P. Cohen

发表

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

P. Greengard, H. Hemmings, H. Tung, 1984, Nature.

The development and therapeutic potential of protein kinase inhibitors.

Philip R. Cohen, P. Cohen, 1999, Current opinion in chemical biology.

D 4476 , a cell-permeant inhibitor of CK 1 , suppresses the site-specific phosphorylationandnuclear exclusion of FOXO 1 a

P. Cohen, G. Rena, J. Bain, 2013 .

D4476, a cell‐permeant inhibitor of CK1, suppresses the site‐specific phosphorylation and nuclear exclusion of FOXO1a

P. Cohen, G. Rena, J. Bain, 2004, EMBO reports.

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

P. Cohen, A. Prescott, T. Unterman, 2002, The EMBO journal.

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

P. Cohen, T. Unterman, G. Rena, 1999, The Journal of Biological Chemistry.

Control of enzyme activity by covalent modifications other than limited proteolysis or phosphorylation

P. Cohen, 1983 .

FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.

Philip R. Cohen, P. Cohen, J. Rouse, 1996, The EMBO journal.

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

P. Cohen, D. Alessi, B. Hemmings, 1995, Nature.

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.

Philip R. Cohen, P. Cohen, N. Morrice, 1999, The Biochemical journal.

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

P. Cohen, S. Davies, H. Reddy, 2000, The Biochemical journal.

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Michel Morange, John Rouse, Tim Hunt, 1994, Cell.

Protein kinases — the major drug targets of the twenty-first century?

P. Cohen, 2002, Nature reviews. Drug discovery.

The protein phosphatases involved in cellular regulation

P. Cohen, N. Tonks, Philip Cohen, 1984 .

Regulation of the Epithelial Ca2+ Channel TRPV5 by the NHE Regulating Factor NHERF2 and the Serum and Glucocorticoid Inducible Kinase Isoforms SGK1 and SGK3 Expressed in Xenopus oocytes

P. Cohen, F. Lang, T. Wieder, 2004, Cellular Physiology and Biochemistry.

The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture.

P. Cohen, 2001, European journal of biochemistry.

The specificities of protein kinase inhibitors: an update.

P. Cohen, J. Bain, M. Elliott, 2003, The Biochemical journal.

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.

P. Cohen, R. Biondi, S. Frame, 2001, Molecular Cell.

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

P. Cohen, D. Alessi, C. Downes, 1997, Current Biology.

The selectivity of protein kinase inhibitors: a further update.

P. Cohen, J. Arthur, D. Alessi, 2007, The Biochemical journal.

Genetically engineered calmodulins differentially activate target enzymes.

P. Cohen, C. Klee, A. Means, 1986, The Journal of biological chemistry.

The origins of protein phosphorylation

P. Cohen, Philip Cohen, 2002, Nature Cell Biology.

GSK3 inhibitors: development and therapeutic potential

Michel Goedert, P. Cohen, M. Goedert, 2004, Nature Reviews Drug Discovery.

Enzyme regulation by reversible phosphorylation: the neural and hormonal control of cellular activity

P. Cohen, 1983 .

Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

Eduardo Pauls, P. Cohen, J. Arthur, 2013, The Journal of Immunology.

The hormonal control of activity of skeletal muscle phosphorylase kinase. Amino-acid sequences at the two sites of action of adenosine-3':5'-monophosphate-dependent protein kinase.

P. Cohen, D. Watson, G. Dixon, 1975, European journal of biochemistry.

Purification of glycogen synthase kinase 3 from rabbit skeletal muscle. Copurification with the activating factor (FA) of the (Mg-ATP) dependent protein phosphatase.

P. Cohen, B. Hemmings, D. Yellowlees, 1981, European journal of biochemistry.

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

Philip R. Cohen, D R Alessi, P. Cohen, 1998, Science.

Isolation and characterization of bovine brain calcineurin: a calmodulin-stimulated protein phosphatase.

P. Cohen, C. Klee, M. Krinks, 1983, Methods in enzymology.

Calcineurin is a calcium ion-dependent, calmodulin-stimulated protein phosphatase.

P. Cohen, N. Tonks, 1983, Biochimica et biophysica acta.

The amino acid sequence of the delta subunit (calmodulin) of rabbit skeletal muscle phosphorylase kinase.

P. Cohen, S. Shenolikar, R. Grand, 1981, European journal of biochemistry.

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

M. J. Barratt, P. Cohen, L. Mahadevan, 1996, Current Biology.

Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.

P. Cohen, J. Haavik, G. Thomas, 1997, European journal of biochemistry.

A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells.

P. Cohen, J. Haavik, G. Thomas, 1997, Biochemical Society transactions.

Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting

Christoph H Emmerich, Christoph H. Emmerich, P. Cohen, 2015, Biochemical and biophysical research communications.

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

P. Cohen, S. Mittnacht, N. Morrice, 2008, Nature Cell Biology.

Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.

P. Cohen, N. Morrice, A. Knebel, 2002, The Biochemical journal.

The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle.

A. Nairn, P. Cohen, S. Shenolikar, 1979, European journal of biochemistry.

Regulation of the aminoacyl-tRNA synthetase complex of rat liver by phosphorylation/dephosphorylation in vitro and in vivo.

P. Cohen, Z. Damuni, F. Caudwell, 1982, European journal of biochemistry.

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

P. Cohen, M. Goedert, S. Lawler, 1998, Current Biology.

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP‐K2 and its interaction with cytokine mRNAs

P. Cohen, M. Gaestel, D. Campbell, 2002, The EMBO journal.

Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.

P. Cohen, D. Campbell, J. Murray, 2004, The Biochemical journal.

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.

P. Cohen, J. Arthur, A. Cuenda, 2004, The Biochemical journal.

Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.

P. Cohen, D. Campbell, N. Morrice, 2005, The Biochemical journal.

KESTREL: a powerful method for identifying the physiological substrates of protein kinases.

P. Cohen, A. Knebel, 2006, The Biochemical journal.

IL-1β-stimulated activation of ERK1/2 and p38α MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-α in HeLa cells

P. Cohen, S. Rousseau, Huei-Ting Yang, 2008 .

Debranching enzyme from rabbit skeletal muscle. Purification, properties and physiological role.

P. Cohen, J. C. Kernohan, C. Taylor, 1975, European journal of biochemistry.

Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages.

P. Cohen, C. Bryant, J. Murray, 1999, Cellular signalling.

Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis*

P. Cohen, A. Cuenda, 1999, The Journal of Biological Chemistry.

The anti‐inflammatory compound BAY‐11‐7082 is a potent inhibitor of protein tyrosine phosphatases

P. Cohen, N. Tonks, Navasona Krishnan, 2013, The FEBS journal.

Regulation of tyrosine hydroxylase by stress‐activated protein kinases

P. Cohen, J. Haavik, N. Morrice, 2002, Journal of neurochemistry.

Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.

P. Cohen, J. Woodgett, P. Vulliet, 1984, The Journal of biological chemistry.

Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.

A. Ashworth, P. Cohen, D. Alessi, 1995, Methods in enzymology.

Phosphorylation of Tyrosine Hydroxylase in Isolated Mice Adrenal Glands

P. Cohen, J. Haavik, R. Kleppe, 2002, Annals of the New York Academy of Sciences.

Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation

P. Cohen, M. Nelen, S. M. Lange, 2020, Structure.

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

P. Cohen, M. Félix, E. Karsenti, 1990, The EMBO journal.

IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.

P. Cohen, D. Baltzis, M. Peggie, 2009, The Biochemical journal.

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.

Philip R. Cohen, P. Cohen, D. Alessi, 1998, The Biochemical journal.

PPP1R6, a novel member of the family of glycogen‐targetting subunits of protein phosphatase 1

P. Cohen, G. Browne, P. Cohen, 1997, FEBS letters.

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β*

P. Cohen, J. Arthur, A. Ordureau, 2011, The Journal of Biological Chemistry.

A comparison of the substrate specificity of MAPKAP kinase‐2 and MAPKAP kinase‐3 and their activation by cytokines and cellular stress

Philip R. Cohen, P. Cohen, P. Young, 1996, FEBS letters.

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase.

P. Cohen, M. Goedert, J. H. Wang, 1995, Journal of neurochemistry.

Recently discovered systems of enzyme regulation by reversible phosphorylation

P. Cohen, 1980 .

IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1

P. Cohen, F. Lang, T. Kobayashi, 2002, Pflügers Archiv - European Journal of Physiology.

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease

P. Cohen, M. Goedert, R. Jakes, 1992, FEBS letters.

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β

P. Cohen, S. Bakshi, Jordan Taylor, 2017, The Biochemical journal.

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

P. Cohen, M. Peggie, Lorna Plater, 2009, Journal of Biological Chemistry.

Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism

P. Cohen, B. Hemmings, T. Resink, 1982, FEBS letters.

Glycogen synthase kinase 3

P. Cohen, S. Frame, 2010 .

CHAPTER 91 – Glycogen Synthase Kinase 3

P. Cohen, S. Frame, 2003 .

Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.

