D. Ly

发表

Mitotic misregulation and human aging.

D. Lockhart, D. Ly, R. Lerner, 2000, Science.

Multicolor Coding of Cells with Cationic Peptide Coated Quantum Dots

D. Ly, M. Bruchez, Hongjian Liu, 2004 .

RNA‐Templated Concatenation of Triplet Nucleic‐Acid Probe

D. Ly, A. Manna, R. Bahal, 2018, Chembiochem : a European journal of chemical biology.

Electronic barcoding of a viral gene at the single-molecule level.

D. Ly, A. Meller, A. Singer, 2012, Nano letters.

Sequence specificity at targeting double-stranded DNA with a gamma-PNA oligomer modified with guanidinium G-clamp nucleobases

D. Ly, M. Frank-Kamenetskii, H. Kuhn, 2010, Artificial DNA, PNA & XNA.

Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor.

D. Ly, Yabin Song, Fu-Sen Liang, 2020, Bioorganic & medicinal chemistry.

Supramolecular Chirality. Topics in Current Chemistry, 265 Edited by Mercedes Crego-Calama and David N. Reinhoudt (University of Twente, Enschede, The Netherland). Springer: Berlin, Heidelberg, New York. 2006. xii + 312 pp. $299.00. ISBN 3-540-32151-9.

D. Ly, Danith H. Ly, 2007 .

Rapid self‐assembly of γPNA nanofibers at constant temperature

Rebecca E. Taylor, D. Ly, Sriram Kumar, 2021, Biopolymers.

High affinity γPNA sandwich hybridization assay for rapid detection of short nucleic acid targets with single mismatch discrimination.

Johnathan M Goldman, D. Ly, Li Zhang, 2013, Biomacromolecules.

Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

Simion I. Chiosea, Simon C Watkins, D. Ly, 2013, ACS chemical biology.

Synthesis and Characterization of Conformationally-Preorganized , MiniPEG-Containing γ PNAs with Superior Hybridization Properties and Water Solubility

D. Ly, B. Armitage, R. Bahal, 2011 .

Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5

D. Ly, P. Glazer, W. Saltzman, 2013, Artificial DNA, PNA & XNA.

Strand invasion of mixed-sequence, double-helical B-DNA by γ-peptide nucleic acids containing G-clamp nucleobases under physiological conditions.

D. Ly, R. Bahal, Danith H. Ly, 2011, Biochemistry.

In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery

Christopher J. Cheng, D. Ly, P. Glazer, 2019 .

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

Christopher J. Cheng, D. Ly, P. Glazer, 2016, Nature Communications.

Synthesis of ( R)- and ( S)-Fmoc-Protected Diethylene Glycol Gamma PNA Monomers with High Optical Purity.

D. Ly, Ashif Y. Shaikh, Shivaji A Thadke, 2019, The Journal of organic chemistry.

Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1.

D. Ly, K. Sobczak, C. Thornton, 2018, Biochemistry.

Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis.

D. Ly, B. Armitage, P. Opresko, 2014, Organic & biomolecular chemistry.

Coordination-driven inversion of handedness in ligand-modified PNA.

D. Ly, Y. Skorik, C. Achim, 2011, Inorganic chemistry.

Development of the Right- and Left-Handed Gamma Peptide Nucleic Acid Building Blocks for On-Resin Chemical Functionalization.

D. Ly, I. Dhami, Shivaji A. Thadke, 2022, The Journal of organic chemistry.

A Robust Method for Preparing Optically Pure MiniPEG-Containing Gamma PNA Monomers.

D. Ly, Wei-Che Hsieh, 2020, Methods in molecular biology.

Synthesis of optically pure γPNA monomers: a comparative study.

D. Ly, A. Manna, G. Sureshkumar, 2015, Tetrahedron.

Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition.

D. Ly, P. Glazer, W. Saltzman, 2014, Current gene therapy.

A Simple Cytosine to G‐Clamp Nucleobase Substitution Enables Chiral γ‐PNAs to Invade Mixed‐Sequence Double‐Helical B‐form DNA

D. Ly, E. Pedroso, Venugopal Chenna, 2008, Chembiochem : a European journal of chemical biology.

Strand Invasion of DNA Quadruplexes by PNA: Comparison of Homologous and Complementary Hybridization

D. Ly, W. Wilson, B. Armitage, 2013, Chembiochem : a European journal of chemical biology.

Crystal structure of chiral gammaPNA with complementary DNA strand: insights into the stability and specificity of recognition and conformational preorganization.

Joanne I. Yeh, D. Ly, R. Gil, 2010, Journal of the American Chemical Society.

High yield, large scale synthesis of thiolate-protected Ag7 clusters.

