I. Tsai

发表

Comparative proteomics and subtyping of venom phospholipases A2 and disintegrins of Protobothrops pit vipers.

I. Tsai, Yi-Hsuan Chen, Ying-ming Wang, 2004, Biochimica et biophysica acta.

Sequences, geographic variations and molecular phylogeny of venom phospholipases and threefinger toxins of eastern India Bungarus fasciatus and kinetic analyses of its Pro31 phospholipases A2

I. Tsai, Hsin-Yu Tsai, A. Saha, 2007, The FEBS journal.

Crystallization and preliminary X-ray diffraction studies of the neurotoxic, heterodimeric phospholipase A2 from the Taiwan viper (Vipera russelli formosensis).

I. Tsai, C. Betzel, K. Rajashankar, 1999, Acta crystallographica. Section D, Biological crystallography.

Effect of site directed mutagenesis on the activity of recombinant trimucrotoxin, a neurotoxic phospholipase from Trimeresurus mucrosquamatus venom.

I. Tsai, Y. M. Wang, 1998, Toxicon : official journal of the International Society on Toxinology.

LYS-49 phospholipase A2 homologs from venoms of Deinagkistrodon acutus and Trimeresurus mucrosquamatus have identical protein sequence.

I. Tsai, Y. M. Wang, J. H. Wang, 1996, Toxicon : official journal of the International Society on Toxinology.

Trimucytin: A Collagen-Like Aggregating Inducer Isolated from Trimeresurus mucrosquamatus Snake Venom

I. Tsai, C. Teng, F. Ko, 1993, Thrombosis and Haemostasis.

Glycan structures and intrageneric variations of venom acidic phospholipases A2 from Tropidolaemus pitvipers

I. Tsai, K. Khoo, Hui-Ching Chang, 2012, The FEBS journal.

New insights into the functions and N‐glycan structures of factor X activator from Russell’s viper venom

I. Tsai, K. Khoo, Chia-wei Lin, 2008, The FEBS journal.

Correlation between the Glycan Variations and Defibrinogenating Activities of Acutobin and Its Recombinant Glycoforms

I. Tsai, Ying-ming Wang, K. Khoo, 2014, PloS one.

A Novel Heparin-dependent Inhibitor of Activated Protein C That Potentiates Consumptive Coagulopathy in Russell's Viper Envenomation*

I. Tsai, Hua-Lin Wu, G. Shi, 2012, The Journal of Biological Chemistry.

P-III hemorrhagic metalloproteinases from Russell's viper venom: cloning, characterization, phylogenetic and functional site analyses.

I. Tsai, Ying-ming Wang, Hsin-Yu Tsai, 2008, Biochimie.

The hemolymph clottable proteins of tiger shrimp, Penaeus monodon, and related species.

I. Tsai, Yuh-Ling Chen, Y. L. Chen, 1998, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Purification, cloning and sequence analyses for pro-metalloprotease-disintegrin variants from Deinagkistrodon acutus venom and subclassification of the small venom metalloproteases.

I. Tsai, Ying-ming Wang, Y. M. Wang, 2000, European journal of biochemistry.

Functional proteomic approach to discover geographic variations of king cobra venoms from Southeast Asia and China.

I. Tsai, Hui-Ching Chang, T. Tsai, 2013, Journal of proteomics.

F‐spondin plays a critical role in murine neuroblastoma survival by maintaining IL‐6 expression

I. Tsai, S. Liang, C. Liang, 2009, Journal of neurochemistry.

Comparison of the kinetic specificity of subtilisin and thiolsubtilisin toward n-alkyl p-nitrophenyl esters.

I. Tsai, M. L. Bender, M. Philipp, 1979, Biochemistry.

The role of enzyme activity and charge properties on the presynaptic neurotoxicity and the contracture-inducing activity of snake venom phospholipases A2.

I. Tsai, C. Ho, C. Y. Lee, 1986, Toxicon : official journal of the International Society on Toxinology.

Mutagenesis analyses explore residues responsible for the neurotoxic and anticoagulant activities of Trimucrotoxin, a pit-viper venom Asn6-phospholipase A2.

I. Tsai, Ying-ming Wang, M. Hseu, 2011, Biochimie.

Properties of two chymotrypsins from the digestive gland of prawn Penaeus monodon

I. Tsai, K. Chuang, Hsien-Ching Liu, 1986 .

Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.

I. Tsai, G. Chang, Ku-Chung Chen, 2017, Food & function.

The midgut chymotrypsins of shrimps (Penaeus monodon, Penaeus japonicus and Penaeus penicillatus).

I. Tsai, J. Chuang, P. Lu, 1991, Biochimica et biophysica acta.

Collagenolytic activity of crustacean midgut serine proteases: comparison with the bacterial and mammalian enzymes.