P. Cohen, P. Cohen, 1989, The Biochemical journal.

The protein phosphatases involved in cellular regulation. Purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscle.

P. Cohen, P. Strålfors, A. Hiraga, 1985, European journal of biochemistry.

Protein phosphorylation and oocyte maturation. II. Inhibition of starfish oocyte maturation by intracellular microinjection of protein phosphatases 1 and 2A and alkaline phosphatase.

H. Tung, P. Cohen, L. Meijer, 1986, Experimental cell research.

The hormonal control of glycogen metabolism in mammalian muscle by multivalent phosphorylation.

P. Cohen, 1979, Biochemical Society transactions.

The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

P. Cohen, J. Rinehart, Y. Thomas, 2018, PloS one.

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

P. Cohen, M. Peggie, M. Windheim, 2008, The Biochemical journal.

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro : comparison with protein kinase B α

P. Cohen, D. Alessi, A. Paterson, 1998 .

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

P. Cohen, D. Alessi, A. Paterson, 1998, The Biochemical journal.

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

P. Cohen, A. Syvänen, L. Rönnblom, 2019, Annals of the rheumatic diseases.

Genetic variations in A 20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

P. Cohen, L. Rönnblom, S. Rantapää-Dahlqvist, 2019 .

The discovery of glycogenin and the priming mechanism for glycogen biogenesis.

P. Cohen, C. Smythe, Philip Cohen, 1991, European journal of biochemistry.

Cell-free fusion of endocytic vesicles is regulated by phosphorylation

P. Cohen, G. Warren, P. Woodman, 1992, The Journal of cell biology.

p34cdc2 phosphorylation sites in histone H1 are dephosphorylated by protein phosphatase 2A1.

P. Cohen, T. Langan, M. Sola, 1991, Biochimica et biophysica acta.

Identification of different specificity requirements between SGK1 and PKBα

P. Cohen, J. Murray, Lorna Cummings, 2005, FEBS letters.

The regulation of protein function by multisite phosphorylation--a 25 year update.

P. Cohen, P Cohen, 2000, Trends in biochemical sciences.

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle

P. Cohen, J. Woodgett, B. Hemmings, 1982, FEBS letters.

Identification of novel phosphorylation sites required for activation of MAPKAP kinase‐2.

Philip R. Cohen, P. Cohen, N. Morrice, 1995, The EMBO journal.

Isolation and structural analysis of a peptide containing the novel tyrosyl‐glucose linkage in glycogenin.

P. Cohen, C. Smythe, M. Ferguson, 1988, The EMBO journal.

Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.

P. Cohen, C. Smythe, J. Pitcher, 1988, European journal of biochemistry.

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

P. Cohen, L. Hesson, M. Peggie, 2008, FEBS letters.

An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice

P. Cohen, N. Akbar, J. Belch, 2015, Arthritis Research & Therapy.

Targeting protein kinases for the development of anti-inflammatory drugs.

P. Cohen, 2009, Current opinion in cell biology.

Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts.

P. Cohen, 1991, Methods in enzymology.

NHE-3 isoform of the Na+/H+ exchanger in human gallbladder. Localization of specific mRNA by in situ hybridization.

P. Cohen, A. Massacrier, P. Cau, 1997, Journal of hepatology.

Evidence for communication between nerve growth factor and protein tyrosine phosphorylation

P. Cohen, N. Tonks, C. Morrison, 1990, FEBS letters.

A new p 38 MAP kinase-regulated transcriptional coactivator that stimulates p 53-dependent apoptosis

P. Cohen, S. Llanos, A. Cuadrado, 2007 .

A new p38 MAP kinase‐regulated transcriptional coactivator that stimulates p53‐dependent apoptosis

P. Cohen, S. Llanos, A. Cuadrado, 2007, The EMBO journal.

The role of cyclic-AMP-dependent protein kinase in the regulation of glycogen metabolism in mammalian skeletal muscle.

P. Cohen, 1978, Current topics in cellular regulation.

Hormonal control of protein phosphorylation.

P. Cohen, H. G. Nimmo, 1977, Advances in cyclic nucleotide research.

The substrate specificity and regulation of the protein phosphatases involved in the control of glycogen metabolism in mammalian skeletal muscle.

P. Cohen, J. Antoniw, G. Nimmo, 1977, Advances in enzyme regulation.

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

P. Cohen, N. Gray, Tinghu Zhang, 2017, The Biochemical journal.

University of Dundee Lys 63 / Met 1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling

Christoph H Emmerich, Christoph H. Emmerich, P. Cohen, 2016 .

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling

Christoph H Emmerich, Christoph H. Emmerich, P. Cohen, 2016, Biochemical and biophysical research communications.

The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle.

H. Tung, P. Cohen, S. Alemany, 1985, European journal of biochemistry.

The amino acid sequence of rabbit skeletal muscle glycogenin.

P. Cohen, D. Campbell, P. Cohen, 1989, European journal of biochemistry.

Nogo-B is a new physiological substrate for MAPKAP-K2.

P. Cohen, D. Campbell, M. Peggie, 2005, The Biochemical journal.

Applications of recombinant DNA technology to studies of metabolic regulation.

P. Cohen, H. G. Nimmo, 1987, The Biochemical journal.

The major myosin phosphatase in skeletal muscle is a complex between the β‐isoform of protein phosphatase 1 and the MYPT2 gene product

Philip R. Cohen, P. Cohen, G. Moorhead, 1998, FEBS letters.

Protein phosphatase-2C from rabbit skeletal muscle and liver: an Mg2+-dependent enzyme.

P. Cohen, C. McGowan, C. Mcgowan, 1988, Methods in enzymology.

Protein phosphorylation and hormone action — An overview

P. Cohen, 1983 .

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells*

P. Cohen, K. Docherty, Stuart B. Smith, 1997, The Journal of Biological Chemistry.

The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel α,β,γ-ENaC

P. Cohen, S. Bröer, T. Risler, 2003, Pflügers Archiv.

Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.

P. Cohen, S. G. Rønn, N. Billestrup, 2006, Molecular endocrinology.

The cyanobacterial toxin microcystin binds covalently to cysteine‐273 on protein phosphatase 1

P. Cohen, D. Campbell, K. Dalby, 1995, FEBS letters.

Macrophages in RAW 264 β Cyclooxygenase-2 and IL-1 Lipopolysaccharide-Stimulated Induction of Cascades in Mediating Role of Mitogen-Activated Protein Kinase

P. Cohen, M. Caivano, 2000 .

Identification of the C-terminus of rabbit skeletal muscle glycogen synthase.

P. Cohen, B. Gibson, D. Williams, 1986, Biochemical and biophysical research communications.

11 Muscle Glycogen Synthase

P. Cohen, 1986 .

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.

P. Cohen, Philip Cohen, 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Phosphorylation of the skeletal muscle glycogen‐targetting subunit of protein phosphatase 1 in response to adrenaline in vivo

P. Cohen, P. Watt, K. Walker, 2000, FEBS letters.

Glycogen synthetase kinase 2 (GSK 2); The identification of a new protein kinase in skeletal muscle

P. Cohen, H. G. Nimmo, 1974, FEBS letters.

The molecular mechanism by which adrenalin inhibits glycogen synthesis.

P. Cohen, D. Campbell, S. Nakielny, 1991, European journal of biochemistry.

Glycogen synthase from rabbit skeletal muscle; effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo.

P. Cohen, P. Parker, F. Caudwell, 2005, European journal of biochemistry.

THE ROLE OF PROTEIN PHOSPHORYLATION IN THE COORDINATED CONTROL OF INTERMEDIARY METABOLISM

P. Cohen, S. Shenolikar, G. Nimmo, 1979 .

The regulation of fatty acid biosynthesis

P. Cohen, D. Grahame Hardie, 1978, FEBS letters.

Salt-inducible kinases are required for the IL-33–dependent secretion of cytokines and chemokines in mast cells

P. Cohen, J. Arthur, Nicola J. Darling, 2021, The Journal of biological chemistry.

Glycogen synthase kinase-3 from rabbit skeletal muscle.

P. Cohen, B. Hemmings, D. Rylatt, 1981, Methods in enzymology.

The purification and properties of rabbit skeletal muscle glycogen synthase.

P. Cohen, C. Proud, H. G. Nimmo, 1976, European journal of biochemistry.

Glycogen Synthase from Rabbit Skeletal Muscle

P. Cohen, A. Aitken, D. Rylatt, 2005 .

Further studies on the role of glycogenin in glycogen biosynthesis.

P. Cohen, C. Smythe, P. Watt, 1990, European journal of biochemistry.

Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzyme.