D. Ly, R. Jin, Zhikun Wu, 2009, Journal of the American Chemical Society.

Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA).

D. Ly, A. Waggoner, G. Fisher, 2003, Journal of the American Chemical Society.

Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility.

D. Ly, B. Armitage, R. Bahal, 2011, The Journal of organic chemistry.

In utero nanoparticle delivery for site-specific genome editing

D. Ly, P. Glazer, W. Saltzman, 2018, Nature Communications.

A Simple γ-Backbone Modification Preorganizes Peptide Nucleic Acid into a Helical Structure

Brian M. Frezza, D. Ly, C. Gayathri, 2006 .

Stereochemical conversion of nucleic acid circuits via strand displacement

D. Ly, Danith H. Ly, Wei-Che Hsieh, 2018, Communications Chemistry.

Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly.

D. Ly, A. Manna, Arun K. Manna, 2015, Journal of the American Chemical Society.

Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs.

D. Ly, H. Sugiyama, K. Hashiya, 2018, Chemistry.

Strand Invasion of Mixed-Sequence B-DNA by Acridine-Linked, γ-Peptide Nucleic Acid (γ-PNA)

D. Ly, B. Armitage, Subhadeep Roy, 2007 .

The NIH Somatic Cell Genome Editing program

David R. Liu, Benjamin S. Freedman, Daniel G. Anderson, 2021, Nature.

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.

D. Ly, W. Wilson, B. Armitage, 2011, Chemical communications.

Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.

D. Ly, W. Wilson, B. Armitage, 2009, Journal of the American Chemical Society.

High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element.

D. Ly, W. Wilson, B. Armitage, 2007, Biochemistry.

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase.

D. Ly, P. Schultz, G. Konopka, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy

D. Ly, P. Glazer, W. Saltzman, 2017, Molecular therapy. Nucleic acids.

Sequence‐Unrestricted, Watson–Crick Recognition of Double Helical B‐DNA by (R)‐MiniPEG‐γPNAs

D. Ly, R. Bahal, Danith H. Ly, 2012, Chembiochem : a European journal of chemical biology.

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

Simion I. Chiosea, Joanne I. Yeh, D. Ly, 2012, Cancer discovery.

Peptide Nucleic Acids (PNAs)

D. Ly, B. Armitage, J. W. Schneider, 2008 .

Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties.

D. Ly, Anca Dragulescu-Andrasi, Heather O'keefe, 2006, Bioorganic & medicinal chemistry letters.

Cell-permeable GPNA with appropriate backbone stereochemistry and spacing binds sequence-specifically to RNA.

D. Ly, Anca Dragulescu-Andrasi, Gaofei He, 2005, Chemical communications.

Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes.

D. Ly, D. Beratan, D. Waldeck, 2012, Journal of the American Chemical Society.

First-inHuman Trial of a STAT 3 Decoy Oligonucleotide in Head and Neck Tumors : Implications for Cancer Therapy

Simion I. Chiosea, Joanne I. Yeh, D. Ly, 2012 .

The structure of a gamma-modified peptide nucleic acid duplex.

D. Ly, R. Gil, M. Madrid, 2010, Molecular bioSystems.

Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-peptide nucleic acids (gammaGPNAs).

K. Livak, D. Ly, G. Zon, 2009, The Journal of organic chemistry.

Mechanism of Charge Transport in DNA: Internally-Linked Anthraquinone Conjugates Support Phonon-Assisted Polaron Hopping

Gary B. Schuster, D. Ly, G. Schuster, 1999 .

Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease.

D. Ly, R. Gil, A. Mukherjee, 2018, Biochemistry.

Shape selective bifacial recognition of double helical DNA

D. Ly, R. Gil, A. Mukherjee, 2018, Communications Chemistry.

Cleavage of DNA by Irradiation of Substituted Anthraquinones: Intercalation Promotes Electron Transfer and Efficient Reaction at GG Steps

D. Ly, G. Schuster, Danith H. Ly, 1996 .

Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

D. Ly, R. Bahal, Danith H. Ly, 2011, Journal of nucleic acids.

β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid.

D. Ly, Jing Yang, S. Monga, 2013, Current cancer drug targets.

Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs.

D. Ly, R. Bahal, Raman Bahal, 2009, Journal of the American Chemical Society.

A simple gamma-backbone modification preorganizes peptide nucleic acid into a helical structure.

Brian M. Frezza, D. Ly, R. Gil, 2006, Journal of the American Chemical Society.

Cell-permeable peptide nucleic acid designed to bind to the 5'-untranslated region of E-cadherin transcript induces potent and sequence-specific antisense effects.

D. Ly, G. Zon, Anca Dragulescu-Andrasi, 2006, Journal of the American Chemical Society.