I. Tsai, Y. L. Chen, P. Lu, 1991, Comparative biochemistry and physiology. B, Comparative biochemistry.

Biochemical characterization and cloning of transglutaminases responsible for hemolymph clotting in Penaeus monodon and Marsupenaeus japonicus.

I. Tsai, Chang-jen Huang, L. Kao, 2006, Biochimica et biophysica acta.

Cloning and characterization of hemolymph clottable proteins of kuruma prawn (Marsupenaeus japonicus) and white shrimp (Litopenaeus vannamei).

I. Tsai, W. Cheng, Chang-jen Huang, 2008, Developmental and comparative immunology.

Chymotrypsins in digestive tracts of crustacean decapods (Shrimps)

I. Tsai, J. Chuang, Kuei-Lien Chuano, 1986 .

Tissue-specific expression and regulation of the haemolymph clottable protein of tiger shrimp (Penaeus monodon).

I. Tsai, Chang-jen Huang, M. Yeh, 2007, Fish & shellfish immunology.

Molecular cloning and characterization of a hemolymph clottable protein from tiger shrimp (Penaeus monodon).

I. Tsai, J. Leu, Y. Lee, 1999, European journal of biochemistry.

Identification and cloning of a selenophosphate synthetase (SPS) from tiger shrimp, Penaeus monodon, and its transcription in relation to molt stages and following pathogen infection.

I. Tsai, W. Cheng, Chang-jen Huang, 2012, Developmental and comparative immunology.

Two types of Russell's viper revealed by variation in phospholipases A2 from venom of the subspecies.

I. Tsai, J. Su, P. Lu, 1996, Toxicon : official journal of the International Society on Toxinology.

Phospholipases A2 from Callosellasma rhodostoma venom gland cloning and sequencing of 10 of the cDNAs, three-dimensional modelling and chemical modification of the major isozyme.

I. Tsai, Ying-ming Wang, T. Ko, 2000, European journal of biochemistry.

Russtoxin: A new family of two-component phospholipase A 2 toxins from Russell’s vipers

I. Tsai, Y. Su, P. Lu, 1994 .

Cloning, characterization and phylogenetic analyses of members of three major venom families from a single specimen of Walterinnesia aegyptia.

I. Tsai, Hsin‐Yu Tsai, Y. Wang, 2008, Toxicon : official journal of the International Society on Toxinology.

Purification, sequencing, and phylogenetic analyses of novel Lys-49 phospholipases A(2) from the venoms of rattlesnakes and other pit vipers.

I. Tsai, A. Tu, Y. Chen, 2001, Archives of biochemistry and biophysics.

Transcriptome and proteome of the highly neurotoxic venom of Gloydius intermedius.

I. Tsai, Ying-ming Wang, Zhe-Zhi Wang, 2015, Toxicon : official journal of the International Society on Toxinology.

Effects of single N-glycosylation site knockout on folding and defibrinogenating activities of acutobin recombinants from HEK293T.

I. Tsai, Ying-ming Wang, Kai-Fa Huang, 2015, Toxicon : official journal of the International Society on Toxinology.

Serine protease isoforms in Gloydius intermedius venom: Full sequences, molecular phylogeny and evolutionary implications.

I. Tsai, Ying-ming Wang, Huiying Yu, 2017, Journal of proteomics.

Serine protease isoforms of Deinagkistrodon acutus venom: cloning, sequencing and phylogenetic analysis.

I. Tsai, Ying-ming Wang, Y. M. Wang, 2001, The Biochemical journal.

Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom.

I. Tsai, Ying-ming Wang, Y. M. Wang, 1994, Biochimica et biophysica acta.

Prey envenomation does not improve digestive performance in Taiwanese pit vipers (Trimeresurus gracilis and T. stejnegeri stejnegeri).

I. Tsai, Yao-sung Lin, M. Tu, 2009, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Structures and functions of crotoxin-like heterodimers and acidic phospholipases A2 from Gloydius intermedius venom: Insights into the origin of neurotoxic-type rattlesnakes.

I. Tsai, Ying-ming Wang, Zhe-Zhi Wang, 2015, Journal of proteomics.

PHOSPHOLIPASES A2 OF ASIAN SNAKE VENOMS

I. Tsai, 1997 .

Characterization of Protobothrops mucrosquamatus venomVEGF

I. Tsai, T. Hong, Yuh-Ling Chen, 2017 .

Crotalid venom vascular endothelial growth factors has preferential affinity for VEGFR-1

I. Tsai, T. Hong, Tse-Ming Hong, 2005, Thrombosis and Haemostasis.

Functional and sequence characterization of coagulation factor IX/factor X-binding protein from the venom of Echis carinatus leucogaster.