P. Cohen, M. Hubbard, 1989, European journal of biochemistry.

Identification of the Ca2+‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase

P. Cohen, T. Vanaman, J. Foulkes, 1978, FEBS letters.

Activation of phosphorylase kinase from rabbit skeletal muscle by calmodulin and troponin

P. Cohen, C. Klee, C. Picton, 1979, FEBS letters.

Ontogeny of Protein Phosphatases 1 and 2A in Developing Rat Lung

P. Cohen, D. Warburton, 1988, Pediatric Research.

The protein phosphatases of Drosophila melanogaster and their inhibitors.

P. Cohen, Y. Dudai, S. Orgad, 1987, European journal of biochemistry.

Identification of protein phosphatases-1 and 2A and inhibitor-2 in oocytes of the starfish Asterias rubens and Marthasterias glacialis.

P. Cohen, P. Pondaven, 1987, European journal of biochemistry.

Identification of two isoenzymes of protein phosphatase 2C in both rabbit skeletal muscle and liver.

P. Cohen, C. McGowan, C. Mcgowan, 1987, European journal of biochemistry.

Analysis of the in vivo phosphorylation state of protein phosphatase inhibitor-2 from rabbit skeletal muscle by fast-atom bombardment mass spectrometry.

P. Cohen, N. Tonks, C. Holmes, 1987, Biochimica et biophysica acta.

Identification of the sites on rabbit skeletal muscle protein phosphatase inhibitor-2 phosphorylated by casein kinase-II.

P. Cohen, J. Kuret, C. Holmes, 1986, Biochimica et biophysica acta.

Identification of high levels of protein phosphatase‐1 in rat liver nuclei

P. Cohen, J. Kuret, H. Bell, 1986, FEBS letters.

The protein phosphatases involved in cellular regulation. Evidence that dephosphorylation of glycogen phosphorylase and glycogen synthase in the glycogen and microsomal fractions of rat liver are catalysed by the same enzyme: protein phosphatase-1.

P. Cohen, S. Alemany, S. Pelech, 1986, European journal of biochemistry.

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Identification of the sites phosphorylated by casein kinase-I.

P. Cohen, J. Woodgett, J. Kuret, 1982, European journal of biochemistry.

The protein phosphatases involved in cellular regulation. Influence of polyamines on the activities of protein phosphatase-1 and protein phosphatase-2A.

H. Tung, P. Cohen, M. J. Fisher, 1985, European journal of biochemistry.

Selective effects of CAPP1-calmodulin on its target proteins.

P. Cohen, D. Newton, C. Klee, 1985, Biochimica et biophysica acta.

The protein phosphatases involved in cellular regulation. Glycolysis, gluconeogenesis and aromatic amino acid breakdown in rat liver.

P. Cohen, M. J. Fisher, S. Pelech, 1984, European journal of biochemistry.

The protein phosphatases involved in cellular regulation. 2. Glycogen metabolism.

P. Cohen, T. Ingebritsen, J. Foulkes, 1983, European journal of biochemistry.

Calsequestrin, myosin, and the components of the protein-glycogen complex in rabbit skeletal muscle.

P. Cohen, J. Antoniw, B. Caudwell, 1978, European journal of biochemistry.

The protein phosphatases involved in cellular regulation. Comparison of native and reconstituted Mg-ATP-dependent protein phosphatases from rabbit skeletal muscle.

H. Tung, P. Cohen, 1984, European journal of biochemistry.

Amino acid sequence at the site on protein phosphatase inhibitor-2, phosphorylated by glycogen synthase kinase-3.

P. Cohen, D. Williams, A. Aitken, 1984, Biochimica et biophysica acta.

Comparison of the substrate specificities of protein phosphatases involved in the regulation of glycogen metabolism in rabbit skeletal muscle.

P. Cohen, J. Antoniw, H. G. Nimmo, 1977, The Biochemical journal.

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.

P. Silver, P. Cohen, B. Perry, 2007, Blood.

angiogenesis a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling ) , is Solenopsis invicta Solenopsin , the alkaloidal component of the fire ant

P. Silver, P. Cohen, B. Perry, 2006 .

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

P. Cohen, N. Gray, M. Peggie, 2014, Proceedings of the National Academy of Sciences.

Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.

P. Cohen, J. Maller, J. Avruch, 1991, European journal of biochemistry.

A cDNA encoding rabbit muscle protein phosphatase 1 alpha complements the Aspergillus cell cycle mutation, bimG11.

P. Cohen, J. Doonan, C. MacKintosh, 1991, The Journal of biological chemistry.

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

Jun O. Liu, S. Schreiber, P. Cohen, 1992, Biochemistry.

Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B.

P. Cohen, F. Lang, H. Endou, 2004, Biochemical and biophysical research communications.

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.

P. Cohen, F. Lang, D. Pearce, 2002, Journal of the American Society of Nephrology : JASN.

Primary structure of the site on bovine hormone‐sensitive lipase phosphorylated by cyclic AMP‐dependent protein kinase

P. Cohen, D. Campbell, S. Yeaman, 1988, FEBS letters.

Dissection of the protein phosphorylation cascades involved in insulin and growth factor action.

P. Cohen, 1993, Biochemical Society transactions.

The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling

P. Cohen, S. Akira, O. Takeuchi, 2011, Proceedings of the National Academy of Sciences.

Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity

P. Cohen, A. Lamond, L. Trinkle-Mulcahy, 1997, FEBS letters.

Isolation and sequence analysis of a cDNA clone encoding a type‐1 protein phosphatase catalytic subunit: Homology with protein phosphatase 2A

P. Cohen, E. F. da Cruz e Silva, D. Campbell, 1987, FEBS letters.

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

Philip R. Cohen, P. Cohen, T. Hunt, 1993, FEBS letters.

Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi.

P. Cohen, L. Trinkle-Mulcahy, J. Lucocq, 2001, The Biochemical journal.

Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.

P. Cohen, D. Campbell, N. Moleleki, 2006, The Biochemical journal.

Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.

P. Cohen, A. Aitken, D. Rylatt, 1980, European journal of biochemistry.

DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA*

P. Cohen, A. Prescott, A. Ordureau, 2013, The Journal of Biological Chemistry.

DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.

P. Cohen, M. Peggie, S. Rousseau, 2009, Biochemical and biophysical research communications.

Multisite phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G by cyclic AMP‐dependent protein kinase and glycogen synthase kinase‐3

P. Cohen, P. Dent, D. Campbell, 1989, FEBS letters.

Comparison of calmodulin‐dependent glycogen synthase kinase from skeletal muscle and calmodulin‐dependent protein kinase‐II from brain

P. Cohen, J. Woodgett, T. Yamauchi, 1984, FEBS letters.

Phosphorylation of K-casein by glycogen synthase kinase-3 from rabbit skeletal muscle.

P. Cohen, B. Hemmings, L. Pinna, 1983, Biochimica et biophysica acta.

Glycogen synthase from rabbit skeletal muscle. State of phosphorylation of the seven phosphoserine residues in vivo in the presence and absence of adrenaline.

P. Cohen, P. Parker, N. Embi, 1982, European journal of biochemistry.

Glycogen synthase kinase-2 and phosphorylase kinase are the same enzyme.

P. Cohen, D. Rylatt, N. Embi, 1979, European journal of biochemistry.

Amino acid sequences at the two sites on glycogen synthetase phosphorylated by cyclic AMP‐dependent protein kinase and their dephosphorylation by protein phosphatase‐III

P. Cohen, C. Proud, D. Rylatt, 1977, FEBS letters.

The hormonal control of activity of skeletal muscle phosphorylase kinase. Phosphorylation of the enzyme at two sites in vivo in response to adrenalin.

P. Cohen, S. Yeaman, Philip Cohen, 1975, European journal of biochemistry.

Keep Nibbling at the Edges

P. Cohen, 2009, The Journal of Biological Chemistry.

Debranching enzyme from rabbit skeletal muscle; Evidence for the location of two active centres on a single polypeptide chain

P. Cohen, J. C. Kernohan, C. Taylor, 1975, FEBS letters.

The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.

P. Cohen, S. Bröer, T. Risler, 2003, Pflugers Archiv : European journal of physiology.

Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems

P. Cohen, 2005 .

Interleukin‐1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

P. Cohen, M. Peggie, N. Morrice, 2006, FEBS letters.

Phosphorylation of microtubule‐associated protein tau by isoforms of c‐Jun N‐terminal kinase (JNK)

P. Cohen, M. Goedert, C. J. Hastie, 2004, Journal of neurochemistry.

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.

Philip R. Cohen, P. Cohen, D. Stokoe, 1993, The Biochemical journal.

Role of Translocation in the Activation and Function of Protein Kinase B*

P. Cohen, M. Andjelkovic, D. Alessi, 1997, The Journal of Biological Chemistry.

Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase‐1

P. Cohen, S. Alemany, 1986, FEBS letters.

The structure and regulation of protein phosphatases.

