I. Graef

发表

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

K. Deisseroth, R. Tsien, I. Graef, 1999, Nature.

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Xin Gao, I. Graef, J. Neilson, 2006, Nature.

Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation

I. Graef, G. Crabtree, J. Ranish, 2009, Science.

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.

I. Graef, Fang Liu, R. Zamboni, 2018, Journal of medicinal chemistry.

Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP 70 of myristoylation was to bring the src-like tyrosine kinases

S. Schreiber, I. Graef, G. Crabtree, 2013 .

The Transcriptional Paradox: Octamer Factors and B and T Cells

I. Graef, G. Crabtree, 1997, Science.

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

F. Alt, I. Graef, G. Crabtree, 1998, Current Biology.

Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis (cid:1)

I. Graef, G. Crabtree, Xiaoyong Yang, 2006 .

A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis

I. Graef, K. Stankunas, J. Neilson, 2004, Cell.

Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes

I. Graef, G. Crabtree, Anirvan Ghosh, 2007, Neuron.

An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development

R. Aebersold, I. Graef, G. Crabtree, 2007, Neuron.

Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

I. Graef, G. Crabtree, A. Nishi, 2022, Molecular Brain.

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.

G. Fishell, I. Graef, Mercedes F. Paredes, 2018, Cell reports.

Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

Feng Chen, Ann Kuo, I. Graef, 2001, Cell.

The mechanism of action of cyclosporin A and FK506.

L Timmermann, I. Graef, G. Crabtree, 1996, Clinical immunology and immunopathology.

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

E. Wagner, I. Graef, M. Karin, 2001, The Journal of experimental medicine.

Lower brain pH as a shared endophenotype of psychotic disorders

I. Graef, G. Crabtree, K. Nakayama, 2016, bioRxiv.

NFAT signaling and the invention of vertebrates.

I. Graef, G. Crabtree, Hai Wu, 2007, Trends in cell biology.

Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development.

I. Graef, K. Stankunas, J. Neilson, 1999, Cold Spring Harbor symposia on quantitative biology.

Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).

E. Wagner, I. Graef, G. Crabtree, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Proximity and orientation underlie signaling by the non‐receptor tyrosine kinase ZAP70

S. Schreiber, I. Graef, G. Crabtree, 1997, The EMBO journal.

Bursting into the Nucleus

I. Graef, G. Crabtree, 2008, Science Signaling.

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

T. Oliver, Xiaoping Zhou, I. Graef, 2007, Proceedings of the National Academy of Sciences.

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

I. Graef, I. Wilson, M. Liedtke, 2013, Proceedings of the National Academy of Sciences.

Calcineurin Signaling Regulates Neural Induction through Antagonizing the BMP Pathway

I. Graef, Marius Wernig, Erik L. Miller, 2014, Neuron.

Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis

I. Graef, G. Crabtree, Xiaoyong Yang, 2006, Molecular and Cellular Biology.

Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons

Fan Wang, Marc Tessier-Lavigne, Frederic Charron, 2003, Cell.

NFAT signaling in vertebrate development.

I. Graef, G. Crabtree, F. Chen, 2001, Current opinion in genetics & development.

Recruitment of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Signaling Pathway to the NFATc4 Transcription Activation Complex

I. Graef, G. Crabtree, C. Chow, 2005, Molecular and Cellular Biology.

A general strategy for producing conditional alleles of Src-like tyrosine kinases.

S. Schreiber, I. Graef, G. Crabtree, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Both human and mouse cells expressing H-2Kb and ovalbumin process the same peptide, SIINFEKL.

I. Graef, H. Rammensee, N. Shastri, 1993, Cellular immunology.

‘Nature-inspired’ drug–protein complexes as inhibitors of Aβ aggregation

I. Graef, G. Crabtree, J. Gestwicki, 2005 .

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Keiichi I Nakayama, Tsuyoshi Miyakawa, Hirotaka Shoji, 2017, Neuropsychopharmacology.

Evolutionary relationships among Rel domains indicate functional diversification by recombination

I. Graef, G. Crabtree, U. Francke, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

I. Graef, I. Wilson, J. Kelly, 2011, Science Translational Medicine.

Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis

I. Graef, Zhenjie Zhang, Lu Chen, 2015, Proceedings of the National Academy of Sciences.

Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology

I. Graef, K. Mitchell, A. Chédotal, 2016, bioRxiv.

Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid ß Aggregation

Jason E Gestwicki, I. Graef, G. Crabtree, 2004, Science.

Activity Regulates Cell De ath within Cortical Interneurons through a Calcineurin-Dependent Mechanism Graphical

G. Fishell, I. Graef, Mercedes F. Paredes, 2018 .

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

K. Yamakawa, H. Kasai, I. Graef, 2024, eLife.

Design of β-amyloid aggregation inhibitors from a predicted structural motif.

V. Pande, I. Graef, A. Esteras-Chopo, 2012, Journal of medicinal chemistry.

Calcineurin/NFAT Signaling in Development and Function of the Nervous System

I. Graef, G. Crabtree, Fan Wang, 2006 .

Abstract 19616: AG10 Stabilizes Pathogenic TTR Variants With High Potency - Potential for an Effective Treatment for TTR Cardiomyopathy

I. Graef, D. Judge, M. Liedtke, 2017 .

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

I. Graef, I. Wilson, E. Powers, 2011, Science Translational Medicine.

Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation

I. Graef, G. Crabtree, J. Ranish, 2009, Science.