I. Tsai, Y. L. Chen, 1996, Biochemistry.

Characterization and molecular cloning of neurotoxic phospholipases A2 from Taiwan viper (Vipera russelli formosensis).

I. Tsai, C. Ho, Y. M. Wang, 1992, European journal of biochemistry.

The amino acid sequence and properties of an edema-inducing Lys-49 phospholipase A2 homolog from the venom of Trimeresurus mucrosquamatus.

I. Tsai, C. Chang, J. Chen, 1991, Biochimica et biophysica acta.

Snake Venom Phospholipase A2: Evolution and Diversity

I. Tsai, 2016 .

Tracing the evolution of venom phospholipases A2 in Gloydius strauchii and related pitvipers: A tale of two acidic isozymes

I. Tsai, Zhe-Zhi Wang, Zhen-zhen Liu, 2018, Toxicon : official journal of the International Society on Toxinology.

Molecular evolution and structure-function relationships of crotoxin-like and asparagine-6-containing phospholipases A2 in pit viper venoms.

I. Tsai, Yi-Hsuan Chen, Ying-ming Wang, 2004, The Biochemical journal.

N-terminal region of snake venom neurotoxic phospholipase A2 is involved in its binding to presynaptic receptors

I. Tsai, M. Tzeng, 1992 .

Cloning and characterization of Trimeresurus gracilis venom phospholipases A(2): comparison with Ovophis okinavensis venom and the systematic implications.

I. Tsai, Ying-ming Wang, Hui-Ching Chang, 2012, Toxicon : official journal of the International Society on Toxinology.

Functional and sequence characterization of agkicetin, a new glycoprotein Ib antagonist isolated from Agkistrodon acutus venom. offf2p4.

I. Tsai, Yuh-Ling Chen, Y. L. Chen, 1995, Biochemical and biophysical research communications.

Venom phospholipases of Russell's vipers from Myanmar and eastern India--cloning, characterization and phylogeographic analysis.

I. Tsai, Ying-ming Wang, D. Warrell, 2007, Biochimica et biophysica acta.

Glycoprotein Ib-binding Protein from the Venom of Deinagkistrodon acutus – cDNA Sequence, Functional Characterization, and Three-Dimensional Modeling

I. Tsai, T. Hong, Yuh-Ling Chen, 2000, Thrombosis and Haemostasis.

Binding of a venom Lys-49 phospholipase A(2) to LPS and suppression of its effects on mouse macrophages.

I. Tsai, Ying-ming Wang, S. Tsai, 2007, Toxicon : official journal of the International Society on Toxinology.

Toxicon research paper Structural and bioinformatic analyses of Azemiops venom serine proteases reveal close phylogeographic relationships to pitvipers from eastern China and the New World.

I. Tsai, Ying-ming Wang, Kai-Fa Huang, 2021, Toxicon : official journal of the International Society on Toxinology.

REVISED SYSTEMATICS OF TAIWANESE VIPERID SNAKES AND THE CORRELATION TO VENOM DIVERSITY AND EVOLUTION

I. Tsai, 2005 .

Differential expression and geographic variation of the venom phospholipases A2 of Calloselasma rhodostoma and Trimeresurus mucrosquamatus.

I. Tsai, Y. Chen, Y. M. Wang, 2001, Archives of biochemistry and biophysics.

Venom phospholipases A2 of bamboo viper (Trimeresurus stejnegeri): molecular characterization, geographic variations and evidence of multiple ancestries.

I. Tsai, Yi-Hsuan Chen, Ying-ming Wang, 2004, The Biochemical journal.

Geographic variations, cloning, and functional analyses of the venom acidic phospholipases A2 of Crotalus viridis viridis.

I. Tsai, A. Tu, Y. Wang, 2003, Archives of biochemistry and biophysics.

Snake venom glutaminyl cyclases: purification, cloning, kinetic study, recombinant expression, and comparison with the human enzyme.

I. Tsai, Ying-ming Wang, Kai-Fa Huang, 2014, Toxicon : official journal of the International Society on Toxinology.

EVOLUTIONARY REDUCTION OF ENZYMATIC ACTIVITIES OF SNAKE VENOM PHOSPHOLIPASES A2

I. Tsai, 2007 .

Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom.

I. Tsai, An-Chun Cheng, 2014, Biochimica et biophysica acta.

Cloning, characterization and mutagenesis of Russell's viper venom L-amino acid oxidase: Insights into its catalytic mechanism.

I. Tsai, Ying-ming Wang, Kai-Fa Huang, 2012, Biochimie.

Sequence determination and bioinformatic comparison of ten venom serine proteases of Trimeresurus gracilis, a Taiwanese endemic pitviper with controversial taxonomy.

