Brady, Michael C. Rusch, 2021, Cancer discovery.

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

S. Shurtleff, J. Cleveland, C. Sherr, 1991, Nature.

MN1 overexpression is an important step in the development of inv(16) AML

S. Shurtleff, E. Zwarthoff, G. Grosveld, 2007, Leukemia.

Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia

S. Shurtleff, F. Behm, S. Raimondi, 2003, Cancer.

12 p Abnormalities and the TEL Gene ( ETV 6 ) in Childhood Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, F. Behm, 1997 .

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Xiaotu Ma, Jinghui Zhang, Scott Newman, 2018, Nature Communications.

Frequent Deletion of p16*NK4a/MTSl and in Pediatric Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, F. Behm, 2011 .

Frequent Deletion of p 16 * NK 4 a / MTSl and i Pediatric Acute Lymphoblastic Leukemia

Downing, S. Shurtleff, F. Behm, 2002 .

Genetic analysis of patients with defects in early B‐cell development

S. Shurtleff, H. Kanegane, T. Miyawaki, 2005, Immunological reviews.

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations.

J. Downing, S. Shurtleff, I. Radtke, 2010, Blood.

Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.

J. Downing, S. Shurtleff, V. Valentine, 1995, Genomics.

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Heather L. Mulder, Michael C. Rusch, Michael N. Edmonson, 2016, Nature Genetics.

ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy

S. Shurtleff, S. Raimondi, M. Relling, 2012, Leukemia.

12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia.

J. Downing, S. Shurtleff, F. Behm, 1997, Blood.

Impact of tyrosine kinase inhibitors on minimal residual disease and outcome in childhood Philadelphia chromosome‐positive acute lymphoblastic leukemia

S. Shurtleff, S. Raimondi, Cheng Cheng, 2014, Cancer.

High incidence of TEL/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan.

J. Downing, S. Shurtleff, C. Pui, 1996, Leukemia.

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

S. Shurtleff, K. Cornetta, S. Rosenberg, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Aman N. Patel, Erin K. Hedlund, J. Downing, 2018, Nature Communications.

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Kiran C. Bobba, Kimberly J. Johnson, R. Wilson, 2011 .

Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells

J. Downing, S. Shurtleff, Cheng Cheng, 2015, Scientific Reports.

Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome.

S. Shurtleff, F. Behm, S. Raimondi, 2006, Cancer genetics and cytogenetics.

in pediatric patients transplantation excision circle before allogeneic hematopoietic stem cell Prediction of T-cell reconstitution by assessment of T-cell receptor

S. Shurtleff, F. Behm, G. Neale, 2013 .

ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases.

J. Downing, S. Shurtleff, F. Behm, 2003, Blood.

Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma

Aman N. Patel, Michael N. Edmonson, J. Downing, 2019, Cold Spring Harbor molecular case studies.

γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies

S. Shurtleff, S. Raimondi, R. Shackelford, 2017, Case reports in hematology.

The Genomic Landscape of Childhood and Adolescent Melanoma

Li Ding, Jinghui Zhang, Matthew Parker, 2014, The Journal of investigative dermatology.

Disseminated intrathoracic desmoplastic small round-cell tumor: a case report.

J. Downing, S. Shurtleff, A. Pappo, 1996, Journal of pediatric hematology/oncology.

Universal monitoring of minimal residual disease in acute myeloid leukemia.

J. Downing, S. Shurtleff, D. Campana, 2018, JCI insight.

An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase

Torsten Haferlach, Giuseppe Basso, Robin Foà, 2008, British journal of haematology.

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

J. Downing, S. Shurtleff, Xiaodong Zhou, 2007, Leukemia.

Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia

S. Shurtleff, C. Mullighan, S. Baker, 2013, Clinical Cancer Research.

Factor 1 Receptor Detect Ligand-Induced Conformational Changesanda Binding Site forPhosphatidylinositol

J. Downing, S. Shurtleff, C. Sherr, 1991 .

FLT3-Targeted Therapy Selectively Kills MLL-Rearranged Infant and Childhood ALL Blasts In Vitro and in Vivo.

J. Downing, S. Shurtleff, D. Campana, 2004 .

Corrigendum: C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

Heather L. Mulder, Erin K. Hedlund, R. Wilson, 2014, Nature.

Frequent mutations in SH2D1A (XLP) in males presenting with high‐grade mature B‐cell neoplasms

S. Shurtleff, M. Conley, E. Horwitz, 2013, Pediatric blood & cancer.

Emergence of polyclonal FLT 3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT 3-ITD-positive acute myeloid leukemia

S. Shurtleff, C. Mullighan, S. Baker, 2013 .

Cancer Therapy : Clinical Emergence of Polyclonal FLT 3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT 3-ITD – Positive Acute Myeloid Leukemia

S. Shurtleff, C. Mullighan, S. Baker, 2013 .

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Heather L. Mulder, J. Downing, S. Shurtleff, 2019, Nature Medicine.

Transcriptome profiling of patient derived xenograft models established from pediatric acute myeloid leukemia patients confirm maintenance of FLT3-ITD mutation

S. Shurtleff, J. Klco, D. Finkelstein, 2017, Leukemia & lymphoma.

Nature GeNetics ADVANCE ONLINE PUBLICATION

Heather L. Mulder, Erin K. Hedlund, Michael C. Rusch, 2013 .

Children's Research Hospital Acute mixed lineage leukemia in children: the experience of St Jude

S. Shurtleff, D. Campana, C. Pui, 2012 .

Calcium and cholecalciferol supplementation provides no added benefit to nutritional counseling to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL)

S. Shurtleff, M. Relling, C. Pui, 2014, Pediatric blood & cancer.

Analysis of error profiles in deep next-generation sequencing data

Xiaotu Ma, Jinghui Zhang, Scott Newman, 2019, Genome Biology.

Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project

Erin K. Hedlund, E. Mardis, J. Downing, 2014 .

Comparative Analysis of Different Approaches to Measure Treatment Response in Acute Myeloid Leukemia

J. Downing, S. Shurtleff, S. Raimondi, 2012 .

Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project

Michael C. Rusch, E. Mardis, J. Downing, 2011 .

NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction Analysis for Detection of the t(2;5) Translocation of Non-Hodgkin's Lymphoma.

J. Downing, S. Shurtleff, S. Morris, 1996, Methods in molecular medicine.

Ultra-High Resolution Analysis of Genomic Alterations in High-Risk Acute Lymphoblastic Leukemia.

J. Downing, S. Shurtleff, Jing Ma, 2008 .

Genome-Wide Analysis of Genetic Alterations in Chronic Myelogenous Leukemia.

J. Downing, S. Shurtleff, I. Radtke, 2008 .

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, Jing Ma, 2008, Science.

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.

Erin K. Hedlund, Michael C. Rusch, E. Mardis, 2014, Cancer discovery.

Clinical Activity, Pharmacokinetics, and Pharmacodynamics of Sorafenib In Pediatric Acute Myeloid Leukemia.

S. Shurtleff, D. Campana, C. Pui, 2010 .

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Erin K. Hedlund, Michael C. Rusch, L. Fulton, 2013 .

A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease

S. Shurtleff, A. K. Dobbs, D. Farmer, 2008, Clinical and experimental immunology.

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Michael C. Rusch, S. Ranade, E. Mardis, 2012, Cancer cell.