P. Cohen, 1989, Annual review of biochemistry.

Purification of the hepatic glycogen‐associated form of protein phosphatase‐1 by microcystin‐Sepharose affinity chromatography

P. Cohen, C. MacKintosh, N. Morrice, 1995, FEBS letters.

The discovery of protein phosphatases: from chaos and confusion to an understanding of their role in cell regulation and human disease.

P. Cohen, 1994, BioEssays : news and reviews in molecular, cellular and developmental biology.

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.

P. Cohen, P. Ferrigno, P. Cohen, 1993, Molecular biology of the cell.

Characterization of the major phosphofructokinase-dephosphorylating protein phosphatases from Ascaris suum muscle.

P. Cohen, H. Hofer, C. MacKintosh, 1992, Biochimica et biophysica acta.

Targeting subunits for protein phosphatases.

P. Cohen, M. Hubbard, 1991, Methods in enzymology.

An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A.

P. Cohen, L. Pinna, H. Meyer, 1990, Biochimica et biophysica acta.

P. Cohen, M. Stark, D. Schelling, 1989, FEBS letters.

The major type-1 protein phosphatase catalytic subunits are the same gene products in rabbit skeletal muscle and rabbit liver.

P. Cohen, P. Cohen, H. M. Barker, 1989, Biochimica et biophysica acta.

Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.

P. Cohen, M. Gelb, M. Goedert, 1999, European journal of biochemistry.

Ubiquitin chains as second messengers

P. Cohen, 2018, Nature Reviews Molecular Cell Biology.

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

P. Cohen, D. Campbell, M. Peggie, 2009, Proceedings of the National Academy of Sciences.

Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.

Philip R. Cohen, P. Cohen, F. Hofmann, 2005, European journal of biochemistry.

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 rsk That Are Inducible by MAPK*

P. Cohen, J. Avruch, K. Dalby, 1998, The Journal of Biological Chemistry.

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

P. Cohen, U. Rapp, H. Paterson, 1993, Oncogene.

The glycogen-binding subunit of protein phosphatase-1G from rabbit skeletal muscle. Further characterisation of its structure and glycogen-binding properties.

P. Cohen, M. Hubbard, 1989, European journal of biochemistry.

Amino acid sequence of a region on the glycogen‐binding subunit of protein phosphatase‐1 phosphorylated by cyclic AMP‐dependent protein kinase

P. Cohen, F. Caudwell, A. Hiraga, 1986, FEBS letters.

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

P. Cohen, N. Morrice, S. Frame, 2002, FEBS letters.

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation.

P. Cohen, 2009, The Biochemical journal.

Tyrosine phosphorylation of a c-Src-like protein is increased in membranes of CD4- CD8- T lymphocytes from lpr/lpr mice

P. Cohen, J. Ting, T. Katagiri, 1989, Molecular and cellular biology.

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli

P. Cohen, L. Mahadevan, A. Cuenda, 1997, Oncogene.

Okadaic acid‐sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

P. Cohen, P. Blackshear, P. Clarke, 1993, FEBS letters.

Mechanism of activation of protein kinase B by insulin and IGF‐1.

P. Cohen, M. Andjelkovic, D. Alessi, 1996, The EMBO journal.

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro.

P. Cohen, D. Campbell, M. Peggie, 2003, The Biochemical journal.

Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons

P. Cohen, E. Karran, R. Kinloch, 2002, Neuroscience Letters.

Characterization of the reversible phosphorylation and activation of ERK8.

P. Cohen, M. Peggie, N. Morrice, 2006, The Biochemical journal.

Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells*

P. Cohen, H. Choi, M. Peggie, 2012, The Journal of Biological Chemistry.

Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.

P. Cohen, T. Haystead, P. Cohen, 1996, European journal of biochemistry.

erum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN 5 A

P. Cohen, F. Lang, B. Pieske, 2003 .

Characterisation of neprilysin (EC 3.4.24.11) S2′ subsite

P. Cohen, P. Crine, P. Cohen, 1997, FEBS letters.

Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2.

Philip R. Cohen, P. Cohen, L. Mahadevan, 1996, Oncogene.

The role of TBK1 and IKKε in the expression and activation of Pellino 1.

P. Cohen, J. Lescar, R. Gourlay, 2011, The Biochemical journal.

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.

P. Cohen, R. Crowther, M. Vandermeeren, 1994, The Biochemical journal.

Assay of protein kinases using radiolabeled ATP: a protocol

P. Cohen, C. J. Hastie, H. Mclauchlan, 2006, Nature Protocols.

Mechanism of activation and function of protein kinase B.

P. Cohen, D. Alessi, 1998, Current opinion in genetics & development.

Regulation of glycogen phosphorylase and glycogen synthase by adrenalin in soleus muscle of phosphorylase-kinase-deficient mice.

P. Cohen, P. Cohen, Y. Le Marchand Brustel, 2005, European journal of biochemistry.

The amino acid sequence of a mammalian MAP kinase kinase.

A. Ashworth, P. Cohen, S. Nakielny, 1992, Oncogene.

Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6).

P. Cohen, M. Goedert, M. Craxton, 1997, Biochemical Society transactions.

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways.

Edward M. Rosser, P. Cohen, A. Hulme, 2004, Organic & biomolecular chemistry.

The control of phosphorylase kinase phosphatase by “second site phosphorylation”; A new form of enzyme regulation

P. Cohen, J. Antoniw, 1973, FEBS letters.

Identification of three in vivo phosphorylation sites on the glycogen‐binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline

P. Cohen, P. Dent, D. Campbell, 1990, FEBS letters.

Phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G in response to adrenalin

P. Cohen, D. Campbell, C. MacKintosh, 1988, FEBS letters.

Further studies on the structure of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscle.

P. Cohen, B. Kemp, A. Hiraga, 1987, European journal of biochemistry.

The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function.

H. Tung, P. Cohen, S. Shenolikar, 1984, European journal of biochemistry.

Antagonistic effects of insulin and beta-adrenergic agonists on the activity of protein phosphatase inhibitor-1 in skeletal muscle of the perfused rat hemicorpus.

P. Cohen, L. Jefferson, J. Foulkes, 1982, The Journal of biological chemistry.

Specificity of a protein phosphatase inhibitor from rabbit skeletal muscle.

P. Cohen, J. Antoniw, G. Nimmo, 1977, The Biochemical journal.

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

P. Cohen, A. Casamayor, D. Alessi, 1999, The Biochemical journal.

THE ROLE OF GLYCOGEN SYNTHASE KINASE 2 IN THE REGULATION OF GLYCOGEN SYNTHASE

P. Cohen, S. Shenolikar, C. Proud, 1978 .

Molecular mass of inhibitor-2 from rabbit liver.

P. Cohen, A. A. Chisholm, 1985, Biochimica et biophysica acta.

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Organisation of the seven sites in the polypeptide chain.

P. Cohen, A. Aitken, C. Picton, 1982, European journal of biochemistry.

Amino acid sequence at the site on rabbit skeletal muscle glycogen synthase phosphorylated by the endogenous glycogen synthase kinase‐2 activity

P. Cohen, D. Rylatt, 1979, FEBS letters.

Glycogen synthase kinase‐2 from rabbit skeletal muscle is activated by the calcium‐dependent regulator protein

P. Cohen, D. Rylatt, N. Embi, 1979, FEBS letters.

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

P. Cohen, J. van der Kaay, C. Downes, 1997, FEBS letters.

IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.

P. Cohen, S. Rousseau, Huei-Ting Yang, 2008, Cellular signalling.

The broad specificity protein phosphatase from mammalian liver

P. Cohen, T. Ingebritsen, J. Foulkes, 1980, FEBS letters.

Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin.

P. Cohen, A. A. Chisholm, 1988, Biochimica et biophysica acta.

Primary structure analysis proves that protein phosphatases 2C1 and 2C2 are isozymes.

P. Cohen, D. Campbell, C. McGowan, 1987, Biochimica et biophysica acta.

The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles

P. Cohen, A. A. Chisholm, 1988 .

Insulin activates glycogen synthase in phosphorylase kinase deficient mice

P. Cohen, Y. Le Marchand-Brustel, P. Cohen, 1979, FEBS letters.

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.

P. Cohen, T. Unterman, G. Rena, 2001, The Biochemical journal.

Protein phosphorylation and hormone action.

P. Cohen, J. Antoniw, H. G. Nimmo, 1988, Ciba Foundation symposium.

The protein phosphatases involved in cellular regulation. 4. Classification of two homogeneous myosin light chain phosphatases from smooth muscle as protein phosphatase-2A1 and 2C, and a homogeneous protein phosphatase from reticulocytes active on protein synthesis initiation factor eIF-2 as protein

P. Cohen, B. Safer, D. Crouch, 1983, European journal of biochemistry.

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

P. Cohen, A. Ordureau, M. Peggie, 2008, The Biochemical journal.

Tau protein in Alzheimer's disease.