I. Tsai, Ying-ming Wang, T. Tsai, 2021, Toxicon : official journal of the International Society on Toxinology.

Structures of Azemiops feae venom phospholipases and cys-rich-secretory protein and implications for taxonomy and toxinology.

I. Tsai, Ying-ming Wang, Kai-Fa Huang, 2016, Toxicon : official journal of the International Society on Toxinology.

cDNA cloning, structural, and functional analyses of venom phospholipases A₂ and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi.

I. Tsai, Ying-ming Wang, Y. Utkin, 2011, Toxicon : official journal of the International Society on Toxinology.

Effect of red cell membrane binding on the catalytic activity of glyceraldehyde-3-phosphate dehydrogenase.

I. Tsai, T. Steck, T L Steck, 1982, The Journal of biological chemistry.

Inhibition of porcine elastase and anhydroelastase by boronic acids.

I. Tsai, M. L. Bender, 1984, Archives of biochemistry and biophysics.

Conformation of the active site of thiolsubtilisin: reaction with specific chloromethyl ketones and arylacryloylimidazoles.

I. Tsai, M. L. Bender, 1979, Biochemistry.

Variations of Phospholipases A2 in the Geographic Venom Samples of Pitvipers

I. Tsai, Yi-Hsuan Chen, Ying-ming Wang, 2003 .

Molecular cloning and deduced primary structures of acidic and basic phospholipases A2 from the venom of Deinagkistrodon acutus.

I. Tsai, Y. M. Wang, J. H. Wang, 1996, Toxicon : official journal of the International Society on Toxinology.

Revised amino acid sequences of the three major phospholipases A2 from Bungarus fasciatus (banded krait) venom.

I. Tsai, C. Chang, J. Chen, 1990, Toxicon : official journal of the International Society on Toxinology.

Terminal disialylated multiantennary complex-type N-glycans carried on acutobin define the glycosylation characteristics of the Deinagkistrodon acutus venom.

I. Tsai, Ying-ming Wang, K. Khoo, 2011, Glycobiology.

Purification and characterization of the venom phospholipases A2 from Asian monotypic crotalinae snakes.

I. Tsai, Y. M. Wang, K. Chang, 1999, Journal of natural toxins.

Proteomic Analyses on the Venom of an Individual Protobothrops mangshanensis

I. Tsai, Ying-ming Wang, Hai Lan, 2010 .

Complete amino acid sequence of a phospholipase A2 from the venom of Naja naja atra (Taiwan cobra).

I. Tsai, S. H. Wu, T. Lo, 1981, Toxicon : official journal of the International Society on Toxinology.

Full sequencing and comparison of five venom metalloproteases of Trimeresurus gracilis: The PI-enzyme is most similar to okinalysin but the PIII-enzyme is most similar to Crotalus venom enzymes.

I. Tsai, T. Tsai, 2023, Toxicon : official journal of the International Society on Toxinology.

Venom Proteomics of Trimeresurus gracilis, a Taiwan-Endemic Pitviper, and Comparison of Its Venom Proteome and VEGF and CRISP Sequences with Those of the Most Related Species

I. Tsai, T. Tsai, Tsz-chun Tse, 2023, Toxins.

Molecular cloning and characterization of a neurotoxic phospholipase A2 from the venom of Taiwan habu (Trimeresurus mucrosquamatus).

I. Tsai, Ying-ming Wang, C. Ho, 1995, The Biochemical journal.

Unusual venom phospholipases A2 of two primitive tree vipers Trimeresurus puniceus and Trimeresurus borneensis

I. Tsai, Ying-ming Wang, Hao-Fan Peng, 2005, The FEBS journal.

A novel phospholipase A(2) from the venom glands of Bungarus candidus: cloning and sequence-comparison.

I. Tsai, Ying-ming Wang, Inn-Ho Tsai, 2002, Toxicon : official journal of the International Society on Toxinology.

Absence of phospholipase A(2) in most Crotalus horridus venom due to translation blockage: comparison with Crotalus horridus atricaudatus venom.

I. Tsai, Ying-ming Wang, J. Parmelee, 2010, Toxicon : official journal of the International Society on Toxinology.

Structure of the heterodimeric neurotoxic complex viperotoxin F (RV-4/RV-7) from the venom of Vipera russelli formosensis at 1.9 A resolution.

I. Tsai, S. Banumathi, M. Perbandt, 2003, Acta crystallographica. Section D, Biological crystallography.

A Novel Heparin-dependent Inhibitor of Activated Protein C That Potentiates Consumptive Coagulopathy in Russell's Viper Envenomation*

I. Tsai, Hua-Lin Wu, G. Shi, 2012, Journal of Biological Chemistry.

cDNA cloning, structural, and functional analyses of venom phospholipases A₂ and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi.

I. Tsai, Ying-ming Wang, Y. Utkin, 2011, Toxicon.