P. Cohen, R. Crowther, E. Vanmechelen, 1995, Biochemical Society transactions.

Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase.

P. Cohen, J. Coggins, C. MacKintosh, 1991, The Biochemical journal.

The phosphorylation of stathmin by MAP kinase

P. Cohen, D. Campbell, P. Curmi, 1993, Molecular and Cellular Biochemistry.

Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.

P. Cohen, Y. Kim, H. Matthews, 1993, The Journal of biological chemistry.

Comparative study of dogfish and rabbit muscle phosphorylases.

P. Cohen, E. Fischer, J. C. Saari, 1973, Biochemistry.

Phosphorylase from dogfish skeletal muscle. Purification and a comparison of its physical properties to those of rabbit muscle phosphorylase.

P. Cohen, E. Fischer, T. Duewer, 1971, Biochemistry.

Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.

P. Cohen, M. Shaw, 1999, FEBS letters.

Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4 and glycogen synthase kinase 5 from rabbit skeletal muscle.

A Aitken, P. Cohen, A. Aitken, 1982, European journal of biochemistry.

Protein phosphatases: properties and role in cellular regulation.

P. Cohen, T. Ingebritsen, P. Cohen, 1983, Science.

The protein phosphatases involved in cellular regulation. 6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues; an assessment of their physiological roles.

P. Cohen, T. Ingebritsen, A. Stewart, 1983, European journal of biochemistry.

Regulation and Physiological Roles of Serum- and Glucocorticoid-Induced Protein Kinase Isoforms

P. Cohen, F. Lang, 2001, Science's STKE.

GSK3 takes centre stage more than 20 years after its discovery.

P. Cohen, S. Frame, P Cohen, 2001, The Biochemical journal.

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

P. Cohen, D. Rylatt, N. Embi, 1980, European journal of biochemistry.

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.

P. Cohen, M. Goedert, P. Eyers, 1998, Chemistry & biology.

Regulation of the activity and expression of ERK8 by DNA damage

P. Cohen, Iva Klevernic, N. Martin, 2009, FEBS letters.

Specificity and mechanism of action of some commonly used protein kinase inhibitors

P. Cohen, S. Davies, H. Reddy, 2000 .

Discovery of A Ca2+‐and calmodulin‐dependent protein phosphatase

P. Cohen, C. Klee, T. Ingebritsen, 1982, FEBS letters.

Signal integration at the level of protein kinases, protein phosphatases and their substrates.

P. Cohen, P Cohen, 1992, Trends in biochemical sciences.

The calmodulin-dependent glycogen synthase kinase from rabbit skeletal muscle. Purification, subunit structure and substrate specificity.

M. T. Davison, P. Cohen, J. Woodgett, 1983, European journal of biochemistry.

The role of protein phosphorylation in neural and hormonal control of cellular activity

P. Cohen, Philip Cohen, 1982, Nature.

The coordinated control of metabolic pathways by broad-specificity protein kinases and phosphatases.

P. Cohen, 1985, Current topics in cellular regulation.

Classification of Protein Phosphatases Involved in Cellular Regulation

P. Cohen, J. Goris, B. Hemmings, 1981 .

The subunit structure of rabbit-skeletal-muscle phosphorylase kinase, and the molecular basis of its activation reactions.

P. Cohen, Philip Cohen, 1973, European journal of biochemistry.

Biotinylated anisomycin: a comparison of classical and "click" chemistry approaches.

P. Cohen, A. Hulme, R. Viguier, 2007, Bioconjugate chemistry.

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.

Stefan Knapp, Panagis Filippakopoulos, Jenny Bain, 2009, Journal of medicinal chemistry.

The role of protein phosphorylation in the hormonal control of enzyme activity.

P. Cohen, P. Cohen, 1985, European journal of biochemistry.

Identification of the sites in MAP kinase kinase‐1 phosphorylated by p74raf‐1.

A. Ashworth, P. Cohen, D. Alessi, 1994, The EMBO journal.

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.

P. Cohen, N. Gómez, H. Paterson, 1992, The Biochemical journal.

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

P. Cohen, N. Gómez, 1991, Nature.

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

P. Cohen, A. Ullrich, C. Marshall, 1994, Current Biology.

A multifunctional calmodulin‐dependent protein kinase

P. Greengard, P. Cohen, J. Woodgett, 1983, FEBS letters.

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.

P. Cohen, J. Mallet, J. Haavik, 1993, European journal of biochemistry.

[26] Phosphorylase kinase from rabbit skeletal muscle

P. Cohen, 1983 .

The protein phosphatases involved in cellular regulation. 1. Classification and substrate specificities.

P. Cohen, T. Ingebritsen, P Cohen, 1983, European journal of biochemistry.

Complete primary structure of protein phosphatase inhibitor-1 from rabbit skeletal muscle.

P. Cohen, A. Aitken, T. Bilham, 2005, European journal of biochemistry.

Glycogen synthase kinase-3 from rabbit skeletal muscle.

P. Cohen, B. Hemmings, B A Hemmings, 2005, Methods in enzymology.

The MgATP-dependent protein phosphatase and protein phosphatase 1 have identical substrate specificities.

P. Cohen, W. Merlevede, J. Goris, 2005, European journal of biochemistry.

A reinvestigation of the phosphorylation of rabbit skeletal-muscle glycogen synthase by cyclic-AMP-dependent protein kinase. Identification of the third site of phosphorylation as serine-7.

P. Cohen, P. Parker, N. Embi, 1981, European journal of biochemistry.

CALCIUM CONTROL OF MUSCLE PHOSPHORYLASE KINASE THROUGH THE COMBINED ACTION OF CALMODULIN AND TROPONIN *

P. Cohen, S. Shenolikar, C. Klee, 1980, Annals of the New York Academy of Sciences.

Phosphorylation of rabbit skeletal muscle phosphorylase kinase by cyclic GMP‐dependent protein kinase

P. Cohen, 1980, FEBS letters.

The role of calcium ions, calmodulin and troponin in the regulation of phosphorylase kinase from rabbit skeletal muscle.

P. Cohen, Philip Cohen, 1980, European journal of biochemistry.

Classification of an eIF‐2 phosphatase as a type‐2 protein phosphatase

P. Cohen, B. Safer, D. Crouch, 1980, FEBS letters.

The hormonal control of glycogen metabolism: dephosphorylation of protein phosphatase inhibitor‐1 in vivo in response to insulin

P. Cohen, L. Jefferson, J. Foulkes, 1980, FEBS letters.

The regulation of glycogen metabolism. Purification and properties of protein phosphatase inhibitor-2 from rabbit skeletal muscle.

P. Cohen, J. Foulkes, 1980, European journal of biochemistry.

The Hormonal Control of Glycogen Metabolism

P. Cohen, J. Foulkes, J. Foulkes, 1979 .

Evidence for the involvement of protein phosphatase‐1 in the regulation of metabolic processes other than glycogen metabolism

P. Cohen, J. Foulkes, A. Burchell, 1978, FEBS letters.

The Regulation of Glycogen Metaabolism

P. Cohen, G. Nimmo, 1978 .

The hormonal control of glycogen metabolism: The amino acid sequence at the phosphorylation site of protein phosphatase inhibitor‐1

P. Cohen, D. Rylatt, G. Nimmo, 1977, FEBS letters.

The substrate specificity of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of rabbit skeletal muscle.

P. Cohen, D. Watson, S. Yeaman, 1977, The Biochemical journal.

Separation of two phosphorylase kinase phosphatases from rabbit skeletal muscle.

P. Cohen, J. Antoniw, 1976, European journal of biochemistry.

PDK1, one of the missing links in insulin signal transduction? 1

P. Cohen, D. Alessi, D. Cross, 1997, FEBS letters.

The renaissance of GSK3

P. Cohen, S. Frame, Philip Cohen, 2001, Nature Reviews Molecular Cell Biology.

Protein phosphorylation and the control of glycogen metabolism in skeletal muscle.

P. Cohen, 1983, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Philip R. Cohen, P. Cohen, John C. Lee, 1995, FEBS letters.

Okadaic acid: a new probe for the study of cellular regulation.

P. Cohen, C. Holmes, Y. Tsukitani, 1990, Trends in biochemical sciences.

Role of Mitogen-Activated Protein Kinase Cascades in Mediating Lipopolysaccharide-Stimulated Induction of Cyclooxygenase-2 and IL-1β in RAW264 Macrophages1

P. Cohen, M. Caivano, 2000, The Journal of Immunology.

The protein phosphatases involved in cellular regulation. Primary structure of inhibitor-2 from rabbit skeletal muscle.

P. Cohen, A. Aitken, D. Campbell, 1986, European journal of biochemistry.

Purification and subunit structure of glycogen-branching enzyme from rabbit skeletal muscle.

P. Cohen, F. Caudwell, 1980, European journal of biochemistry.

The protein phosphatases involved in cellular regulation. 5. Purification and properties of a Ca2+/calmodulin-dependent protein phosphatase (2B) from rabbit skeletal muscle.

P. Cohen, T. Ingebritsen, P Cohen, 1983, European journal of biochemistry.

The Rigulation of Glycogen Metabolism

P. Cohen, G. Nimmo, 1978 .

Isolation and characterisation of active fragments of protein phosphatase inhibitor‐1 from rabbit skeletal muscle

P. Cohen, A. Aitken, Alastair Aitken, 1982, FEBS letters.

A specific substrate from rabbit cerebellum for guanosine-3':5'-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites.

P. Greengard, P. Cohen, D. Aswad, 1981, The Journal of biological chemistry.

Characterisation of a reconstituted Mg-ATP-dependent protein phosphatase.

H. Tung, P. Cohen, B. Hemmings, 1983, European journal of biochemistry.

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

P. Cohen, M. Israel, N. Rosen, 1986, The Journal of biological chemistry.

The protein phosphatases involved in cellular regulation. 1. Modulation of protein phosphatases-1 and 2A by histone H1, protamine, polylysine and heparin.

P. Cohen, S. Pelech, 1985, European journal of biochemistry.

Phosphorylase kinase from rabbit skeletal muscle: identification of the calmodulin-binding subunits.

P. Cohen, C. Klee, C. Picton, 1980, European journal of biochemistry.

Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban.

P. Cohen, L. Jones, L. MacDougall, 1991, European journal of biochemistry.

Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclin·CDK6 Phosphorylation of Caldesmon*

P. Cohen, S. Mittnacht, N. Morrice, 2005, Journal of Biological Chemistry.

Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle.

P. Cohen, Toshio Kitazawa, M. Ikebe, 1992, The Journal of biological chemistry.

The phosphorylation of rabbit skeletal muscle glycogen synthase by glycogen synthase kinase-2 and adenosine-3':5'-monophosphate-dependent protein kinase.

P. Cohen, C. Proud, H. G. Nimmo, 1976, European journal of biochemistry.

Role of protein kinase B and the MAP kinase cascade in mediating the EGF‐dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells 1

P. Cohen, M. Shaw, 1999 .

The search for physiological substrates of MAP and SAP kinases in mammalian cells.

P. Cohen, P Cohen, 1997, Trends in cell biology.

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Patrick G. A. Pedrioli, Christoph H. Emmerich, P. Cohen, 2013, Proceedings of the National Academy of Sciences.

The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

P. Cohen, E. Phizicky, M. Peggie, 2005, The EMBO journal.

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

P. Cohen, A. Ordureau, R. Toth, 2011, The Journal of experimental medicine.

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.

P. Cohen, A. Prescott, T. Unterman, 2001, The Biochemical journal.

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.

P. Cohen, P. Eyers, M. Gaestel, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Distribution of isoenzymes of the glycogenolytic cascade in different types of muscle fibre

P. Cohen, A. Burchell, P. Cohen, 1976, FEBS letters.

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease

P. Cohen, T. Hurd, S. Ralston, 2015, Cell reports.

The TLR and IL-1 signalling network at a glance

P. Cohen, 2014, Journal of Cell Science.

Immune diseases caused by mutations in kinases and components of the ubiquitin system

P. Cohen, Philip Cohen, 2014, Nature Immunology.

Molecular control of the NEMO family of ubiquitin-binding proteins

P. Cohen, S. Nanda, K. Clark, 2013, Nature Reviews Molecular Cell Biology.

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

Christoph H. Emmerich, P. Cohen, J. Arthur, 2017, Proceedings of the National Academy of Sciences.

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

P. Cohen, V. Poli, J. Arthur, 2000, Current Biology.

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence*

P. Cohen, T. Unterman, G. Rena, 1999, The Journal of Biological Chemistry.

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

P. Cohen, M. Gaestel, M. Lubas, 2015, RNA.

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.

P. Cohen, M. Peggie, Lorna Plater, 2009, The Journal of biological chemistry.

Activation of the MAP kinase pathway by the protein kinase raf

P. Cohen, C. Marshall, S. Nakielny, 1992, Cell.

Novel cross-talk within the IKK family controls innate immunity.

P. Cohen, J. Madwed, M. Peggie, 2011, The Biochemical journal.

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

P. Cohen, J. Arthur, S. Ley, 2018, The Journal of Immunology.

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1

P. Cohen, J. Arthur, F. Marchesi, 2016, The Journal of Immunology.

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

P. Cohen, T. Lawrence, M. Peggie, 2014, The Biochemical journal.

TAB3, a new binding partner of the protein kinase TAK1.

P. Cohen, A. Nebreda, P. Cheung, 2004, The Biochemical journal.

Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.

P. Cohen, M. Goedert, M. Spillantini, 1999, The Journal of biological chemistry.

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress‐ and cytokine‐stimulated monocytes and epithelial cells.

P. Cohen, M. Jones, A. Nebreda, 1996, The EMBO journal.

Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells.

Philip R. Cohen, P. Cohen, J. Rouse, 1996, European journal of biochemistry.

Molecular dissection of the paired helical filament

P. Cohen, E. Vanmechelen, M. Goedert, 1995, Neurobiology of Aging.

ABIN1 dysfunction as a genetic basis for lupus nephritis.

R. K. Oliver, P. Gaffney, P. Cohen, 2013, Journal of the American Society of Nephrology : JASN.

The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways

P. Cohen, S. Strickson, 2017, Cell Death and Differentiation.

University of Dundee The role of hybrid ubiquitin chains in the MyD 88 and other innate immune signalling pathways

P. Cohen, S. Strickson, 2017 .

ERF Nuclear Shuttling, a Continuous Monitor of Erk Activity That Links It to Cell Cycle Progression

P. Cohen, B. Biteau, G. Mavrothalassitis, 2004, Molecular and Cellular Biology.

The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells.

P. Cohen, J. Vandenheede, Y. Saito, 1994, The Biochemical journal.

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.

Philip R. Cohen, P. Cohen, M. Goedert, 2001, The Biochemical journal.

Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.

P. Cohen, M. Peggie, Lorna Plater, 2007, The Biochemical journal.

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

P. Cohen, M. Tcherpakov, Philip Cohen, 2010, Cell.

How does insulin stimulate glycogen synthesis?

P. Cohen, C. Proud, H. G. Nimmo, 1978, Biochemical Society symposium.

Structural and functional studies on rabbit liver glycogenin.

P. Cohen, C. Smythe, C. Villar-Palasi, 1989, European journal of biochemistry.

Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.

P. Cohen, A. Ullrich, C. Downes, 1995, European journal of biochemistry.

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.

P. Cohen, J. Lizcano, N. Morrice, 2000, The Biochemical journal.

Differential phosphorylation of ribosomal protein S6 in isolated rat hepatocytes after incubation with insulin and glucagon

P. Cohen, R. Wettenhall, R. Holland, 1982, FEBS letters.

The Induction of Cyclooxygenase-2 mRNA in Macrophages Is Biphasic and Requires both CCAAT Enhancer-binding protein β (C/EBPβ) and C/EBPδ Transcription Factors*

P. Cohen, V. Poli, M. Caivano, 2001, The Journal of Biological Chemistry.

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

P. Cohen, M. Andjelkovic, D. Alessi, 1996, FEBS letters.

Kinase drug discovery--what's next in the field?

Dario R Alessi, P. Cohen, D. Alessi, 2013, ACS chemical biology.

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

P. Cohen, G. Sapkota, F. Newell, 2007, The Biochemical journal.

Stimulation of enzyme activities by fragments of calmodulin

P. Cohen, J. Kuźnicki, Z. Grabarek, 1981, FEBS letters.

Protein phosphatase-2B from rabbit skeletal muscle: a Ca2+-dependent, calmodulin-stimulated enzyme.

P. Cohen, A. Stewart, 1988, Methods in enzymology.

TAK1-binding protein 1 is a pseudophosphatase.

P. Cohen, A. W. Schüttelkopf, D. V. van Aalten, 2006, The Biochemical journal.

Isolation and characterisation of cyclic AMP‐dependent phosphorylation sites from rat liver ribosomal protein S6

P. Cohen, R. Wettenhall, 1982, FEBS letters.

BI-D 1870 is a specific inhibitor of the p 90 RSK ( ribosomal S 6 kinase ) isoforms in vitro and in vivo

P. Cohen, G. Sapkota, F. Newell, 2006 .

Nuts and bolts of the salt-inducible kinases (SIKs)

P. Cohen, Nicola J. Darling, 2021, The Biochemical journal.

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

Patrick G. A. Pedrioli, Nathanael S. Gray, P. Cohen, 2012, Proceedings of the National Academy of Sciences.

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

P. Cohen, N. Gray, K. Westover, 2014, Journal of medicinal chemistry.

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

P. Cohen, S. Klumpp, D. Schelling, 1989, FEBS letters.

On target with a new mechanism for the regulation of protein phosphorylation.

P. Cohen, P Cohen, M J Hubbard, 1993, Trends in biochemical sciences.

MAP kinase activator from insulin‐stimulated skeletal muscle is a protein threonine/tyrosine kinase.

Philip R. Cohen, P. Cohen, T. Sturgill, 1992, The EMBO journal.

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

P. Cohen, N. Gray, A. Prescott, 2015, The Biochemical journal.

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

P. Cohen, D. Alessi, N. Gómez, 1995, Current Biology.

Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage.

P. Cohen, Iva Klevernic, Simon Morton, 2009, The Biochemical journal.

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.

P. Cohen, S. Ghosh, M. Gaestel, 2008, The Biochemical journal.

Roles for TAB 1 in regulating the IL-1-dependent phosphorylation of the TAB 3 regulatory subunit and activity of the TAK 1 complex

P. Cohen, S. Ghosh, M. Gaestel, 2008 .

A reinvestigation of the multisite phosphorylation of the transcription factor c‐Jun

P. Cohen, Simon Morton, R. Davis, 2003, The EMBO journal.

The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor.

W. Fiers, P. Cohen, John C. Lee, 1996, The EMBO journal.

Requirement of Mitogen-Activated Protein Kinases and IκB Phosphorylation for Induction of Proinflammatory Cytokines Synthesis by Macrophages Indicates Functional Similarity of Receptors Triggered by Glycosylphosphatidylinositol Anchors from Parasitic Protozoa and Bacterial Lipopolysaccharide1

P. Cohen, I. C. Almeida, M. Ferguson, 2001, The Journal of Immunology.

Lipopolysaccharidefrom Parasitic Protozoa and Bacterial by Glycosylphosphatidylinositol Anchors Functional Similarity of Receptors Triggered Synthesis by Macrophages Indicates Induction of Proinflammatory Cytokines B Phosphorylation for k Kinases and I Requirement of Mitogen-Activated Protein

P. Cohen, I. C. Almeida, M. Ferguson, 2001 .

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

P. Cohen, M. Goedert, A. Paterson, 2000, The Biochemical journal.

Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3

P. Cohen, M. Peggie, Thomas Macartney, 2017, The Biochemical journal.

Dephosphorylation and activation of Acetyl‐CoA‐carboxylase from lactating rabbit mammary gland

P. Cohen, D. Hardie, P. Cohen, 1979, FEBS letters.

Signalling pathways involved in multisite phosphorylation of the transcription factor ATF‐2

P. Cohen, Simon Morton, R. Davis, 2004, FEBS letters.

The initiation of biological function by limited proteolysis

P. Cohen, 1983 .

The purification and characterization of protein phosphatase inhibitor-1 from rabbit skeletal muscle.

P. Cohen, G. Nimmo, 1978, Biochemical Society transactions.

The regulation of glycogen metabolism. Purification and characterisation of protein phosphatase inhibitor-1 from rabbit skeletal muscle.

P. Cohen, G. Nimmo, 1978, European journal of biochemistry.

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

P. Cohen, V. Rao, J. Arthur, 2019, Life Science Alliance.

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

P. Cohen, M. Goedert, P. Hedge, 1999, Oncogene.

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

P. Cohen, C. Sutherland, C. Sutherland, 1993, The Biochemical journal.

The regulation of protein function by multisite phosphorylation

P. Cohen, 1976 .

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Patrick G. A. Pedrioli, P. Cohen, H. Cai, 2012, PloS one.

Feedback control of the protein kinase TAK1 by SAPK2a/p38α

P. Cohen, D. Campbell, A. Nebreda, 2003, The EMBO journal.

Multisite phosphorylation of glycogen synthase. Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5).

Philip R. Cohen, P. Cohen, J. Woodgett, 1984, Biochimica et biophysica acta.

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.

P. Cohen, Takayasu Kobayashi, T. Kobayashi, 1999, The Biochemical journal.

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.

P. Cohen, S. Akira, J. Arthur, 2012, The Biochemical journal.

Report Optineurin Negatively Reg ulates Osteoclast Differentiation by Modulating NFk B and Interferon Signaling : Implications for Paget ’ s Disease Graphical Abstract Highlights

P. Cohen, T. Hurd, S. Ralston, 2015 .

A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin

P. Cohen, M. Goedert, I. Nathke, 1999, FEBS letters.

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

David Stokoe, P. Cohen, M. Gaestel, 1992, FEBS letters.

The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

P. Cohen, C. Sutherland, 1994, FEBS letters.

Rat mammary gland ATP‐citrate lyase is phosphorylated by cyclic AMP‐dependent protein kinase

P. Cohen, D. Hardie, P. Guy, 1980, FEBS letters.

Paradoxical activation of Raf by a novel Raf inhibitor.

Philip R. Cohen, P. Cohen, M. Goedert, 1999, Chemistry & biology.

The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

P. Cohen, D. Alessi, M. Ikebe, 1992, European journal of biochemistry.

A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin.

P. Cohen, P. Dent, D. Campbell, 1992, European journal of biochemistry.

Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.

H. Tung, P. Cohen, B. Hemmings, 1988, Methods in enzymology.

Dissection of protein kinase cascades that mediate cellular response to cytokines and cellular stress.

P. Cohen, 1996, Advances in pharmacology.

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr‐180 and Tyr‐182 and both residues are phosphorylated in chemically stressed KB cells

P. Cohen, A. Nebreda, A. Cuenda, 1995, FEBS letters.

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase.

Philip R. Cohen, P. Cohen, D. Campbell, 1993, European journal of biochemistry.

MAP kinase kinase from rabbit skeletal muscle A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone‐dependent signal transduction

P. Cohen, D. Campbell, S. Nakielny, 1992, FEBS letters.

Substrate specificity of a multifunctional calmodulin-dependent protein kinase.

P. Cohen, J. Woodgett, R. Pearson, 1985, The Journal of biological chemistry.

MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts

P. Cohen, J. Arthur, Victoria Murray-Tait, 2002, Molecular and Cellular Biology.

Novel protein serine/threonine phosphatases: variety is the spice of life.

P. Cohen, P T Cohen, 1997, Trends in biochemical sciences.

Phosphorylation of the Cytoplasmic Domain of the Integrin CD18 Chain by Protein Kinase C Isoforms in Leukocytes*

P. Cohen, S. Fagerholm, C. Gahmberg, 2002, The Journal of Biological Chemistry.

The molecular basis of skeletal muscle phosphorylase kinase deficiency.

P. Cohen, A. Burchell, P. Cohen, 1976, European journal of biochemistry.

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Christoph H. Emmerich, P. Cohen, D. Campbell, 2013, The Biochemical journal.

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.

Wei Zhang, P. Cohen, Shuai Liu, 2016, Blood.

Targeting IRAK1/IRAK4 Signaling in Waldenstrom's Macroglobulinemia

P. Cohen, N. Gray, S. Treon, 2015 .

CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway.

P. Cohen, M. Tessier-Lavigne, M. Gaestel, 2006, Cellular signalling.

Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases*

P. Cohen, J. Yates, M. Gelb, 2000, The Journal of Biological Chemistry.

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.

P. Cohen, F. Lang, Dietmar Kuhl, 2004, The Biochemical journal.

Protein phosphatases come of age.

P. Cohen, P Cohen, P T Cohen, 1989, The Journal of biological chemistry.

An analysis of the substrate specificity of insulin-stimulated protein kinase-1, a mammalian homologue of S6 kinase-II.

P. Cohen, A. Lavoinne, L. Pinna, 1993, Biochimica et biophysica acta.

Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of IκBα Kinase

P. Cohen, M. Peggie, M. Stafford, 2008, Molecular and Cellular Biology.

The structure of the B subunit of calcineurin.

P. Cohen, C. Klee, A. Aitken, 1984, European journal of biochemistry.

Identification of a calmodulin‐dependent glycogen synthase kinase in rabbit skeletal muscle, distinct from phosphorylase kinase

P. Cohen, J. Woodgett, N. Tonks, 1982, FEBS letters.

Identification of N-terminal myristyl blocking groups in proteins.

P. Cohen, A. Aitken, 1984, Methods in enzymology.

PROTEIN PHOSPHORYLATION AND THE NEURAL AND HORMONAL CONTROL OF ENZYME ACTIVITY1

P. Cohen, J. Woodgett, A. Aitken, 1983 .

The regulation of muscle phosphorylase kinase by calcium ions, calmodulin and troponin-C.

P. Cohen, C. Klee, C. Picton, 1981, Cell calcium.

The Neural and Hormonal Control of Glycogen Metabolism in Mammalian Skeletal Muscle

P. Cohen, 1981 .

Immunolocalisation of protein phosphatase inhibitor-1 in the cerebral cortex of the rat, cat and ferret

P. Cohen, P. Lowenstein, L. MacDougall, 1995, Brain Research.

Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid

P. Cohen, T. Flatmark, J. Haavik, 1989, FEBS letters.

Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues.

P. Cohen, D. Campbell, M. Hubbard, 1989, Biochimica et biophysica acta.

Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic-AMP-dependent protein kinase promotes translocation of the phosphatase from glycogen to cytosol in rabbit skeletal muscle.

P. Cohen, A. Hiraga, 1986, European journal of biochemistry.

A kinetic analysis of the effects of inhibitor-1 and inhibitor-2 on the activity of protein phosphatase-1.

P. Cohen, P. Henderson, J. Foulkes, 1983, European journal of biochemistry.

Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

P. Cohen, C. Hall-Jackson, Y. N. Doza, 1998, Oncogene.

The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells.

P. Cohen, A. Cuenda, F. Thomson, 1995, The Biochemical journal.

Identification of high levels of type 1 and type 2A protein phosphatases in higher plants.

P. Cohen, C. MacKintosh, 1989, The Biochemical journal.

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid.

P. Cohen, M. Goedert, 1998, Chemistry & biology.

The specificity of adenosine 3':5'-cyclic monophosphate-dependent protein kinase.

P. Cohen, S. Yeaman, 1976, Biochemical Society transactions.

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells

P. Cohen, J. Arthur, A. Knebel, 2019, Proceedings of the National Academy of Sciences.

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event.

Adam Cole, P. Cohen, A. Cole, 2004, The Biochemical journal.

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

P. Cohen, L. Pearl, M. Peggie, 2005, Molecular cell.

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

P. Cohen, G. Sapkota, C. Hill, 2019, Cell Death & Disease.

Amino acid sequence and expression of the hepatic glycogen‐binding (GL‐subunit of protein phosphatase‐1

P. Cohen, G. Moorhead, N. Morrice, 1995, FEBS letters.

Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA*

P. Cohen, D. Barford, J. Arthur, 2012, The Journal of Biological Chemistry.

A non-radioactive method for the assay of many serine/threonine-specific protein kinases.

P. Cohen, H. Ross, Philip Cohen, 2002, The Biochemical journal.

Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin.

P. Cohen, C. Smythe, D. Campbell, 1987, European journal of biochemistry.

The protein phosphatases involved in cellular regulation. Identification of the inhibitor-2 phosphatases in rabbit skeletal muscle.

P. Cohen, N. Tonks, 1984, European journal of biochemistry.

BI-D 1870 is a specific inhibitor of the p 90 Ribosomal S 6 Kinase ( RSK ) isoforms in vitro and in vivo

P. Cohen, G. Sapkota, F. Newell, 2006 .

The Proteink Phosphatases Involved in Cellur Regulation

P. Cohen, J. Foulkes, Thomas S. Ingerbritsen, 1983 .

The past and future of protein phosphatase research.

P. Cohen, 2003, Methods in Enzymology.

Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

P. Cohen, B. Blagoev, V. Akimov, 2022, The Biochemical journal.

15-Deoxy-Δ12,14-prostaglandin J2 Regulates Endogenous Cot MAPK Kinase Kinase 1 Activity Induced by Lipopolysaccharide*

P. Cohen, S. Alemany, M. Caivano, 2003, Journal of Biological Chemistry.

Regulation of protein phosphatase-1G from rabbit skeletal muscle. 2. Catalytic subunit translocation is a mechanism for reversible inhibition of activity toward glycogen-bound substrates.

P. Cohen, P. Cohen, M. Hubbard, 1989, European journal of biochemistry.

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium.

P. Cohen, D. Alessi, S. Kobayashi, 1992, The Journal of biological chemistry.

The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products.

H. Tung, P. Cohen, S. Shenolikar, 1984, European journal of biochemistry.

THE STRUCTURE AND REGIJLATION OF PROTEIN PHOSPHAT ASES

P. Cohen, 1989 .

K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK

P. Cohen, F. Lang, G. Henke, 2002, Pflügers Archiv.

Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages.

P. Cohen, M. Caivano, 2000, Journal of immunology.

TAK1 Inhibition in the DFG‐Out Conformation

Peter G. Dodd, P. Cohen, W. P. Hoorn, 2013, Chemical biology & drug design.

Protein phosphatase inhibitor-1 and inhibitor-2 from rabbit skeletal muscle.

P. Cohen, N. Tonks, C. Holmes, 1988, Methods in enzymology.

Mitogen-activated protein kinase (MAP kinase), MAP kinase kinase and c-Mos stimulate glucose transport in Xenopus oocytes.

P. Cohen, D. Stokoe, A. Nebreda, 1993, The Biochemical journal.

Separation of two phosphorylase kinase phosphatase activities in rabbit skeletal muscle.

P. Cohen, J. Antoniw, 1975, Biochemical Society transactions.

Structure and Regulation of Enzymes for the Degradation and Resynthesis of Glycogen

P. Cohen, C. Proud, J. Antoniw, 1975 .

Glycogen synthetase kinase 2 and adenosine 3':5'-cyclic monophosphate-independent protein kinase activities in rabbit skeletal muscle.

P. Cohen, H. G. Nimmo, 1975, Biochemical Society Transactions.

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

P. Cohen, S. Arthur, C. Eyers, 2005, The Biochemical journal.

Enzyme regulation by reversible phosphorylation : further advances

P. Cohen, 1984 .

Hormones, second messengers and the reversible phosphorylation of proteins: An overview

P. Cohen, 1985 .

Stress-activated Protein Kinase-3 Interacts with the PDZ Domain of α1-Syntrophin

P. Cohen, M. Goedert, M. Spillantini, 1999, The Journal of Biological Chemistry.

The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors.

P. Cohen, V. Poli, M. Caivano, 2001, The Journal of biological chemistry.

The role of phosphorylase kinase in the nervous and hormonal control of glycogenolysis in muscle.

P. Cohen, 1974, Biochemical Society symposium.

Chapter 9 – The Role of Calmodulin and Troponin in the Regulation of Phosphorylase Kinase from Mammalian Skeletal Muscle

P. Cohen, 1980 .

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

P. Cohen, J. Bain, P. Moreau, 2010, Bioorganic & Medicinal Chemistry.

Targetting of protein phosphatase 1 to the sarcoplasmic reticulum of rabbit skeletal muscle by a protein that is very similar or identical to the G subunit that directs the enzyme to glycogen.

P. Cohen, C. Smythe, P. Dent, 1990, European journal of biochemistry.

Distinct type-1 protein phosphatases are associated with hepatic glycogen and microsomes.

P. Cohen, D. Leader, V. Zammit, 1988, Biochimica et biophysica acta.

Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A.

Florian Lang, Heinrich Brinkmeier, Burkert Pieske, 2003, Cardiovascular research.

Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction.

P. Cohen, M. Gaestel, N. Morrice, 2002, Archives of biochemistry and biophysics.

Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.

P. Cohen, D. Alessi, P. Cohen, 1993, European journal of biochemistry.

The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles.

P. Cohen, A. A. Chisholm, 1988, Biochimica et biophysica acta.

MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.

P. Cohen, H. Hidaka, D. Stokoe, 1992, The EMBO journal.

Homology between the catalytic subunits of protein phosphatases 1 and 2A deduced from the cDNA.

P. Cohen, D. Campbell, N. Berndt, 1988, Advances in experimental medicine and biology.

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.

P. Cohen, J. Arthur, J. Bryans, 2012, Bioorganic & medicinal chemistry letters.

MAPPING THE REGULATORY PATHWAYS OF GLYCOGEN METABOLISM IN MAMMALIAN SKELETAL MUSCLE

P. Cohen, 1978 .

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing.

P. Cohen, A. Lamond, J. E. Mermoud, 1992, Nucleic acids research.

The role of calmodulin, troponin, and cyclic AMP in the regulation of glycogen metabolism in mammalian skeletal muscle.

P. Cohen, 1981, Advances in cyclic nucleotide research.

Activation and phosphorylation of the subunits of phosphorylase kinase.

P. Cohen, 1972, The Biochemical journal.

Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.

P. Cohen, 1993, Biochemical Society transactions.

Control of Enzyme Activity

P. Cohen, Philip Cohen, 1976 .

Molecular mechanisms involved in the control of glycogenolysis in skeletal muscle by calcium ions and cyclic AMP.

P. Cohen, 1987, Biochemical Society transactions.

The structure and regulation of protein phosphatases.

P. Cohen, 1989, Annual review of biochemistry.

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β

P. Cohen, S. Bakshi, Jordan Taylor, 2017, The Biochemical journal.

The Role of the α and β Subunits in the Regulation of Phosphorylase Kinase Activity

M. T. Davison, P. Cohen, J. Antoniw, 1974 .

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

P. Cohen, A. Casamayor, D. Alessi, 1999, The Biochemical journal.